Anti-inflammatory activity of extra virgin olive oil polyphenols: Which role in the prevention and treatment of immune-mediated inflammatory diseases?

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 18, Issue 1, 2018, Pages 36-50

  Santangelo, Carmela ^a   Varì, Rosaria ^a   Scazzocchio, Beatrice ^a   de Sanctis, Patrizia ^a   Giovannini, Claudio ^a   D'Archivio, Massimo ^a   Masella, Roberta ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Anti inflammatory; Antioxidant; EVOO polyphenols; Extra virgin olive oil; Immune mediated inflammatory diseases; Phenolic compounds

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; EXTRA VIRGIN OLIVE OIL; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 6; LUTEOLIN 7 GLUCOSIDE; OLEUROPEIN; POLYPHENOL DERIVATIVE; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; ANTIOXIDANT; NONSTEROID ANTIINFLAMMATORY AGENT; OLIVE OIL; POLYPHENOL; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; STAT PROTEIN; TRANSFORMING GROWTH FACTOR;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CANCER RISK; DIET SUPPLEMENTATION; DYSBIOSIS; GENETIC TRANSCRIPTION; HEART PROTECTION; HUMAN; IMMUNE MEDIATED INJURY; IMMUNOMODULATION; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY DISEASE; INTESTINE FLORA; LYMPHOCYTIC INFILTRATION; MAPK SIGNALING; MULTIPLE SCLEROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; RISK FACTOR; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TH17 CELL; ANALYSIS; ANIMAL; CHEMISTRY; DIET THERAPY; DIETARY SUPPLEMENT; EVIDENCE BASED MEDICINE; FOOD QUALITY; FUNCTIONAL FOOD; IMMUNOLOGY; IMMUNOPATHOLOGY; MEDITERRANEAN DIET; CELL DIFFERENTIATION; DIETARY INTAKE; IMMUNE MEDIATED INFLAMMATORY DISEASE; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; T LYMPHOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; DIET, MEDITERRANEAN; DIETARY SUPPLEMENTS; EVIDENCE-BASED MEDICINE; FOOD QUALITY; FUNCTIONAL FOOD; HUMANS; IMMUNE SYSTEM DISEASES; IMMUNOMODULATION; OLIVE OIL; POLYPHENOLS;

EID: 85041335544     PISSN: 18715303     EISSN: 22123873     Source Type: Journal    
DOI: 10.2174/1871530317666171114114321     Document Type: Review

References (201)

1. Lesuis, N.; Befrits, R.; Nyberg, F.; van Vollenhoven, R.F. Gender and the treatment of immune-mediated chronic inflammatory diseases: rheumatoid arthritis, inflammatory bowel disease and psoriasis: an observational study. BMC Med., 2012, 10, 82.
2. Bayry, J.; Radstake, T.R. Immune-mediated inflammatory diseases: progress in molecular pathogenesis and therapeutic strategies. Expert. Rev. Clin. Immunol., 2013, 9, 297-929.
3. Marrie, R.A.; Cohen, J.; Stuve, O.; Trojano, M.; Sorensen, P.S.; Reingold, S.; Cutter, G.; Reider, N. A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview. Mult. Scler., 2015, 21, 263-281.
4. Svensson, A.L.; Christensen, R.; Persson, F.; Logstrup, B.B.; Giraldi, A.; Graugaard, C.; Fredberg, U.; Blegvad, J.; Thygesen, T.; Hansen, I. M.; Colic, A.; Bagdat, D.; Ahlquist, P.; Jensen, H.S.; Horslev-Petersen, K.; Sheetal, E.; Christensen, T.G.; Svendsen, L.; Emmertsen, H.; Ellingsen, T. Multifactorial intervention to prevent cardiovascular disease in patients with early rheumatoid arthritis: protocol for a multicentre randomised controlled trial. BMJ Open, 2016, 6, e009134.
5. Gianfrancesco, M.A.; Barcellos, L.F. Obesity and multiple sclerosis susceptibility: a review. J. Neurol. Neuromed., 2016, 1, 1-5.
6. Ananthakrishnan, A.N. Environmental risk factors for inflammatory bowel diseases: a review. Dig. Dis. Sci., 2015, 60, 290-298.
7. Hedstrom, A.K.; Alfredsson, L.; Olsson, T. Environmental factors and their interactions with risk genotypes in MS susceptibility. Curr. Opin. Neurol., 2016, 29, 293-298.
8. Ballestar, E. Epigenetic alterations in autoimmune rheumatic diseases. Nat. Rev. Rheumatol., 2011, 7, 263-271.
9. Chen, B.; Sun, L.; Zhang, X. Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases. J. Autoimmun., 2017, 83, 31-42.
10. Kau, A.L.; Ahern, P.P.; Griffin, N.W.; Goodman, A.L.; Gordon, J.I. Human nutrition, the gut microbiome and the immune system. Nature, 2011, 474, 327-336.
11. Forbes, J.D.; Van Domselaar, G.; Bernstein, C.N. The gut microbiota in immune-mediated inflammatory diseases. Front. Microbiol., 2016, 7, 1081.
12. Versini, M.; Jeandel, P.Y.; Rosenthal, E.; Shoenfeld, Y. Obesity in autoimmune diseases: not a passive bystander. Autoimmun. Rev., 2014, 13, 981-1000.
13. Winer, S.; Paltser, G.; Chan, Y.; Tsui, H.; Engleman, E.; Winer, D.; Dosch, H.M. Obesity predisposes to Th17 bias. Eur. J. Immunol., 2009, 39, 2629-2635.
14. UNESCO culture intangible heritage lists & register inscribed elements Mediterraneandiet"2013. Available from: http://www.unesco.org/culture/ich/index.php?lg=en&pg=00011&R L=884 [Accessed October 20, 17]
15. Gotsis, E.; Anagnostis, P.; Mariolis, A.; Vlachou, A.; Katsiki, N.; Karagiannis, A. Health benefits of the Mediterranean Diet: an update of research over the last 5 years. Angiology, 2015, 66, 304-318.
16. Sofi, F.; Macchi, C.; Abbate, R.; Gensini, G.F.; Casini, A. Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public. Health. Nutr., 2014, 17, 2769-2782.
17. Esposito, K.; Maiorino, M.I.; Bellastella, G.; Chiodini, P.; Panagiotakos, D.; Giugliano, D. A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. BMJ Open, 2015, 5, e008222.
18. Santangelo, C.; Filesi, C.; Vari, R.; Scazzocchio, B.; Filardi, T.; Fogliano, V.; D'Archivio, M.; Giovannini, C.; Lenzi, A.; Morano, S.; Masella, R. Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin. J. Endocrinol. Invest., 2016, 39, 1295-1301.
