Agonist-induced functional desensitization of the μ-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein

Molecular Pharmacology

Volumn 50, Issue 5, 1996, Pages 1214-1222

  Pak, Youngshil ^a   Kouvelas, Angeliki ^a   Scheideler, Mark A ^c   Rasmussen, Jesper ^c   O'Dowd, Brian F ^a,b   George, Susan R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHO CELL; DRUG RECEPTOR BINDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RECEPTOR OCCUPANCY; SECOND MESSENGER;

ANALGESICS; ANIMALS; BINDING SITES; CELL LINE; CELL MEMBRANE; CHO CELLS; CRICETINAE; CYCLIC AMP; DOWN-REGULATION; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; FORSKOLIN; GTP-BINDING PROTEINS; KIDNEY; KINETICS; NALTREXONE; NARCOTIC ANTAGONISTS; RECEPTORS, OPIOID, MU; SENSITIVITY AND SPECIFICITY; STIMULATION, CHEMICAL; TRANSFECTION;

EID: 0029804995     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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