A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: Overview

Multiple Sclerosis Journal

Volumn 21, Issue 3, 2015, Pages 263-281

  Marrie, Ruth Ann ^a   Cohen, Jeffrey ^b   Stuve, Olaf ^c   Trojano, Maria ^d   Sørensen, Per Soelberg ^e   Reingold, Stephen ^f   Cutter, Gary ^g   Reider, Nadia ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b LERNER RESEARCH INSTITUTE   (United States)

^c University of Texas Southwestern   (United States)

^d UNIVERSITY OF BARI   (Italy)

^e Rigshospitalet   (Denmark)

^f Scientific and Clinical Review Associates LLC   (United States)

^g UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

comorbidity; incidence; Multiple sclerosis; prevalence; systematic review

Indexed keywords

ADRENAL CORTEX INSUFFICIENCY; ALCOHOL ABUSE; ALOPECIA AREATA; ANKYLOSING SPONDYLITIS; ANXIETY DISORDER; ARTHROPATHY; ASTHMA; BILIARY TRACT DISEASE; BIPOLAR DISORDER; BREAST CANCER; BULLOUS PEMPHIGOID; CATARACT; CELIAC DISEASE; CEREBROVASCULAR ACCIDENT; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; COMORBIDITY; CONGESTIVE HEART FAILURE; DEPRESSION; DERMATOMYOSITIS; DIABETES MELLITUS; DIGESTIVE SYSTEM CANCER; EPILEPSY; FIBROMYALGIA; GALLBLADDER DISEASE; GASTROESOPHAGEAL REFLUX; GLAUCOMA; HEART ARRHYTHMIA; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; INCIDENCE; INFLAMMATORY BOWEL DISEASE; IRRITABLE COLON; ISCHEMIC HEART DISEASE; KIDNEY DISEASE; LIVER DISEASE; MENINGIOMA; MULTIPLE SCLEROSIS; MYASTHENIA GRAVIS; OSTEOARTHRITIS; PEMPHIGUS VULGARIS; PEPTIC ULCER; PERIPHERAL VASCULAR DISEASE; PERNICIOUS ANEMIA; PERSONALITY DISORDER; POLYMYOSITIS; PREVALENCE; PRIMARY BILIARY CIRRHOSIS; PSORIASIS; PSYCHOSIS; QUANTITATIVE ANALYSIS; RESTLESS LEGS SYNDROME; RETINA DISEASE; REVIEW; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SUBSTANCE ABUSE; SYSTEMATIC REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; THYROID DISEASE; TRANSIENT ISCHEMIC ATTACK; UTERINE CERVIX CANCER; UVEITIS; VALVULAR HEART DISEASE; VITILIGO; WEGENER GRANULOMATOSIS; ANXIETY; AUTOIMMUNE DISEASE; CHRONIC LUNG DISEASE; CONGESTIVE CARDIOMYOPATHY; DRUG ABUSE; EYE DISEASE; GASTROINTESTINAL DISEASE; MALIGNANT NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS;

COMORBIDITY; HUMANS; INCIDENCE; MULTIPLE SCLEROSIS; PREVALENCE;

EID: 84924805293     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458514564491     Document Type: Review

References (273)