19. Tomasello, G.; Mazzola, M.; Leone, A.; Sinagra, E.; Zummo, G.; Farina, F.; Damiani, P.; Cappello, F.; Gerges Geagea, A.; Jurjus, A.; Bou Assi, T.; Messina, M.; Carini, F. Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases. Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc Czech Repub., 2016, 160, 461-466.
20. Martinez-Gonzalez, M.A.; Garcia-Arellano, A.; Toledo, E.; Salas-Salvado, J.; Buil-Cosiales, P.; Corella, D.; Covas, M. I.; Schroder, H.; Aros, F.; Gomez-Gracia, E.; Fiol, M.; Ruiz-Gutierrez, V.; Lapetra, J.; Lamuela-Raventos, R. M.; Serra-Majem, L.; Pinto, X.; Munoz, M. A.; Warnberg, J.; Ros, E.; Estruch, R.; PREDIMED study Investigators. A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial. PloS One, 2012, 7, e43134.
21. Casas, R.; Sacanella, E.; Urpi-Sarda, M.; Corella, D.; Castaner, O.; Lamuela-Raventos, R. M.; Salas-Salvado, J.; Martinez-Gonzalez, M. A.; Ros, E.; Estruch, R. Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High Risk of Cardiovascular Disease in the PREvencion con DIeta MEDiterranea (PREDIMED) Randomized Controlled Trial. J. Nutr., 2016, 146, 1684-1693.
22. Bach-Faig, A.; Berry, E.M.; Lairon, D.; Reguant, J.; Trichopoulou, A.; Dernini, S.; Medina, F. X.; Battino, M.; Belahsen, R.; Miranda, G.; Serra-Majem, L. Mediterranean Diet Foundation Expert, G. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr., 2011, 14, 2274-2284.
23. Covas, M.I.; de la Torre, R.; Fito, M. Virgin olive oil: a key food for cardiovascular risk protection. Br. J. Nutr., 2015, 113, S19-28.
24. Hashmi, M.A.; Khan, A.; Hanif, M.; Farooq, U.; Perveen, S. Traditional uses, phytochemistry, and pharmacology of Olea europaea (Olive). Evid. Based Complement. Alternat. Med., 2015, 2015, 541591.
25. Rigacci, S.; Stefani, M. Nutraceutical properties of olive oil polyphenols. An itinerary from cultured cells through animal models to humans. Int. J. Mol. Sci., 2016, 17.
26. Martin-Pelaez, S.; Mosele, J.I.; Pizarro, N.; Farras, M.; de la Torre, R.; Subirana, I.; Perez-Cano, F.J.; Castaner, O.; Sola, R.; Fernandez-Castillejo, S.; Heredia, S.; Farre, M.; Motilva, M.J.; Fito, M. Effect of virgin olive oil and thyme phenolic compounds on blood lipid profile: implications of human gut microbiota. Eur. J. Nutr., 2017, 56, 119-131.
27. Serra, A.; Rubio, L.; Borras, X.; Macia, A.; Romero, M.P.; Motilva, M.J. Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake. Mol. Nutr. Food Res., 2012, 56, 486-496.
28. Carito, V.; Ceccanti, M.; Tarani, L.; Ferraguti, G.; Chaldakov, G.N.; Fiore, M. Neurotrophins' modulation by olive polyphenols. Curr. Med. Chem., 2016, 23, 3189-3197.
29. Rodriguez-Morato, J.; Xicota, L.; Fito, M.; Farre, M.; Dierssen, M.; de la Torre, R. Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases. Molecules, 2015, 20, 4655-4680.
30. Piroddi, M.; Albini, A.; Fabiani, R.; Giovannelli, L.; Luceri, C.; Natella, F.; Rosignoli, P.; Rossi, T.; Taticchi, A.; Servili, M.; Galli, F. Nutrigenomics of extra-virgin olive oil: A review. BioFactors, 2017, 43, 17-41.
31. Giovannini, C.; Straface, E.; Modesti, D.; Coni, E.; Cantafora, A.; De Vincenzi, M.; Malorni, W.; Masella, R. Tyrosol, the major olive oil biophenol, protects against oxidized-LDL-induced injury in Caco-2 cells. J. Nutr., 1999, 129, 1269-1277.
32. Coni, E.; Di Benedetto, R.; Di Pasquale, M.; Masella, R.; Modesti, D.; Mattei, R.; Carlini, E. A. Protective effect of oleuropein, an olive oil biophenol, on low density lipoprotein oxidizability in rabbits. Lipids, 2000, 35, 45-54.
33. Covas, M.I. Olive oil and the cardiovascular system. Pharmacol. Res., 2007, 55, 175-186.
34. Rivellese, A.A.; Giacco, R.; Annuzzi, G.; De Natale, C.; Patti, L.; Di Marino, L.; Minerva, V.; Costabile, G.; Santangelo, C.; Masella, R.; Riccardi, G. Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes. Clin. Nutr., 2008, 27, 133-141.
35. Gennaro, L.; Bocca, A.P.; Modesti, D.; Masella, R.; Coni, E. Effect of biophenols on olive oil stability evaluated by thermogravimetric analysis. J. Agric. Food. Chem., 1998, 46, 4465-4469.
36. Bendini, A.; Cerretani, L.; Carrasco-Pancorbo, A.; Gomez-Caravaca, A.M.; Segura-Carretero, A.; Fernandez-Gutierrez, A.; Lercker, G. Phenolic molecules in virgin olive oils: a survey of their sensory properties, health effects, antioxidant activity and analytical methods. An overview of the last decade. Molecules, 2007, 12, 1679-1719.
37. Martin-Pelaez, S.; Covas, M.I.; Fito, M.; Kusar, A.; Pravst, I. Health effects of olive oil polyphenols: recent advances and possibilities for the use of health claims. Mol. Nutr. Food Res., 2013, 57, 760-771.
38. Rodriguez-Morato, J.; Boronat, A.; Kotronoulas, A.; Pujadas, M.; Pastor, A.; Olesti, E.; Perez-Mana, C.; Khymenets, O.; Fito, M.; Farre, M.; de la Torre, R. Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol. Drug Metab. Rev., 2016, 48, 218-236.
39. Parkinson, L.; Cicerale, S. The health benefiting mechanisms of virgin olive oil phenolic compounds. Molecules, 2016, 21, 1734.
40. Masella, R.; Giovannini, C.; Vari, R.; Di Benedetto, R.; Coni, E.; Volpe, R.; Fraone, N.; Bucci, A. Effects of dietary virgin olive oil phenols on low density lipoprotein oxidation in hyperlipidemic patients. Lipids, 2001, 36, 1195-1202.
41. Masella, R.; Di Benedetto, R.; Vari, R.; Filesi, C.; Giovannini, C. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J. Nutr. Biochem., 2005, 16, 577-586.
42. D'Archivio, M.; Santangelo, C.; Scazzocchio, B.; Vari, R.; Filesi, C.; Masella, R.; Giovannini, C. Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention. Int. J. Mol. Sci., 2008, 9, 213-228.
