Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Su, Ding Lei ^a,b   Lu, Zhi Min ^a   Shen, Min Ning ^b   Li, Xia ^a   Sun, Ling Yun ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; CYTOKINE; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA;

ADAPTIVE IMMUNITY; CYTOKINE RELEASE; GENE EXPRESSION; HUMAN; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; MOLECULAR PROBE; NONHUMAN; PATHOGENESIS; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS; TH1 CELL; TH17 CELL; UPREGULATION; IMMUNOLOGY;

CYTOKINES; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC;

EID: 84863238148     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/347141     Document Type: Review

References (172)

1. Govinden R., Bhoola K. D., Genealogy, expression, and cellular function of transforming growth factor-β Pharmacology Therapeutics 2003 98 2 257 265 (Pubitemid 36513779)
2. Yoshimura A., Wakabayashi Y., Mori T., Cellular and molecular basis for the regulation of inflammation by TGF-β The Journal of Biochemistry 2010 147 6 781 792
3. Li M., Wan Y. Y., Sanjabi S., Robertson A. K. L., Flavell R. A., Transforming growth factor- regulation of immune responses Annual Review of Immunology 2006 24 99 146
4. Li M. O., Flavell R. A., Contextual regulation of inflammation: a duet by transforming growth factor- and interleukin-10 Immunity 2008 28 4 468 476 (Pubitemid 351467045)
5. Fadok V. A., Bratton D. L., Konowal A., Freed P. W., Westcott J. Y., Henson P. M., Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-, PGE2, and PAF The Journal of Clinical Investigation 1998 101 4 890 898 (Pubitemid 28096086)
6. Strobl H., Knapp W., TGF- 1 regulation of dendritic cells Microbes and Infection 1999 1 15 1283 1290
7. Laouar Y., Sutterwala F. S., Gorelik L., Flavell R. A., Transforming growth factor- controls T helper type 1 cell development through regulation of natural killer cell interferon- Nature Immunology 2005 6 6 600 607 (Pubitemid 41710731)
8. Wolfraim L. A., Walz T. M., James Z., Fernandez T., Letterio J. J., p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF- -mediated G1 arrest through modulation of IL-2 responsiveness The Journal of Immunology 2004 173 5 3093 3102 (Pubitemid 39142015)
9. Gorelik L., Constant S., Flavell R. A., Mechanism of transforming growth factor -induced inhibition of T helper type 1 differentiation The Journal of Experimental Medicine 2002 195 11 1499 1505 (Pubitemid 34602827)
10. Heath V. L., Murphy E. E., Crain C., Tomlinson M. G., O'Garra A., TGF- 1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression European Journal of Immunology 2000 30 9 2639 2649
11. Ichiyama K., Yoshida H., Wakabayashi Y., Chinen T., Saeki K., Nakaya M., Takaesu G., Hori S., Yoshimura A., Kobayashi T., Foxp3 inhibits ROR t-mediated IL-17A mRNA transcription through direct interaction with ROR t The Journal of Biological Chemistry 2008 283 25 17003 17008
12. Chen W.-J., Jin W.-W., Hardegen N., Lei K. J., Li L., Marinos N., McGrady G., Wahl S. M., Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF- induction of transcription factor Foxp3 The Journal of Experimental Medicine 2003 198 12 1875 1886 (Pubitemid 38032120)
13. Xing Q., Su H., Cui J., Wang B., Role of Treg cells and TGF- 1 in patients with systemic lupus erythematosus: a possible relation with lupus nephritis Immunological investigations 2012 41 1 15 27
14. Antiga E., Bianco E. D., Difonzo E. M., Fabbri P., Caproni M., Serum levels of the regulatory cytokines transforming growth factor- and interleukin-10 are reduced in patients with discoid lupus erythematosus Lupus 2011 20 6 556 560
15. Elbeldi-Ferchiou A., Ahmed M. B., Smiti-Khanfir M., Houman M. H., Abdeladhim M., Hmida N. B., Cerf-Bensussan N., Louzir H., Resistance to exogenous TGF- effects in patients with systemic lupus erythematosus Journal of Clinical Immunology 2011 31 4 574 583
16. Becker-Merok A., Eilertsen G., Nossent J. C., Levels of transforming growth factor- are low in systemic lupus erythematosus patients with active disease The Journal of Rheumatology 2010 37 10 2039 2045
17. Hammad A. M., Youssef H. M., El-Arman M. M., Transforming growth factor beta 1 in children with systemic lupus erythematosus: a possible relation with clinical presentation of lupus nephritis Lupus 2006 15 9 608 612 (Pubitemid 44661750)
18. Guo H., Leung J.-C., Chan L.-Y., Lui S.-L., Tsang A.-W., Lai K.-N., Modulation of intra-pulmonary TGF- expression by mycophenolate mofetil in lupus prone MRL/lpr mice Lupus 2005 14 8 583 592 (Pubitemid 41296994)