1. Marrie RA, Horwitz RI, Cutter G, et al. Comorbidity delays diagnosis and increases disability at diagnosis in MS. Neurology. 2009 ; 72: 117-124
2. Marrie RA, Rudick R, Horwitz R, et al. Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis. Neurology. 2010 ; 74: 1041-1047
3. Turpin KV, Carroll LJ, Cassidy JD, et al. Deterioration in the health-related quality of life of persons with multiple sclerosis: The possible warning signs. Mult Scler. 2007 ; 13: 1038-1045
4. Warren SA, Turpin KV, Pohar SL, et al. Comorbidity and health-related quality of life in people with multiple sclerosis. Int J MS Care. 2009 ; 11: 6-16
5. Weinstock-Guttman B, Zivadinov R, Horakova D, et al. Lipid profiles are associated with lesion formation over 24 months in interferon- treated patients following the first demyelinating event. J Neurol Neurosurg Psychiatry. 2013 ; 84: 1186-1191
6. Fromont A, Binquet C, Rollot F, et al. Comorbidities at multiple sclerosis diagnosis. J Neurol. 2013 ; 260: 2629-2637
7. Kang JH, Chen YH, Lin HC. Comorbidities amongst patients with multiple sclerosis: A population-based controlled study. Eur J Neurol. 2010 ; 17: 1215-1219
8. Marrie RA, Horwitz R, Cutter G, et al. Comorbidity, socioeconomic status, and multiple sclerosis. Mult Scler. 2008 ; 14: 1091-1098
9. Christiansen CF, Christensen S, Farkas DK, et al. Risk of arterial cardiovascular diseases in patients with multiple sclerosis: A population-based cohort study. Neuroepidemiology. 2010 ; 35: 267-274
10. Jadidi E, Mohammadi M, Moradi T. High risk of cardiovascular diseases after diagnosis of multiple sclerosis. Mult Scler. 2013 ; 19: 1336-1340
11. Marrie R, Reider N, Cohen J, et al. The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review. Mult Scler. 2015 ; 21 (3). 303-317
12. Marrie R, Reider N, Cohen J, et al. A systematic review of the incidence and prevalence of cancer in multiple sclerosis. Mult Scler. 2015 ; 21 (3). 294-301
13. Marrie R, Reider N, Cohen J, et al. A systematic review of the incidence and prevalence of cardiac, cerebrovascular and peripheral vascular disease in multiple sclerosis. Mult Scler. 2015 ; 21 (3). 318-331
14. Marrie R, Reider N, Cohen J, et al. The incidence and prevalence of comorbid gastrointestinal, musculoskeletal, ocular, pulmonary, and renal disorders in multiple sclerosis: A systematic review. Mult Scler. 2015 ; 21 (3). 332-341
15. Marrie R, Reider N, Cohen J, et al. A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis. Mult Scler. 2015 ; 21 (3). 342-349
16. Marrie R, Reider N, Cohen J, et al. A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis. Mult Scler. 2015 ; 21 (3). 282-293
17. Evans C, Beland S, Kulaga S, et al. Incidence and prevalence of multiple sclerosis in the Americas: A systematic review. Neuroepidemiology. 2013 ; 40: 195-210
18. Boyle MH. Guidelines for evaluating prevalence studies. Evid Based Ment Health. 1998 ; 1: 37-39
19. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003 ; 327: 557-560
20. Neyeloff J, Fuchs S, Moreira L. Meta-analyses and Forest plots using a Microsoft Excel spreadsheet: Step-by-step guide focusing on descriptive data analysis. BMC Res Notes. 2012 ; 5: 52
21. Cox DR. The continuity correction. Biometrika. 1970 ; 57: 217-219
22. Kontopantelis E, Reeves D. Performance of statistical methods for meta-analysis when true study effects are non-normally distributed: A simulation study. Stat Methods Med Res. 2012 ; 21: 409-426
23. Achiron A, Barak Y, Gail M, et al. Cancer incidence in multiple sclerosis and effects of immunomodulatory treatments. Breast Cancer Res Treat. 2005 ; 89: 265-270
24. Allen AN, Seminog OO, Goldacre MJ. Association between multiple sclerosis and epilepsy: Large population-based record-linkage studies. BMC Neurol. 2013 ; 13: 189
25. Allen NB, Lichtman JH, Cohen HW, et al. Vascular disease among hospitalized multiple sclerosis patients. Neuroepidemiology. 2008 ; 30: 234-238
26. Alschuler KN, Jensen MP, Ehde DM. The association of depression with pain-related treatment utilization in patients with multiple sclerosis. Pain Med. 2012 ; 13: 1648-1657
27. Amato MP, Ponziani G, Rossi F, et al. Quality of life in multiple sclerosis: The impact of depression, fatigue and disability. Mult Scler. 2001 ; 7: 340-344
28. Annunziata P, De Santi L, Di Rezze S, et al. Clinical features of Sjogren's syndrome in patients with multiple sclerosis. Acta Neurol Scand. 2011 ; 124: 109-114
29. Auger C, Montplaisir J, Duquette P. Increased frequency of restless legs syndrome in a French-Canadian population with multiple sclerosis. Neurology. 2005 ; 65: 1652-1653
30. Avasarala JR, Cross AH, Trinkaus K. Comparative assessment of Yale Single Question and Beck Depression Inventory Scale in screening for depression in multiple sclerosis. Mult Scler. 2003 ; 9: 307-310
31. Bahmanyar S, Montgomery SM, Hillert J, et al. Cancer risk among patients with multiple sclerosis and their parents. Neurology. 2009 ; 72: 1170-1177
32. Baker HW, Balla JI, Burger HG, et al. Multiple sclerosis and autoimmune diseases. Aust N Z J Med. 1972 ; 2: 256-260
33. Bamer AM, Johnson KL, Amtmann D, et al. Prevalence of sleep problems in individuals with multiple sclerosis. Mult Scler. 2008 ; 14: 1127-1130
34. Barcellos LF, Kamdar BB, Ramsay PP, et al. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: A descriptive study. Lancet Neurol. 2006 ; 5: 924-931
35. Basiri K, Etemadifar M, Maghzi AH, et al. Frequency of myasthenia gravis in multiple sclerosis: Report of five cases from Isfahan, Iran. Neurol India. 2009 ; 57: 638-640
36. Baumstarck-Barrau K, Simeoni MC, Reuter F, et al. Cognitive function and quality of life in multiple sclerosis patients: A cross-sectional study. BMC Neurol. 2011 ; 11: 17
37. Bazelier MT, Mueller-Schotte S, Leufkens HG, et al. Risk of cataract and glaucoma in patients with multiple sclerosis. Mult Scler. 2012 ; 18: 628-638
38. Beiske AG, Svensson E, Sandanger I, et al. Depression and anxiety amongst multiple sclerosis patients. Eur J Neurol. 2008 ; 15: 239-245
39. Bergamaschi R, Villani S, Crabbio M, et al. Inverse relationship between multiple sclerosis and allergic respiratory diseases. Neurol Sci. 2009 ; 30: 115-118