43. Masella, R.; Santangelo, C.; D'Archivio, M.; Li Volti, G.; Giovannini, C.; Galvano, F. Protocatechuic acid and human disease prevention: biological activities and molecular mechanisms. Curr. Med. Chem., 2012, 19, 2901-2917.
44. Del Corno, M.; Scazzocchio, B.; Masella, R.; Gessani, S. Regulation of Dendritic Cell Function by Dietary Polyphenols. Crit. Rev. Food Sci. Nutr., 2016, 56, 737-747.
45. Vari, R.; Scazzocchio, B.; Santangelo, C.; Filesi, C.; Galvano, F.; D'Archivio, M.; Masella, R.; Giovannini, C. Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNK/Nrf2 Survival Signals in Macrophages. Oxid. Med. Cell. Longev., 2015, 2015, 351827.
46. Scazzocchio, B.; Vari, R.; Filesi, C.; Del Gaudio, I.; D'Archivio, M.; Santangelo, C.; Iacovelli, A.; Galvano, F.; Pluchinotta, F.R.; Giovannini, C.; Masella, R. Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity. Mol. Nutr. Food Res., 2015, 59, 1472-1481.
47. Hernaez, A.; Remaley, A.T.; Farras, M.; Fernandez-Castillejo, S.; Subirana, I.; Schroder, H.; Fernandez-Mampel, M.; Munoz-Aguayo, D.; Sampson, M.; Sola, R.; Farre, M.; de la Torre, R.; Lopez-Sabater, M.C.; Nyyssonen, K.; Zunft, H.J.; Covas, M.I.; Fito, M. Olive oil polyphenols decrease LDL concentrations and LDL atherogenicity in men in a randomized controlled trial. J. Nutr., 2015, 145, 1692-1697.
48. Shah, Z.H.; Hamooh, B.T.; Daur, I.; Rehman, H.M.; Alghabari, F. Transcriptomics and biochemical profiling: current dynamics in elucidating the potential attributes of olive. Curr. Issues Mol. Biol., 2017, 21, 73-98.
49. Mitra, J.; Shrivastava, S.L.; Rao, P.S. Onion dehydration: a review. J. Food Sci. Technol., 2012, 49, 267-277.
50. Richard, N.; Arnold, S.; Hoeller, U.; Kilpert, C.; Wertz, K.; Schwager, J. Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages. Planta Med., 2011, 77, 1890-1897.
51. Vogel, P.; Kasper Machado, I.; Garavaglia, J.; Zani, V.T.; de Souza, D.; Morelo Dal Bosco, S. Polyphenols benefits of olive leaf (Olea europaea L) to human health. Nutr. Hosp., 2014, 31, 1427-1433.
52. Boss, A.; Bishop, K.S.; Marlow, G.; Barnett, M.P.; Ferguson, L.R. Evidence to support the anti-cancer effect of olive leaf extract and future directions. Nutrients, 2016, 8.
53. Japon-Lujan, R.; Luque-Rodriguez, J.M.; Luque de Castro, M.D. Dynamic ultrasound-assisted extraction of oleuropein and related biophenols from olive leaves. J. Chromatogr. A., 2006, 1108, 76-82.
54. Ranalli, A.; Contento, S.; Lucera, L.; Di Febo, M.; Marchegiani, D.; Di Fonzo, V. Factors affecting the contents of iridoid oleuropein in olive leaves (Olea europaea L.). J. Agric. Food Chem., 2006, 54, 434-440.
55. Servili, M.; Montedoro, G. Contribution of phenolic compounds to virgin olive oil quality. Eur. J. Lipid Sci. Tech., 2002, 104, 602-613.
56. Vissers, M.N.; Zock, P.L.; Katan, M.B. Bioavailability and antioxidant effects of olive oil phenols in humans: a review. Eur. J. Clin. Nutr., 2004, 58, 955-965.
57. Corona, G.; Spencer, J.P.; Dessi, M.A. Extra virgin olive oil phenolics: absorption, metabolism, and biological activities in the GI tract. Toxicol. Ind. Health., 2009, 25, 285-293.
58. Soler, A.; Romero, M.P.; Macia, A.; Saha, S.; Furniss, C.S.M.; Kroon, P.A.; Motilva, M.J. Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human smallintestinal epithelial Caco-2/TC7 cell line. Food Chem., 2010, 119, 703-714.
59. Corona, G.; Tzounis, X.; Assunta Dessi, M.; Deiana, M.; Debnam, E.S.; Visioli, F.; Spencer, J.P. The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation. Free Radic. Res., 2006, 40, 647-658.
60. D'Archivio, M.; Filesi, C.; Vari, R.; Scazzocchio, B.; Masella, R. Bioavailability of the polyphenols: status and controversies. Int. J. Mol. Sci., 2010, 11, 1321-1342.
61. de Bock, M.; Thorstensen, E.B.; Derraik, J.G.; Henderson, H. V.; Hofman, P.L.; Cutfield, W. S. Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract. Mol. Nutr. Food Res., 2013, 57, 2079-2085.
62. Mosele, J.I.; Martin-Pelaez, S.; Macia, A.; Farras, M.; Valls, R.M.; Catalan, U.; Motilva, M.J. Faecal microbial metabolism of olive oil phenolic compounds: in vitro and in vivo approaches. Mol. Nutr. Food Res., 2014, 58, 1809-1819.
63. Vilaplana-Perez, C.; Aunon, D.; Garcia-Flores, L.A.; Gil-Izquierdo, A. Hydroxytyrosol and potential uses in cardiovascular diseases, cancer, and AIDS. Front. Nutr., 2014, 1, 18.
64. E.N. Panel Scientific Opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage. EFSA J., 9(2011), pp. 2033. Available from: http://dx.doi.org/10.2903/jefsa20112033 [Accessed October 20, 2017].
65. Guo, B. IL-10 modulates Th17 pathogenicity during autoimmune diseases. J. Clin. Cell Immunol., 2016, 7.
66. Guan, S.Y.; Leng, R.X.; Khan, M.I.; Qureshi, H.; Li, X. P.; Ye, D.Q.; Pan, H. F. Interleukin-35: A potential therapeutic agent for autoimmune diseases. Inflammation, 2017, 40, 303-310.
67. Diller, M.L.; Kudchadkar, R.R.; Delman, K.A.; Lawson, D.H.; Ford, M.L. Balancing Inflammation: The link between Th17 and eegulatory T cells. Mediators inflamm., 2016, 2016, 6309219.
68. Kaulmann, A.; Bohn, T. bioactivity of polyphenols: preventive and adjuvant strategies toward reducing inflammatory bowel diseasespromises, perspectives, and pitfalls. Oxid. Med. Cell. Longev., 2016, 2016, 9346470.