19. Saxena V., Lienesch D. W., Zhou M., Bommireddy R., Azhar M., Doetschman T., Singh R. R., Dual roles of immunoregulatory cytokine TGF- in the pathogenesis of autoimmunity-mediated organ damage The Journal of Immunology 2008 180 3 1903 1912
20. Kaplan J. M., Woodworth L., Smith K., Coco J., Vitsky A., McPherson J. M., Therapeutic benefit of treatment with anti-thymocyte globulin and latent TGF- 1 in the MRL/lpr lupus mouse model Lupus 2008 17 9 822 831
21. Rhodes K. A., Andrew E. M., Newton D. J., Tramonti D., Carding S. R., A subset of IL-10-producing T cells protect the liver from Listeria-elicited, CD8 + T cell-mediated injury European Journal of Immunology 2008 38 8 2274 2283
22. Yanaba K., Bouaziz J. D., Matsushita T., Tsubata T., Tedder T. F., The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals The Journal of Immunology 2009 182 12 7459 7472
23. Vanden Eijnden S., Goriely S., De Wit D., Willems F., Goldman M., IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human European Journal of Immunology 2005 35 2 469 475 (Pubitemid 40331324)
24. McGeachy M. J., Bak-Jensen K. S., Chen Y., Tato C. M., Blumenschein W., McClanahan T., Cua D. J., TGF- and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T H -17 cell-mediated pathology Nature Immunology 2007 8 12 1390 1397 (Pubitemid 350138974)
25. Boonstra A., Rajsbaum R., Holman M., Marques R., Asselin-Paturel C., Pereira J. P., Bates E. E. M., Akira S., Vieira P., Liu Y. J., Trinchieri G., O'Garra A., Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals The Journal of Immunology 2006 177 11 7551 7558 (Pubitemid 44846270)
26. Moore K. W., de Waal Malefyt R., Coffman R. L., O'Garra A., Interleukin-10 and the interleukin-10 receptor Annual Review of Immunology 2001 19 683 765 (Pubitemid 32368050)
27. Ding L., Linsley P. S., Huang L.-Y., Germain R. N., Shevach E. M., IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression The Journal of Immunology 1993 151 3 1224 1234 (Pubitemid 23219258)
28. McBride J. M., Jung T., de Vries J. E., Aversa G., IL-10 alters DC function via modulation of cell surface molecules resulting in impaired T-cell responses Cellular Immunology 2002 215 2 162 172
29. Romagnani S., Biology of human TH1 and TH2 cells Journal of Clinical Immunology 1995 15 3 121 129
30. Joss A., Akdis M., Faith A., Blaser K., Akdis C. A., IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway European Journal of Immunology 2000 30 6 1683 1690 (Pubitemid 30342811)
31. Schuetze N., Schoeneberger S., Mueller U., Freudenberg M. A., Alber G., Straubinger R. K., IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophages International Immunology 2005 17 5 649 659 (Pubitemid 41417862)
32. Llorente L., Zou W., Levy Y., Richaud-Patin Y., Wijdenes J., Alcocer-Varela J., Morel-Fourrier B., Brouet J. C., Alarcon-Segovia D., Galanaud P., Emilie D., Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus The Journal of Experimental Medicine 1995 181 3 839 844
33. Levy Y., Brouet J. C., Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein The Journal of Clinical Investigation 1994 93 1 424 428 (Pubitemid 24030864)
34. Park Y. B., Lee S. K., Kim D.-S., Lee J., Lee C. H., Song C. H., Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus Clinical and Experimental Rheumatology 1998 16 3 283 288 (Pubitemid 28219167)
35. Lauwerys B. R., Garot N., Renauld J. C., Houssiau F. A., Interleukin-10 blockade corrects impaired in vitro cellular immune responses of systemic lupus erythematosus patients Arthritis Rheumatism 2000 43 9 1976 1981
36. Llorente L., Richaud-Patin Y., Garcia-Padilla C., Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic Lupus erythematosus Arthritis Rheumatism 2000 43 8 1790 1800
37. Wang H.-J., Xu J., Ji X., Yang X., Sun K., Liu X., Shen Y., The abnormal apoptosis of T cell subsets and possible involvement of IL-10 in systemic lupus erythematosus Cellular Immunology 2005 235 2 117 121 (Pubitemid 41597475)
38. Nakano S., Morimoto S., Suzuki J., Nozawa K., Amano H., Tokano Y., Takasaki Y., Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus Rheumatology 2008 47 2 145 149 (Pubitemid 351168222)
39. Ishida H., Muchamuel T., Sakaguchi S., Andrade S., Menon S., Howard M., Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice The Journal of Experimental Medicine 1994 179 1 305 310 (Pubitemid 24012996)
40. Yin Z.-N., Bahtiyar G., Zhang N.-Z., Liu L.-Z., Zhu P., Robert M. E., McNiff J., Madaio M. P., Craft J., IL-10 regulates murine lupus The Journal of Immunology 2002 169 4 2148 2155 (Pubitemid 34857682)
41. Undeutsch R., Humrich J. Y., Papendieck A., Riemekasten G., CD4 T cells producing IL-10 have a beneficial effect in murine lupus Annals of the Rheumatic Diseases 2011 70 supplement 2 A70 A73
