Cloning and stable expression of the mGluR1b subtype of human metabotropic receptors and pharmacological comparison with the mGluR5a subtype

Neuropharmacology

Volumn 36, Issue 7, 1997, Pages 917-931

  Lin, F F ^a   Varney, M ^a   Sacaan, A I ^a   Jachec, C ^a   Daggett, L P ^a   Rao, S ^a   Flor, P ^b   Kuhn, R ^b   Kerner, J A ^c   Standaert, D ^c   Young, A B ^c   Velicelebi G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cloning; Distribution; Functional expression; Pharmacological profiling

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 3,5 DIHYDROXYPHENYLGLYCINE; 4 CARBOXY 3 HYDROXYPHENYLGLYCINE; COMPLEMENTARY DNA; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; METABOTROPIC RECEPTOR; QUISQUALIC ACID; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; BRAIN REGION; CHO CELL; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR SENSITIVITY;

ANIMALS; BRAIN; CELL LINE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; MICE; QUISQUALIC ACID; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, MESSENGER;

EID: 17644436692     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00078-6     Document Type: Article

References (44)

1. 2+ signal transduction. Journal of Biological Chemistry 267: 13361-13368.
2. Aramori I. and Nakanishi S. (1992) Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron 8: 757-765.
3. Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith J. A. and Struhl K. (1990) In Current Protocols in Molecular Biology (Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith J. A. and Struhl K. Eds) pp. 9.1.1-9.1.4. Wiley-Greene Publishing, NY.
4. Brabet I., Mary S., Bockaert J. and Pin J.-P. (1995) Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses. Neuropharmacology 34: 895-903.
5. Catania M. V., Aronica E., Sortino M. A., Canonico P. L. and Nicoletti F. (1991) Desensitization of metabotropic glutamate receptors in neuronal cultures. Journal of Neurochemistry 56: 1329-1335.
6. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634.
7. Collingridge G. L. and Singer W. (1990) Excitatory amino acid receptors and synaptic plasticity. Trends in Pharmacological Science 11: 290-296.
8. Daggett L. P., Sacaan A. I., Akong M., Rao S. P., Hess S. D., Liaw C., Urrutia A., Jachec C., Ellis S. B., Dreessen J., Knöpfel T., Landwehrmeyer G. B., Testa C. M., Young A. B., Varney M., Johnson E. C. and Veliçelebi G. (1995) Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5. Neuropharmacology 34: 871-886.
9. Desai M. A., Burnett J. P., Mayne N. G. and Schoepp D. D. (1995) Cloning and expression of a human metabotropic glutamate receptor 1α: enhanced coupling on co-transfection with a glutamate transporter. Molecular Pharmacology 48: 648-657.
10. Desai M. A., Burnett J. P., Mayne N. G. and Schoepp D. D. (1996) Pharmacological characterization of desensitization in a human mGlu1α-expressing non-neuronal cell line co-transfected with a glutamate transporter. British Journal of Pharmacology 118: 1558-1564.
11. Dingledine R., McBain C. J. and McNamara J. O. (1990) Excitatory amino acid receptors in epilepsy. Trends in Pharmacological Science 11: 334-338.
12. Flor P. J., Gomeza J., Tones M. A., Kuhn R., Pin J.-P. and Knöpfel T. (1996) The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists. Journal of Neurochemistry 67: 58-63.
13. Flor P. J., Lindauer K., Püttner I., Rüegg D., Lukic S., Knöpfel T. and Kuhn R. (1995a) Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. European Journal of Neuroscience 7: 622-629.
14. Flor P. J., Lukic S., Rüegg D., Leonhardt T., Knöpfel T. and Kuhn R. (1995b) Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4. Neuropharmacology 34: 149-155.
15. Grandes P., Mateos J. M., Rüegg D., Kuhn R. and Knöpfel T. (1994) Differential cellular localization of three splice variants of the mGluR1 metabotropic glutamate receptor in rat cerebellum. NeuroReport 5: 2249-2252.
16. Hayashi Y., Sekiyama N., Nakanishi S., Jane D. E., Sunter D. C., Birse E. F., Udvarhelyi P. M. and Watkins J. C. (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. Journal of Neuroscience 14: 3370-3377.
17. Hollmann M. and Heinemann S. (1994) Cloned glutamate receptors. Annual Reviews in Neuroscience 17: 31-108.
18. Houamed K. M., Kuijper J. L., Gilbert T. L., Haldeman B. A., O'Hara P. J., Mulvihill E. R., Almers W. and Hagen F. S. (1991) Cloning, expression and gene structure of a G-protein-coupled glutamate receptor from rat brain. Science 252: 1318-1321.
