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Volumn 3, Issue 4, 1999, Pages 433-440

Metabotropic G-protein-coupled glutamate receptors as therapeutic targets

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR;

EID: 0033178258     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(99)80064-7     Document Type: Article
Times cited : (83)

References (50)
  • 1
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn PJ, Pin JP: Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 1997, 37:205-237.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 2
    • 0029983948 scopus 로고    scopus 로고
    • Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS
    • Parmentier ML, Pin J-P, Bockaert J, Grau Y: Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS. J Neurosci 1996, 16:6687-6694.
    • (1996) J Neurosci , vol.16 , pp. 6687-6694
    • Parmentier, M.L.1    Pin, J.-P.2    Bockaert, J.3    Grau, Y.4
  • 3
    • 0032923165 scopus 로고    scopus 로고
    • Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: Focus on (2R,1′S,2′R,3′S-2-(2′-carboxy-3′-phenylcyclopropylglycine versus 2,3-dihydroxyphenylglycine
    • Albani Torregrossa S, Attucci S, Marinozzi M, Pellicciari R, Moroni F, Pellegrini-Giampietro DE: Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: Focus on (2R,1′S,2′R,3′S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine versus 2,3-dihydroxyphenylglycine. Mol Pharmacol 1999, 55:699-707. The pharmacology of a new class of phospholipase D (PLD)-coupled metabotropic glutamate receptors is described. PCCG-13, a new potent, selective and competitive antagonist, the first so far described, is pharmacologically characterized and will allow a better understanding of the role played by the novel class of PLD-coupled receptors.
    • (1999) Mol Pharmacol , vol.55 , pp. 699-707
    • Albani Torregrossa, S.1    Attucci, S.2    Marinozzi, M.3    Pellicciari, R.4    Moroni, F.5    Pellegrini-Giampietro, D.E.6
  • 4
    • 0026539743 scopus 로고
    • Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices
    • Boss VK, Conn PJ: Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices. J Neurochem 1992, 59:2340-2343.
    • (1992) J Neurochem , vol.59 , pp. 2340-2343
    • Boss, V.K.1    Conn, P.J.2
  • 5
    • 0028319266 scopus 로고
    • ⌊-Cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to phospholipase D activity
    • Boss VK, Nutt M, Conn PJ: ⌊-Cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to phospholipase D activity. Mol Pharmacol 1994, 45:1177-1182.
    • (1994) Mol Pharmacol , vol.45 , pp. 1177-1182
    • Boss, V.K.1    Nutt, M.2    Conn, P.J.3
  • 6
    • 0031906593 scopus 로고    scopus 로고
    • Glutamatergic activation of hippocampal phospholipase D: Postnatal fading and receptor desensitization
    • Klein J, Vakil M, Bergman F, Holler T, Iovino M, Löffelholz K: Glutamatergic activation of hippocampal phospholipase D: Postnatal fading and receptor desensitization. J Neurochem 1998, 70:1679-1685.
    • (1998) J Neurochem , vol.70 , pp. 1679-1685
    • Klein, J.1    Vakil, M.2    Bergman, F.3    Holler, T.4    Iovino, M.5    Löffelholz, K.6
  • 7
    • 0029903640 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 is a disulfide-linked dimer
    • Romano C, Yang WL, O'Malley K: Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem 1996, 271:28612-28616.
    • (1996) J Biol Chem , vol.271 , pp. 28612-28616
    • Romano, C.1    Yang, W.L.2    O'Malley, K.3
  • 9
    • 0032557433 scopus 로고    scopus 로고
    • Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1
    • Okamoto T, Sekiyama N, Otsu M, Shimada Y, Sato A, Nakanishi S, Jingami H: Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1. J Biol Chem 1998, 273:13089-13096. A soluble form of the amino-terminal domain of metabotropic glutamate receptor subtype 1 is expressed, purified and shown to retain the binding characteristic of native receptors. This observation demonstrates that the binding event can occur outside the membrane environment and permits anticipation of a future crystallization of the amino-terminal domain.
    • (1998) J Biol Chem , vol.273 , pp. 13089-13096
    • Okamoto, T.1    Sekiyama, N.2    Otsu, M.3    Shimada, Y.4    Sato, A.5    Nakanishi, S.6    Jingami, H.7
  • 11
    • 0029819599 scopus 로고    scopus 로고
    • Homology modeling of metabotropic glutamate receptors (mGluRs). Structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists
    • Costantino G, Pellicciari R: Homology modeling of metabotropic glutamate receptors (mGluRs). Structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists. J Med Chem 1996, 39:3998-4006.