42. Blenman K. R. M., Duan B., Xu Z., Wan S., Atkinson M. A., Flotte T. R., Croker B. P., Morel L., IL-10 regulation of lupus in the NZM2410 murine model Laboratory Investigation 2006 86 11 1136 1148 (Pubitemid 44624150)
43. Hiran T., IL-6 and its receptor International Reviews of Immunology 1998 16 249 284
44. Naka T., Nishimoto N., Kishimoto T., The paradigm of IL-6: from basic science to medicine Arthritis Research 2002 4 supplement 3 S233 S242
45. Dienz O., Eaton S. M., Bond J. P., Neveu W., Moquin D., Noubade R., Briso E. M., Charland C., Leonard W. J., Ciliberto G., Teuscher C., Haynes L., Rincon M., The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4 + T cells The Journal of Experimental Medicine 2009 206 1 69 78
46. Acosta-Rodriguez E. V., Napolitani G., Lanzavecchia A., Sallusto F., Interleukins 1 and 6 but not transforming growth factor- are essential for the differentiation of interleukin 17-producing human T helper cells Nature Immunology 2007 8 9 942 949 (Pubitemid 47300008)
47. Suzuki H., Yasukawa K., Saito T., Narazaki M., Hasegawa A., Taga T., Kishimoto T., Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal European Journal of Immunology 1993 23 5 1078 1082 (Pubitemid 23120169)
48. Cash H., Relle M., Menke J., Brochhausen C., Jones S. A., Topley N., Galle P. R., Schwarting A., Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Fas lpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus The Journal of Rheumatology 2010 37 1 60 70
49. Finck B. K., Chan B., Wofsy D., Interleukin 6 promotes murine lupus in NZB/NZW F1 mice The Journal of Clinical Investigation 1994 94 2 585 591 (Pubitemid 24250987)
50. Mihara M., Takagi N., Takeda Y., Ohsugi Y., IL-6 receptor blockage inhibits the onset of autoimmune kidney disease in NZB/WF1 mice Clinical Experimental Immunology 1998 112 3 397 402 (Pubitemid 28267419)
51. Ryffel B., Car B. D., Gunn H., Roman D., Hiestand P., Mihatsch M. J., Interleukin-6 exacerbates glomerulonephritis in (NZBxNZW)F1 mice The American Journal of Pathology 1994 144 5 927 937
52. Grondal G., Gunnarsson I., Ronnelid J., Rogberg S., Klareskog L., Lundberg I., Cytokine production, serum levels and disease activity in systemic lupus erythematosus Clinical and Experimental Rheumatology 2000 18 5 565 570
53. Tsai C.-Y., Wu T.-H., Yu C.-L., Lu J.-Y., Tsai Y.-Y., Increased excretions of 2-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritis Nephron 2000 85 3 207 214 (Pubitemid 30429324)
54. Herrera-Esparza R., Barbosa-Cisneros O., Villalobos-Hurtado R., Avalos-Daz E., Renal expression of IL-6 and TNF genes in lupus nephritis Lupus 1998 7 3 154 158 (Pubitemid 28190678)
55. Hirohata S., Kanai Y., Mitsuo A., Tokano Y., Hashimoto H., Accuracy of cerebrospinal fluid IL-6 testing for diagnosis of lupus psychosis. A multicenter retrospective study Clinical Rheumatology 2009 28 11 1319 1323
56. Ripley B. J. M., Goncalves B., Isenberg D. A., Latchman D. S., Rahman A., Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia Annals of the Rheumatic Diseases 2005 64 6 849 853 (Pubitemid 40733907)
57. Al-Mutairi S., Al-Awadhi A., Raghupathy R., Al-Khawari H., Sada P., Al-Herz A., Rawoot P., Lupus patients with pulmonary involvement have a pro-inflammatory cytokines profile Rheumatology International 2007 27 7 621 630 (Pubitemid 46625345)
58. Eilertsen G., Nikolaisen C., Merok A. B., Nossent J. C., Interleukin-6 promotes arthritis and joint deformation in patients with systemic lupus erythematosus Lupus 2011 20 6 607 613
59. Linker-Israeli M., Deans R. J., Wallace D. J., Prehn J., Ozeri-Chen T., Klinenberg J. R., Elevated levels of endogenous IL-6 in systemic lupus erythematosus: a putative role in pathogenesis The Journal of Immunology 1991 147 1 117 123
60. Kitani A., Hara M., Hirose T., Harigai M., Suzuki K., Kawakami M., Kawaguchi Y., Hidaka T., Kawagoe M., Nakamura H., Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression Clinical Experimental Immunology 1992 88 1 75 83
61. Hillion S., Garaud S., Devauchelle V., Bordron A., Berthou C., Youinou P., Jamin C., Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus Immunology 2007 122 3 371 380 (Pubitemid 47556474)
62. Takeno M., Nagafuchi H., Kaneko S., Wakisaka S., Oneda K., Takeba Y., Yamashita N., Suzuki N., Kaneoka H., Sakane T., Autoreactive T cell clones from patients with systemic lupus erythematosus support polyclonal autoantibody production The Journal of Immunology 1997 158 7 3529 3538 (Pubitemid 127484075)
63. Sun K. H., Yu C. L., Tang S. J., Sun G. H., Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1, IL-6, IL-8, IL-10 and TNF- from normal human mononuclear cells involving in the lupus pathogenesis Immunology 2000 99 3 352 360
