메뉴 건너뛰기




Volumn 61, Issue 3, 2017, Pages

Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats

Author keywords

Inflammation; Mediterranean diet; Mitochondrial and hepatic oxidative stress; Nonalcoholic Fatty liver disease; Olive oil polyphenols

Indexed keywords

ADIPOCYTOKINE; CYTOKINE; GLUCOSE; OLIVE OIL; POLYPHENOL; TOCOPHEROL;

EID: 85007043667     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201600418     Document Type: Article
Times cited : (63)

References (57)
  • 1
    • 84902546574 scopus 로고    scopus 로고
    • World gastroenterology organisation global guidelines: nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
    • Review, T., LaBrecque, D. R., Abbas, Z., Anania, F. et al., World gastroenterology organisation global guidelines: nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J. Clin. Gastroenterol. 2014, 48, 467–473.
    • (2014) J. Clin. Gastroenterol. , vol.48 , pp. 467-473
    • Review, T.1    LaBrecque, D.R.2    Abbas, Z.3    Anania, F.4
  • 2
    • 77954748222 scopus 로고    scopus 로고
    • Weight loss: cornerstone in the treatment of nonalcoholic fatty liver disease
    • Tilg, H., Moschen, A., Weight loss: cornerstone in the treatment of nonalcoholic fatty liver disease. Minerva Gastroenterol. Dietol. 2010, 56, 159–167.
    • (2010) Minerva Gastroenterol. Dietol. , vol.56 , pp. 159-167
    • Tilg, H.1    Moschen, A.2
  • 3
    • 84946494125 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
    • Ashraf, N. U., Sheikh, T. A., Endoplasmic reticulum stress and oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. Free Radic. Res. 2015, 49, 1405–1418.
    • (2015) Free Radic. Res. , vol.49 , pp. 1405-1418
    • Ashraf, N.U.1    Sheikh, T.A.2
  • 4
    • 84884984539 scopus 로고    scopus 로고
    • Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
    • Begriche, K., Massart, J., Robin, M. A., Bonnet, F. et al., Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology 2013, 58, 1497–1507.
    • (2013) Hepatology , vol.58 , pp. 1497-1507
    • Begriche, K.1    Massart, J.2    Robin, M.A.3    Bonnet, F.4
  • 5
    • 84884520213 scopus 로고    scopus 로고
    • Free radical biology for medicine: learning from nonalcoholic fatty liver disease
    • Serviddio, G., Bellanti, F., Vendemiale, G., Free radical biology for medicine: learning from nonalcoholic fatty liver disease. Free Radic. Biol. Med. 2013, 65, 952–968.
    • (2013) Free Radic. Biol. Med. , vol.65 , pp. 952-968
    • Serviddio, G.1    Bellanti, F.2    Vendemiale, G.3
  • 6
    • 84884176199 scopus 로고    scopus 로고
    • Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance
    • Asrih, M., Jornayvaz, F. R., Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance. J. Endocrinol. 2013, 218, R25–R36.
    • (2013) J. Endocrinol. , vol.218 , pp. R25-R36
    • Asrih, M.1    Jornayvaz, F.R.2
  • 7
    • 84951832157 scopus 로고    scopus 로고
    • Adipokines in nonalcoholic fatty liver disease
    • Polyzos, S. A., Kountouras, J., Mantzoros, C. S., Adipokines in nonalcoholic fatty liver disease. Metabolism 2015, 65, 1062–1079.
    • (2015) Metabolism , vol.65 , pp. 1062-1079
    • Polyzos, S.A.1    Kountouras, J.2    Mantzoros, C.S.3
  • 9
    • 84900852672 scopus 로고    scopus 로고
    • Role of innate immune response in nonalcoholic fatty liver disease: metabolic complications and therapeutic tools
    • Meli, R., Mattace Raso, G., Calignano, A., Role of innate immune response in nonalcoholic fatty liver disease: metabolic complications and therapeutic tools. Front. Immunol. 2014, 5, 177.
