Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages

Planta Medica

Volumn 77, Issue 17, 2011, Pages 1890-1897

  Richard, Nathalie ^a   Arnold, Sabine ^a   Hoeller, Ulrich ^a   Kilpert, Claus ^a   Wertz, Karin ^a   Schwager, Joseph ^a  

^a DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

Author keywords

chemokine; cytokine; hydroxytyrosol; inflammation; olive; polyphenols

Indexed keywords

ANTIINFLAMMATORY AGENT; CHEMOKINE; CXCL1 CHEMOKINE; CYTOKINE; EOTAXIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GELATINASE B; HYDROXYTYROSOL; ICOSANOID; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OLIVE VEGETATION WATER; PLANT EXTRACT; PROSTAGLANDIN E2; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACROPHAGE; NONHUMAN; OLIVE; PLEIOTROPY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CHEMOKINES; CYTOKINES; DINOPROSTONE; GENE EXPRESSION REGULATION; HUMANS; INHIBITORY CONCENTRATION 50; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; OLEA; PHENYLETHYL ALCOHOL; PLANT EXTRACTS; POLYPHENOLS; RNA;

MURINAE;

EID: 82155197149     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280022     Document Type: Article

References (33)

1. Tuck K L., Hayball P J. Major phenolic compounds in olive oil: metabolism and health effects. J Nutr Biochem 2002 13 636-644 (Pubitemid 35341709)
2. Cicerale S, Conlan X A., Sinclair A J., Keast R S. Chemistry and health of olive oil phenolics. Crit Rev Food Sci Nutr 2009 49 218-236
3. Owen R W., Giacosa A, Hull W E., Haubner R, Spiegelhalder B, Bartsch H. The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur J Cancer 2000 36 1235-1247 (Pubitemid 30407011)
4. Visioli F, Galli C. Biological properties of olive oil phytochemicals. Crit Rev Food Sci Nutr 2002 42 209-221
5. Miles E A., Wallace F A., Calder P C. An olive oil-rich diet reduces scavenger receptor mRNA in murine macrophages. Br J Nutr 2001 85 185-191 (Pubitemid 32236805)
6. Moreno J J., Carbonell T, Sanchez T, Miret S, Mitjavila M T. Olive oil decreases both oxidative stress and the production of arachidonic acid metabolites by the prostaglandin G/H synthase pathway in rat macrophages. J Nutr 2001 131 2145-2149 (Pubitemid 32720645)
7. Yaqoob P, Calder P. Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages. Cell Immunol 1995 163 120-128
8. Owen R W., Haubner R, Mier W, Giacosa A, Hull W E., Spiegelhalder B, Bartsch H. Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes. Food Chem Toxicol 2003 41 703-717 (Pubitemid 36349552)
9. O'Dowd Y, Driss F, Dang P M., Elbim C, Gougerot-Pocidalo M A., Pasquier C, El-Benna J. Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. Biochem Pharmacol 2004 68 2003-2008 (Pubitemid 39346190)
10. Visioli F, Bellomo G, Galli C. Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun 1998 247 60-64 (Pubitemid 28412525)
11. Visioli F, Caruso D, Plasmati E, Patelli R, Mulinacci N, Romani A, Galli G, Galli C. Hydroxytyrosol, as a component of olive mill waste water, is dose-dependently absorbed and increases the antioxidant capacity of rat plasma. Free Radic Res 2001 34 301-305 (Pubitemid 32331658)
12. Salami M, Galli C, De Angelis L, Visioli F. Formation of F2-isoprostanes in oxidized low density lipoprotein: inhibitory effect of hydroxytyrosol. Pharmacol Res 1995 31 275-279
13. Grignaffini P, Roma P, Galli C, Catapano A L. Protection of low-density lipoprotein from oxidation by 3,4-dihydroxyphenylethanol. Lancet 1994 343 1296-1297 (Pubitemid 24158066)
14. Carluccio M A., Siculella L, Ancora M A., Massaro M, Scoditti E, Storelli C, Visioli F, Distante A, De Caterina R. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol 2003 23 622-629 (Pubitemid 36438075)