64. Takemura T., Yoshioka K., Murakami K., Akano N., Okada M., Aya N., Maki S., Cellular localization of inflammatory cytokines in human glomerulonephritis Virchows Archiv 1994 424 5 459 464 (Pubitemid 24213602)
65. Malide D., Russo P., Bendayan M., Presence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients Human Pathology 1995 26 5 558 564
66. Pflegerl P., Vesely P., Hantusch B., Schlederer M., Zenz R., Janig E., Steiner G., Meixner A., Petzelbauer P., Wolf P., Soleiman A., Egger G., Moriggl R., Kishimoto T., Wagner E. F., Kenner L., Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling Proceedings of the National Academy of Sciences of the United States of America 2009 106 48 20423 20428
67. Wan S. G., Xia C. Q, Morel L., IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4 + CD25 + T cell regulatory functions The Journal of Immunology 2007 178 1 271 279 (Pubitemid 46033610)
68. Pramanik R., Jrgensen T. N., Xin H., Kotzin B. L., Choubey D., Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility The Journal of Biological Chemistry 2004 279 16 16121 16127 (Pubitemid 38509303)
69. Illei G. G., Shirota Y., Yarboro C. H., Daruwalla J., Tackey E., Takada K., Fleisher T., Balow J. E., Lipsky P. E., Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study Arthritis Rheumatism 2010 62 2 542 552
70. Khan W. N., B cell receptor and BAFF receptor signaling regulation of B cell homeostasis The Journal of Immunology 2009 183 6 3561 3567
71. MacKay F., Schneider P., Cracking the BAFF code Nature Reviews Immunology 2009 9 7 491 502
72. Lpez-Fraga M., Fernndez R., Albar J. P., Hahne M., Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase EMBO Reports 2001 2 10 945 951 (Pubitemid 33040585)
73. Hsu B. L., Harless S. M., Lindsley R. C., Hilbert D. M., Cancro M. P., Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators The Journal of Immunology 2002 168 12 5993 5996 (Pubitemid 34620011)
74. O'Connor B. P., Raman V. S., Erickson L. D., Cook W. J., Weaver L. K., Ahonen C., Lin L. L., Mantchev G. T., Bram R. J., Noelle R. J., BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells The Journal of Experimental Medicine 2004 199 1 91 98
75. Daridon C., Youinou P., Pers J. O., BAFF, APRIL, TWE-PRIL: who's who? Autoimmunity Reviews 2008 7 4 267 271 (Pubitemid 351273682)
76. Benson M. J., Dillon S. R., Castigli E., Geha R. S., Xu S., Lam K. P., Noelle R. J., Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL The Journal of Immunology 2008 180 6 3655 3659
77. Hatzoglou A., Roussel J., Bourgeade M. F., Rogier E., Madry C., Inoue J., Devergne O., Tsapis A., TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF- B, Elk-1, c-jun N-terminal kinase, and p38 mitogen-activated protein kinase The Journal of Immunology 2000 165 3 1322 1330 (Pubitemid 30604561)
78. Xu L. G., Shu H. B., TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF- B activation and IL-10 production The Journal of Immunology 2002 169 12 6883 6889
79. Craxton A., Magaletti D., Ryan E. J., Clark E. A., Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF Blood 2003 101 11 4464 4471 (Pubitemid 36857815)
80. Mecklenbruker I., Kalled S. L., Lettges M., Mackay F., Tarakhovsky A., Regulation of B-cell survival by BAFF-dependent PKC -mediated nuclear signalling Nature 2004 431 7007 456 461 (Pubitemid 39329585)
81. George-Chandy A., Trysberg E., Eriksson K., Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms Arthritis Research Therapy 2008 10 4
82. Kayagaki N., Yan M., Seshasayee D., Wang H., Lee W., French D. M., Grewal I. S., Cochran A. G., Gordon N. C., Yin J., Starovasnik M. A., Dixit V. M., BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF- B2 Immunity 2002 17 4 515 524 (Pubitemid 35223539)
83. Petri M., Stohl W., Chatham W., McCune W. J., Chevrier M., Ryel J., Recta V., Zhong J., Freimuth W., Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus Arthritis Rheumatism 2008 58 8 2453 2459
84. Kim J., Gross J. A., Dillon S. R., Min J.-K., Elkon K. B., Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation Autoimmunity 2011 44 2 69 81
85. Yoshimoto K., Takahashi Y., Ogasawara M., Setoyama Y., Suzuki K., Tsuzaka K., Abe T., Takeuchi T., Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy International Immunology 2006 18 7 1189 1196 (Pubitemid 43923436)
86. Morimoto S., Nakano S., Watanabe T., Tamayama Y., Mitsuo A., Nakiri Y., Suzuki J., Nozawa K., Amano H., Tokano Y., Kobata T., Takasaki Y., Expression of B-cell activating factor of the tumour necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus: the role of BAFF in T cell-dependent B cell pathogenic autoantibody production Rheumatology 2007 46 7 1083 1086 (Pubitemid 47050608)