40. Bloomgren G, Sperling B, Cushing K, et al. Assessment of malignancy risk in patients with multiple sclerosis treated with intramuscular interferon beta-1a: Retrospective evaluation using a health insurance claims database and postmarketing surveillance data. Ther Clin Risk Manag. 2012 ; 8: 313-321
41. Bodini B, Mandarelli G, Tomassini V, et al. Alexithymia in multiple sclerosis: Relationship with fatigue and depression. Acta Neurol Scand. 2008 ; 118: 18-23
42. Bombardier CH, Blake KD, Ehde DM, et al. Alcohol and drug abuse among persons with multiple sclerosis. Mult Scler. 2004 ; 10: 35-40
43. Borhani Haghighi A, Ansari N, Mokhtari M, et al. Multiple sclerosis and gluten sensitivity. Clin Neurol Neurosurg. 2007 ; 109: 651-653
44. Brajkovic L, Bras M, Milunovic V, et al. The connection between coping mechanisms, depression, anxiety and fatigue in multiple sclerosis. Coll Antropol. 2009 ; 33: 135-140
45. Braley TJ, Segal BM, Chervin RD. Sleep-disordered breathing in multiple sclerosis. Neurology. 2012 ; 79: 929-936
46. Brichetto G, Uccelli MM, Mancardi GL, et al. Symptomatic medication use in multiple sclerosis. Mult Scler. 2003 ; 9: 458-460
47. Brown T. Measuring up rates for adverse health behaviors in MS. Mult Scler. 2009 ; 15: 647
48. Buchanan RJ, Schiffer R, Stuifbergen A, et al. Demographic and disease characteristics of people with multiple sclerosis living in urban and rural areas. Int J MS Care. 2006 ; 8: 89-98
49. Buchanan RJ, Wang S, Tai-Seale M, et al. Analyses of nursing home residents with multiple sclerosis and depression using the Minimum Data Set. Mult Scler. 2003 ; 9: 171-188
50. Buchanan RJ, Zuniga MA, Carrillo-Zuniga G, et al. A pilot study of Latinos with multiple sclerosis: Demographic, disease, mental health, and psychosocial characteristics. J Soc Work Disabil Rehabil. 2011 ; 10: 211-231
51. Burns MN, Nawacki E, Siddique J, et al. Prospective examination of anxiety and depression before and during confirmed and pseudoexacerbations in patients with multiple sclerosis. Psychosom Med. 2013 ; 75: 76-82
52. Carta MG, Moro MF, Lorefice L, et al. The risk of bipolar disorders in multiple sclerosis. J Affect Disord. 2014 ; 155: 255-260
53. Catenoix H, Marignier R, Ritleng C, et al. Multiple sclerosis and epileptic seizures. Mult Scler. 2011 ; 17: 96-102
54. Cendrowski W. Multiple sclerosis and diseases of autoimmune or related origin. Mater Med Pol. 1989 ; 21: 327-329
55. Cendrowski W, Majkowski J. Epilepsy in multiple sclerosis. J Neurol Sci. 1972 ; 17: 389-398
56. Cetin K, Johnson KL, Ehde DM, et al. Antidepressant use in multiple sclerosis: Epidemiologic study of a large community sample. Mult Scler. 2007 ; 13: 1046-1053
57. Cheng MY, Wai YY, Ro LS, et al. Seizures and multiple sclerosis in Chinese patients: A clinical and magnetic resonance imaging study. Epilepsy Res. 2012 ; 101: 166-173
58. Chwastiak L, Ehde DM, Gibbons LE, et al. Depressive symptoms and severity of illness in multiple sclerosis: Epidemiologic study of a large community sample. Am J Psychiatry. 2002 ; 159: 1862-1868
59. da Silva AM, Vilhena E, Lopes A, et al. Depression and anxiety in a Portuguese MS population: Associations with physical disability and severity of disease. J Neurol Sci. 2011 ; 306: 66-70
60. Dahl OP, Stordal E, Lydersen S, et al. Anxiety and depression in multiple sclerosis. A comparative population-based study in Nord-Trøndelag County, Norway. Mult Scler. 2009 ; 15: 1495-1501
61. Dallmeijer AJ, Beckerman H, de Groot V, et al. Long-term effect of comorbidity on the course of physical functioning in patients after stroke and with multiple sclerosis. J Rehabil Med. 2009 ; 41: 322-326
62. De Keyser J. Autoimmunity in multiple sclerosis. Neurology. 1988 ; 38: 371-374
63. de Seze J, Canva-Delcambre V, Fajardy I, et al. Autoimmune hepatitis and multiple sclerosis: A coincidental association?. Mult Scler. 2005 ; 11: 691-693
64. Demakis GJ, Buchanan R, Dewald L. A longitudinal study of cognition in nursing home residents with multiple sclerosis. Disabil Rehabil. 2009 ; 31: 1734-1741
65. Deretzi G, Kountouras J, Koutlas E, et al. Familial prevalence of autoimmune disorders in multiple sclerosis in Northern Greece. Mult Scler. 2010 ; 16: 1091-1101
66. Deriu M, Cossu G, Molari A, et al. Restless legs syndrome in multiple sclerosis: A case-control study. Mov Disord. 2009 ; 24: 697-701
67. Dias RA, Hardin KA, Rose H, et al. Sleepiness, fatigue, and risk of obstructive sleep apnea using the STOP-BANG questionnaire in multiple sclerosis: A pilot study. Sleep Breath. 2012 ; 16: 1255-1265
68. Drake WE, Macrae D. Epilepsy in multiple sclerosis. Neurology. 1961 ; 11: 810-816
69. Durelli L, Oggero A, Verdun E, et al. Thyroid function and anti-thyroid antibodies in MS patients screened for interferon treatment. A multicenter study. J Neurol Sci. 2001 ; 193: 17-22
70. Durmus H, Kurtuncu M, Tuzun E, et al. Comparative clinical characteristics of early- and adult-onset multiple sclerosis patients with seizures. Acta Neurol Belg. 2013 ; 113: 421-426
71. Eaton WW, Rose NR, Kalaydjian A, et al. Epidemiology of autoimmune diseases in Denmark. J Autoimmun. 2007 ; 29: 1-9
72. Edwards LJ, Constantinescu CS. A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult Scler. 2004 ; 10: 575-581
73. Einarsson U, Gottberg K, Fredrikson S, et al. Multiple sclerosis in Stockholm County. A pilot study exploring the feasibility of assessment of impairment, disability and handicap by home visits. Clin Rehabil. 2003 ; 17: 294-303
74. Engelsen BA, Gronning M. Epileptic seizures in patients with multiple sclerosis. Is the prognosis of epilepsy underestimated?. Seizure. 1997 ; 6: 377-382
75. Eriksson M, Ben-Menachem E, Andersen O. Epileptic seizures, cranial neuralgias and paroxysmal symptoms in remitting and progressive multiple sclerosis. Mult Scler. 2002 ; 8: 495-499
76. Espinola-Nadurille M, Colin-Piana R, Ramirez-Bermudez J, et al. Mental disorders in Mexican patients with multiple sclerosis. J Neuropsychiatry Clin Neurosci. 2010 ; 22: 63-69
77. Etemadifar M, Abtahi SH, Roomizadeh P. Epileptic seizures in multiple sclerosis: A population-based survey in Iran. Acta Neurol Belg. 2013 ; 113: 271-278
78. Etemadifar M, Abtahi SH, Tabrizi N. Epileptic seizures in early-onset multiple sclerosis. Arch Iran Med. 2012 ; 15: 381-383