    • (2014) Front. Immunol , vol.5 , pp. 177
    • Meli, R.1    Mattace Raso, G.2    Calignano, A.3
  • 10
    • 84917696613 scopus 로고    scopus 로고
    • Focus on emerging drugs for the treatment of patients with nonalcoholic fatty liver disease
    • Federico, A., Zulli, C., de Sio, I., Del Prete, A. et al., Focus on emerging drugs for the treatment of patients with nonalcoholic fatty liver disease. World J. Gastroenterol. 2014, 20, 16841–16857.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 16841-16857
    • Federico, A.1    Zulli, C.2    de Sio, I.3    Del Prete, A.4
  • 11
    • 84879136876 scopus 로고    scopus 로고
    • The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with nonalcoholic fatty liver disease
    • Ryan, M. C., Itsiopoulos, C., Thodis, T., Ward, G. et al., The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with nonalcoholic fatty liver disease. J. Hepatol. 2013, 59, 138–143.
    • (2013) J. Hepatol. , vol.59 , pp. 138-143
    • Ryan, M.C.1    Itsiopoulos, C.2    Thodis, T.3    Ward, G.4
  • 12
    • 77649223901 scopus 로고    scopus 로고
    • Biological activities of phenolic compounds present in virgin olive oil
    • Cicerale, S., Lucas, L., Keast, R., Biological activities of phenolic compounds present in virgin olive oil. Int. J. Mol. Sci. 2010, 11, 458–479.
    • (2010) Int. J. Mol. Sci. , vol.11 , pp. 458-479
    • Cicerale, S.1    Lucas, L.2    Keast, R.3
  • 13
    • 84890696397 scopus 로고    scopus 로고
    • Overview of metabolism and bioavailability enhancement of polyphenols
    • Lewandowska, U., Szewczyk, K., Hrabec, E., Janecka, A. et al., Overview of metabolism and bioavailability enhancement of polyphenols. J. Agric. Food Chem. 2013, 61, 12183–12199.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 12183-12199
    • Lewandowska, U.1    Szewczyk, K.2    Hrabec, E.3    Janecka, A.4
  • 14
    • 84923358567 scopus 로고    scopus 로고
    • Oleuropein suppresses LPS-induced inflammatory responses in RAW 264.7 cell and zebrafish
    • Ryu, S. J., Choi, H. S., Yoon, K. Y., Lee, O. H. et al., Oleuropein suppresses LPS-induced inflammatory responses in RAW 264.7 cell and zebrafish. J. Agric. Food Chem. 2015, 63, 2098–2105.
    • (2015) J. Agric. Food Chem. , vol.63 , pp. 2098-2105
    • Ryu, S.J.1    Choi, H.S.2    Yoon, K.Y.3    Lee, O.H.4
  • 15
    • 77952921830 scopus 로고    scopus 로고
    • Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line
    • Iacono, A., Gomez, R., Sperry, J., Conde, J. et al., Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line. Arthritis Rheum. 2010, 62, 1675–1682.
    • (2010) Arthritis Rheum , vol.62 , pp. 1675-1682
    • Iacono, A.1    Gomez, R.2    Sperry, J.3    Conde, J.4
  • 16
    • 84877952121 scopus 로고    scopus 로고
    • Oleocanthal inhibits proliferation and MIP-1alpha expression in human multiple myeloma cells
    • Scotece, M., Gomez, R., Conde, J., Lopez, V. et al., Oleocanthal inhibits proliferation and MIP-1alpha expression in human multiple myeloma cells. Curr. Med. Chem. 2013, 20, 2467–2475.
    • (2013) Curr. Med. Chem. , vol.20 , pp. 2467-2475
    • Scotece, M.1    Gomez, R.2    Conde, J.3    Lopez, V.4
  • 17
    • 84953638995 scopus 로고    scopus 로고
    • Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic beta-cell through JNK signaling
    • Lee, H., Im, S. W., Jung, C. H., Jang, Y. J. et al., Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic beta-cell through JNK signaling. Biochem. Biophys. Res. Commun. 2016, 469, 748–752.
    • (2016) Biochem. Biophys. Res. Commun. , vol.469 , pp. 748-752
    • Lee, H.1    Im, S.W.2    Jung, C.H.3    Jang, Y.J.4
  • 18
    • 84962122628 scopus 로고    scopus 로고
    • Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD
    • Pirozzi, C., Lama, A., Simeoli, R., Paciello, O. et al., Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. J. Nutr. Biochem. 2016, 30, 108–115.
    • (2016) J. Nutr. Biochem. , vol.30 , pp. 108-115
    • Pirozzi, C.1    Lama, A.2    Simeoli, R.3    Paciello, O.4
  • 19
    • 0029065480 scopus 로고
    • Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice
    • Surwit, R. S., Feinglos, M. N., Rodin, J., Sutherland, A. et al., Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 1995, 44, 645–651.