87. Smedby K. E., Askling J., Mariette X., Baecklund E., Autoimmune and inflammatory disorders and risk of malignant lymphomasan update Journal of Internal Medicine 2008 264 6 514 527
88. Katsenelson N., Kanswal S., Puig M., Mostowski H., Verthelyi D., Akkoyunlu M., Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion European Journal of Immunology 2007 37 7 1785 1795 (Pubitemid 47065118)
89. Treml L. S., Carlesso G., Hoek K. L., Stadanlick J. E., Kambayashi T., Bram R. J., Cancro M. P., Khan W. N., TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells The Journal of Immunology 2007 178 12 7531 7539 (Pubitemid 46898021)
90. Chu V. T., Enghard P., Schrer S., Steinhauser G., Rudolph B., Riemekasten G., Berek C., Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus Arthritis Rheumatism 2009 60 7 2083 2093
91. Lfstrm B., Backlin C., Pettersson T., Lundberg I. E., Baecklund E., Expression of APRIL in diffuse large B cell lymphomas from patients with systemic lupus erythematosus and rheumatoid arthritis The Journal of Rheumatology 2011 38 9 1891 1897
92. He B., Raab-Traub N., Casali P., Cerutti A., EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching The Journal of Immunology 2003 171 10 5215 5224 (Pubitemid 37432806)
93. He B., Chadburn A., Jou E., Schattner E. J., Knowles D. M., Cerutti A., Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL The Journal of Immunology 2004 172 5 3268 3279 (Pubitemid 38263719)
94. Lech-Maranda E., Baseggio L., Bienvenu J., Charlot C., Berger F., Rigal D., Warzocha K., Coiffier B., Salles G., Interleukin-10 gene promoter polymorphisms influence the clinical outcome of diffuse large B-cell lymphoma Blood 2004 103 9 3529 3534 (Pubitemid 38525688)
95. Blay J. Y., Burdin N., Rousset F., Lenoir G., Biron P., Philip T., Banchereau J., Favrot M. C., Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor Blood 1993 82 7 2169 2174 (Pubitemid 23294002)
96. Furie R., Stohl W., Ginzler E. M., Becker M., Mishra N., Chatham W., Merrill J. T., Weinstein A., Joseph W. J., Zhong J., Cai W., Freimuth W., Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus Arthritis Research Therapy 2008 10 5
97. Wallace D. J., Stohl W., Furie R. A., Lisse J. R., McKay J. D., Merrill J. T., Petri M. A., Ginzler E. M., Chatham W. W., McCune W. J., Fernandez V., Chevrier M. R., Zhong Z. J., Freimuth W. W., A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus Arthritis Care Research 2009 61 9 1168 1178
98. Jacobi A. M., Huang W., Wang T., Freimuth W., Sanz I., Furie R., Mackay M., Aranow C., Diamond B., Davidson A., Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study Arthritis Rheumatism 2010 62 1 201 210
99. Navarra S., Guzman R., Gallacher A., Belimumab, a BLyS-specific inhibitor, reduced disease activity, flares and prednisone use in patients with active SLE: efficacy and safety results from the phase 3 BLISS-52 study Proceedings of the American College of Rheumatology Annual Scientific Meeting 2009 Philadelphia, Pa, USA
100. GlaxoSmithKline, GlaxoSmithKline and Human Genome Sciences announce positive results in second of two phase 3 trials of Benlysta in systemic lupus erythematosus. 2009, http://www.gsk.com/media/pressreleases/2009/ 2009pressrelease10121.htm
101. Vugmeyster Y., Seshasayee D., Chang W., Storn A., Howell K., Sa S., Nelson T., Martin F., Grewal I., Gilkerson E., Wu B., Thompson J., Ehrenfels B. N., Ren S., Song A., Gelzleichter T. R., Danilenko D. M., A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys The American Journal of Pathology 2006 168 2 476 489 (Pubitemid 43271146)
102. Mackay F., Schneider P., Rennert P., Browning J., BAFF and APRIL: a tutorial on B cell survival Annual Review of Immunology 2003 21 231 264 (Pubitemid 37174532)
103. Dall'Era M., Chakravarty E., Wallace D., Genovese M., Weisman M., Kavanaugh A., Kalunian K., Dhar P., Vincent E., Pena-Rossi C., Wofsy D., Alum N., Dubois A., Kinnman N., Picard M., Bortolotti A., O'Grady L., Hill J., Nestorov I., Salmon E., Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial Arthritis Rheumatism 2007 56 12 4142 4150 (Pubitemid 350262342)
104. Dall'Era M., Wofsy D., Systemic lupus erythematosus clinical trialsan interim analysis Nature Reviews Rheumatology 2009 5 6 348 351
105. Pestka S., Krause C. D., Walter M. R., Interferons, interferon-like cytokines, and their receptors Immunological Reviews 2004 202 8 32 (Pubitemid 39576902)
106. Takeuchi O., Akira S., Innate immunity to virus infection Immunological Reviews 2009 227 1 75 86