15. Bitler C M., Viale T M., Damaj B, Crea R. Hydrolyzed olive vegetation water in mice has anti-inflammatory activity. J Nutr 2005 135 1475-1479 (Pubitemid 40799613)
16. D'Angelo S, Manna C, Migliardi V, Mazzoni O, Morrica P, Capasso G, Pontoni G, Galletti P, Zappia V. Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil. Drug Metab Dispos 2001 29 1492-1498 (Pubitemid 33000698)
17. Tuck K L., Hayball P J., Stupans I. Structural characterization of the metabolites of hydroxytyrosol, the principal phenolic component in olive oil, in rats. J Agric Food Chem 2002 50 2404-2409 (Pubitemid 34275317)
18. Miro-Casas E, Covas M I., Farre M, Fito M, Ortuno J, Weinbrenner T, Roset P, de la Torre R. Hydroxytyrosol disposition in humans. Clin Chem 2003 49 945-952 (Pubitemid 36623475)
19. Visioli F, Romani A, Mulinacci N, Zarini S, Conte D, Vincieri F F., Galli C. Antioxidant and other biological activities of olive mill waste waters. J Agric Food Chem 1999 47 3397-3401 (Pubitemid 29422046)
20. Richard N, Porath D, Radspieler A, Schwager J. Effects of resveratrol, piceatannol, tri-acetoxystilbene, and genistein on the inflammatory response of human peripheral blood leukocytes. Mol Nutr Food Res 2005 49 431-442 (Pubitemid 40780390)
21. D'Acquisto F, Cicatiello L, Iuvone T, Ialenti A, Ianaro A, Esumi H, Weisz A, Carnuccio R. Inhibition of inducible nitric oxide synthase gene expression by glucocorticoid-induced protein(s) in lipopolysaccharide-stimulated J774 cells. Eur J Pharmacol 1997 339 87-95 (Pubitemid 28015435)
22. Christian M S., Sharper V A., Hoberman A M., Seng J E., Fu L, Covell D, Diener R M., Bitler C M., Crea R. The toxicity profile of hydrolyzed aqueous olive pulp extract. Drug Chem Toxicol 2004 27 309-330 (Pubitemid 39506936)
23. Turner R, Etienne N, Alonso M G., de Pascual-Teresa S, Minihane A M., Weinberg P D., Rimbach G. Antioxidant and anti-atherogenic activities of olive oil phenolics. Int J Vitam Nutr Res 2005 75 61-70 (Pubitemid 40387177)
24. Visioli F, Galli C. Antiatherogenic components of olive oil. Curr Atheroscler Rep 2001 3 64-67
25. Maiuri M C., De Stefano D, Di Meglio P, Irace C, Savarese M, Sacchi R, Cinelli M P., Carnuccio R. Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation. Naunyn Schmiedebergs Arch Pharmacol 2005 371 457-465 (Pubitemid 41218965)
26. Zhang X, Cao J, Jiang L, Zhong L. Suppressive effects of hydroxytyrosol on oxidative stress and nuclear Factor-kappaB activation in THP-1 cells. Biol Pharm Bull 2009 32 578-582
27. Visioli F, Bellosta S, Galli C. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci 1998 62 541-546 (Pubitemid 28050072)
28. Fulkerson P C., Zimmermann N, Hassman L M., Finkelman F D., Rothenberg M E. Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma. J Immunol 2004 173 7565-7574 (Pubitemid 39628198)
29. Coma G, Pena R, Blanco J, Rosell A, Borras F E., Este J A., Clotet B, Ruiz L, Parkhouse R M., Bofill M. Treatment of monocytes with interleukin (IL)-12 plus IL-18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9, and CXCL10. Clin Exp Immunol 2006 145 535-544 (Pubitemid 44252497)
30. Libby P. Inflammation in atherosclerosis. Nature 2002 420 868-874 (Pubitemid 36019640)
31. Galis Z S., Sukhova G K., Lark M W., Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994 94 2493-2503 (Pubitemid 24379627)
32. Covas M I., de la Torre K, Farre-Albaladejo M, Kaikkonen J, Fito M, Lopez-Sabater C, Pujadas-Bastardes M A., Joglar J, Weinbrenner T, Lamuela-Raventos R M., de la Torre R. Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans. Free Radic Biol Med 2006 40 608-616 (Pubitemid 43170812)
33. Petroni A, Blasevich M, Salami M, Servili M, Montedoro G F., Galli C. A phenolic antioxidant extracted from olive oil inhibits platelet aggregation and arachidonic acid metabolism in vitro. World Rev Nutr Diet 1994 75 169-172