79. Fanouriakis A, Mastorodemos V, Pamfil C, et al. Coexistence of systemic lupus erythematosus and multiple sclerosis: Prevalence, clinical characteristics, and natural history. Semin Arthritis Rheum. 2014 ; 43: 751-758
80. Feinstein A. An examination of suicidal intent in patients with multiple sclerosis. Neurology. 2002 ; 59: 674-678
81. Feinstein A, O'Connor P, Feinstein K. Multiple sclerosis, interferon beta-1b and depression: A prospective investigation. J Neurol. 2002 ; 249: 815-820
82. Ferini-Strambi L, Filippi M, Martinelli V, et al. Nocturnal sleep study in multiple sclerosis: Correlations with clinical and brain magnetic resonance imaging findings. J Neurol Sci. 1994 ; 125: 194-197
83. Ferrando SJ, Samton J, Mor N, et al. Patient Health Questionnaire-9 to screen for depression in outpatients with multiple sclerosis. Int J MS Care. 2007 ; 9: 99-103
84. Finlayson M, Preissner K, Cho C. Impact of comorbidity on fatigue management intervention outcomes among people with multiple sclerosis. Int J MS Care. 2013 ; 15: 21-26
85. Fisk JD, Morehouse SA, Brown MG, et al. Hospital-based psychiatric service utilization and morbidity in multiple sclerosis. Can J Neurol Sci. 1998 ; 25: 230-235
86. Fleming ST, Blake RL. Patterns of comorbidity in elderly patients with multiple sclerosis. J Clin Epidemiol. 1994 ; 47: 1127-1132
87. Forbes A, While A, Mathes L, et al. Health problems and health-related quality of life in people with multiple sclerosis. Clin Rehabil. 2006 ; 20: 67-78
88. Foroughipour M, Behdani F, Hebrani P, et al. Frequency of obsessive-compulsive disorder in patients with multiple sclerosis: A cross-sectional study. J Res Med Sci. 2012 ; 17: 248-253
89. Fragoso YD, Finkelsztejn A, Gomes S, et al. Restless legs syndrome and multiple sclerosis: A Brazilian multicenter study and meta-analysis of the literature. Arq Neuropsiquiatr. 2011 ; 69: 180-183
90. Füvesi J, Bencsik K, Losonczi E, et al. Factors influencing the health-related quality of life in Hungarian multiple sclerosis patients. J Neurol Sci. 2010 ; 293: 59-64
91. Galeazzi G, Ferrari S, Giaroli G, et al. Psychiatric disorders and depression in multiple sclerosis outpatients: Impact of disability and interferon beta therapy. Neurol Sci. 2005 ; 26: 255-262
92. Gambardella A, Valentino P, Labate A, et al. Temporal lobe epilepsy as a unique manifestation of multiple sclerosis. Can J Neurol Sci. 2003 ; 30: 228-232
93. Garfield AC, Lincoln NB. Factors affecting anxiety in multiple sclerosis. Disabil Rehabil. 2012 ; 34: 2047-2052
94. Ghadirian P, Dadgostar B, Azani R, et al. A case-control study of the association between sociodemographic, lifestyle and medical history factors and multiple sclerosis. Can J Public Health. 2001 ; 92: 281-285
95. Ghajarzadeh M, Sahraian MA, Fateh R, et al. Fatigue, depression and sleep disturbances in Iranian patients with multiple sclerosis. Acta Med Iran. 2012 ; 50: 244-249
96. Ghezzi A, Montanini R, Basso PF, et al. Epilepsy in multiple sclerosis. Eur Neurol. 1990 ; 30: 218-223
97. Gold SM, Schulz H, Mönch A, et al. Cognitive impairment in multiple sclerosis does not affect reliability and validity of self-report health measures. Mult Scler. 2003 ; 9: 404-410
98. Goldacre MJ, Seagroatt V, Yeates D, et al. Skin cancer in people with multiple sclerosis: A record linkage study. J Epidemiol Community Health. 2004 ; 58: 142-144
99. Gómez-Choco M, Iranzo A, Blanco Y, et al. Prevalence of restless legs syndrome and REM sleep behavior disorder in multiple sclerosis. Mult Scler. 2007 ; 13: 805-808
100. Goodin DS. Survey of multiple sclerosis in northern California. Northern California MS Study Group. Mult Scler. 1999 ; 5: 78-88
101. Goretti B, Ghezzi A, Portaccio E, et al. Psychosocial issue in children and adolescents with multiple sclerosis. Neurol Sci. 2010 ; 31: 467-470
102. Goretti B, Portaccio E, Zipoli V, et al. Coping strategies, psychological variables and their relationship with quality of life in multiple sclerosis. Neurol Sci. 2009 ; 30: 15-20
103. Gottberg K, Einarsson U, Fredrikson S, et al. A population-based study of depressive symptoms in multiple sclerosis in Stockholm county: Association with functioning and sense of coherence. J Neurol Neurosurg Psychiatry. 2007 ; 78: 60-65
104. Hakim EA, Bakheit AM, Bryant TN, et al. The social impact of multiple sclerosis - a study of 305 patients and their relatives. Disabil Rehabil. 2000 ; 22: 288-293
105. Hanrahan PS, Russell AS, McLean DR. Ankylosing spondylitis and multiple sclerosis: An apparent association?. J Rheumatol. 1988 ; 15: 1512-1514
106. Harel Y, Barak Y, Achiron A. Dysregulation of affect in multiple sclerosis: New phenomenological approach. Psychiatry Clin Neurosci. 2007 ; 61: 94-98
107. Hemminki K, Liu X, Försti A, et al. Effect of autoimmune diseases on incidence and survival in subsequent multiple myeloma. J Hematol Oncol. 2012 ; 5: 59
108. Hemminki K, Liu X, Försti A, et al. Subsequent brain tumors in patients with autoimmune disease. Neuro Oncol. 2013 ; 15: 1142-1150
109. Hemminki K, Liu X, Försti A, et al. Subsequent leukaemia in autoimmune disease patients. Br J Haematol. 2013 ; 161: 677-687
110. Hemminki K, Liu X, Ji J, et al. Autoimmune disease and subsequent digestive tract cancer by histology. Ann Oncol. 2012 ; 23: 927-933
111. Hemminki K, Liu X, Ji J, et al. Subsequent COPD and lung cancer in patients with autoimmune disease. Eur Respir J. 2011 ; 37: 463-465
112. Henderson RD, Bain CJ, Pender MP. The occurrence of autoimmune diseases in patients with multiple sclerosis and their families. J Clin Neurosci. 2000 ; 7: 434-437
113. Hjalgrim H, Rasmussen S, Rostgaard K, et al. Familial clustering of Hodgkin lymphoma and multiple sclerosis. J Natl Cancer Inst. 2004 ; 96: 780-784
114. Holper L, Coenen M, Weise A, et al. Characterization of functioning in multiple sclerosis using the ICF. J Neurol. 2010 ; 257: 103-113
115. Hopman WM, Coo H, Edgar CM, et al. Factors associated with health-related quality of life in multiple sclerosis. Can J Neurol Sci. 2007 ; 34: 160-166
116. Hoppenbrouwers IA, Cortes LM, Aulchenko YS, et al. Familial clustering of multiple sclerosis in a Dutch genetic isolate. Mult Scler. 2007 ; 13: 17-24
117. Horton M, Rudick RA, Hara-Cleaver C, et al. Validation of a self-report comorbidity questionnaire for multiple sclerosis. Neuroepidemiology. 2010 ; 35: 83-90
