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Volumn 13, Issue 11, 2017, Pages 633-643

Adapting to obesity with adipose tissue inflammation

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; INSULIN; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 85031317304     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2017.90     Document Type: Review
Times cited : (900)

References (176)
  • 1
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil, G. S. Inflammation and metabolic disorders. Nature 444, 860-867 (2006).
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 2
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng, C. N. & Saltiel, A. R. Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121, 2111-2117 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 3
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky, J. M. & Glass, C. K. Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72, 219-246 (2010).
    • (2010) Annu. Rev. Physiol. , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 4
    • 84923357083 scopus 로고    scopus 로고
    • Homeostasis, inflammation, and disease susceptibility
    • Kotas, M. E. & Medzhitov, R. Homeostasis, inflammation, and disease susceptibility. Cell 160, 816-827 (2015).
    • (2015) Cell , vol.160 , pp. 816-827
    • Kotas, M.E.1    Medzhitov, R.2
  • 5
    • 44949163013 scopus 로고    scopus 로고
    • Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
    • Buettner, C. et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat. Med. 14, 667-675 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 667-675
    • Buettner, C.1
  • 6
    • 0031821693 scopus 로고    scopus 로고
    • Leptin induction of UCP1 gene expression is dependent on sympathetic innervation
    • Scarpace, P. J. & Matheny, M. Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. Am. J. Physiol. 275, E259-E264 (1998).
    • (1998) Am. J. Physiol. , vol.275 , pp. E259-E264
    • Scarpace, P.J.1    Matheny, M.2
  • 7
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1
  • 8
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich, R. C. et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1, 1311-1314 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 1311-1314
    • Frederich, R.C.1
  • 9
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine, R. V. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295 (1996).
    • (1996) N. Engl. J. Med. , vol.334 , pp. 292-295
    • Considine, R.V.1
  • 10
    • 33947277216 scopus 로고    scopus 로고
    • In vivo effects of leptin on autonomic nerve activity and lipolysis in rats
    • Shen, J., Tanida, M., Niijima, A. & Nagai, K. In vivo effects of leptin on autonomic nerve activity and lipolysis in rats. Neurosci. Lett. 416, 193-197 (2007).
    • (2007) Neurosci. Lett. , vol.416 , pp. 193-197
    • Shen, J.1    Tanida, M.2    Niijima, A.3    Nagai, K.4
  • 11
    • 0034611675 scopus 로고    scopus 로고
    • Obesity in the new millennium
    • Friedman, J. M. Obesity in the new millennium. Nature 404, 632-634 (2000).
    • (2000) Nature , vol.404 , pp. 632-634
    • Friedman, J.M.1
  • 12
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A. R. & Kahn, C. R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806 (2001).
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 13
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    • Fisher, F. M. et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271-281 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 271-281
    • Fisher, F.M.1
  • 14
    • 84893849860 scopus 로고    scopus 로고
    • Interplay between FGF21 and insulin action in the liver regulates metabolism
    • Emanuelli, B. et al. Interplay between FGF21 and insulin action in the liver regulates metabolism. J. Clin. Invest. 124, 515-527 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 515-527
    • Emanuelli, B.1
  • 15
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares, E. et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J. Biol. Chem. 286, 12983-12990 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 12983-12990
    • Hondares, E.1
  • 16
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    • Yamauchi, T. et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762-769 (2003).
    • (2003) Nature , vol.423 , pp. 762-769
    • Yamauchi, T.1
  • 17
    • 13244284806 scopus 로고    scopus 로고
    • Adiponectin - Journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
    • Trujillo, M. E. & Scherer, P. E. Adiponectin - journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J. Intern. Med. 257, 167-175 (2005).
    • (2005) J. Intern. Med. , vol.257 , pp. 167-175
    • Trujillo, M.E.1    Scherer, P.E.2
  • 18
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis, J. et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl Acad. Sci. USA 98, 2005-2010 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2005-2010
    • Fruebis, J.1
  • 19
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi, T. et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7, 941-946 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 941-946
    • Yamauchi, T.1
  • 20
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg, A. H., Combs, T. P., Du, X., Brownlee, M. & Scherer, P. E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7, 947-953 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 21
    • 0036710513 scopus 로고    scopus 로고
    • An adipocentric view of signaling and intracellular trafficking
    • Mora, S. & Pessin, J. E. An adipocentric view of signaling and intracellular trafficking. Diabetes Metab. Res. Rev. 18, 345-356 (2002).