107. Theofilopoulos A. N., Baccala R., Beutler B., Kono D. H., Type I interferons ( / ) in immunity and autoimmunity Annual Review of Immunology 2005 23 307 336
108. Rnnblom L., Eloranta M. L., Alm G. V., The type I interferon system in systemic lupus erythematosus Arthritis Rheumatism 2006 54 2 408 420 (Pubitemid 43228615)
109. Pittau E., Bogliolo A., Tinti A., Mela Q., Ibba G., Salis G., Perpignano G., Development of arthritis and hypothyroidism during alpha-interferon therapy for chronic hepatitis C Clinical and Experimental Rheumatology 1997 15 4 415 419 (Pubitemid 27324005)
110. Rnnblom L., Alm G. V., A pivotal role for the natural interferon -producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus The Journal of Experimental Medicine 2001 194 12 F59 F63
111. Banchereau J., Pascual V., Type I interferon in systemic lupus erythematosus and other autoimmune diseases Immunity 2006 25 3 383 392 (Pubitemid 44354221)
112. Liu Z., Bethunaickan R., Huang W., Lodhi U., Solano I., Madaio M. P., Davidson A., Interferon- accelerates murine systemic lupus erythematosus in a T cell-dependent manner Arthritis Rheumatism 2011 63 1 219 229
113. Santer D. M., Yoshio T., Minota S., Mller T., Elkon K. B., Potent induction of IFN- and chemokines by autoantibodies in the cerebrospinal fluid of patients with neuropsychiatric lupus The Journal of Immunology 2009 182 2 1192 1201
114. Thacker S. G., Berthier C. C., Mattinzoli D., Rastaldi M. P., Kretzler M., Kaplan M. J., The detrimental effects of IFN- on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction The Journal of Immunology 2010 185 7 4457 4469
115. Li J., Fu Q., Cui H., Qu B., Pan W., Shen N., Bao C., Interferon- priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon- and atherosclerosis in lupus Arthritis Rheumatism 2011 63 2 492 502
116. Santiago-Raber M. L., Baccala R., Haraldsson K. M., Choubey D., Stewart T. A., Kono D. H., Theofilopoulos A. N., Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice The Journal of Experimental Medicine 2003 197 6 777 788 (Pubitemid 36350872)
117. Braun D., Geraldes P., Demengeot J., Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice Journal of Autoimmunity 2003 20 1 15 25 (Pubitemid 36207624)
118. Mathian A., Gallegos M., Pascual V., Banchereau J., Koutouzov S., Interferon- induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZBNZW)F1 mice but not in BALB/c mice European Journal of Immunology 2011 41 3 863 872
119. Deng Y., Tsao B.-P., Genetic susceptibility to systemic lupus erythematosus in the genomic era Nature Reviews Rheumatology 2010 6 12 683 692
120. Wenzel J., Zahn S., Bieber T., Tting T., Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus Archives of Dermatological Research 2009 301 1 83 86
121. Feng X., Wu H., Grossman J. M., Hanvivadhanakul P., FitzGerald J. D., Park G. S., Dong X., Chen W., Kim M. H., Weng H. H., Furst D. E., Gorn A., McMahon M., Taylor M., Brahn E., Hahn B. H., Tsao B. P., Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus Arthritis Rheumatism 2006 54 9 2951 2962 (Pubitemid 44497776)
122. Rozzo S. J., Allard J. D., Choubey D., Vyse T. J., Izui S., Peltz G., Kotzin B. L., Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus Immunity 2001 15 3 435 443 (Pubitemid 32907390)
123. Wetter D. A., Davis M. D. P., Lupus-like syndrome attributable to anti-tumor necrosis factor therapy in 14 patients during an 8-year period at mayo clinic Mayo Clinic Proceedings 2009 84 11 979 984
124. Palucka A. K., Blanck J. P., Bennett L., Pascual V., Banchereau J., Cross-regulation of TNF and IFN- in autoimmune diseases Proceedings of the National Academy of Sciences of the United States of America 2005 102 9 3372 3377 (Pubitemid 40328052)
125. de Rycke L., Baeten D., Kruithof E., Van den Bosch F., Veys E. M., De Keyser F., Infliximab, but not etanercept, induces IgM anti-double-stranded DNA autoantibodies as main antinuclear reactivity: biologic and clinical implications in autoimmune arthritis Arthritis Rheumatism 2005 52 7 2192 2201 (Pubitemid 40994342)
126. Iwamoto S., Iwai S. I., Tsujiyama K., Kurahashi C., Takeshita K., Naoe M., Masunaga A., Ogawa Y., Oguchi K., Miyazaki A., TNF- drives human CD14 + monocytes to differentiate into CD70 + dendritic cells evoking Th1 and Th17 responses The Journal of Immunology 2007 179 3 1449 1457
127. Kleindienst P., Wiethe G., Lutz M. B., Brocker T., Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells The Journal of Immunology 2005 174 7 3941 3947 (Pubitemid 40395968)
128. Blanco P., Palucka A. K., Gill M., Pascual V., Banchereau J., Induction of dendritic cell differentiation by IFN- in systemic lupus erythematosus Science 2001 294 5546 1540 1543 (Pubitemid 33063928)
