The rat mGlu(1d) receptor splice variant shares functional properties with the other short isoforms of mGlu1 receptor

European Journal of Pharmacology

Volumn 335, Issue 1, 1997, Pages 65-72

  Mary, Sophie ^a   Stephan, Danielle ^b   Gomeza, Jesus ^a   Bockaert, Joël ^a   Pruss, Rebecca M ^b   Pin, Jean Philippe ^a  

^a CCIPE   (France)

^b SANOFI   (France)

Author keywords

Alternative splicing; Constitutive activity; G protein coupled receptor; Metabotropic glutamate receptor; Phospholipase C coupling

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; GLUTAMIC ACID; METABOTROPIC RECEPTOR; PHOSPHOLIPASE C; QUISQUALIC ACID; COMPLEMENTARY DNA;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HISTOCHEMISTRY; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN VARIANT; RAT; SPECIES DIFFERENCE; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; DRUG POTENTIATION; GENETICS; ISOMERISM; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RNA SPLICING; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; DNA, COMPLEMENTARY; HUMANS; ISOMERISM; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASE C; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RNA SPLICING;

EID: 0030609103     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01155-2     Document Type: Article

References (36)

1. Aramori I., Nakanishi S. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron. 8:1992;757-765.
2. Brown E.M., Gamba G., Riccardi D., Lombardi M., Butters R., Kifor O., Sun A., Hediger M.A., Lytton J., Hebert S.C. Cloning and characterization of an extracellular Ca2++sensing receptor from bovine parathyroid. Nature. 366:1993;575-580.
3. Conn P., Pin J.-P. Pharmacology and functions of metabotropic glutamate receptors. Ann. Rev. Pharmacol. Toxicol. 37:1997;205-237.
4. Conquet F., Bashir Z.I., Davies C.H., Daniel H., Ferraguti F., Bordi F., Franz-Bacon K., Reggiani A., Matarese V., Condé F., Colingridge G.L., Crépel F. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature. 372:1994;237-243.
5. Flor P.J., Gomeza J., Tones M.A., Kuhn R., Pin J.P., Knöpfel T. The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists. J. Neurochem. 67:1996;58-63.
6. Fong T.M., Anderson S.A., Yu H., Huang R.-R., Strader C.D. Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. Mol. Pharmacol. 41:1992;24-30.
7. Gabellini N., Manev R.M., Candeo P., Favaron M., Manev H. Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways. NeuroReport. 4:1993;531-534.
8. Gabellini N., Manev R.M., Manev H. Is the heterologous expression of metabotropic glutamate receptors (mGluRs) an appropriate method to study the mGluR function? Experience with human embryonic kidney 293 cells transfected with mGluR1. Neurochem. Int. 24:1994;533-539.
9. Gomeza J., Joly C., Kuhn R., Knöpfel T., Bockaert J., Pin J.-P. The second intracellular loop of mGluR1 cooperates with the other intracellular domains to control coupling to G-protein. J. Biol. Chem. 271:1996;2199-2205.
10. Gomeza J., Mary S., Brabet I., Parmentier M.-L., Restituito S., Bockaert J., Pin J.-P. Coupling of mGluR2 and mGluR4 to Gα15, Gα16 and chimeric Gαq/i proteins: Characterization of new antagonists. Mol. Pharmacol. 50:1996;923-930.
11. Hampson D.R., Theriault E., Huang X.P., Kristensen P., Pickering D.S., Franck J.E., Mulvihill E.R. Characterization of two alternatively spliced forms of a metabotropic glutamate receptor in the central nervous system of the rat. Neuroscience. 60:1994;325-336.
12. Houamed K.M., Kuijper J.L., Gilbert T.L., Haldeman B.A., O'Hara P.J., Mulvihill E.R., Almers W., Hagen F.S. Cloning, expression, and gene structure of a G-protein-coupled glutamate receptor from rat brain. Science. 252:1991;1318-1321.
