Direct radiolabeling by [3H]quisqualic acid of group I metabotropic glutamate receptor in rat brain synaptic membranes

Brain Research

Volumn 881, Issue 2, 2000, Pages 199-203

  Hinoi, Eiichi ^a   Ogita, Kiyokazu ^c   Takeuchi, Yutaka ^b   Ohashi, Hiroshi ^b   Maruyama, Takaharu ^b   Yoneda, Yukio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b BANYU PHARMACEUTICAL CO LTD   (Japan)

^c SETSUNAN UNIVERSITY   (Japan)

Author keywords

3H QA binding; Group I agonists; GTP; Metabotropic glutamate receptor; Scatchard analysis

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 3,5 DIHYDROXYPHENYLGLYCINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMIC ACID; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; GUANYLYLIMIDODIPHOSPHATE; KAINIC ACID; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; QUISQUALIC ACID; RADIOLIGAND; RECEPTOR SUBTYPE; TRITIUM; AMINO ACID RECEPTOR STIMULATING AGENT; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; HISTOCHEMISTRY; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SYNAPTIC MEMBRANE; TECHNIQUE; ANIMAL; METABOLISM; WISTAR RAT;

ANIMALS; BRAIN; EXCITATORY AMINO ACID AGONISTS; GUANOSINE TRIPHOSPHATE; MALE; QUISQUALIC ACID; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPTIC MEMBRANES;

EID: 0034721615     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02809-2     Document Type: Article

References (24)

1. 2+ signal transduction
2. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice
3. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
4. Beta-amyloid-induced apoptosis of cerebellar granule cells and cortical neurons: exacerbation by selective inhibition of group I metabotropic glutamate receptors
5. Differential expression of group I metabotropic glutamate receptors in rat spinal cord somatic and autonomic motoneurons: possible implications for the pathogenesis of amyotrophic lateral sclerosis
6. 3H]glutamate labels the metabotropic excitatory amino acid receptor in rodent brain
7. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene
8. Radioligand binding studies of adrenergic receptors: new insights into molecular and physiological regulation
9. + conductance increase in aplysia neurons that appears to be independent of G proteins
10. Beta-adrenergic receptor: ligand binding properties and the interaction with adenyl cyclase
11. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate
12. 3H]glutamate binding sites in brain synaptic membranes
13. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex
14. Distribution of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain
15. 3H]LY341495, a highly potent, selective and novel radioligand for labeling group II metabotropic glutamate receptor
16. (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor
17. 3H]glutamate receptor binding in membranes
18. Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons
19. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat
20. Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells
21. 3H]MK-801 binding by ferrous (II) but not ferric (III) ions in a manner different from that by sodium nitroprusside (II) in rat brain synaptic membranes
22. 3H]-MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine
23. 3H]glutamate binding sites in the rat brain