129. Mohty M., Vialle-Castellano A., Nunes J. A., Isnardon D., Olive D., Gaugler B., IFN- skews monocyte differentiation into toll-like receptor 7-expressing dendritic cells with potent functional activities The Journal of Immunology 2003 171 7 3385 3393 (Pubitemid 37254538)
130. Ravelli A., Macrophage activation syndrome Current Opinion in Rheumatology 2002 14 5 548 552 (Pubitemid 34953793)
131. Billiau A. D., Roskams T., Van Damme-Lombaerts R., Matthys P., Wouters C., Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN- -producing lymphocytes and IL-6- and TNF- -producing macrophages Blood 2005 105 4 1648 1651 (Pubitemid 40223686)
132. Forastiero R. R., Martinuzzo M. E., de Larraaga G. F., Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodies Lupus 2005 14 2 129 136 (Pubitemid 40327663)
133. Bennett L., Palucka A. K., Arce E., Cantrell V., Borvak J., Banchereau J., Pascual V., Interferon and granulopoiesis signatures in systemic lupus erythematosus blood The Journal of Experimental Medicine 2003 197 6 711 723 (Pubitemid 36350866)
134. Yao Y., Richman L., Higgs B. W., Morehouse C. A., De Los Reyes M., Brohawn P., Zhang J., White B., Coyle A. J., Kiener P. A., Jallal B., Neutralization of interferon- / -inducible genes and downstream effect in a phase I trial of an anti-interferon- monoclonal antibody in systemic lupus erythematosus Arthritis Rheumatism 2009 60 6 1785 1796
135. Gottenberg J. E., Chiocchia G., Dendritic cells and interferon-mediated autoimmunity Biochimie 2007 89 6-7 856 871 (Pubitemid 47008948)
136. Verthelyi D., Petri M., Ylamus M., Klinman D. M., Disassociation of sex hormone levels and cytokine production in SLE patients Lupus 2001 10 5 352 358 (Pubitemid 32536658)
137. Harigai M., Kawamoto M., Hara M., Kubota T., Kamatani N., Miyasaka N., Excessive production of IFN- in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B The Journal of Immunology 2008 181 3 2211 2219
138. Hayashi T., Therapeutic strategies for SLE involving cytokines: mechanism-oriented therapies especially IFN- targeting gene therapy Journal of Biomedicine and Biotechnology 2010 2010 19
139. Viallard J. F., Pellegrin J. L., Ranchin V., Schaeverbeke T., Dehais J., Longy-Boursier M., Ragnaud J. M., Leng B., Moreau J. F., Th1 (IL-2, interferon-gamma (IFN- )) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE) Clinical Experimental Immunology 1999 115 1 189 195 (Pubitemid 29030384)
140. Lit L. C. W., Wong C. K., Li E. K. M., Tam L. S., Lam C. W. K., Lo Y. M. D., Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus The Journal of Rheumatology 2007 34 1 89 96
141. Tucci M., Lombardi L., Richards H. B., Dammacco F., Silvestris F., Overexpression of interleukin-12 and T helper 1 predominance in lupus nephritis Clinical Experimental Immunology 2008 154 2 247 254
142. Chan R. W., Lai F. M., Li E. K., Tam L. S., Chow K. M., Lai K. B., Li P. K. T., Szeto C. C., Intrarenal cytokine gene expression in lupus nephritis Annals of the Rheumatic Diseases 2007 66 7 886 892 (Pubitemid 46999788)
143. Nicoletti F., Di Marco R., Zaccone P., Xiang M., Magro G., Grasso S., Morrone S., Santoni A., Shoenfeld Y., Garotta G., Meroni P., Dichotomic effects of IFN- on the development of systemic lupus erythematosus-like syndrome in MRL-lpr/lpr mice European Journal of Immunology 2000 30 2 438 447 (Pubitemid 30098836)
144. Mohan C., Datta S. K., Lupus: key pathogenic mechanisms and contributing factors Clinical Immunology and Immunopathology 1995 77 3 209 220
145. Santiago-Raber M. L., Baccala R., Haraldsson K. M., Choubey D., Stewart T. A., Kono D. H., Theofilopoulos A. N., Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice The Journal of Experimental Medicine 2003 197 6 777 788 (Pubitemid 36350872)
146. Lawson B. R., Prud'homme G. J., Chang Y., Gardner H. A., Kuan J., Kono D. H., Theofilopoulos A. N., Treatment of murine lupus with cDNA encoding IFN- R/Fc The Journal of Clinical Investigation 2000 106 2 207 215 (Pubitemid 30483124)
147. Steinmetz O. M., Turner J. E., Paust H. J., Lindner M., Peters A., Heiss K., Velden J., Hopfer H., Fehr S., Krieger T., Meyer-Schwesinger C., Meyer T. N., Helmchen U., Mittrcker H. W., Stahl R. A. K., Panzer U., CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis The Journal of Immunology 2009 183 7 4693 4704
148. Kim K., Cho S. K., Sestak A., Namjou B., Kang C., Bae S. C., Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus Annals of the Rheumatic Diseases 2010 69 6 1247 1250