    • (2002) Diabetes Metab. Res. Rev. , vol.18 , pp. 345-356
    • Mora, S.1    Pessin, J.E.2
  • 22
    • 84877340732 scopus 로고    scopus 로고
    • Evidence for two types of brown adipose tissue in humans
    • Lidell, M. E. et al. Evidence for two types of brown adipose tissue in humans. Nat. Med. 19, 631-634 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 631-634
    • Lidell, M.E.1
  • 23
    • 84906519417 scopus 로고    scopus 로고
    • Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue
    • Tews, D. et al. Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue. Mol. Cell. Endocrinol. 395, 41-50 (2014).
    • (2014) Mol. Cell. Endocrinol. , vol.395 , pp. 41-50
    • Tews, D.1
  • 24
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu, J. et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-376 (2012).
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1
  • 25
    • 84891741382 scopus 로고    scopus 로고
    • MRI detection of brown adipose tissue with low fat content in newborns with hypothermia
    • Hu, H. H. et al. MRI detection of brown adipose tissue with low fat content in newborns with hypothermia. Magn. Reson. Imaging 32, 107-117 (2014).
    • (2014) Magn. Reson. Imaging , vol.32 , pp. 107-117
    • Hu, H.H.1
  • 26
    • 0021319695 scopus 로고
    • Brown adipose tissue in the parametrial fat pad of the mouse
    • Young, P., Arch, J. R. & Ashwell, M. Brown adipose tissue in the parametrial fat pad of the mouse. FEBS Lett. 167, 10-14 (1984).
    • (1984) FEBS Lett. , vol.167 , pp. 10-14
    • Young, P.1    Arch, J.R.2    Ashwell, M.3
  • 27
    • 84883354892 scopus 로고    scopus 로고
    • A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes
    • Liu, W. et al. A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes. J. Cell Sci. 126, 3527-3532 (2013).
    • (2013) J. Cell Sci , vol.126 , pp. 3527-3532
    • Liu, W.1
  • 28
    • 84983416317 scopus 로고    scopus 로고
    • Control of brown and beige fat development
    • Wang, W. & Seale, P. Control of brown and beige fat development. Nat. Rev. Mol. Cell Biol. 17, 691-702 (2016).
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , pp. 691-702
    • Wang, W.1    Seale, P.2
  • 29
    • 84961290714 scopus 로고    scopus 로고
    • Brown and beige fat in humans: Thermogenic adipocytes that control energy and glucose homeostasis
    • Sidossis, L. & Kajimura, S. Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J. Clin. Invest. 125, 478-486 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 478-486
    • Sidossis, L.1    Kajimura, S.2
  • 30
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • Brestoff, J. R. & Artis, D. Immune regulation of metabolic homeostasis in health and disease. Cell 161, 146-160 (2015).
    • (2015) Cell , vol.161 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 31
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: Development, function and therapeutic potential
    • Harms, M. & Seale, P. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19, 1252-1263 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 32
    • 84982105808 scopus 로고    scopus 로고
    • Biology of beige adipocyte and possible therapy for type 2 diabetes and obesity
    • Lizcano, F. & Vargas, D. Biology of beige adipocyte and possible therapy for type 2 diabetes and obesity. Int. J. Endocrinol. 2016, 9542061 (2016).
    • (2016) Int. J. Endocrinol. , vol.2016 , pp. 9542061
    • Lizcano, F.1    Vargas, D.2
  • 34
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani, P. D. et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57, 1470-1481 (2008).
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1
  • 35
    • 84983784787 scopus 로고    scopus 로고
    • Linking gut microbiota and inflammation to obesity and insulin resistance
    • Saad, M. J., Santos, A. & Prada, P. O. Linking gut microbiota and inflammation to obesity and insulin resistance. Physiology (Bethesda) 31, 283-293 (2016).
    • (2016) Physiology (Bethesda) , vol.31 , pp. 283-293
    • Saad, M.J.1    Santos, A.2    Prada, P.O.3
  • 36
    • 34848872799 scopus 로고    scopus 로고
    • Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    • Kim, J. Y. et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J. Clin. Invest. 117, 2621-2637 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 2621-2637
    • Kim, J.Y.1
  • 37
    • 84904044334 scopus 로고    scopus 로고
    • Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
    • Wernstedt Asterholm, I. et al. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 20, 103-118 (2014).