118. Hussein WI, Reddy SS. Prevalence of diabetes in patients with multiple sclerosis. Diabetes Care. 2006 ; 29: 1984-1985
119. Janardhan V, Bakshi R. Quality of life in patients with multiple sclerosis: The impact of fatigue and depression. J Neurol Sci. 2002 ; 205: 51-58
120. Janssens AC, Buljevac D, van Doorn PA, et al. Prediction of anxiety and distress following diagnosis of multiple sclerosis: A two-year longitudinal study. Mult Scler. 2006 ; 12: 794-801
121. Janssens AC, van Doorn PA, de Boer JB, et al. Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis. Mult Scler. 2003 ; 9: 397-403
122. Joffe RT, Lippert GP, Gray TA, et al. Mood disorder and multiple sclerosis. Arch Neurol. 1987 ; 44: 376-378
123. Johansson S, Ytterberg C, Claesson IM, et al. High concurrent presence of disability in multiple sclerosis. Associations with perceived health. J Neurol. 2007 ; 254: 767-773
124. Johansson S, Ytterberg C, Hillert J, et al. A longitudinal study of variations in and predictors of fatigue in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008 ; 79: 454-457
125. Jønsson A, Dock J, Ravnborg MH. Quality of life as a measure of rehabilitation outcome in patients with multiple sclerosis. Acta Neurol Scand. 1996 ; 93: 229-235
126. Julian LJ, Vella L, Frankel D, et al. ApoE alleles, depression and positive affect in multiple sclerosis. Mult Scler. 2009 ; 15: 311-315
127. Kaminska M, Kimoff RJ, Benedetti A, et al. Obstructive sleep apnea is associated with fatigue in multiple sclerosis. Mult Scler. 2012 ; 18: 1159-1169
128. Kanjwal K, Karabin B, Kanjwal Y, et al. Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis. Int J Med Sci. 2010 ; 7: 62-67
129. Karara AM, Macky TA, Sharawy MH. Pattern of uveitis in an Egyptian population with multiple sclerosis: A hospital-based study. Ophthalmic Res. 2013 ; 49: 25-29
130. Kargarfard M, Eetemadifar M, Mehrabi M, et al. Fatigue, depression, and health-related quality of life in patients with multiple sclerosis in Isfahan, Iran. Eur J Neurol. 2012 ; 19: 431-437
131. Karimi P, Modarresi SZ, Sahraian MA, et al. The relation of multiple sclerosis with allergy and atopy: A case control study. Iran J Allergy Asthma Immunol. 2013 ; 12: 182-189
132. Karni A, Abramsky O. Association of MS with thyroid disorders. Neurology. 1999 ; 53: 883-885
133. Kehler MD, Hadjistavropoulos HD. Is health anxiety a significant problem for individuals with multiple sclerosis?. J Behav Med. 2009 ; 32: 150-161
134. Ketelslegers IA, Catsman-Berrevoets CE, Boon M, et al. Fatigue and depression in children with multiple sclerosis and monophasic variants. Eur J Paediatr Neurol. 2010 ; 14: 320-325
135. Khan F, Pallant J, Brand C. Caregiver strain and factors associated with caregiver self-efficacy and quality of life in a community cohort with multiple sclerosis. Disabil Rehabil. 2007 ; 29: 1241-1250
136. Kingwell E, van der Kop M, Zhao Y, et al. Relative mortality and survival in multiple sclerosis: Findings from British Columbia, Canada. J Neurol Neurosurg Psychiatry. 2012 ; 83: 61-66
137. Kinnunen E, Wikström J. Prevalence and prognosis of epilepsy in patients with multiple sclerosis. Epilepsia. 1986 ; 27: 729-733
138. Klevan G, Jacobsen CO, Aarseth JH, et al. Health related quality of life in patients recently diagnosed with multiple sclerosis. Acta Neurol Scand. 2014 ; 129: 21-26
139. Korostil M, Feinstein A. Anxiety disorders and their clinical correlates in multiple sclerosis patients. Mult Scler. 2007 ; 13: 67-72
140. Koshiol J, Lam TK, Gridley G, et al. Racial differences in chronic immune stimulatory conditions and risk of non-Hodgkin's lymphoma in veterans from the United States. J Clin Oncol. 2011 ; 29: 378-385
141. Krökki O, Bloigu R, Ansakorpi H, et al. Neurological comorbidity and survival in multiple sclerosis. Mult Scler Relat Disord. 2013 ; 3: 72-77
142. Landgren AM, Landgren O, Gridley G, et al. Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4.5 million US male veterans. Cancer. 2011 ; 117: 1163-1171
143. Langer-Gould A, Albers K, Van Den Eeden S, et al. Autoimmune diseases prior to the diagnosis of multiple sclerosis: A population-based case-control study. Mult Scler. 2010 ; 16: 855-861
144. Laroni A, Calabrese M, Perini P, et al. Multiple sclerosis and autoimmune diseases: Epidemiology and HLA-DR association in North-east Italy. J Neurol. 2006 ; 253: 636-639
145. Lavela SL, Prohaska TR, Furner S, et al. Chronic diseases in male veterans with multiple sclerosis. Prev Chronic Dis. 2012 ; 9: E55
146. Lawrenson R, Wyndaele JJ, Vlachonikolis I, et al. Renal failure in patients with neurogenic lower urinary tract dysfunction. Neuroepidemiology. 2001 ; 20: 138-143
147. Le Scanff J, Seve P, Renoux C, et al. Uveitis associated with multiple sclerosis. Mult Scler. 2008 ; 14: 415-417
148. Lebrun C, Debouverie M, Vermersch P, et al. Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis. Mult Scler. 2008 ; 14: 399-405
149. Lebrun C, Vermersch P, Brassat D, et al. Cancer and multiple sclerosis in the era of disease-modifying treatments. J Neurol. 2011 ; 258: 1304-1311
150. Lehan T, Arango-Lasprilla JC, Macias MÁ, et al. Distress associated with patients' symptoms and depression in a sample of Mexican caregivers of individuals with MS. Rehabil Psychol. 2012 ; 57: 301-307
151. Leonaviius R, Adomaitiene A. Impact of depression on multiple sclerosis patients. Cent Eur J Med. 2012 ; 7: 685-690
152. Leonaviius R, Adomaitiene A. Anxiety and social activities in multiple sclerosis patients. Cent Eur J Med. 2013 ; 8: 56-61
153. Leonaviius R, Adomaitiene A, Leskauskas D. The relationships between depression and life activities and well-being of multiple sclerosis patients. Cent Eur J Med. 2011 ; 6: 652-661
154. Levinthal DJ, Rahman A, Nusrat S, et al. Adding to the burden: Gastrointestinal symptoms and syndromes in multiple sclerosis. Mult Scler Int. 2013 ; 2013: 319201
155. Li Y, Munger KL, Batool-Anwar S, et al. Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women. Neurology. 2012 ; 78: 1500-1506
156. Lindegård B. Diseases associated with multiple sclerosis and epilepsy. A population cohort study of 159,200 middle-aged, urban, native Swedes observed over 10 years (1970-79). Acta Neurol Scand. 1985 ; 71: 267-277
157. Liu X, Ji J, Försti A, et al. Autoimmune disease and subsequent urological cancer. J Urol. 2013 ; 189: 2262-2268