69. Aparicio-Soto, M.; Sanchez-Hidalgo, M.; Cardeno, A.; Rosillo, M.A.; Sanchez-Fidalgo, S.; Utrilla, J.; Martin-Lacave, I.; Alarconde-la-Lastra, C. Dietary extra virgin olive oil attenuates kidney injury in pristane-induced SLE model via activation of HO-1/Nrf-2 antioxidant pathway and suppression of JAK/STAT, NF-kappaB and MAPK activation. J. Nutr. Biochem., 2016, 27, 278-288.
70. Schwartz, D.M.; Bonelli, M.; Gadina, M.; O'Shea, J.J. Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nat. Rev. Rheumatol., 2016, 12, 25-36.
71. Miossec, P.; Kolls, J.K. Targeting IL-17 and TH17 cells in chronic inflammation. Nat. Rev. Drug Discov., 2012, 11, 763-776.
72. Paley, M.A.; Strand, V.; Kim, A.H. From mechanism to therapies in systemic lupus erythematosus. Curr. Opin. Rheumatol., 2017, 29, 178-186.
73. Fasching, P.; Stradner, M.; Graninger, W.; Dejaco, C.; Fessler, J. Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders. Molecules, 2017, 22, 134.
74. Fito, M.; Cladellas, M.; de la Torre, R.; Marti, J.; Munoz, D.; Schroder, H.; Alcantara, M.; Pujadas-Bastardes, M.; Marrugat, J.; Lopez-Sabater, M.C.; Bruguera, J.; Covas, M.I.; Investigators, S. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial. Eur. J. Clin. Nutr., 2008, 62, 570-574.
75. Lama, A.; Pirozzi, C.; Mollica, M.P.; Trinchese, G.; Di Guida, F.; Cavaliere, G.; Calignano, A.; Mattace Raso, G.; Berni Canani, R.; Meli, R. Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats. Mol. Nutr. Food Res., 2017, 61(3). doi: 10.1002/mnfr.201600418.
76. Jurado-Ruiz, E.; Varela, L.M.; Luque, A.; Berna, G.; Cahuana, G.; Martinez-Force, E.; Gallego-Duran, R.; Soria, B.; de Roos, B.; Romero Gomez, M.; Martin, F. An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high-fat "Western-type" diet in mice. Mol. Nutr. Food Res., 2017, 61. doi: 10.1002/mnfr.201600549.
77. D'Amore, S.; Vacca, M.; Cariello, M.; Graziano, G.; D'Orazio, A.; Salvia, R.; Sasso, R.C.; Sabba, C.; Palasciano, G.; Moschetta, A. Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil. Biochim. Biophys. Acta, 2016, 1861, 1671-1680.
78. Boss, A.; Kao, C.H.; Murray, P.M.; Marlow, G.; Barnett, M.P.; Ferguson, L.R. Human intervention study to assess the effects of supplementation with olive leaf extract on peripheral blood mononuclear cell gene expression. Int. J. Mol. Sci., 2016, 17, 2019.
79. Fito, M.; Cladellas, M.; de la Torre, R.; Marti, J.; Alcantara, M.; Pujadas-Bastardes, M.; Marrugat, J.; Bruguera, J.; Lopez-Sabater, M.C.; Vila, J.; Covas, M.I.; Members of the SOLOS Investigators. Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis, 2005, 181, 149-158.
80. Rosillo, M.A.; Sanchez-Hidalgo, M.; Sanchez-Fidalgo, S.; Aparicio-Soto, M.; Villegas, I.; Alarcon-de-la-Lastra, C. Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis. Eur. J. Nutr., 2016, 55, 315-325.
81. Cicerale, S.; Lucas, L.; Keast, R. Biological activities of phenolic compounds present in virgin olive oil. Int. J. Mol. Sci., 2010, 11, 458-479.
82. Barbaro, B.; Toietta, G.; Maggio, R.; Arciello, M.; Tarocchi, M.; Galli, A.; Balsano, C. Effects of the olive-derived polyphenol oleuropein on human health. Int. J. Mol. Sci., 2014, 15, 18508-18524.
83. Bulotta, S.; Celano, M.; Lepore, S.M.; Montalcini, T.; Pujia, A.; Russo, D. Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases. J. Transl. Med., 2014, 12, 219.
84. Lu, J.; Huang, G.; Wang, Z.; Zhuang, S.; Xu, L.; Song, B.; Xiong, Y.; Guan, S. Tyrosol exhibits negative regulatory effects on LPS response and endotoxemia. Food Chem. Toxicol., 2013, 62, 172-178.
85. Beauchamp, G.K.; Keast, R.S.; Morel, D.; Lin, J.; Pika, J.; Han, Q.; Lee, C.H.; Smith, A.B.; Breslin, P. A. Phytochemistry: ibuprofenlike activity in extra-virgin olive oil. Nature, 2005, 437, 45-46.
86. Omar, S.H. Oleuropein in olive and its pharmacological effects. Sci. Pharm., 2010, 78, 133-154.
87. Khalatbary, A.R.; Zarrinjoei, G.R. Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma. Iran Red. Crescent Med. J., 2012, 14, 229-234.
88. Kimura, Y.; Sumiyoshi, M. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiationinduced skin damage and carcinogenesis in hairless mice. J. Nutr., 2009, 139, 2079-2086.
89. Cao, K.; Xu, J.; Zou, X.; Li, Y.; Chen, C.; Zheng, A.; Li, H.; Li, H.; Szeto, I.M.; Shi, Y.; Long, J.; Liu, J.; Feng, Z. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic. Biol. Med., 2014, 67, 396-407.
90. Carito, V.; Ciafre, S.; Tarani, L.; Ceccanti, M.; Natella, F.; Iannitelli, A.; Tirassa, P.; Chaldakov, G.N.; Ceccanti, M.; Boccardo, C.; Fiore, M. TNF-alpha and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation. Ann. Ist. Super. Sanita., 2015, 51, 382-386.
91. Qosa, H.; Batarseh, Y.S.; Mohyeldin, M.M.; El Sayed, K.A.; Keller, J.N.; Kaddoumi, A. Oleocanthal enhances amyloid-beta clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model. ACS Chem. Neurosci., 2015, 6, 1849-1859.
92. Martin, M.A.; Ramos, S.; Granado-Serrano, A.B.; Rodriguez-Ramiro, I.; Trujillo, M.; Bravo, L.; Goya, L. Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells. Mol. Nutr. Food Res., 2010, 54, 956-966.
93. Sato, K.; Mihara, Y.; Kanai, K.; Yamashita, Y.; Kimura, Y.; Itoh, N. Tyrosol ameliorates lipopolysaccharide-induced ocular inflammation in rats via inhibition of nuclear factor (NF)-kappaB activation. J. Vet. Med. Sci., 2016, 78, 1429-1438.