    • (1995) Metabolism , vol.44 , pp. 645-651
    • Surwit, R.S.1    Feinglos, M.N.2    Rodin, J.3    Sutherland, A.4
  • 20
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw, S., Nihal, M., Ahmad, N., Dose translation from animal to human studies revisited. FASEB J. 2008, 22, 659–661.
    • (2008) FASEB J , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 21
    • 84889571833 scopus 로고    scopus 로고
    • Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet
    • Raso, G. M., Simeoli, R., Iacono, A., Santoro, A. et al., Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. J. Nutr. Biochem. 2014, 25, 81–90.
    • (2014) J. Nutr. Biochem. , vol.25 , pp. 81-90
    • Raso, G.M.1    Simeoli, R.2    Iacono, A.3    Santoro, A.4
  • 22
    • 84879830881 scopus 로고    scopus 로고
    • Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high-fat diet
    • Mattace Raso, G., Simeoli, R., Russo, R., Iacono, A. et al., Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high-fat diet. PLoS One 2013, 8, e68626.
    • (2013) PLoS One , vol.8
    • Mattace Raso, G.1    Simeoli, R.2    Russo, R.3    Iacono, A.4
  • 23
    • 0027238915 scopus 로고
    • Estimation of body composition changes during weight cycling by bioelectrical impedance analysis in rats
    • Ilagan, J., Bhutani, V., Archer, P., Lin, P. K. et al., Estimation of body composition changes during weight cycling by bioelectrical impedance analysis in rats. J. Appl. Physiol. (1985) 1993, 74, 2092–2098.
    • (1993) J. Appl. Physiol. (1985) , vol.74 , pp. 2092-2098
    • Ilagan, J.1    Bhutani, V.2    Archer, P.3    Lin, P.K.4
  • 24
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch, J., Lees, M., Sloane Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 1957, 226, 497–509.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 25
    • 3042523006 scopus 로고    scopus 로고
    • Modulation of hepatic mitochondrial energy efficiency with age
    • Lionetti, L., Crescenzo, R., Mollica, M. P., Tasso, R. et al., Modulation of hepatic mitochondrial energy efficiency with age. Cell. Mol. Life Sci. 2004, 61, 1366–1371.
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 1366-1371
    • Lionetti, L.1    Crescenzo, R.2    Mollica, M.P.3    Tasso, R.4
  • 26
    • 0015384891 scopus 로고
    • Determination of protein: a modification of the Lowry method that gives a linear photometric response
    • Hartree, E. F., Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal. Biochem. 1972, 48, 422–427.
    • (1972) Anal. Biochem , vol.48 , pp. 422-427
    • Hartree, E.F.1
  • 27
    • 0031830796 scopus 로고    scopus 로고
    • Mitochondrial oxidative phosphorylation thermodynamic efficiencies reflect physiological organ roles
    • Cairns, C. B., Walther, J., Harken, A. H., Banerjee, A., Mitochondrial oxidative phosphorylation thermodynamic efficiencies reflect physiological organ roles. Am. J. Physiol. 1998, 274, R1376–R1383.
    • (1998) Am. J. Physiol. , vol.274 , pp. R1376-R1383
    • Cairns, C.B.1    Walther, J.2    Harken, A.H.3    Banerjee, A.4
  • 28
    • 0032439245 scopus 로고    scopus 로고
    • Mitochondrial free radical production and aging in mammals and birds
    • Barja, G., Mitochondrial free radical production and aging in mammals and birds. Ann. N. Y. Acad. Sci. 1998, 854, 224–238.
    • (1998) Ann. N. Y. Acad. Sci. , vol.854 , pp. 224-238
    • Barja, G.1
  • 29
    • 0029819752 scopus 로고    scopus 로고
    • Measuring nitric oxide and superoxide: rate constants for aconitase reactivity
    • Hausladen, A., Fridovich, I., Measuring nitric oxide and superoxide: rate constants for aconitase reactivity. Methods Enzymol. 1996, 269, 37–41.
    • (1996) Methods Enzymol , vol.269 , pp. 37-41
    • Hausladen, A.1    Fridovich, I.2
  • 30
    • 0027946058 scopus 로고
    • Ethanol-induced oxygen radical formation and lipid peroxidation in rat brain: effect of chronic alcohol consumption
    • Montoliu, C., Valles, S., Renau-Piqueras, J., Guerri, C., Ethanol-induced oxygen radical formation and lipid peroxidation in rat brain: effect of chronic alcohol consumption. J. Neurochem. 1994, 63, 1855–1862.