158. Lobentanz IS, Asenbaum S, Vass K, et al. Factors influencing quality of life in multiple sclerosis patients: Disability, depressive mood, fatigue and sleep quality. Acta Neurol Scand. 2004 ; 110: 6-13
159. Lu E, Zhao Y, Zhu F, et al. Birth hospitalization in mothers with multiple sclerosis and their newborns. Neurology. 2013 ; 80: 447-452
160. Lutterotti A, Vedovello M, Reindl M, et al. Olfactory threshold is impaired in early, active multiple sclerosis. Mult Scler. 2011 ; 17: 964-969
161. Manconi M, Fabbrini M, Bonanni E, et al. High prevalence of restless legs syndrome in multiple sclerosis. Eur J Neurol. 2007 ; 14: 534-539
162. Manconi M, Ferini-Strambi L, Filippi M, et al. Multicenter case-control study on restless legs syndrome in multiple sclerosis: The REMS study. Sleep. 2008 ; 31: 944-952
163. Maor Y, Olmer L, Mozes B. The relation between objective and subjective impairment in cognitive function among multiple sclerosis patients - the role of depression. Mult Scler. 2001 ; 7: 131-135
164. Marrie RA, Fisk JD, Yu BN, et al. Mental comorbidity and multiple sclerosis: Validating administrative data to support population-based surveillance. BMC Neurol. 2013 ; 13: 16
165. Marrie RA, Horwitz RI, Cutter G, et al. The burden of mental comorbidity in multiple sclerosis: Frequent, underdiagnosed, and under-treated. Mult Scler. 2009 ; 15: 385-392
166. Marrie RA, Horwitz RI, Cutter G, et al. Smokers with multiple sclerosis are more likely to report comorbid autoimmune diseases. Neuroepidemiology. 2011 ; 36: 85-90
167. Marrie RA, Horwitz RI, Cutter G, et al. Association between comorbidity and clinical characteristics of MS. Acta Neurol Scand. 2011 ; 124: 135-141
168. Marrie RA, Yu B, Leung S, et al. Rising prevalence of vascular comorbidities in MS: Validation of administrative definitions for diabetes, hypertension, hyperlipidemia. Mult Scler. 2012 ; 18: 1310-1319
169. Marrie RA, Yu BN, Leung S, et al. The utility of administrative data for surveillance of comorbidity in multiple sclerosis: A validation study. Neuroepidemiology. 2013 ; 40: 85-92
170. Marrie RA, Yu BN, Leung S, et al. Prevalence and incidence of ischemic heart disease in multiple sclerosis: A population-based validation study. Mult Scler Relat Disord. 2013 ; 2: 355-361
171. Marrie RA, Yu BN, Leung S, et al. The incidence and prevalence of fibromyalgia are higher in multiple sclerosis than the general population: A population-based study. Mult Scler Relat Disord. 2012 ; 1: 162-167
172. Marrie RA, Yu BN, Leung S, et al. The incidence and prevalence of thyroid disease do not differ in the multiple sclerosis and general populations: A validation study using administrative data. Neuroepidemiology. 2012 ; 39: 135-142
173. Marrosu MG, Cocco E, Lai M, et al. Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: A cohort study. Lancet. 2002 ; 359: 1461-1465
174. Marrosu MG, Sardu C, Cocco E, et al. Bias in parental transmission of the HLA-DR3 allele in Sardinian multiple sclerosis. Neurology. 2004 ; 63: 1084-1086
175. Martínez-Lapiscina EH, Ayuso T, Lacruz F, et al. Cortico-juxtacortical involvement increases risk of epileptic seizures in multiple sclerosis. Acta Neurol Scand. 2013 ; 128: 24-31
176. Mattioli F, Bellomi F, Stampatori C, et al. Depression, disability and cognitive impairment in multiple sclerosis: A cross sectional Italian study. Neurol Sci. 2011 ; 32: 825-832
177. McGuigan C, Hutchinson M. Unrecognised symptoms of depression in a community-based population with multiple sclerosis. J Neurol. 2006 ; 253: 219-223
178. Merlino G, Fratticci L, Lenchig C, et al. Prevalence of 'poor sleep' among patients with multiple sclerosis: An independent predictor of mental and physical status. Sleep Med. 2009 ; 10: 26-34
179. Metz LM, Seland P, Fritzler M. An analysis of the frequency of Sjogren's syndrome in a population of multiple sclerosis patients. J Clin Lab Immunol. 1989 ; 30: 121-125
180. Midgard R, Glattre E, Grønning M, et al. Multiple sclerosis and cancer in Norway. A retrospective cohort study. Acta Neurol Scand. 1996 ; 93: 411-415
181. Midgard R, Grønning M, Riise T, et al. Multiple sclerosis and chronic inflammatory diseases. A case-control study. Acta Neurol Scand. 1996 ; 93: 322-328
182. Miri S, Rohani M, Sahraian MA, et al. Restless legs syndrome in Iranian patients with multiple sclerosis. Neurol Sci. 2013 ; 34: 1105-1108
183. Miró J, Peña-Sagredo JL, Berciano J, et al. Prevalence of primary Sjögren's syndrome in patients with multiple sclerosis. Ann Neurol. 1990 ; 27: 582-584
184. Mohr DC, Hart SL, Julian L, et al. Screening for depression among patients with multiple sclerosis: Two questions may be enough. Mult Scler. 2007 ; 13: 215-219
185. Møller H, Kneller RW, Boice JD, et al. Cancer incidence following hospitalization for multiple sclerosis in Denmark. Acta Neurol Scand. 1991 ; 84: 214-220
186. Montel SR, Bungener C. Coping and quality of life in one hundred and thirty five subjects with multiple sclerosis. Mult Scler. 2007 ; 13: 393-401
187. Monzani F, Caraccio N, Meucci G, et al. Effect of 1-year treatment with interferon-beta1b on thyroid function and autoimmunity in patients with multiple sclerosis. Eur J Endocrinol. 1999 ; 141: 325-331
188. Moreau T, Schmidt N, Joyeux O, et al. Coping strategy and anxiety evolution in multiple sclerosis patients initiating interferon-beta treatment. Eur Neurol. 2009 ; 62: 79-85
189. Moreau T, Sochurkova D, Lemesle M, et al. Epilepsy in patients with multiple sclerosis: Radiological-clinical correlations. Epilepsia. 1998 ; 39: 893-896
190. Moreira NC, Damasceno RS, Medeiros CA, et al. Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients. Braz J Med Biol Res. 2008 ; 41: 932-937
191. Munteis E, Cano JF, Flores JA, et al. Prevalence of autoimmune thyroid disorders in a Spanish multiple sclerosis cohort. Eur J Neurol. 2007 ; 14: 1048-1052
192. Nicholl CR, Lincoln NB, Francis VM, et al. Assessment of emotional problems in people with multiple sclerosis. Clin Rehabil. 2001 ; 15: 657-668
193. Nicoletti A, Sofia V, Biondi R, et al. Epilepsy and multiple sclerosis in Sicily: A population-based study. Epilepsia. 2003 ; 44: 1445-1448
194. Niederwieser G, Buchinger W, Bonelli RM, et al. Prevalence of autoimmune thyroiditis and non-immune thyroid disease in multiple sclerosis. J Neurol. 2003 ; 250: 672-675