94. Scoditti, E.; Massaro, M.; Carluccio, M.A.; Pellegrino, M.; Wabitsch, M.; Calabriso, N.; Storelli, C.; De Caterina, R. Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic Acid and hydroxytyrosol in human adipocytes. PloS One, 2015, 10, e0128218.
95. Ryu, S.J.; Choi, H.S.; Yoon, K.Y.; Lee, O.H.; Kim, K.J.; Lee, B.Y. Oleuropein suppresses LPS-induced inflammatory responses in RAW 264.7 cell and zebrafish. J. Agric. Food Chem., 2015, 63, 2098-2105.
96. Di Benedetto, R.; Vari, R.; Scazzocchio, B.; Filesi, C.; Santangelo, C.; Giovannini, C.; Matarrese, P.; D'Archivio, M.; Masella, R. Tyrosol, the major extra virgin olive oil compound, restored intracellular antioxidant defences in spite of its weak antioxidative effectiveness. Nutr. Metab. Cardiovasc. Dis., 2007, 17, 535-545.
97. Masella, R.; Vari, R.; D'Archivio, M.; Di Benedetto, R.; Matarrese, P.; Malorni, W.; Scazzocchio, B.; Giovannini, C. Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J. Nutr., 2004, 134, 785-791.
98. Giovannini, C.; Filesi, C.; D'Archivio, M.; Scazzocchio, B.; Santangelo, C.; Masella, R. [Polyphenols and endogenous antioxidant defences: effects on glutathione and glutathione related enzymes]. Ann. Ist. Super. Sanita, 2006, 42, 336-347.
99. McInnes, I.B.; Schett, G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med., 2011, 365, 2205-2219.
100. Boissier, M.C.; Semerano, L.; Challal, S.; Saidenberg-Kermanac'h, N.; Falgarone, G. Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction. J. Autoimmun., 2012, 39, 222-228.
101. Semerano, L.; Minichiello, E.; Bessis, N.; Boissier, M.C. Novel immunotherapeutic avenues for rheumatoid arthritis. Trends Mol. Med., 2016, 22, 214-229.
102. Lai, X.; Wang, H.; Cao, J.; Li, Y.; Dai, Y.; Xiang, Y.; Zhang, L. Circulating IL-27 is elevated in rheumatoid arthritis patients. Molecules., 2016, 21, 1565.
103. Zaky, D.S.; El-Nahrery, E.M. Role of interleukin-23 as a biomarker in rheumatoid arthritis patients and its correlation with disease activity. Int. Immunopharmacol., 2016, 31, 105-108.
104. Nakano, S.; Morimoto, S.; Suzuki, S.; Tsushima, H.; Yamanaka, K.; Sekigawa, I.; Takasaki, Y. Immunoregulatory role of IL-35 in T cells of patients with rheumatoid arthritis. Rheumatology., 2015, 54, 1498-1506.
105. Ciccia, F.; Ferrante, A.; Guggino, G.; Triolo, G. The role of the gastrointestinal tract in the pathogenesis of rheumatic diseases. Best Pract. Res. Clin. Rheumatol., 2016, 30, 889-900.
106. Navegantes, K.C.; de Souza Gomes, R.; Pereira, P.A. T.; Czaikoski, P.G.; Azevedo, C. H.M.; Monteiro, M.C. Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity. J. Transl. Med., 2017, 15, 36.
107. Albrecht, K. Gender-specific differences in comorbidities of rheumatoid arthritis. Z. Rheumatol., 2014, 73, 607-614.
108. Aurrecoechea, E.; Llorca Diaz, J.; Diez Lizuain, M.L.; McGwin, G. Jr.; Calvo-Alen, J. Gender-associated comorbidities in rheumatoid arthritis and their impact on outcome: data from GENIRA. Rheumatol. Int., 2017, 37, 479-485.
109. Ljung, L.; Rantapaa-Dahlqvist, S. Abdominal obesity, gender and the risk of rheumatoid arthritis-a nested case-control study. Arthritis Res. Ther., 2016, 18, 277.
110. Wruck, C.J.; Fragoulis, A.; Gurzynski, A.; Brandenburg, L.O.; Kan, Y.W.; Chan, K.; Hassenpflug, J.; Freitag-Wolf, S.; Varoga, D.; Lippross, S.; Pufe, T. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann. Rheum. Dis., 2011, 70, 844-850.
111. Cicerale, S.; Lucas, L.J.; Keast, R.S. Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr. Opin. Biotechnol., 2012, 23, 129-135.
112. Islam, M.A.; Alam, F.; Solayman, M.; Khalil, M.I.; Kamal, M.A.; Gan, S.H. Dietary phytochemicals: Natural swords combating inflammation and oxidation-mediated degenerative diseases. Oxid. Med. Cell. Longev., 2016, 2016, 5137431.
113. Tedeschi, S.K.; Costenbader, K.H. Is there a role for diet in the therapy of rheumatoid arthritis? Curr. Rheumatol. Rep., 2016, 18, 23.
114. Rosillo, M.A.; Alcaraz, M.J.; Sanchez-Hidalgo, M.; Fernandez-Bolanos, J.G.; Alarcon-de-la Lastra, C.; Ferrandiz, M. L. Antiinflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis. J. Nutr. Biochem., 2014, 25, 1275-1281.
115. Rosillo, M.A.; Sanchez-Hidalgo, M.; Gonzalez-Benjumea, A.; Fernandez-Bolanos, J.G.; Lubberts, E.; Alarcon-de-la-Lastra, C. Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis. Mol. Nutr Food Res., 2015, 59, 2537-2546.
116. Silva, S.; Sepodes, B.; Rocha, J.; Direito, R.; Fernandes, A.; Brites, D.; Freitas, M.; Fernandes, E.; Bronze, M.R.; Figueira, M.E. Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis. J. Nutr. Biochem., 2015, 26, 360-368.
117. Impellizzeri, D.; Esposito, E.; Mazzon, E.; Paterniti, I.; Di Paola, R.; Morittu, V.M.; Procopio, A.; Britti, D.; Cuzzocrea, S. Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in mice. J. Pharmacol. Exp. Ther., 2011, 339, 859-869.
118. Castejon, M.L.; Rosillo, M.A.; Montoya, T.; Gonzalez-Benjumea, A.; Fernandez-Bolanos, J.M.; Alarcon-de-la-Lastra, C. Oleuropein down-regulated IL-1beta-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982. Food Funct., 2017, 8, 1890-1898.
119. Scotece, M.; Gomez, R.; Conde, J.; Lopez, V.; Gomez-Reino, J.J.; Lago, F.; Smith, A.B. 3rd; Gualillo, O. Further evidence for the anti-inflammatory activity of oleocanthal: inhibition of MIP-1alpha and IL-6 in J774 macrophages and in ATDC5 chondrocytes. Life Sci., 2012, 91, 1229-1235.