    • (1994) J. Neurochem. , vol.63 , pp. 1855-1862
    • Montoliu, C.1    Valles, S.2    Renau-Piqueras, J.3    Guerri, C.4
  • 31
    • 0023713495 scopus 로고
    • Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion
    • Mullane, K. M., Westlin, W., Kraemer, R., Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. Ann. N. Y. Acad. Sci. 1988, 524, 103–121.
    • (1988) Ann. N. Y. Acad. Sci. , vol.524 , pp. 103-121
    • Mullane, K.M.1    Westlin, W.2    Kraemer, R.3
  • 32
    • 78249259701 scopus 로고    scopus 로고
    • Dietary alpha- and gamma-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis
    • Chung, M. Y., Yeung, S. F., Park, H. J., Volek, J. S. et al., Dietary alpha- and gamma-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis. J. Nutr. Biochem. 2010, 21, 1200–1206.
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 1200-1206
    • Chung, M.Y.1    Yeung, S.F.2    Park, H.J.3    Volek, J.S.4
  • 33
    • 84937054161 scopus 로고    scopus 로고
    • The Mediterranean diet: health, science, and society
    • Gerber, M., Hoffman, R., The Mediterranean diet: health, science, and society. Br. J. Nutr. 2015, 113(Suppl 2), S4–S10.
    • (2015) Br. J. Nutr. , vol.113 , pp. S4-S10
    • Gerber, M.1    Hoffman, R.2
  • 34
    • 84962054217 scopus 로고    scopus 로고
    • Anti-inflammatory effect of mediterranean diet in type 2 diabetes is durable: 8-year follow-up of a controlled trial
    • Maiorino, M. I., Bellastella, G., Petrizzo, M., Scappaticcio, L. et al., Anti-inflammatory effect of mediterranean diet in type 2 diabetes is durable: 8-year follow-up of a controlled trial. Diabetes Care 2016, 39, e44–e45.
    • (2016) Diabetes Care , vol.39 , pp. e44-e45
    • Maiorino, M.I.1    Bellastella, G.2    Petrizzo, M.3    Scappaticcio, L.4
  • 35
    • 84956762894 scopus 로고    scopus 로고
    • A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Non Alcoholic Fatty Liver Disease (MEDINA): study protocol
    • Papamiltiadous, E. S., Roberts, S. K., Nicoll, A. J., Ryan, M. C. et al., A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Non Alcoholic Fatty Liver Disease (MEDINA): study protocol. BMC Gastroenterol. 2016, 16, 14.
    • (2016) BMC Gastroenterol , vol.16 , pp. 14
    • Papamiltiadous, E.S.1    Roberts, S.K.2    Nicoll, A.J.3    Ryan, M.C.4
  • 36
    • 84955118432 scopus 로고    scopus 로고
    • Adherence to a Mediterranean diet is associated with reduced risk of heart failure in men
    • Tektonidis, T. G., Akesson, A., Gigante, B., Wolk, A. et al., Adherence to a Mediterranean diet is associated with reduced risk of heart failure in men. Eur. J. Heart Fail 2016, 18, 253–259.
    • (2016) Eur. J. Heart Fail , vol.18 , pp. 253-259
    • Tektonidis, T.G.1    Akesson, A.2    Gigante, B.3    Wolk, A.4
  • 37
    • 84937042308 scopus 로고    scopus 로고
    • Virgin olive oil: a key food for cardiovascular risk protection
    • Covas, M. I., de la Torre, R., Fito, M., Virgin olive oil: a key food for cardiovascular risk protection. Br. J. Nutr. 2015, 113(Suppl 2), S19–S28.
    • (2015) Br. J. Nutr. , vol.113 , pp. S19-S28
    • Covas, M.I.1    de la Torre, R.2    Fito, M.3
  • 38
    • 84957802260 scopus 로고    scopus 로고
    • Extra virgin olive oil rich in polyphenols modulates VEGF-induced angiogenic responses by preventing NADPH oxidase activity and expression
    • Calabriso, N., Massaro, M., Scoditti, E., D'Amore, S. et al., Extra virgin olive oil rich in polyphenols modulates VEGF-induced angiogenic responses by preventing NADPH oxidase activity and expression. J. Nutr. Biochem. 2016, 28, 19–29.