13. Joly C., Gomeza J., Brabet I., Curry K., Bockaert J., Pin J.-P. Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: Comparison with mGluR1. J. Neurosci. 15:1995;3970-3981.
14. B receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386:1997;239-246.
15. Kunkel M.T., Peralta E.G. Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor. EMBO J. 12:1993;3809-3815.
16. Laurie D.J., Boddeke H.W.G.M., Hiltscher R., Sommer B. HmGlu1d, a novel splice variant of the human type-I metabotropic glutamate receptor. Eur. J. Pharmacol. 296:1996;R1-R3.
17. Lechleiter J., Hellmiss R., Duerson K., Ennulat D., David N., Clapham D., Peralta E. Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. EMBO J. 9:1990;4381-4390.
18. Lechleiter J., Girard S., Clapham D., Peralta E. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. Nature. 350:1991;505-508.
19. Masu M., Tanabe Y., Tsuchida K., Shigemoto R., Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. Nature. 349:1991;760-765.
20. Nakanishi S. Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity. Neuron. 13:1994;1031-1037.
21. O'Hara P.J., Sheppard P.O., Thøgersen H., Venezia D., Haldeman B.A., McGrane V., Houamed K.M., Thomsen C., Gilbert T.L., Mulvihill E.R. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron. 11:1993;41-52.
22. Pickering D.S., Thomsen C., Suzdak P.D., Fletcher E.J., Robitaille R., Salter M.W., MacDonald J.F., Huang X.-P., Hampson D.R. A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositides turnover. J. Neurochem. 61:1993;85-92.
23. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: Structure and functions. Neuropharmacology. 34:1995;1-26.
24. Pin J.-P., Waeber C., Prézeau L., Bockaert J., Heinemann S.F. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proc. Natl. Acad. Sci. USA. 89:1992;10331-10335.
25. Pin J.-P., Joly C., Heinemann S.F., Bockaert J. Domains involved in the specificity of G protein activation in phospholipase C coupled metabotropic glutamate receptor. EMBO J. 13:1994;342-348.
26. Pin, J.-P., Gomeza, J., Prézeau, L., Joly, C., Bockaert, J., 1996. The metabotropic glutamate receptors: Differences and similarities with the other G-protein coupled receptors. In: Schwartz, T.W., Hjorth, S.A., Sandholm Kastrup, J. (Eds.), Alfred Benzon Symposium 39 - Structure and Function of 7TM Receptors. Munksgaard, Copenhagen, pp. 343-356.
27. Ponce M., Micol J. PCR amplification of long DNA fragments. Nucleic Acids Res. 20:1992;623.
28. Prézeau L., Gomeza J., Ahern S., Mary S., Galvez T., Bockaert J., Pin J.-P. Changes of the C-terminal domain of mGluR1 by alternative splicing generate receptors with different agonist independent activity. Mol. Pharmacol. 49:1996;422-429.
29. Romano C., Yang W.-L., O'Malley K.L. Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J. Biol. Chem. 271:1996;28612-28616.
30. Sambrook, J., Fritsh, E.F., Maniatis, T., 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
31. Simoncini L., Haldeman B.A., Yamagiwa T., Mulvihill E. Functional characterization of metabotropic glutamate receptor subtypes. Biophys. J. 64:1993;A84.
32. Spengler D., Waeber C., Pantaloni C., Holsboer F., Bockaert J., Seeburg P.H., Journot L. Differential signal transduction by five splice variants of the PACAP receptor. Nature. 365:1993;170-175.
33. Takahashi K., Tsuchida K., Tanabe Y., Masu M., Nakanishi S. Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination. J. Biol. Chem. 268:1993;19341-19345.
34. Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 8:1992;169-179.
35. Thomsen C. Metabotropic glutamate receptor subtype 1A activates adenylate cyclase when expressed in baby hamster kidney cells. Prog. Neuro-Psych. Biol. Psych. 20:1996;709-726.
36. Tones M.A., Bendali H., Flor P.J., Knopfel T., Kuhn R. The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain. Neuroreport. 7:1995;117-120.