120. Bohlooli, S.; Jastan, M.; Nakhostin-Roohi, B.; Mohammadi, S.; Baghaei, Z. A pilot double-blinded, randomized, clinical trial of topical virgin olive oil versus piroxicam gel in osteoarthritis of the knee. J. Clin. Rheumatol., 2012, 18, 99-101.
121. Nakhostin-Roohi, B.; Khoshkhahesh, F.; Bohlooli, S. Effect of virgin olive oil versus piroxicam phonophoresis on exerciseinduced anterior knee pain. Avicenna J. Phytomed., 2016, 6, 535-541.
122. Ng, S.F.; Tan, L.S.; Buang, F. Transdermal anti-inflammatory activity of bilayer film containing olive compound hydroxytyrosol: physical assessment, in vivo dermal safety and efficacy study in Freund's adjuvant-induced arthritic rat model. Drug Dev. Ind. Pharm., 2017, 43, 108-119.
123. Berbert, A.A.; Kondo, C.R.; Almendra, C.L.; Matsuo, T.; Dichi, I. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis. Nutrition, 2005, 21, 131-136.
124. Musumeci, G.; Trovato, F.M.; Pichler, K.; Weinberg, A.M.; Loreto, C.; Castrogiovanni, P. Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression. J. Nutr. Biochem., 2013, 24, 2064-2075.
125. Schulberg, J.; De Cruz, P. Characterisation and therapeutic manipulation of the gut microbiome in inflammatory bowel disease. Intern. Med. J., 2016, 46, 266-273.
126. Furuzawa Carballeda, J.; Fonseca Camarillo, G.; Yamamoto-Furusho, J. K. Interleukin 27 is up-regulated in patients with active inflammatory bowel disease. Immunol. Res., 2016, 64, 901-907.
127. Verstockt, B.; Van Assche, G.; Vermeire, S.; Ferrante, M. Biological therapy targeting the IL-23/IL-17 axis in inflammatory bowel disease. Expert. Opin. Biol. Ther., 2017, 17, 31-47.
128. Abraham, C.; Dulai, P.S.; Vermeire, S.; Sandborn, W.J. Lessons learned from trials targeting cytokine pathways in patients with inflammatory bowel diseases. Gastroenterology, 2017, 152, 374-388 e4.
129. Andrews, C.; McLean, M.H.; Durum, S.K. Interleukin-27 as a novel therapy for inflammatory bowel disease: a critical review of the literature. Inflamm. Bowel. Dis., 2016, 22, 2255-2264.
130. Farzaei, M.H.; Rahimi, R.; Abdollahi, M. The role of dietary polyphenols in the management of inflammatory bowel disease. Curr. Pharm. Biotechnol., 2015, 16, 196-210.
131. Sarbagili-Shabat, C.; Sigall-Boneh, R.; Levine, A. Nutritional therapy in inflammatory bowel disease. Curr. Opin. Gastroenterol., 2015, 31, 303-308.
132. De Filippis, F.; Pellegrini, N.; Vannini, L.; Jeffery, I.B.; La Storia, A.; Laghi, L.; Serrazanetti, D.I.; Di Cagno, R.; Ferrocino, I.; Lazzi, C.; Turroni, S.; Cocolin, L.; Brigidi, P.; Neviani, E.; Gobbetti, M.; O'Toole, P.W.; Ercolini, D. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut, 2016, 65, 1812-1821.
133. Martin-Pelaez, S.; Castaner, O.; Sola, R.; Motilva, M. J.; Castell, M.; Perez-Cano, F.J.; Fito, M. Influence of phenol-enriched olive oils on human intestinal immune function. Nutrients, 2016, 8, 213.
134. Sanchez-Fidalgo, S.; Sanchez de Ibarguen, L.; Cardeno, A.; Alarcon de la Lastra, C. Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model. Eur. J. Nutr., 2012, 51, 497-506.
135. Reddy, K.V.; Naidu, K.A. Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; in vitro and in vivo studies. Int. Immunopharmacol., 2016, 35, 29-42.
136. Giner, E.; Recio, M.C.; Rios, J.L.; Giner, R.M. Oleuropein protects against dextran sodium sulfate-induced chronic colitis in mice. J. Nat. Prod., 2013, 76, 1113-1120.
137. Giner, E.; Recio, M.C.; Rios, J.L.; Cerda-Nicolas, J.M.; Giner, R.M. Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice. Mol. Nutr. Food. Res., 2016, 60, 242-255.
138. Larussa, T.; Oliverio, M.; Suraci, E.; Greco, M.; Placida, R.; Gervasi, S.; Marasco, R.; Imeneo, M.; Paolino, D.; Tucci, L.; Gulletta, E.; Fresta, M.; Procopio, A.; Luzza, F. Oleuropein decreases cyclooxygenase-2 and interleukin-17 expression and attenuates inflammatory damage in colonic samples from ulcerative colitis patients. Nutrients, 2017, 9, 391.
139. Muto, E.; Dell'Agli, M.; Sangiovanni, E.; Mitro, N.; Fumagalli, M.; Crestani, M.; De Fabiani, E.; Caruso, D. Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells. Mol. Nutr. Food. Res., 2015, 59, 1217-1221.
140. Barker, D.J.; Martyn, C.N. The maternal and fetal origins of cardiovascular disease. J. Epidemiol. Commun. Health, 1992, 46, 8-11.
141. Ley, D.; Desseyn, J.L.; Mischke, M.; Knol, J.; Turck, D.; Gottrand, F. Early-life origin of intestinal inflammatory disorders. Nutr. Rev., 2017, 75, 175-187.
142. Milo, R.; Miller, A. Revised diagnostic criteria of multiple sclerosis. Autoimmun. Rev., 2014, 13, 518-524.
143. Dos Passos, G.R.; Sato, D.K.; Becker, J.; Fujihara, K. Th17 cells pathways in multiple sclerosis and neuromyelitis optica spectrum disorders: pathophysiological and therapeutic implications. Mediators Inflamm., 2016, 2016, 5314541.
144. Wekerle, H. B cells in multiple sclerosis. Autoimmunity, 2017, 50, 57-60.
145. Marrie, R.A. Comorbidity in multiple sclerosis: implications for patient care. Nat. Rev. Neurol., 2017, 13, 375-382.
146. Capone, F.; Ferraro, E.; Florio, L.; Marcoccia, A.; Di Lazzaro, V.; Di Battista, G. Comorbidity influences therapeutic approach in multiple sclerosis. Clin. Neurol Neurosurg., 2017, 155, 14-16.
147. Tramacere, I.; Del Giovane, C.; Salanti, G.; D'Amico, R.; Filippini, G. Immunomodulators and immunosuppressants for relapsingremitting multiple sclerosis: a network meta-analysis. The Cochrane Database Syst. Rev., 2015, CD011381.