    • (2014) Cell Metab. , vol.20 , pp. 103-118
    • Wernstedt Asterholm, I.1
  • 38
    • 84893839605 scopus 로고    scopus 로고
    • Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes
    • Jayashree, B. et al. Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes. Mol. Cell. Biochem. 388, 203-210 (2014).
    • (2014) Mol. Cell. Biochem. , vol.388 , pp. 203-210
    • Jayashree, B.1
  • 39
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen, M. T. et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J. Biol. Chem. 282, 35279-35292 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1
  • 40
    • 2342435824 scopus 로고    scopus 로고
    • Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
    • Lee, J. Y. et al. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J. Biol. Chem. 279, 16971-16979 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 16971-16979
    • Lee, J.Y.1
  • 41
    • 56149118396 scopus 로고    scopus 로고
    • Acute modulation of Toll-like receptors by insulin
    • Ghanim, H. et al. Acute modulation of Toll-like receptors by insulin. Diabetes Care 31, 1827-1831 (2008).
    • (2008) Diabetes Care , vol.31 , pp. 1827-1831
    • Ghanim, H.1
  • 42
    • 42949109139 scopus 로고    scopus 로고
    • Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue
    • Vitseva, O. I. et al. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring) 16, 932-937 (2008).
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 932-937
    • Vitseva, O.I.1
  • 43
    • 16844379483 scopus 로고    scopus 로고
    • The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities
    • Makowski, L., Brittingham, K. C., Reynolds, J. M., Suttles, J. & Hotamisligil, G. S. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J. Biol. Chem. 280, 12888-12895 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 12888-12895
    • Makowski, L.1    Brittingham, K.C.2    Reynolds, J.M.3    Suttles, J.4    Hotamisligil, G.S.5
  • 44
    • 84961291656 scopus 로고    scopus 로고
    • Proinflammatory effects of arachidonic acid in a lipopolysaccharide-induced inflammatory microenvironment in 3T3 L1 adipocytes in vitro
    • Cranmer-Byng, M. M., Liddle, D. M., De Boer, A. A., Monk, J. M. & Robinson, L. E. Proinflammatory effects of arachidonic acid in a lipopolysaccharide-induced inflammatory microenvironment in 3T3 L1 adipocytes in vitro. Appl. Physiol. Nutr. Metab. 40, 142-154 (2015).
    • (2015) Appl. Physiol. Nutr. Metab. , vol.40 , pp. 142-154
    • Cranmer-Byng, M.M.1    Liddle, D.M.2    De Boer, A.A.3    Monk, J.M.4    Robinson, L.E.5
  • 45
    • 85019597066 scopus 로고    scopus 로고
    • The role of dietary fatty acid intake in inflammatory gene expression: A critical review
    • Rocha, D. M., Bressan, J. & Hermsdorff, H. H. The role of dietary fatty acid intake in inflammatory gene expression: a critical review. Sao Paulo Med. J. 135, 157-168 (2017).
    • (2017) Sao Paulo Med. J. , vol.135 , pp. 157-168
    • Rocha, D.M.1    Bressan, J.2    Hermsdorff, H.H.3
  • 46
    • 0030584718 scopus 로고    scopus 로고
    • Metabolism of gammalinolenic acid in human neutrophils
    • Chilton, L. et al. Metabolism of gammalinolenic acid in human neutrophils. J. Immunol. 156, 2941-2947 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 2941-2947
    • Chilton, L.1
  • 47
    • 84960126712 scopus 로고    scopus 로고
    • An increase in the omega-6/ omega-3 fatty acid ratio increases the risk for obesity
    • Simopoulos, A. P. An increase in the omega-6/ omega-3 fatty acid ratio increases the risk for obesity. Nutrients 8, 128 (2016).
    • (2016) Nutrients , vol.8 , pp. 128
    • Simopoulos, A.P.1
  • 48
    • 84928734718 scopus 로고    scopus 로고
    • Unraveling the complex relationship triad between lipids, obesity, and inflammation
    • Khan, S. A. et al. Unraveling the complex relationship triad between lipids, obesity, and inflammation. Mediators Inflamm. 2014, 502749 (2014).