149. Karonitsch T., Feierl E., Steiner C. W., Dalwigk K., Korb A., Binder N., Rapp A., Steiner G., Scheinecker C., Smolen J., Aringer M., Activation of the interferon- signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells Arthritis Rheumatism 2009 60 5 1463 1471
150. Serra M., Forcales S.-V., Pereira-Lopes S., Lloberas J., Celada A., Characterization of Trex1 induction by IFN- in murine macrophages The Journal of Immunology 2011 186 4 2299 2308
151. Kastelein R. A., Hunter C. A., Cua D. J., Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation Annual Review of Immunology 2007 25 221 242 (Pubitemid 46697908)
152. Riol-Blanco L., Lazarevic V., Awasthi A., Mitsdoerffer M., Wilson B. S., Croxford A., Waisman A., Kuchroo V. K., Glimcher L. H., Oukka M., IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections The Journal of Immunology 2010 184 4 1710 1720
153. Langrish C. L., Chen Y., Blumenschein W. M., Mattson J., Basham B., Sedgwick J. D., McClanahan T., Kastelein R. A., Cua D. J., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation The Journal of Experimental Medicine 2005 201 2 233 240 (Pubitemid 40189432)
154. Huang X., Hua J., Shen N., Chen S., Dysregulated expression of interleukin-23 and interleukin-12 subunits in systemic lupus erythematosus patients Modern Rheumatology 2007 17 3 220 223 (Pubitemid 46929907)
155. Rnnblom L., Eloranta M. L., Alm G. V., The type I interferon system in systemic lupus erythematosus Arthritis Rheumatism 2006 54 2 408 420 (Pubitemid 43228615)
156. Li Y., Liang W. B., Li C., The association between interleukin-23 receptor gene polymorphisms and systemic lupus erythematosus DNA and Cell Biology 2010 29 2 79 82
157. Weaver C. T., Hatton R. D., Mangan P. R., Harrington L. E., IL-17 family cytokines and the expanding diversity of effector T cell lineages Annual Review of Immunology 2007 25 821 852 (Pubitemid 46697925)
158. Dong C., Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells Nature Reviews Immunology 2006 6 4 329 333
159. Korn T., Bettelli E., Oukka M., Kuchroo V. K., IL-17 and Th17 cells Annual Review of Immunology 2009 27 485 517
160. Albanesi C., Cavani A., Girolomoni G., IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN- and TNF- The Journal of Immunology 1999 162 1 494 502 (Pubitemid 29018959)
161. Doreau A., Belot A., Bastid J., Riche B., Trescol-Biemont M. C., Ranchin B., Fabien N., Cochat P., Pouteil-Noble C., Trolliet P., Durieu I., Tebib J., Kassai B., Ansieau S., Puisieux A., Eliaou J. F., Bonnefoy-Bérard N., Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus Nature Immunology 2009 10 7 778 785
162. Shah K., Lee W. W., Lee S. H., Kim S. H., Kang S. W., Craft J., Kang I., Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus Arthritis research amp; therapy 2010 12 2
163. Zhang Z., Kyttaris V. C., Tsokos G. C., The role of IL-23/IL-17 axis in lupus nephritis The Journal of Immunology 2009 183 5 3160 3169
164. Crispn J. C., Oukka M., Bayliss G., Cohen R. A., Van Beek C. A., Stillman I. E., Kyttaris V. C., Juang Y. T., Tsokos G. C., Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys The Journal of Immunology 2008 181 12 8761 8766
165. Kwan B. C., Tam L. S., Lai K. B., Lai F. M. M., Li E. K. M., Wang G., Chow K. M., Li P. K. T., Szeto C. C., The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus Rheumatology 2009 48 12 1491 1497
166. Crispn J. C., Tsokos G. C., Interleukin-17-producing T cells in lupus Current Opinion in Rheumatology 2010 22 5 499 503
167. Edgerton C., Crispn J. C., Moratz C. M., Bettelli E., Oukka M., Simovic M., Zacharia A., Egan R., Chen J., Dalle Lucca J. J., Juang Y. T., Tsokos G. C., IL-17 producing CD4 + T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice Clinical Immunology 2009 130 3 313 321
168. McKenzie B. S., Kastelein R. A., Cua D. J., Understanding the IL-23-IL-17 immune pathway Trends in Immunology 2006 27 1 17 23 (Pubitemid 43083560)
169. Wong C. K., Lit L. C. W., Tam L. S., Li E. K. M., Wong P. T. Y., Lam C. W. K., Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity Clinical Immunology 2008 127 3 385 393
170. Cheng F., Guo Z., Xu H., Yan D., Li Q., Decreased plasma IL22 levels, but not increased IL17 and IL23 levels, correlate with disease activity in patients with systemic lupus erythematosus Annals of the Rheumatic Diseases 2009 68 4 604 606
171. Kyttaris V. C., Zhang Z., Kuchroo V. K., Oukka M., Tsokos G. C., Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice The Journal of Immunology 2010 184 9 4605 4609
172. Kikly K., Liu L., Na S., Sedgwick J. D., The IL-23/Th 17 axis: therapeutic targets for autoimmune inflammation Current Opinion in Immunology 2006 18 6 670 675 (Pubitemid 44635178)