Allosteric activation of the Ca2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568

Molecular Pharmacology

Volumn 53, Issue 6, 1998, Pages 1083-1088

  Hammerland, Lance G ^a   Garrett, James E ^a   Hung, Benjamin C P ^a   Levinthal, Cynthia ^a   Nemeth, Edward F ^a  

^a NPS Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 METHOXYPHENYL) N (3 PHENYLPROPYL)ETHYLAMINE; METABOTROPIC RECEPTOR; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; PHENYLALKYLAMINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; CALCIUM; CALCIUM BINDING PROTEIN; CHLORIDE CHANNEL; N (2 CHLOROPHENYLPROPYL) 1 (3 METHOXYPHENYL)ETHYLAMINE; N-(2-CHLOROPHENYLPROPYL)-1-(3-METHOXYPHENYL)ETHYLAMINE; NPS R-467; RECOMBINANT PROTEIN;

ARTICLE; CALCIUM HOMEOSTASIS; CHLORIDE CURRENT; CONCENTRATION RESPONSE; ENANTIOMER; EXTRACELLULAR CALCIUM; NONHUMAN; OOCYTE DEVELOPMENT; PARATHYROID CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TARGET CELL; XENOPUS LAEVIS; ALLOSTERISM; ANIMAL; CATTLE; DRUG EFFECT; FEMALE; HUMAN; METABOLISM; OOCYTE; PHYSIOLOGY;

ALLOSTERIC REGULATION; ANILINE COMPOUNDS; ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CATTLE; CHLORIDE CHANNELS; FEMALE; HUMANS; OOCYTES; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 0031595986     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Barnard EA and Bilbe G (1987). Functional expression in the Xenopus oocyte of mRNAs for receptors and ion channels, in Neurochemistry: A Practical Approach (Turner AJ and Bachelard HS, eds) pp 243-270, ICL Press, Oxford, Washington, DC.
2. 2+ and other ions as extracellular (first) messengers. Physiol Rev 71:371-411.
3. Brown EM, Butters R, Katz C, and Kifor O (1991a) Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells. Endocrinology 128:3047-3054.
4. 2+-sensing receptor from bovine parathyroid. Nature (Lond) 366:575-580.
5. Brown EM, Katz C, Butters R, and Kifor O (1991b) Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells. J Bone Miner Res 6:1217-1225.
6. Brown EM, Pollak M, Seidman CE, Seidman JG, Chou Y-HW, Riccardi D, and Hebert SC (1995) Calcium ion-sensing cell-surface receptors. N Eng J Med 333: 234-240.
7. Feng G, Hannan F, Reale V, Hon YY, Kousky CT, Evans PD, and Hall LM (1996) Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. J Neurosci 16:3925-3933.
8. Flor PJ, Gomeza J, Tones MA, Kuhn R, Pin J-P, and Knopfel T (1996) The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists. J Neurochem 67:58-63.
9. Garrett JE, Capuano IV, Hammerland LG, Hung BCP, Brown EM, Hebert SC, Fuller F, and Nemeth EF (1995) Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J Biol Chem 270:12919-12925.
10. Goldin AL (1992) Maintenance of Xenopus laevis and oocyte injection. Methods Enzymol 207:266-279.
11. Hammerland LG, Garrett JE, Krapcho KJ, Simin R, Capuano IV, Alasti N, Nemeth EF, and Fuller FH (1996) NPS R-467 activation of chimeric calcium-metabotropic glutamate receptors and a calcium receptor deletion mutant indicates a site of action within the transmembrane of the calcium receptor. J Bone Miner Res 11:P272.
12. Hammerland LG, Krapcho KJ, Alasti N, Simin R, Garrett JE, Capuano IV, Hung BCP, and Fuller FH (1995) Cation binding determinants of the calcium receptor revealed by functional analysis of chimeric receptors and a deletion mutant. J Bone Miner Res 10:70.
13. Ji H, Sandberg K, and Catt KJ (1991) Novel angiotensin II antagonists distinguish amphibian from mammalian angiotensin II receptors expressed in Xenopus laevis oocytes. Mol Pharmacol 39:120-123.
14. Masu M, Tanabe Y, Tsuchida K, Shigemoto R, and Nakanishi S (1991) Sequence and expression of a metabotropic glutamate receptor. Nature (Lond) 349:760-765.
15. Nakanishi S (1991) Mammalian tachykinin receptors. Annu Rev Neurosci 14:123-136.
16. Nemeth EF (1996) Calcium receptors as novel drug targets, in Principles of Bone Biology (Bilezikian JP, Raisz LG, and Rodan GA, eds) pp 1019-1035, Academic Press, San Diego.
17. 2+ in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor. J Biol Chem 262:5188-5196.
18. Silverberg SJ, Bone HG, Marriott TB, Locker FG, Thys-Jacobs S, Dziem G, Kaatz S, Sanguinetti EL, and Bilezikian JP (1997) Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism. N Engl J Med 337:1506-1510.
19. Steffey ME, Fox J, VanWagenen BC, Delmar EG, Balandrin MF, and Nemeth EF (1993) Calcimimetics: structurally and mechanistically novel compounds that inhibit parathyroid hormone secretion from parathyroid cells. J Bone Miner Res 8:S175.
20. Stuhmer W (1992) Electrophysiological recording from Xenopus oocytes. Methods Enzymol 207:319-339.