    • (2014) Mediators Inflamm. , vol.2014 , pp. 502749
    • Khan, S.A.1
  • 49
    • 84946090653 scopus 로고    scopus 로고
    • Diets containing alpha-linolenic (omega3) or oleic (omega9) fatty acids rescues obese mice from insulin resistance
    • Oliveira, V. et al. Diets containing alpha-linolenic (omega3) or oleic (omega9) fatty acids rescues obese mice from insulin resistance. Endocrinology 156, 4033-4046 (2015).
    • (2015) Endocrinology , vol.156 , pp. 4033-4046
    • Oliveira, V.1
  • 50
    • 84934921383 scopus 로고    scopus 로고
    • Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1beta secretion and insulin resistance despite obesity
    • Finucane, O. M. et al. Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1beta secretion and insulin resistance despite obesity. Diabetes 64, 2116-2128 (2015).
    • (2015) Diabetes , vol.64 , pp. 2116-2128
    • Finucane, O.M.1
  • 51
    • 84932605075 scopus 로고    scopus 로고
    • Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic acid and hydroxytyrosol in human adipocytes
    • Scoditti, E. et al. Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic acid and hydroxytyrosol in human adipocytes. PLoS ONE 10, e0128218 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0128218
    • Scoditti, E.1
  • 52
    • 84875787136 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with a Mediterranean diet
    • Estruch, R. et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N. Engl. J. Med. 368, 1279-1290 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1279-1290
    • Estruch, R.1
  • 53
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti, S. et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46, 2347-2355 (2005).
    • (2005) J. Lipid Res. , vol.46 , pp. 2347-2355
    • Cinti, S.1
  • 54
    • 79960735393 scopus 로고    scopus 로고
    • Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages
    • Fischer-Posovszky, P., Wang, Q. A., Asterholm, I. W., Rutkowski, J. M. & Scherer, P. E. Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology 152, 3074-3081 (2011).
    • (2011) Endocrinology , vol.152 , pp. 3074-3081
    • Fischer-Posovszky, P.1    Wang, Q.A.2    Asterholm, I.W.3    Rutkowski, J.M.4    Scherer, P.E.5
  • 55
    • 36849012057 scopus 로고    scopus 로고
    • Adipocyte death, adipose tissue remodeling, and obesity complications
    • Strissel, K. J. et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 56, 2910-2918 (2007).
    • (2007) Diabetes , vol.56 , pp. 2910-2918
    • Strissel, K.J.1
  • 56
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng, C. N., Deyoung, S. M., Bodzin, J. L. & Saltiel, A. R. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56, 16-23 (2007).
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 57
    • 84894559222 scopus 로고    scopus 로고
    • Local proliferation of macrophages in adipose tissue during obesity-induced inflammation
    • Haase, J. et al. Local proliferation of macrophages in adipose tissue during obesity-induced inflammation. Diabetologia 57, 562-571 (2014).
    • (2014) Diabetologia , vol.57 , pp. 562-571
    • Haase, J.1
  • 58
    • 84881192566 scopus 로고    scopus 로고
    • Innate sensors of pathogen and stress: Linking inflammation to obesity
    • Jin, C. & Flavell, R. A. Innate sensors of pathogen and stress: linking inflammation to obesity. J. Allergy Clin. Immunol. 132, 287-294 (2013).
    • (2013) J. Allergy Clin. Immunol. , vol.132 , pp. 287-294
    • Jin, C.1    Flavell, R.A.2
  • 59
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516-521 (2003).
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 60
    • 58049202273 scopus 로고    scopus 로고
    • Inflammasomes: Guardians of cytosolic sanctity
    • Lamkanfi, M. & Dixit, V. M. Inflammasomes: guardians of cytosolic sanctity. Immunol. Rev. 227, 95-105 (2009).
    • (2009) Immunol. Rev. , vol.227 , pp. 95-105
    • Lamkanfi, M.1    Dixit, V.M.2
  • 61
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 179-188
    • Vandanmagsar, B.1
  • 63
    • 84902075318 scopus 로고    scopus 로고
    • Increased adipocyte O2 consumption triggers HIF-1alpha, causing inflammation and insulin resistance in obesity
    • Lee, Y. S. et al. Increased adipocyte O2 consumption triggers HIF-1alpha, causing inflammation and insulin resistance in obesity. Cell 157, 1339-1352 (2014).
    • (2014) Cell , vol.157 , pp. 1339-1352
    • Lee, Y.S.1
  • 64
    • 85036589722 scopus 로고    scopus 로고
    • Effects of hyperoxia on oxygen-related inflammation with a focus on obesity
    • Gonzalez-Muniesa, P. et al. Effects of hyperoxia on oxygen-related inflammation with a focus on obesity. Oxid. Med. Cell. Longev. 2015, 8957827 (2015).