    • (1996) J Med Chem , vol.39 , pp. 3998-4006
    • Costantino, G.1    Pellicciari, R.2
  • 12
    • 0030029427 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
    • Nicoletti F, Bruno V, Copani A, Casabona G, Knopfel T: Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders? Trends Neurosci 1996, 19:267-271.
    • (1996) Trends Neurosci , vol.19 , pp. 267-271
    • Nicoletti, F.1    Bruno, V.2    Copani, A.3    Casabona, G.4    Knopfel, T.5
  • 15
    • 0030014882 scopus 로고    scopus 로고
    • (S)-(+)-2-(3′-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist
    • Pellicciari R, Raimondo M, Marinozzi M, Natalini B, Costantino G, Thomsen C: (S)-(+)-2-(3′-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. J Med Chem 1996, 39:2874-2876.
    • (1996) J Med Chem , vol.39 , pp. 2874-2876
    • Pellicciari, R.1    Raimondo, M.2    Marinozzi, M.3    Natalini, B.4    Costantino, G.5    Thomsen, C.6
  • 16
    • 0030834666 scopus 로고    scopus 로고
    • (+)-2 Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate receptors
    • Clark BP, Baker SR, Goldswothy J, Harris JR, Kingston AE: (+)-2 Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate receptors. Bioorg Med Chem Lett 1997, 7:2777-2780.
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 2777-2780
    • Clark, B.P.1    Baker, S.R.2    Goldswothy, J.3    Harris, J.R.4    Kingston, A.E.5
  • 17
    • 0030894148 scopus 로고    scopus 로고
    • (RS)-2-chloro-5 hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
    • Doherty AJ, Palmer MJ, Henley JM, Collingridge GL, Jane DE: (RS)-2-chloro-5 hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 1997, 36:265-267.
    • (1997) Neuropharmacology , vol.36 , pp. 265-267
    • Doherty, A.J.1    Palmer, M.J.2    Henley, J.M.3    Collingridge, G.L.4    Jane, D.E.5
  • 18
    • 0033028258 scopus 로고    scopus 로고
    • CPCOOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding
    • Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prezeau L, Pin JP, Thomsen C, Kuhn R: CPCOOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol Pharmacol 1999, 55:453-461. This paper is the first to describe the possibility of modulating mGluR1 through noncompetitive antagonists.
    • (1999) Mol Pharmacol , vol.55 , pp. 453-461
    • Litschig, S.1    Gasparini, F.2    Rueegg, D.3    Stoehr, N.4    Flor, P.J.5    Vranesic, I.6    Prezeau, L.7    Pin, J.P.8    Thomsen, C.9    Kuhn, R.10
  • 19
    • 0029876140 scopus 로고    scopus 로고
    • A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates
    • Annoura H, Fukunaga A, Uesugi M, Tatsuoka T, Horikawa Y: A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg Med Chem Lett 1996, 6:763-767.
    • (1996) Bioorg Med Chem Lett , vol.6 , pp. 763-767
    • Annoura, H.1    Fukunaga, A.2    Uesugi, M.3    Tatsuoka, T.4    Horikawa, Y.5
  • 20
    • 0000605332 scopus 로고    scopus 로고
    • Methylphenylethynylpiperldine (MPEP): A novel potent subtype selective and systemically active antagonist at metabotropic glutamate receptor subtype 5
    • in press
    • Gasparini F, Lingenheokl K, Flor PJ, Munier N, Heinrich M, Pagano A, Vranesic I, Biollaz M, Heckendorn R, Allgeier H et al.: Methylphenylethynylpiperldine (MPEP): A novel potent subtype selective and systemically active antagonist at metabotropic glutamate receptor subtype 5. Br J Pharmacol 1999, in press. This paper describes a new, potent and systemically active noncompetitive metabotropic glutamate receptor subtype 5 antagonist, the first so far reported, and highlights its anti-hyperalgesic activities.
    • (1999) Br J Pharmacol
    • Gasparini, F.1    Lingenheokl, K.2    Flor, P.J.3    Munier, N.4    Heinrich, M.5    Pagano, A.6    Vranesic, I.7    Biollaz, M.8    Heckendorn, R.9    Allgeier, H.10
  • 21
    • 0009605613 scopus 로고    scopus 로고
    • AIDA and S-CBPG, two mGlu1 receptor-preferring antagonists reduce neuronal death and in vivo models of cerebral ischemia
    • in press
    • Pellegrini-Giampietro DE, Cozzi A, Peruginelli F, Leonardi P, Meli E, Pellicciari R, Moroni F: AIDA and S-CBPG, two mGlu1 receptor-preferring antagonists reduce neuronal death and in vivo models of cerebral ischemia. Eur J Neurosci 1999, in press. This paper points out the role of metabotropic glutamate receptor subtype 1 antagonist receptors in the pathological mechanisms responsible for the postischemic neuronal death.
