Environmental factors and their interactions with risk genotypes in MS susceptibility

Current Opinion in Neurology

Volumn 29, Issue 3, 2016, Pages 293-298

  Hedstrom A K ^a   Alfredsson, Lars ^b   Olsson, Tomas ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM COUNTY COUNCIL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Epstein Barr virus; gene environment interactions; multiple sclerosis; obesity; smoking

Indexed keywords

ALCOHOL; VITAMIN D;

COFFEE; ENVIRONMENTAL FACTOR; EPSTEIN BARR VIRUS INFECTION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MONONUCLEOSIS; MULTIPLE SCLEROSIS; OBESITY; PASSIVE SMOKING; PATHOGENESIS; REVIEW; SHIFT WORKER; SMOKELESS TOBACCO; SODIUM INTAKE; SUN EXPOSURE; COMPLICATION; GENETIC PREDISPOSITION; GENETICS; LIFESTYLE; PATHOLOGY; RISK FACTOR; SMOKING;

EPSTEIN-BARR VIRUS INFECTIONS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIFE STYLE; MULTIPLE SCLEROSIS; RISK FACTORS; SMOKING;

EID: 84962115595     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0000000000000329     Document Type: Review

References (53)

1. Westerlind H, et al. Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden. Brain 2014; 137:770-778.
2. Westerlind H, et al. Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort. Eur J Hum Genet 2015; 23:688-692.
3. Gale CR, Martyn CN. Migrant studies in multiple sclerosis. Prog Neurobiol 1995; 47:425-448.
4. Berg-Hansen P, et al. Prevalence of multiple sclerosis among immigrants in Norway. Mult Scler 2015; 21:695-702.
5. Ahlgren C, Oden A, Lycke J. A nationwide survey of the prevalence of multiple sclerosis in immigrant populations of Sweden. Mult Scler 2012; 18:1099-1107.
6. Koch-Henriksen N, Sorensen PS. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol 2010; 9:520-532.
7. Westerlind H, Bostrom I, Stawiarz L, et al. New data identify an increasing sex ratio of multiple sclerosis in Sweden. Mult Scler 2014; 20:1578-1583.
8. Rothman KJ, Greenland S, Walker AM. Concepts of interaction. Am J Epidemiol 1980; 112:467-470.
9. Rothman KJ, Greenland S, Lash TL. Modern epidemiology. 3rd ed Philadelphia, USA: Lippincott Williams & Wilkins; 2008.
10. Handel AE, Williamson AJ, Disanto G, et al. An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis. PLoS One 2010; 5:e12496.
11. Sundstrom P, Nystrom M, Ruuth K, Lundgren E. Antibodies to specific EBNA-1 domains and HLA DRB1∗1501 interact as riskfactors for multiple sclerosis. J Neuroimmunol 2009; 215:102-107.
12. Sundqvist E, Sundstrom P, Linden M, et al. Epstein-Barr virus and multiple sclerosis: interaction with HLA. Genes Immun 2012; 13:14-20.
13. Nielsen TR, Rostgaard K, Askling J, et al. Effects of infectious mononucleosis and HLA-DRB1 ∗15 in multiple sclerosis. Mult Scler 2009; 15:431-436.
14. Simpson S, Blizzard L, Otahal P, et al. Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry 2011; 82:1132-1141.
15. Lucas RM, Byrne SN, Correale J, et al. Ultraviolet radiation, vitamin D and multiple sclerosis. Neurodegener Dis Manag 2015; 5:413-424.
16. Handunnetthi L, Ramagopalan SV, Ebers GC. Multiple sclerosis, vitamin D, and HLA-DRB1∗15. Neurology 2010; 74:1905-1910.
17. Baarnhielm M, Hedstrom AK, Kockum I, et al. Sunlight is associated with decreased multiple sclerosis risk: no interaction with human leukocyte anti-gen-DRB1 ∗15. Eur J Neurol 2012; 19:955-962.
18. Sandberg L, Bistrom M, Salzer J, et al. Vitamin D and axonal injury in multiple sclerosis. Mult Scler 2015. Oct 13 (Epub ahead of print).
19. Fitzgerald KC, et al. Association of Vitamin D levels with multiple sclerosis activity and progression in patients receiving interferon beta-1b. JAMA Neurol 2015; 72:1458-1465.
20. Hedstrom AK, Hillert J, Olsson T, Alfredsson L. Smoking and multiple sclerosis susceptibility. Eur J Epidemiol 2013; 28:867-874.
21. Hedstrom AK, Baärnhielm M, Olsson T, Alfredsson L. Exposure to environ-mental tobacco smoke is associated with increased riskfor multiple sclerosis. Mult Scler 2011; 17:788-793.
22. Hedstrom AK, Hillert J, Olsson T, Alfredsson L. Nicotine might have a protective effect in the etiology of multiple sclerosis. Mult Scler 2013; 19:1009-1013.
23. Barragan-Martinez C, Speck-Hernandez CA, Montoya-Ortiz G, et al. Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis. PLoS One 2012; 7:e51506.
