Constraints on proper folding of the amino terminal domains of group iii metabotropic glutamate receptors

Molecular Brain Research

Volumn 76, Issue 1, 2000, Pages 180-190

  Peltekova, Vanya ^a   Han, Guangming ^a   Soleymanlou, Nima ^a   Hampson, David R ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Calcium sensing receptor; G protein coupled receptor; GABA(B) receptor; Leucine isoleucine valine binding protein; Periplasmic binding proteins

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BUTYRIC ACID DERIVATIVE; CALCIUM SENSING RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR; PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN CELL; KIDNEY CELL; LIGAND BINDING; PRIORITY JOURNAL;

ANIMALS; CELL LINE; HUMANS; IMMUNOBLOTTING; LIGANDS; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RADIOLIGAND ASSAY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SOLUBILITY; TRANSFECTION;

EID: 0034629424     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00029-2     Document Type: Article

References (24)

1. Wroblewska B., Wroblewski J.T., Pschenichkin S., Surin A., Sullivan S.E., Neale J.H. N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J. Neurochem. 69:1997;174-181.
2. Hampson D.R., Huang X.-P., Pekhletski R., Peltekova V., Hornby G., Thomsen C., Thogersen H. Probing the ligand-binding domain of the mGluR4 subtype of metabotropic glutamate receptor. J. Biol. Chem. 274:1999;33488-33495.
3. Pin J.-P., Duvoisin R. Neurotransmitter receptors I, The metabotropic glutamate receptors: Structure and functions. Neuropharmacology. 34:1995;1-26.
4. Pekhletski R., Gerlai R., Overstreet L., Huang X.-P., Agoypan N., Slater N.T., Abramow-Newerly W., Roder J.C., Hampson D.R. Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. J. Neurosci. 16:1996;6364-6373.
5. Shigemoto R., Kinoshita A., Wada E., Nomura S., Ohishi H., Takada M., Flor P.J., Neki A., Takaaki Abe A., Nakanishi S., Mizuno N. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci. 17:1997;7503-7522.
6. Risso Bradley S., Standaert D.G., Rhodes K.J., Rees H.D., Testa C.M., Levey A.I., Conn P.J. Immunocytochemical localization of subtype 4a metabotropic glutamate receptor in the rat and mouse basal ganglia. J. Comp. Neurol. 407:1999;33-46.
7. Tizzano J.P., Griffey K.I., Schoepp D.D. Induction or protection of limbic seizures in mice by mGluR subtype selective agonists. Neuropharmacology. 34:1995;1063-1067.
8. Tang E., Yip P.K., Chapman A.G., Jane D.E., Meldrum B.S. Prolonged anticonvulsant activity of mGluR agonists in inferior colliculus of the genetically epileptic prone rat. Eur. J. Pharmacol. 327:1997;109-115.
9. Thomsen C., Dalby N.O. Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice. Neuropharmacology. 37:1999;1465-1473.
10. Gasparini F., Bruno V., Battaglia G., Lukic S., Leonhardt T., Inderbitzin W., Laurie D., Sommer B., Varney M.A., Hess S.D., Johnson E.C., Kuhn R., Urwyler S., Sauer D., Portet C., Schmutz M., Nicoletti F., Flor P.J. (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J. Pharmacol. Exp. Ther. 290:1999;1678-1686.
11. Nicoletti F., Bruno V., Copani A., Casabona G., Knopfel T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. 19:1996;267-271.
12. Conn P.J., Pin J.-P. Pharmacology and function of metabotropic glutamate receptors. Ann. Rev. Pharmacol. Tox. 37:1997;205-237.
13. O'Hara P.J., Sheppard P., Thogersen H., Venezia D., Haldeman B.A., McGrane V., Houamed K.M., Thomsen C., Gilbert T.L., Mulvihill E.R. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron. 11:1993;41-52.
14. Malherbe P., Kratzeisen C., Lundstrom K., Richards J.G., Faull R.L.M., Mutel V. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Mol. Brain Res. 67:1999;201-210.
15. Okamoto T., Sekiyama N., Otsu M., Shimada Y., Sato A., Nakanishi S., Jingami H. Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1. J. Biol. Chem. 273:1998;13089-13096.
16. Robbins M.J., Ciruela F., Rhodes A., McIlhinney A.J. Characterization of the dimerization of metabotropic glutamate receptors using an N-terminal truncation of mGluR1. J. Neurochem. 72:1999;2539-2547.
17. Han G., Hampson D.R. Ligand binding to the amino terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J. Biol. Chem. 274:1999;10008-10013.
18. Armstrong N., Sun Y., Chen G.Q., Gouaux E. Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature. 395:1998;913-917.
19. Saugstad J.A., Kinzie J.M., Shinohara M.M., Segerson T.P., Westbrook G.L. Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile. Mol. Pharmacol. 51:1997;119-1125.
20. Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 8:1992;169-179.
21. 3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br. J. Pharmacology. 116:1995;3279-3287.
22. Thomsen C., Pekhletski R., Haldeman B., Gilbert T.A., O'Hara P.J., Hampson D.R. Cloning and characterization of a metabotropic glutamate receptor, mGluR4b. Neuropharmacology. 36:1997;21-30.
23. B receptors is sufficient to specify agonist and antagonist binding. Mol. Pharmacol. 56:1999;448-454.
24. Goldsmith P.K., Fan G.F., Ray K., Shiloach J., McPhie P., Rogers K.V., Spiegel A.M. Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. J. Biol. Chem. 274:1999;11303-11309.