    • (2016) J. Nutr. Biochem. , vol.28 , pp. 19-29
    • Calabriso, N.1    Massaro, M.2    Scoditti, E.3    D'Amore, S.4
  • 39
    • 84978159751 scopus 로고    scopus 로고
    • Polyphenols and glycemic control
    • Kim, Y., Keogh, J. B., Clifton, P. M., Polyphenols and glycemic control. Nutrients 2016, 8, 17.
    • (2016) Nutrients , vol.8 , pp. 17
    • Kim, Y.1    Keogh, J.B.2    Clifton, P.M.3
  • 40
    • 84863989487 scopus 로고    scopus 로고
    • The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
    • Wu, X., Chen, K., Williams, K. J., The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia. Curr. Opin. Lipidol. 2012, 23, 334–344.
    • (2012) Curr. Opin. Lipidol. , vol.23 , pp. 334-344
    • Wu, X.1    Chen, K.2    Williams, K.J.3
  • 41
    • 80052870161 scopus 로고    scopus 로고
    • Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted
    • Dolinsky, V. W., Rueda-Clausen, C. F., Morton, J. S., Davidge, S. T. et al., Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted. Diabetes 2011, 60, 2274–2284.
    • (2011) Diabetes , vol.60 , pp. 2274-2284
    • Dolinsky, V.W.1    Rueda-Clausen, C.F.2    Morton, J.S.3    Davidge, S.T.4
  • 42
    • 84884210651 scopus 로고    scopus 로고
    • Obesity as the common soil of nonalcoholic fatty liver disease and diabetes: role of adipokines
    • Hui, E., Xu, A., Bo Yang, H., Lam, K. S., Obesity as the common soil of nonalcoholic fatty liver disease and diabetes: role of adipokines. J. Diabetes Investig. 2013, 4, 413–425.
    • (2013) J. Diabetes Investig. , vol.4 , pp. 413-425
    • Hui, E.1    Xu, A.2    Bo Yang, H.3    Lam, K.S.4
  • 43
    • 84872819411 scopus 로고    scopus 로고
    • Modulation of lipid metabolism by polyphenol-rich grape skin extract improves liver steatosis and adiposity in high fat fed mice
    • Park, H. J., Jung, U. J., Lee, M. K., Cho, S. J. et al., Modulation of lipid metabolism by polyphenol-rich grape skin extract improves liver steatosis and adiposity in high fat fed mice. Mol. Nutr. Food Res. 2013, 57, 360–364.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 360-364
    • Park, H.J.1    Jung, U.J.2    Lee, M.K.3    Cho, S.J.4
  • 44
    • 84924079162 scopus 로고    scopus 로고
    • Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with nonalcoholic fatty liver disease: a randomized controlled trial
    • Chen, S., Zhao, X., Ran, L., Wan, J. et al., Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Dig. Liver Dis. 2015, 47, 226–232.
    • (2015) Dig. Liver Dis. , vol.47 , pp. 226-232
    • Chen, S.1    Zhao, X.2    Ran, L.3    Wan, J.4
  • 45
    • 84903384321 scopus 로고    scopus 로고
    • Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation
    • Andrade, J. M., Paraiso, A. F., de Oliveira, M. V., Martins, A. M. et al., Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation. Nutrition 2014, 30, 915–919.
    • (2014) Nutrition , vol.30 , pp. 915-919
    • Andrade, J.M.1    Paraiso, A.F.2    de Oliveira, M.V.3    Martins, A.M.4
  • 46
    • 84922460686 scopus 로고    scopus 로고
    • Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease
    • Faghihzadeh, F., Adibi, P., Rafiei, R., Hekmatdoost, A., Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease. Nutr. Res. 2014, 34, 837–843.
    • (2014) Nutr. Res. , vol.34 , pp. 837-843
    • Faghihzadeh, F.1    Adibi, P.2    Rafiei, R.3    Hekmatdoost, A.4
  • 47
    • 84905653265 scopus 로고    scopus 로고
    • Signal transductions and nonalcoholic fatty liver: a mini-review
    • Zeng, L., Tang, W. J., Yin, J. J., Zhou, B. J., Signal transductions and nonalcoholic fatty liver: a mini-review. Int. J. Clin. Exp. Med. 2014, 7, 1624–1631.