24. Shan M, Cheng HF, Song LZ, et al. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med 2009; 1:4ra10.
25. Odoardi F, Sie C, Streyl K, et al. T cells become licensed in the lung to enter the central nervous system. Nature 2012; 488:675-679.
26. Hedstrom AK, Sundqvist E, Baärnhielm M, et al. Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis. Brain 2011; 134:653-664.
27. Hedstrom AK, Baarnhielm M, Olsson T, Alfredsson L. Exposure to environmental tobacco smoke is associated with increased riskfor multiple sclerosis. Mult Scler 2011; 17:788-793.
28. Hedstrom AK, Olsson T, Alfredsson L. Smoking is a major preventable risk factor for multiple sclerosis. Mult Scler 2015. Oct 12 (Epub ahead of print).
29. Ramanujam R, Hedstrom AK, Manouchehrinia A, et al. Effect of smoking cessation on multiple sclerosis prognosis. JAMA Neurol 2015; 72:1117-1123.
30. Hedstrom AK, Alfredsson L, Ryner M, et al. Smokers run increased risk of developing antinatalizumab antibodies. Mult Scler 2013; 20:1081-1085.
31. Hedstrom AK, Ryner M, Fink K, et al. Smoking and risk of treatment-induced antibodies to interferon p-1a. Mult Scler 2014; 20:445-450.
32. Munger KL, Chitnis T, Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology 2009; 73:1543-1550.
33. Hedstrom AK, Olsson T, Alfredsson L. High body mass index before age 20 is associated with increased riskfor multiple sclerosis in both men and women. Mult Scler 2012; 18:1334-1336.
34. Gianfrancesco MA, Acuna B, Shen L, et al. Obestiy during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract 2014; 8:e435-e447.
35. Hedstrom AK, Olsson T, Alfredsson L. Body mass index during adolescence, rather than childhood, is critical in determining MS risk. Mult Scler 2015; Sept 11 [Epub ahead of print]
36. Wesnes K, Riise T, Casetta I, et al. Body size and the risk of multiple sclerosis in Norway and Italy: the EnvIMS study. Mult Scler 2015; 21:388-395.
37. Hedstrom AK, Bomfim IL, Barcellos LF, et al. Interaction between adolescent obesity and HLA risk genes in the development of multiple sclerosis. Neurology 2014; 82:865-872.
38. Matarese G, Carrieri PB, La Cava A, et al. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. Proc Natl Acad Sci USA 2005; 102:5150-5155.
39. Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72:690-693.
40. Hedström AK, Lima Bomfim I, Hillert J, et al. Obesity interacts with infectious mononucleosis in risk of multiple sclerosis. Eur J Neurol 2015; 22:; 2015-2015
41. Karlsson EA, Beck MA. The burden of obesity on infectious disease. Exp Biol Med 2010; 235:1412-1424.
42. Procaccini C, Pucino V, Mantzoros CS, Matarese G. Leptin in autoimmune diseases. Metabolism 2015; 64:92-104.
43. Hedström AK, Akerstedt T, Olsson T, Alfredsson L. Shift work influences multiple sclerosis risk. Mult Scler 2015; 21:1195-1199.
44. Saper CB, Scammell TE, Lu J, et al. Hypothalamic regulation of sleep and circadian rhythms. Nature 2005; 437:1257-1263.
45. Bollinger T, Bollinger A, Skrum L, et al. Sleep-dependent activity of T cells and regulatory T cells. Clin Exp Immunol 2009; 155:231-238.
46. Hedström AK, Hillert J, Olsson T, Alfredsson L. Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk. JAMA Neurol 2014; 71:300-305.
47. Goral J, Karavitis J, Kovacs EJ. Exposure-dependent effects of ethanol on the innate immune system. Alcohol 2008; 42:237-247.
48. Hedström A, Mowry EM, Gianfrancesco MA, et al. High coffee consumption is associated with decreased multiple sclerosis risk; results from two independent studies. J Neurol Neurosurg Psychiatry 2016. (in press).
49. Chen GQ, Chen YY, Wang XS, et al. Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats. Brain Res 2010; 1309:116-125.
50. Horrigan LA, Kelly JP, Connor TJ. Immunomodulatory effects of caffeine: friend or foe? Pharmacol Ther 2006; 111:877-892.
51. Kleinewietfeld M, Manzel A, Titze J, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013; 496:518-522.
52. Wu C, Yosef N, Thalhamer T, et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 2013; 496:513-517.
53. Farez MF, Fiol MP, Gaitan MI, et al. Sodium intake is associated with increased disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry 2015; 86:26-31.