148. Guerrero-Garcia, J.J.; Carrera-Quintanar, L.; Lopez-Roa, R.I.; Marquez-Aguirre, A.L.; Rojas-Mayorquin, A.E.; Ortuno-Sahagun, D. Multiple sclerosis and obesity: possible roles of adipokines. Mediators Inflamm., 2016, 2016, 4036232.
149. Mirza, A.; Mao-Draayer, Y. The gut microbiome and microbial translocation in multiple sclerosis. Clin. Immunol., 2017, S1521-6616. doi: 10.1016/j.clim.2017.03.001.
150. Riccio, P.; Rossano, R. Nutrition facts in multiple sclerosis. ASN Neuro, 2015, 7. doi: 10.1177/1759091414568185.
151. Marck, C.H.; Neate, S.L.; Taylor, K.L.; Weiland, T.J.; Jelinek, G.A. Prevalence of comorbidities, overweight and obesity in an international sample of people with multiple sclerosis and associations with modifiable lifestyle factors. PloS One, 2016, 11, e0148573.
152. Berer, K.; Mues, M.; Koutrolos, M.; Rasbi, Z.A.; Boziki, M.; Johner, C.; Wekerle, H.; Krishnamoorthy, G. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature, 2011, 479, 538-541.
153. Altowaijri, G.; Fryman, A.; Yadav, V. Dietary interventions and multiple sclerosis. Curr. Neurol. Neurosci. Rep., 2017, 17, 28.
154. Sedaghat, F.; Jessri, M.; Behrooz, M.; Mirghotbi, M.; Rashidkhani, B. Mediterranean diet adherence and risk of multiple sclerosis: a case-control study. Asia Pac. J. Clin. Nutr., 2016, 25, 377-384.
155. Riccio, P.; Rossano, R.; Larocca, M.; Trotta, V.; Mennella, I.; Vitaglione, P.; Ettorre, M.; Graverini, A.; De Santis, A.; Di Monte, E.; Coniglio, M.G. Anti-inflammatory nutritional intervention in patients with relapsing-remitting and primary-progressive multiple sclerosis: A pilot study. Exp. Biol. Med. (Maywood)., 2016, 241, 620-635.
156. Bhullar, K.S.; Rupasinghe, H.P. Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid. Med. Cell. Longev., 2013, 2013, 891748.
157. Giovannini, C.; Masella, R. Role of polyphenols in cell death control. Nutr. Neurosci., 2012, 15, 134-149.
158. Davinelli, S.; Maes, M.; Corbi, G.; Zarrelli, A.; Willcox, D.C.; Scapagnini, G. Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges. Immun. Ageing, 2016, 13, 16.
159. Moosavi, F.; Hosseini, R.; Saso, L.; Firuzi, O. Modulation of neurotrophic signaling pathways by polyphenols. Drug Des. Devel. Ther., 2016, 10, 23-42.
160. Zheng, A.; Li, H.; Cao, K.; Xu, J.; Zou, X.; Li, Y.; Chen, C.; Liu, J.; Feng, Z. Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring. J. Nutr. Biochem., 2015, 26, 190-199.
161. Lamy, S.; Ben Saad, A.; Zgheib, A.; Annabi, B. Olive oil compounds inhibit the paracrine regulation of TNF-alpha-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression. J. Nutr. Biochem., 2016, 27, 136-145.
162. Fortuna, G.; Brennan, M.T. Systemic lupus erythematosus: epidemiology, pathophysiology, manifestations, and management. Dent. Clin. North. Am., 2013, 57, 631-655.
163. Long, H.; Yin, H.; Wang, L.; Gershwin, M.E.; Lu, Q. The critical role of epigenetics in systemic lupus erythematosus and autoimmunity. J. Autoimmun., 2016, 74, 118-138.
164. Talaat, R.M.; Mohamed, S.F.; Bassyouni, I.H.; Raouf, A.A. Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity. Cytokine., 2015, 72, 146-153.
165. Xia, L.P.; Li, B.F.; Shen, H.; Lu, J. Interleukin-27 and interleukin-23 in patients with systemic lupus erythematosus: possible role in lupus nephritis. Scand. J. Rheumatol., 2015, 44, 200-205.
166. Lopez, P.; de Paz, B.; Rodriguez-Carrio, J.; Hevia, A.; Sanchez, B.; Margolles, A.; Suarez, A. Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients. Sci. Rep., 2016, 6, 24072.
167. Adinolfi, A.; Valentini, E.; Calabresi, E.; Tesei, G.; Signorini, V.; Barsotti, S.; Tani, C. One year in stemic lupus erythematosus. Clin. Exp. Rheumatol., 2016, 34, 569-574.
168. Shor, D.B.; Dahan, S.; Comaneshter, D.; Cohen, A.D.; Amital, H. Does inflammatory bowel disease coexist with systemic lupus erythematosus? Autoimmun. Rev., 2016, 15, 1034-1037.
169. Harris, H.R.; Simard, J.F.; Arkema, E.V. Endometriosis and systemic lupus erythematosus: a population-based case-control study. Lupus, 2016, 25, 1045-1049.
170. Su, D.L.; Lu, Z.M.; Shen, M.N.; Li, X.; Sun, L.Y., Roles of proand anti-inflammatory cytokines in the pathogenesis of SLE. J. Biomed. Biotechnol., 2012, 2012, 347141.
171. Leng, R.X.; Pan, H.F.; Chen, G.M.; Wang, C.; Qin, W.Z.; Chen, L.L.; Tao, J.H.; Ye, D.Q. IL-23: a promising therapeutic target for systemic lupus erythematosus. Arch. Med. Res., 2010, 41, 221-225.
172. Pan, H.F.; Tao, J.H.; Ye, D.Q. Therapeutic potential of IL-27 in systemic lupus erythematosus. Expert Opin. Ther. Targets, 2010, 14, 479-484.
173. Cai, Z.; Wong, C.K.; Dong, J.; Chu, M.; Jiao, D.; Kam, N.W.; Lam, C.W.; Tam, L.S. Remission of systemic lupus erythematosus disease activity with regulatory cytokine interleukin (IL)-35 in Murphy Roths Large (MRL)/lpr mice. Clin. Exp. Immunol., 2015, 181, 253-266.
174. Selmi, C.; Tsuneyama, K. Nutrition, geoepidemiology, and autoimmunity. Autoimmun. Rev., 2010, 9, A267-270.
175. Borges, M.C.; dos Santos Fde, M.; Telles, R.W.; Lanna, C.C.; Correia, M.I.,ì Nutritional status and food intake in patients with systemic lupus erythematosus. Nutrition, 2012, 28, 1098-1103.
176. Minami, Y.; Sasaki, T.; Arai, Y.; Kurisu, Y.; Hisamichi, S. Diet and systemic lupus erythematosus: a 4 year prospective study of Japanese patients. J. Rheumatol., 2003, 30, 747-754.