195. Nielsen N, Frisch M, Rostgaard K, et al. Autoimmune diseases in patients with multiple sclerosis and their first-degree relatives: A nationwide cohort study in Denmark. Mult Scler. 2008 ; 14: 823-829
196. Nielsen NM, Rostgaard K, Rasmussen S, et al. Cancer risk among patients with multiple sclerosis: A population-based register study. Int J Cancer. 2006 ; 118: 979-984
197. Noseworthy JH, Bass BH, Vandervoort MK, et al. The prevalence of primary Sjögren's syndrome in a multiple sclerosis population. Ann Neurol. 1989 ; 25: 95-98
198. Noy S, Achiron A, Gabbay U, et al. A new approach to affective symptoms in relapsing-remitting multiple sclerosis. Compr Psychiatry. 1995 ; 36: 390-395
199. Nuyen J, Schellevisa FG, Satarianob WA, et al. Comorbidity was associated with neurologic and psychiatric diseases: A general practice-based controlled study. J Clin Epidemiol. 2006 ; 59: 1274-1284
200. Nyquist PA, Cascino GD, Rodriguez M. Seizures in patients with multiple sclerosis seen at Mayo Clinic, Rochester, Minn, 1990-1998. Mayo Clin Proc. 2001 ; 76: 983-986
201. Olafsson E, Benedikz J, Hauser WA. Risk of epilepsy in patients with multiple sclerosis: A population-based study in Iceland. Epilepsia. 1999 ; 40: 745-747
202. Palo J, Duchesne J, Wikström J. Malignant diseases among patients with multiple sclerosis. J Neurol. 1977 ; 216: 217-222
203. Pandya R, Metz L, Patten SB. Predictive value of the CES-D in detecting depression among candidates for disease-modifying multiple sclerosis treatment. Psychosomatics. 2005 ; 46: 131-134
204. Patten SB, Beck CA, Williams JV, et al. Major depression in multiple sclerosis: A population-based perspective. Neurology. 2003 ; 61: 1524-1527
205. Patten SB, Berzins S, Metz LM. Challenges in screening for depression in multiple sclerosis. Mult Scler. 2010 ; 16: 1406-1411
206. Patten SB, Metz LM, Reimer MA. Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population. Mult Scler. 2000 ; 6: 115-120
207. Patten SB, Svenson LW, Metz LM. Psychotic disorders in MS: Population-based evidence of an association. Neurology. 2005 ; 65: 1123-1125
208. Patten SB, Svenson LW, Metz LM. Descriptive epidemiology of affective disorders in multiple sclerosis. CNS Spectr. 2005 ; 10: 365-371
209. Patti F, Cacopardo M, Palermo F, et al. Health-related quality of life and depression in an Italian sample of multiple sclerosis patients. J Neurol Sci. 2003 ; 211: 55-62
210. Patti F, Pozzilli C, Montanari E, et al. Effects of education level and employment status on HRQoL in early relapsing-remitting multiple sclerosis. Mult Scler. 2007 ; 13: 783-791
211. Paz Soldan MM, Pittock SJ, Weigand SD, et al. Statin therapy and multiple sclerosis disability in a population-based cohort. Mult Scler. 2012 ; 18: 358-363
212. Pedotti R, Farinotti M, Falcone C, et al. Allergy and multiple sclerosis: A population-based case-control study. Mult Scler. 2009 ; 15: 899-906
213. Percy AK, Noberga FT, Okazaki H, et al. Multiple sclerosis in Rochester, Minn. A 60-year appraisal. Arch Neurol. 1971 ; 25: 105-111
214. Pittion-Vouyovitch S, Debouverie M, Guillemin F, et al. Fatigue in multiple sclerosis is related to disability, depression and quality of life. J Neurol Sci. 2006 ; 243: 39-45
215. Pitzalis M, Zavattari P, Murru R, et al. Genetic loci linked to type 1 diabetes and multiple sclerosis families in Sardinia. BMC Med Genet. 2008 ; 9: 3
216. Poder K, Ghatavi K, Fisk J, et al. Social anxiety in a multiple sclerosis clinic population. Mult Scler. 2009 ; 15: 393-398
217. Poirier G, Montplaisir J, Dumont M, et al. Clinical and sleep laboratory study of narcoleptic symptoms in multiple sclerosis. Neurology. 1987 ; 37: 693-695
218. Ponsonby AL, Dwyer T, van der Mei I, et al. Asthma onset prior to multiple sclerosis and the contribution of sibling exposure in early life. Clin Exp Immunol. 2006 ; 146: 463-470
219. Porcel J, Río J, Sánchez-Betancourt A, et al. Long-term emotional state of multiple sclerosis patients treated with interferon beta. Mult Scler. 2006 ; 12: 802-807
220. Ramagopalan SV, Dyment DA, Valdar W, et al. The occurrence of autoimmune disease in Canadian families with multiple sclerosis. Lancet Neurol. 2007 ; 6: 604-610
221. Rodrigo L, Hernández-Lahoz C, Fuentes D, et al. Prevalence of celiac disease in multiple sclerosis. BMC Neurol. 2011 ; 11: 31
222. Romberg A, Ruutiainen J, Puukka P, et al. Fatigue in multiple sclerosis patients during inpatient rehabilitation. Disabil Rehabil. 2008 ; 30: 1480-1485
223. Sadovnick A, Paty D, Yannakoulias G. Concurrence of multiple sclerosis and inflammatory bowel disease. N Engl J Med. 1989 ; 321: 762-763
224. Sahraian MA, Jafarian S, Sheikhbahaei S, et al. Respiratory tract rather than cutaneous atopic allergy inversely associate with multiple sclerosis: A case-control study. Clin Neurol Neurosurg. 2013 ; 115: 2099-2102
225. Salter AR, Tyry T, Vollmer T, et al. Seeing in NARCOMS: A look at vision-related quality of life in the NARCOMS registry. Mult Scler. 2013 ; 19: 953-960
226. Salvatore S, Finazzi S, Ghezzi A, et al. Multiple sclerosis and celiac disease: Is there an increased risk?. Mult Scler. 2004 ; 10: 711-712
227. Sandberg-Wollheim M, Axéll T, Hansen BU, et al. Primary Sjögren's syndrome in patients with multiple sclerosis. Neurology. 1992 ; 42: 845-847
228. Scott TF, Allen D, Price TR, et al. Characterization of major depression symptoms in multiple sclerosis patients. J Neuropsychiatry Clin Neurosci. 1996 ; 8: 318-323
229. Seyed Saadat SM, Hosseininezhad M, Bakhshayesh B, et al. Prevalence and predictors of depression in Iranian patients with multiple sclerosis: A population-based study. Neurol Sci. 2014 ; 35: 735-740
230. Seyfert S, Klapps P, Meisel C, et al. Multiple sclerosis and other immunologic diseases. Acta Neurol Scand. 1990 ; 81: 37-42
231. Shaygannejad V, Ardestani PE, Ghasemi M, et al. Restless legs syndrome in Iranian multiple sclerosis patients: A case-control study. Int J Prev Med. 2013 ; 4: S189 - S193
232. Sheu JJ, Lin HC. Association between multiple sclerosis and chronic periodontitis: A population-based pilot study. Eur J Neurol. 2013 ; 20: 1053-1059
233. Shiraishi K, Higuchi Y, Ozawa K, et al. Clinical course and prognosis of 27 patients with childhood onset multiple sclerosis in Japan. Brain Dev. 2005 ; 27: 224-227