19. Joly C., Gomeza J., Brabet I., Curry K., Bockaert J. and Pin J.-P. (1995) Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1. Journal of Neuroscience 15: 3970-3981.
20. Kingston A. E., Burnett J. P., Mayne N. G. and Lodge D. (1995) Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1α and mGluR5a subtypes. Neuropharmacology 34: 887-894.
21. 1d, a novel splice variant of the human type I metabotropic glutamate receptor. European Journal of Pharmacology 296: R1-R3.
22. Leff P. and Dougall I. G. (1993) Further concerns over Cheng-Prusoff analysis. Trends in Pharmacological Science 14: 110-112.
23. Masu M., Tanabe Y., Tsuchida K., Shigemoto R. and Nakanishi S. (1991) Sequence and expression of a metabotropic glutamate receptor. Nature 349: 760-765.
24. Meldrum B. and Garthwaite J. (1990) Excitatory amino acid neurotoxicity and neurodegenerative diseases. Trends in Pharmacological Science 11: 379-387.
25. Minakami R., Katsuki F., Yamamoto T., Nakamura K. and Sugiyama H. (1994) Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5. Biochemistry and Biophysics Research Communication 199: 1136-1143.
26. Monaghan D. T., Bridges R. J. and Cotman C. W. (1989) The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annual Reviews in Pharmacological Toxicology 29: 365-402.
27. Nakajima Y., Iwakabe H., Akazawa C., Nawa H., Shigemoto R., Mizuno N. and Nakanishi S. (1993) Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. Journal of Biological Chemistry 268: 11868-11873.
28. Nakanishi S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603.
29. Ohishi H., Shigemoto R., Nakanishi S. and Mizuno N. (1993a) Distribution of the messenger RNA for a metabotropic glutamate receptor. mGluR2, in the central nervous system of the rat. Neuroscience 53: 1009-1018.
30. Ohishi H., Shigemoto R., Nakanishi S. and Mizuno N. (1993b) Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study. Journal of Comparative Neurology 335: 252-266.
31. Okamoto N., Hori S., Akazawa C., Hayashi Y., Shigemoto R., Mizuno N. and Nakanishi S. (1994) Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Journal of Biological Chemistry 269: 1231-1236.
32. Pickering D. S., Thomsen C., Suzdak P. D., Fletcher E. J., Robitaille R., Salter M. W., MacDonald J. F., Huang X.-P. and Hampson D. R. (1993) A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositide turnover. Journal of Neurochemistry 61: 85-92.
33. Pin J.-P. and Duvoisin R. (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacologv 34: 1-26.
34. Pin J.-P., Waeber C., Prézeau L., Bockaert J. and Heinemann S. F. (1992) Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proceedings of the National Academy of Science U.S.A. 89: 10331-10335.
35. Romano C., Yang W.-L. and O'Malley K. L. (1996) Metabotropic glutamate receptor 5 is a disulfide-linked dimer. Journal of Biological Chemistry 271: 28612-28616.
36. Saugstad J. A., Kinzie J. M., Mulvihill E. R., Segerson T. P. and Westbrook G. L. (1994) Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid sensitive class of metabotropic glutamate receptors. Molecular Pharmacology 45: 367-372.
37. Schoepp D. D., Bockaert J. and Sladeczek F. (1990) Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. Trends in Pharmacological Science 11: 508-515.
38. Schoepp D. D., Goldworthy J., Johnson B. G., Salhoff C. R. and Baker S. R. (1994) 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic receptors in the rat hippocampus. Journal of Neurochemistry 63: 769-772.
39. Szatkowski M. and Attwell D. (1994) Triggering and execution of neuronal death in brain ischemia: two phases of glutamate release by different mechanisms. Trends in Neuroscience 17: 359-365.
40. Tanabe Y., Masu M., Ishii T., Shigemoto R. and Nakanishi S. (1992) A family of metabotropic glutamate receptors. Neuron 8: 169-179.
41. Tanabe Y., Nomura A., Masu M., Shigemoto R., Mizuno N. and Nakanishi S. (1993) Signal transduction, pharmacological properties and expression patterns of two rat metabotropic glutamate receptors. Journal of Neuroscience 13: 1372-1378.
42. Testa C. M., Standaert D. G., Young A. B. and Penney J. B. Jr (1994) Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rats. Journal of Neuroscience 14: 3005-3018.
43. Thomsen C., Boel E. and Suzdak P. D. (1994) Actions of phenylglycine analogues at subtypes of the metabotropic glutamate receptor family. European Journal of Pharmacology (Molecular Pharmacology) 267: 77-84.
44. Tones M. A., Bendali N., Flor P. J., Knöpfel T. and Kuhn R. (1995) The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain. NeuroReport 7: 117-120.