Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 20, 1996, Pages 3998-4006

  Costantino, Gabriele ^a   Pellicciari, Roberto ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 4 CARBOXYPHENYLGLYCINE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; BACTERIAL PROTEIN; GLUTAMIC ACID; IBOTENIC ACID; METABOTROPIC RECEPTOR; QUISQUALIC ACID; RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE;

AGONIST; AMINO TERMINAL SEQUENCE; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HYDROGEN BOND; MOLECULAR MODEL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; COMPUTER SIMULATION; ELECTROCHEMISTRY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; QUISQUALIC ACID; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SEQUENCE HOMOLOGY;

EID: 0029819599     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9601718     Document Type: Article

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