177. Vieira, S.M.; Pagovich, O.E.; Kriegel, M.A. Diet, microbiota and autoimmune diseases. Lupus, 2014, 23, 518-526.
178. Aparicio-Soto, M.; Sanchez-Hidalgo, M.; Cardeno, A.; Lucena, J.M.; Gonzalez-Escribano, F.; Castillo, M.J.; Alarcon-de-la-Lastra, C. The phenolic fraction of extra virgin olive oil modulates the activation and the inflammatory response of T cells from patients with systemic lupus erythematosus and healthy donors. Mol. Nutr. Food Res., 2017, 61. doi: 10.1002/mnfr.201601080.
179. Accardi, G.; Aiello, A.; Gargano, V.; Gambino, C.M.; Caracappa, S.; Marineo, S.; Vesco, G.; Carru, C.; Zinellu, A.; Zarcone, M.; Caruso, C.; Candore, G. Nutraceutical effects of table green olives: a pilot study with Nocellara del Belice olives. Immun. Ageing., 2016, 13, 11.
180. Lu, R.; Munroe, M.E.; Guthridge, J.M.; Bean, K.M.; Fife, D.A.; Chen, H.; Slight-Webb, S.R.; Keith, M.P.; Harley, J.B.; James, J.A. Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies. J. Autoimmun., 2016, 74, 182-193.
181. Barrea, L.; Nappi, F.; Di Somma, C.; Savanelli, M.C.; Falco, A.; Balato, A.; Balato, N.; Savastano, S. Environmental risk factors in psoriasis: the point of view of the nutritionist. Int. J. Environ. Res. Public Health, 2016, 13.
182. Chen, W.; Gong, Y.; Zhang, X.; Tong, Y.; Wang, X.; Fei, C.; Xu, H.; Yu, Q.; Wang, Y.; Shi, Y. Decreased expression of IL-27 in moderate-to-severe psoriasis and its anti-inflammation role in imiquimod-induced psoriasis-like mouse model. J. Dermatol. Sci., 2017, 85, 115-123.
183. Puig, L. The role of IL 23 in the treatment of psoriasis. Expert. Rev. Clin. Immunol., 2017, 13, 525-534.
184. Johansen, C.; Usher, P.A.; Kjellerup, R.B.; Lundsgaard, D.; Iversen, L.; Kragballe, K. Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br. J. Dermatol., 2009, 160, 319-324.
185. Zhang, L.; Yang, X.Q.; Cheng, J.; Hui, R.S.; Gao, T.W. Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity. Clin. Immunol., 2010, 135, 108-117.
186. Scher, J.U.; Ubeda, C.; Artacho, A.; Attur, M.; Isaac, S.; Reddy, S.M.; Marmon, S.; Neimann, A.; Brusca, S.; Patel, T.; Manasson, J.; Pamer, E.G.; Littman, D.R.; Abramson, S.B. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol., 2015, 67, 128-139.
187. Zakostelska, Z.; Malkova, J.; Klimesova, K.; Rossmann, P.; Hornova, M.; Novosadova, I.; Stehlikova, Z.; Kostovcik, M.; Hudcovic, T.; Stepankova, R.; Juzlova, K.; Hercogova, J.; Tlaskalova-Hogenova, H.; Kverka, M. Intestinal microbiota promotes psoriasis-like skin inflammation by enhancing Th17 response. PloS One, 2016, 11, e0159539.
188. Cather, J.C.; Crowley, J.J. Use of biologic agents in combination with other therapies for the treatment of psoriasis. Am. J. Clin. Dermatol., 2014, 15, 467-478.
189. Damsky, W.; King, B.A. JAK inhibitors in dermatology: The promise of a new drug class. J. Am. Acad. Dermatol., 2017, 76, 736-744.
190. Tselios, K.; Yap, K.S.; Pakchotanon, R.; Polachek, A.; Su, J.; Urowitz, M.B.; Gladman, D.D. Psoriasis in systemic lupus erythematosus: a single-center experience. Clin. Rheumatol., 2017, 36, 879-884.
191. Skroza, N.; Proietti, I.; Pampena, R.; La Viola, G.; Bernardini, N.; Nicolucci, F.; Tolino, E.; Zuber, S.; Soccodato, V.; Potenza, C. Correlations between psoriasis and inflammatory bowel diseases. Biomed. Res Int., 2013, 2013, 983902.
192. Onumah, N.; Kircik, L.H. Psoriasis and its comorbidities. J. Drugs Dermatol., 2012, 11, s5-10.
193. Debbaneh, M.; Millsop, J.W.; Bhatia, B.K.; Koo, J.; Liao, W. Diet and psoriasis, part I: Impact of weight loss interventions. J. Am. Acad. Dermatol., 2014, 71, 133-140.
194. Sereflican, B.; Goksugur, N.; Bugdayci, G.; Polat, M.; Haydar Parlak, A. Serum visfatin, adiponectin, and tumor necrosis factor alpha (TNF-alpha) levels in patients with psoriasis and their correlation with disease severity. Acta Dermatovenerol. Croat., 2016, 24, 13-19.
195. Esposito, K.; Giugliano, D. Mediterranean diet for primary prevention of cardiovascular disease. N. Engl. J. Med., 2013, 369, 674-675.
196. Bertoli, S.; Spadafranca, A.; Bes-Rastrollo, M.; Martinez-Gonzalez, M.A.; Ponissi, V.; Beggio, V.; Leone, A.; Battezzati, A. Adherence to the Mediterranean diet is inversely related to binge eating disorder in patients seeking a weight loss program. Clin. Nutr., 2015, 34, 107-114.
197. Barrea, L.; Balato, N.; Di Somma, C.; Macchia, P.E.; Napolitano, M.; Savanelli, M.C.; Esposito, K.; Colao, A.; Savastano, S. Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet? J. Transl. Med., 2015, 13, 18.
198. Solis, M.Y.; de Melo, N.S.; Macedo, M.E.; Carneiro, F.P.; Sabbag, C.Y.; Lancha Junior, A.H.; Frangella, V.S. Nutritional status and food intake of patients with systemic psoriasis and psoriatic arthritis associated. Einstein (Sao Paulo), 2012, 10, 44-52.
199. Michalsen, A.; Eddin, O.; Salama, A. A case series of the effects of a novel composition of a traditional natural preparation for the treatment of psoriasis. J. Tradit. Complement. Med., 2016, 6, 395-398.
200. Klen, T.J.; Vodopivec, B.M. The fate of olive fruit phenols during commercial olive oil processing: Traditional press versus continuous two-and three-phase centrifuge. Lwt-Food Sci. Technol., 2012, 49, 267-274.
201. Palombo, R.; Savini, I.; Avigliano, L.; Madonna, S.; Cavani, A.; Albanesi, C.; Mauriello, A.; Melino, G.; Terrinoni, A. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model. Cell Death Dis., 2016, 7, e2344.