    • (1999) Eur J Neurosci
    • Pellegrini-Giampietro, D.E.1    Cozzi, A.2    Peruginelli, F.3    Leonardi, P.4    Meli, E.5    Pellicciari, R.6    Moroni, F.7
  • 23
    • 0032550134 scopus 로고    scopus 로고
    • Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats
    • Fisher K, Coderre TJ: Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats. Neuroreport 1998, 9:1169-1172.
    • (1998) Neuroreport , vol.9 , pp. 1169-1172
    • Fisher, K.1    Coderre, T.J.2
  • 25
    • 0031737923 scopus 로고    scopus 로고
    • Intrathecal metabotropic glutamate receptor antagonists do not decrease mechanical hyperalgesia in a rat model of post-operative pain
    • Zahn PK, Brennan TJ: Intrathecal metabotropic glutamate receptor antagonists do not decrease mechanical hyperalgesia in a rat model of post-operative pain. Anesth Analg 1998, 87:1354-1359.
    • (1998) Anesth Analg , vol.87 , pp. 1354-1359
    • Zahn, P.K.1    Brennan, T.J.2
  • 26
    • 0029956082 scopus 로고    scopus 로고
    • Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2′-carboxy-3′-phenylcyclopropylglycine. Focus on (2S,1′S,2′S,3′R-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist
    • Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C: Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2′-carboxy-3′-phenylcyclopropyl)glycine. Focus on (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. Med Chem 1996, 39:2259-2269.
    • (1996) Med Chem , vol.39 , pp. 2259-2269
    • Pellicciari, R.1    Marinozzi, M.2    Natalini, B.3    Costantino, G.4    Luneia, R.5    Giorgi, G.6    Moroni, F.7    Thomsen, C.8
  • 27
    • 0032492989 scopus 로고    scopus 로고
    • Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-l, a potent mGluR agonist
    • Kozikowski AP, Steensma D, Araldi GL, Tuckmantel W, Wang S, Pshenichkin S, Surina E, Wroblewski JT: Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-l, a potent mGluR agonist. J Med Chem 1998, 41:1641-1650. The synthesis and the biological evaluation of a new conformationally constrained ⌊-glutamate analog, eqiupotent as a metabotropic glutamate receptor subtype 1 and 2 agonist, is reported. Very interesting structure/activity relationships are shown.
    • (1998) J Med Chem , vol.41 , pp. 1641-1650
    • Kozikowski, A.P.1    Steensma, D.2    Araldi, G.L.3    Tuckmantel, W.4    Wang, S.5    Pshenichkin, S.6    Surina, E.7    Wroblewski, J.T.8
  • 28
    • 15644369847 scopus 로고    scopus 로고
    • Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties
    • Monn JA, Valli MJ, Massey SM, Wright RA, Salhoff CR, Johnson BG, Howe T, Alt CA, Rhodes GA, Robey RL et al.: Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J Med Chem 1997, 40:528-537.
    • (1997) J Med Chem , vol.40 , pp. 528-537
    • Monn, J.A.1    Valli, M.J.2    Massey, S.M.3    Wright, R.A.4    Salhoff, C.R.5    Johnson, B.G.6    Howe, T.7    Alt, C.A.8    Rhodes, G.A.9    Robey, R.L.10
  • 29
    • 0033602516 scopus 로고    scopus 로고
    • Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic ammo acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors
    • Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, Harkness AR, Grutsch JL Jr, Wright RA, Johnson BG et al.: Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic ammo acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem 1999, 42:1027-1040.
    • (1999) J Med Chem , vol.42 , pp. 1027-1040
    • Monn, J.A.1    Valli, M.J.2    Massey, S.M.3    Hansen, M.M.4    Kress, T.J.5    Wepsiec, J.P.6    Harkness, A.R.7    Grutsch J.L., Jr.8    Wright, R.A.9    Johnson, B.G.10
  • 30
    • 0032576734 scopus 로고    scopus 로고
    • 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-y)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution
    • Ornstein PL, Bleisch TJ, Arnold MB, Wright RA, Johnson BG, Schoepp DD: 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-y)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution. J Med Chem 1998, 41:346-357.