    • (2014) Int. J. Clin. Exp. Med. , vol.7 , pp. 1624-1631
    • Zeng, L.1    Tang, W.J.2    Yin, J.J.3    Zhou, B.J.4
  • 48
    • 79956055056 scopus 로고    scopus 로고
    • A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice
    • Sinha-Hikim, I., Sinha-Hikim, A. P., Shen, R., Kim, H. J. et al., A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp. Mol. Pathol. 2011, 91, 419–428.
    • (2011) Exp. Mol. Pathol. , vol.91 , pp. 419-428
    • Sinha-Hikim, I.1    Sinha-Hikim, A.P.2    Shen, R.3    Kim, H.J.4
  • 49
    • 79952736960 scopus 로고    scopus 로고
    • Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice
    • Beltran-Debon, R., Rull, A., Rodriguez-Sanabria, F., Iswaldi, I. et al., Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice. Phytomedicine 2011, 18, 414–424.
    • (2011) Phytomedicine , vol.18 , pp. 414-424
    • Beltran-Debon, R.1    Rull, A.2    Rodriguez-Sanabria, F.3    Iswaldi, I.4
  • 50
    • 84891622890 scopus 로고    scopus 로고
    • Effects of d-alpha-tocopherol supplements on lipid metabolism in a high-fat diet-fed animal model
    • Kim do, Y., Kim, J., Ham, H. J., Choue, R., Effects of d-alpha-tocopherol supplements on lipid metabolism in a high-fat diet-fed animal model. Nutr. Res. Pract. 2013, 7, 481–487.
    • (2013) Nutr. Res. Pract. , vol.7 , pp. 481-487
    • Kim do, Y.1    Kim, J.2    Ham, H.J.3    Choue, R.4
  • 51
    • 58949093381 scopus 로고    scopus 로고
    • Comparative therapeutic effects of metformin and vitamin E in a model of nonalcoholic steatohepatitis in the young rat
    • Raso, G. M., Esposito, E., Iacono, A., Pacilio, M. et al., Comparative therapeutic effects of metformin and vitamin E in a model of nonalcoholic steatohepatitis in the young rat. Eur. J. Pharmacol. 2009, 604, 125–131.
    • (2009) Eur. J. Pharmacol. , vol.604 , pp. 125-131
    • Raso, G.M.1    Esposito, E.2    Iacono, A.3    Pacilio, M.4
  • 52
    • 84990934102 scopus 로고    scopus 로고
    • Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
    • Stojsavljevic, S., Gomercic Palcic, M., Virovic Jukic, L., Smircic Duvnjak, L. et al., Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World J. Gastroenterol. 2014, 20, 18070–18091.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 18070-18091
    • Stojsavljevic, S.1    Gomercic Palcic, M.2    Virovic Jukic, L.3    Smircic Duvnjak, L.4
  • 53
    • 84925677832 scopus 로고    scopus 로고
    • Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease
    • Priore, P., Cavallo, A., Gnoni, A., Damiano, F. et al., Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease. IUBMB Life 2015, 67, 9–17.
    • (2015) IUBMB Life , vol.67 , pp. 9-17
    • Priore, P.1    Cavallo, A.2    Gnoni, A.3    Damiano, F.4
  • 54
    • 40949141493 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
    • Mantena, S. K., King, A. L., Andringa, K. K., Eccleston, H. B. et al., Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic. Biol. Med. 2008, 44, 1259–1272.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 1259-1272
    • Mantena, S.K.1    King, A.L.2    Andringa, K.K.3    Eccleston, H.B.4
  • 55
    • 46449087496 scopus 로고    scopus 로고
    • Fatty acids as modulators of the cellular production of reactive oxygen species
    • Schonfeld, P., Wojtczak, L., Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radic. Biol. Med. 2008, 45, 231–241.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 231-241
    • Schonfeld, P.1    Wojtczak, L.2
  • 56
    • 0025930608 scopus 로고
    • Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation
    • Skulachev, V. P., Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation. FEBS Lett 1991, 294, 158–162.
    • (1991) FEBS Lett , vol.294 , pp. 158-162
    • Skulachev, V.P.1
  • 57
    • 84891031898 scopus 로고    scopus 로고
    • Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomized placebo-controlled clinical trial
    • Magosso, E., Ansari, M. A., Gopalan, Y., Shuaib, I. L. et al., Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomized placebo-controlled clinical trial. Nutr J 2013, 12, 166.
    • (2013) Nutr J , vol.12 , pp. 166
    • Magosso, E.1    Ansari, M.A.2    Gopalan, Y.3    Shuaib, I.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.