234. Siepman TA, Janssens AC, de Koning I, et al. The role of disability and depression in cognitive functioning within 2 years after multiple sclerosis diagnosis. J Neurol. 2008 ; 255: 910-916
235. Simioni S, Ruffieux C, Bruggimann L, et al. Cognition, mood and fatigue in patients in the early stage of multiple sclerosis. Swiss Med Wkly. 2007 ; 137: 496-501
236. Sloka JS, Phillips PW, Stefanelli M, et al. Co-occurrence of autoimmune thyroid disease in a multiple sclerosis cohort. J Autoimmune Dis. 2005 ; 2: 9
237. Smith SJ, Young CA. The role of affect on the perception of disability in multiple sclerosis. Clin Rehabil. 2000 ; 14: 50-54
238. Sokic DV, Stojsavljevic N, Drulovic J, et al. Seizures in multiple sclerosis. Epilepsia. 2001 ; 42: 72-79
239. Sollom AC, Kneebone II. Treatment of depression in people who have multiple sclerosis. Mult Scler. 2007 ; 13: 632-635
240. Solomon AJ, Hills W, Chen Z, et al. Autoantibodies and Sjogren's syndrome in multiple sclerosis, a reappraisal. PLoS One. 2013 ; 8: e65385
241. Somer H, Müller K, Kinnunen E. Myasthenia gravis associated with multiple sclerosis. Epidemiological survey and immunological findings. J Neurol Sci. 1989 ; 89: 37-48
242. Spain LA, Tubridy N, Kilpatrick TJ, et al. Illness perception and health-related quality of life in multiple sclerosis. Acta Neurol Scand. 2007 ; 116: 293-299
243. Striano P, Orefice G, Brescia Morra V, et al. Epileptic seizures in multiple sclerosis: Clinical and EEG correlations. Neurol Sci. 2003 ; 24: 322-328
244. Sumelahti ML, Pukkala E, Hakama M. Cancer incidence in multiple sclerosis: A 35-year follow-up. Neuroepidemiology. 2004 ; 23: 224-227
245. Sun LM, Lin CL, Chung CJ, et al. Increased breast cancer risk for patients with multiple sclerosis: A nationwide population-based cohort study. Eur J Neurol. 2014 ; 21: 238-244
246. Sundgren M, Maurex L, Wahlin A, et al. Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis. Arch Clin Neuropsychol. 2013 ; 28: 144-155
247. Sunesen KG, Nørgaard M, Thorlacius-Ussing O, et al. Immunosuppressive disorders and risk of anal squamous cell carcinoma: A nationwide cohort study in Denmark, 1978-2005. Int J Cancer. 2010 ; 127: 675-684
248. Tachibana N, Howard RS, Hirsch NP, et al. Sleep problems in multiple sclerosis. Eur Neurol. 1994 ; 34: 320-323
249. Tanriverdi D, Okanli A, Sezgin S, et al. Quality of life in patients with multiple sclerosis in Turkey: Relationship to depression and fatigue. J Neurosci Nurs. 2010 ; 42: 267-273
250. Tarrants M, Oleen-Burkey M, Castelli-Haley J, et al. The impact of comorbid depression on adherence to therapy for multiple sclerosis. Mult Scler Int. 2011 ; 2011: 271321
251. Tourbah A, Clapin A, Gout O, et al. Systemic autoimmune features and multiple sclerosis: A 5-year follow-up study. Arch Neurol. 1998 ; 55: 517-521
252. Tremlett HL, Evans J, Wiles CM, et al. Asthma and multiple sclerosis: An inverse association in a case-control general practice population. QJM. 2002 ; 95: 753-756
253. Trouillas P, Courjon J. Epilepsy with multiple sclerosis. Epilepsia. 1972 ; 13: 325-333
254. Turner AP, Hawkins EJ, Haselkorn JK, et al. Alcohol misuse and multiple sclerosis. Arch Phys Med Rehabil. 2009 ; 90: 842-848
255. Uribe-San-Martín R, Ciampi-Díaz E, Suarez-Hernández F, et al. Prevalence of epilepsy in a cohort of patients with multiple sclerosis. Seizure. 2014 ; 23: 81-83
256. Valleroy ML, Kraft GH. Sexual dysfunction in multiple sclerosis. Arch Phys Med Rehabil. 1984 ; 65: 125-128
257. Viveiros CD, Alvarenga RMP. Prevalence of epilepsy in a case series of multiple sclerosis patients. Arq Neuropsiquiatr. 2010 ; 68: 731-736
258. Vogt A, Kappos L, Calabrese P, et al. Working memory training in patients with multiple sclerosis - comparison of two different training schedules. Restor Neurol Neurosci. 2009 ; 27: 225-235
259. Wertman E, Zilber N, Abramsky O. An association between multiple sclerosis and type I diabetes mellitus. J Neurol. 1992 ; 239: 43-45
260. Williams RM, Turner AP, Hatzakis M, et al. Prevalence and correlates of depression among veterans with multiple sclerosis. Neurology. 2005 ; 64: 75-80
261. Wood B, van der Mei I, Ponsonby AL, et al. Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis. Mult Scler. 2013 ; 19: 217-224
262. Wynn DR, Rodriguez M, O'Fallon WM, et al. A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, Minnesota. Neurology. 1990 ; 40: 780-786
263. Zabad RK, Patten SB, Metz LM. The association of depression with disease course in multiple sclerosis. Neurology. 2005 ; 64: 359-360
264. Zettl UK, Bauer-Steinhusen U, Glaser T, et al. Evaluation of an electronic diary for improvement of adherence to interferon beta-1b in patients with multiple sclerosis: Design and baseline results of an observational cohort study. BMC Neurol. 2013 ; 13: 117
265. Zorzon M, de Masi R, Nasuelli D, et al. Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects. J Neurol. 2001 ; 248: 416-421
266. Broemeling A, Watson DE, Prebtani F, et al. Population patterns of chronic health conditions, co-morbidity and health care use in Canada: Implications for policy and practice. Healthc Q. 2008 ; 11: 70-76
267. Culpepper WJ, Ehrmantraut M, Wallin MT, et al. Veterans Health Administration multiple sclerosis surveillance registry: The problem of case-finding from administrative databases. J Rehabil Res Dev. 2006 ; 43: 17
268. Marrie RA, Yu N, Blanchard JF, et al. The rising prevalence and changing age distribution of multiple sclerosis in Manitoba. Neurology. 2010 ; 74: 465-471
269. Bernstein CN, Blanchard JF, Rawsthorne P, et al. Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian Province: A population-based study. Amer J Epidemiol. 1999 ; 149: 916-924
270. Discharge Abstract Database (DAD)/CMG/Plx Data Quality: Re-abstraction Study. Ottawa, Ontario: Canadian Institute for Health Information ; 2003 :
271. Elixhauser A, Steiner C, Harris DR, et al. Comorbidity measures for use with administrative data. Med Care. 1998 ; 36: 8-27
272. Terrin N, Schmid CH, Lau J, et al. Adjusting for publication bias in the presence of heterogeneity. Stat Med. 2003 ; 22: 2113-2126
273. Cohen JA. Emerging therapies for relapsing multiple sclerosis. Arch Neurol. 2009 ; 66: 821-828