    • (1998) J Med Chem , vol.41 , pp. 346-357
    • Ornstein, P.L.1    Bleisch, T.J.2    Arnold, M.B.3    Wright, R.A.4    Johnson, B.G.5    Schoepp, D.D.6
  • 31
    • 0027184291 scopus 로고
    • N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells
    • Wroblewska B, Wroblewski JT, Saab OH, Neale JH: N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells. J Neurochem 1993, 61:943-948.
    • (1993) J Neurochem , vol.61 , pp. 943-948
    • Wroblewska, B.1    Wroblewski, J.T.2    Saab, O.H.3    Neale, J.H.4
  • 32
    • 0032190403 scopus 로고    scopus 로고
    • N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes
    • Wroblewska B, Santi MR, Neale JH: N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes. Glia 1998, 24:172-179.
    • (1998) Glia , vol.24 , pp. 172-179
    • Wroblewska, B.1    Santi, M.R.2    Neale, J.H.3
  • 33
    • 0030873754 scopus 로고    scopus 로고
    • Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: In vivo studies with (2S,1′S,2′S,3′R-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a new potent and selective antagonist
    • Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F: Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: In vivo studies with (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a new potent and selective antagonist. Eur J Neurosci 1997, 9:1350-1355.
    • (1997) Eur J Neurosci , vol.9 , pp. 1350-1355
    • Cozzi, A.1    Attucci, S.2    Peruginelli, F.3    Marinozzi, M.4    Luneia, R.5    Pellicciari, R.6    Moroni, F.7
  • 34
    • 0031933951 scopus 로고    scopus 로고
    • Anxiolytic and side-effect profile of LY354740: A potent, highly selective, orally active agonist for group II metabotropic glutamate receptors
    • Helton DR, Tizzano JP, Monn JA, Schoepp DD, Kallman MJ: Anxiolytic and side-effect profile of LY354740: A potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J Pharmacol Exp Ther 1998, 284:651-660.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 651-660
    • Helton, D.R.1    Tizzano, J.P.2    Monn, J.A.3    Schoepp, D.D.4    Kallman, M.J.5
  • 35
    • 0032575715 scopus 로고    scopus 로고
    • Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats
    • Moghaddam B, Adams BW: Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 1998, 281:1349-1352. The therapeutic potential of group II agonists in the treatment of psychiatric disorders such as schizophrenia is described in this paper. LY354740 is shown to reverse the effect of phenyciclidine in rats, a common experimental model for epilepsy.
    • (1998) Science , vol.281 , pp. 1349-1352
    • Moghaddam, B.1    Adams, B.W.2
  • 36
    • 8944234853 scopus 로고    scopus 로고
    • Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: Identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase
    • Monn JA, Valli MJ, Johnson BG, Salhoff CR, Wright RA, Howe T, Bond A, Lodge D, Spangle LA, Paschal JW et al.: Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: Identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. J Med Chem 1996, 39:2990-3000.
    • (1996) J Med Chem , vol.39 , pp. 2990-3000
    • Monn, J.A.1    Valli, M.J.2    Johnson, B.G.3    Salhoff, C.R.4    Wright, R.A.5    Howe, T.6    Bond, A.7    Lodge, D.8    Spangle, L.A.9    Paschal, J.W.10
  • 37
    • 0031786473 scopus 로고    scopus 로고
    • Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death
    • Battaglia G, Bruno V, Ngomba RT, Di Grezia R, Copani A, Nicoletti F: Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death. Eur J Pharmacol 1998, 356:271-274.
    • (1998) Eur J Pharmacol , vol.356 , pp. 271-274
    • Battaglia, G.1    Bruno, V.2    Ngomba, R.T.3    Di Grezia, R.4    Copani, A.5    Nicoletti, F.6
  • 38
    • 0032550103 scopus 로고    scopus 로고
    • Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia
    • Bond A, O'Neill MJ, Hicks CA, Monn JA, Lodge D: Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. Neuroreport 1998, 9:1191-1193.
    • (1998) Neuroreport , vol.9 , pp. 1191-1193
    • Bond, A.1    O'Neill, M.J.2    Hicks, C.A.3    Monn, J.A.4    Lodge, D.5
  • 39
    • 0032566556 scopus 로고    scopus 로고
    • Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia
    • Lam AG, Soriano MA, Monn JA, Schoepp DD, Lodge D, McCulloch J: Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia. Neurosci Lett 1998, 254:121-123.
    • (1998) Neurosci Lett , vol.254 , pp. 121-123
    • Lam, A.G.1    Soriano, M.A.2    Monn, J.A.3    Schoepp, D.D.4    Lodge, D.5    McCulloch, J.6
  • 40
    • 0032403407 scopus 로고    scopus 로고
    • Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta
    • Bruno V, Battaglia G, Casabona G, Copani A, Caciagli F, Nicoletti F: Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta. J Neurosci 1998, 18:9594-9600. An interesting mechanism for group-II-mediated neuroprotection after excitotoxic insult is proposed and involves the group II agonist-mediated release of neurotrophic factors.
    • (1998) J Neurosci , vol.18 , pp. 9594-9600
    • Bruno, V.1    Battaglia, G.2    Casabona, G.3    Copani, A.4    Caciagli, F.5    Nicoletti, F.6
  • 41
    • 0029966777 scopus 로고    scopus 로고
    • The effects of (RS-alpha cyclopropyl-4-phosphonophenylglycine ([RS]-CPPG), a potent and selective metabotropic glutamate receptor antagonist
    • Toms NJ, Jane DE, Kemp MC, Bedingfield JS, Roberts PJ: The effects of (RS)-alpha cyclopropyl-4-phosphonophenylglycine ([RS])-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol 119:851-854.
    • Br J Pharmacol , vol.119 , pp. 851-854
    • Toms, N.J.1    Jane, D.E.2    Kemp, M.C.3    Bedingfield, J.S.4    Roberts, P.J.5
  • 42
    • 0000068773 scopus 로고    scopus 로고
    • Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor antagonist
    • Flor PJ: Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor antagonist. Soc Neurosci Abstr 24:431.11.
    • Soc Neurosci Abstr , vol.24 , pp. 43111
    • Flor, P.J.1
  • 44
    • 0031950950 scopus 로고    scopus 로고
    • Group III human metabotropic glutamate receptors 4, 7 and 8: Molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells
    • Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR Jr, Johnson BG, Schoepp DD, Belagaje RM: Group III human metabotropic glutamate receptors 4, 7 and 8: Molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res 1998, 53:88-97. The molecular cloning, expression and an interesting pharmacological comparison of three subtypes of group III mGluRs are presented.
    • (1998) Brain Res Mol Brain Res , vol.53 , pp. 88-97
    • Wu, S.1    Wright, R.A.2    Rockey, P.K.3    Burgett, S.G.4    Arnold, J.S.5    Rosteck P.R., Jr.6    Johnson, B.G.7    Schoepp, D.D.8    Belagaje, R.M.9
  • 45
    • 0031831308 scopus 로고    scopus 로고
    • Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor
    • Gerlai R, Roder JC, Hampson DR: Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. Behav Neurosci 1998, 112:525-532.
    • (1998) Behav Neurosci , vol.112 , pp. 525-532
    • Gerlai, R.1    Roder, J.C.2    Hampson, D.R.3
  • 46
    • 0027359582 scopus 로고
    • Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats
    • Holler TE, Cappel E, Klein J, Löffelholz K:. Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats. J Neurochem 1993, 61:1569-1572.
    • (1993) J Neurochem , vol.61 , pp. 1569-1572
    • Holler, T.E.1    Cappel, E.2    Klein, J.3    Löffelholz, K.4
  • 47
    • 0029779307 scopus 로고    scopus 로고
    • Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus
    • Pellegrini-Giampietro DE, Albani Torregrossa S, Moroni F: Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol 1996, 118:1035-1043.
    • (1996) Br J Pharmacol , vol.118 , pp. 1035-1043
    • Pellegrini-Giampietro, D.E.1    Albani Torregrossa, S.2    Moroni, F.3
  • 48
    • 0030892164 scopus 로고    scopus 로고
    • Phospholipase D: Enzymology, mechanisms of regulation, and function
    • Exton JH: Phospholipase D: Enzymology, mechanisms of regulation, and function. Physiol Rev 1997, 77:303-320.
    • (1997) Physiol Rev , vol.77 , pp. 303-320
    • Exton, J.H.1
  • 50
    • 0033566221 scopus 로고    scopus 로고
    • (2R,1′S,2′R,3′S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine (PCCG-13)
    • in press
    • Pellicciari R, Marinozzi M, Costantino G, Natalini B, Pellegrini-Giampietro DE, Moroni F: (2R,1′S,2′R,3′S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of PLD-coupled metabotropic glutamate receptors, asymmetric synthesis and preliminary biological properties. J Med Chem 1999, in press.
    • (1999) J Med Chem
    • Pellicciari, R.1    Marinozzi, M.2    Costantino, G.3    Natalini, B.4    Pellegrini-Giampietro, D.E.5    Moroni, F.6


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