    • (2015) Oxid. Med. Cell. Longev. , vol.2015 , pp. 8957827
    • Gonzalez-Muniesa, P.1
  • 65
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • Ye, J., Gao, Z., Yin, J. & He, Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am. J. Physiol. Endocrinol. Metab. 293, E1118-E1128 (2007).
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293 , pp. E1118-E1128
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 66
    • 84871327751 scopus 로고    scopus 로고
    • Effects of hyperoxia exposure on metabolic markers and gene expression in 3T3-L1 adipocytes
    • Quintero, P., Gonzalez-Muniesa, P., Garcia-Diaz, D. F. & Martinez, J. A. Effects of hyperoxia exposure on metabolic markers and gene expression in 3T3-L1 adipocytes. J. Physiol. Biochem. 68, 663-669 (2012).
    • (2012) J. Physiol. Biochem. , vol.68 , pp. 663-669
    • Quintero, P.1    Gonzalez-Muniesa, P.2    Garcia-Diaz, D.F.3    Martinez, J.A.4
  • 67
    • 47849121225 scopus 로고    scopus 로고
    • Hypoxia in adipose tissue: A basis for the dysregulation of tissue function in obesity Br
    • Trayhurn, P., Wang, B. & Wood, I. S. Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity Br. J. Nutr. 100, 227-235 (2008).
    • (2008) J. Nutr. , vol.100 , pp. 227-235
    • Trayhurn, P.1    Wang, B.2    Wood, I.S.3
  • 68
    • 79955561312 scopus 로고    scopus 로고
    • Regulation of HIF-1 activity in adipose tissue by obesity-associated factors: Adipogenesis, insulin, and hypoxia
    • He, Q. et al. Regulation of HIF-1 activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am. J. Physiol. Endocrinol. Metab. 300, E877-E885 (2011).
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.300 , pp. E877-E885
    • He, Q.1
  • 69
    • 84872290190 scopus 로고    scopus 로고
    • Hypoxia and adipose tissue function and dysfunction in obesity
    • Trayhurn, P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol. Rev. 93, 1-21 (2013).
    • (2013) Physiol. Rev. , vol.93 , pp. 1-21
    • Trayhurn, P.1
  • 70
    • 38149142633 scopus 로고    scopus 로고
    • Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
    • Rausch, M. E., Weisberg, S., Vardhana, P. & Tortoriello, D. V. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int. J. Obes. (Lond.) 32, 451-463 (2008).
    • (2008) Int. J. Obes. (Lond.) , vol.32 , pp. 451-463
    • Rausch, M.E.1    Weisberg, S.2    Vardhana, P.3    Tortoriello, D.V.4
  • 71
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • Rius, J. et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453, 807-811 (2008).
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1
  • 72
    • 84986332733 scopus 로고    scopus 로고
    • Nuclear morphologies: Their diversity and functional relevance
    • Skinner, B. M. & Johnson, E. E. Nuclear morphologies: their diversity and functional relevance. Chromosoma 126, 195-212 (2017).
    • (2017) Chromosoma , vol.126 , pp. 195-212
    • Skinner, B.M.1    Johnson, E.E.2
  • 74
    • 62849107819 scopus 로고    scopus 로고
    • Metabolic dysregulation and adipose tissue fibrosis: Role of collagen VI
    • Khan, T. et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol. Cell. Biol. 29, 1575-1591 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 1575-1591
    • Khan, T.1
  • 75
    • 33646139156 scopus 로고    scopus 로고
    • A pericellular collagenase directs the 3-dimensional development of white adipose tissue.
    • Chun, T. H. et al. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 125, 577-591 (2006).
    • (2006) Cell , vol.125 , pp. 577-591
    • Chun, T.H.1
  • 76
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    • McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K. & Chen, C. S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 6, 483-495 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 483-495
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3    Bhadriraju, K.4    Chen, C.S.5
  • 77
    • 79251468752 scopus 로고    scopus 로고
    • Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch
    • Hara, Y. et al. Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch. Sci. Signal. 4, ra3 (2011).
    • (2011) Sci. Signal. , vol.4 , pp. ra3
    • Hara, Y.1
  • 78
    • 77957165242 scopus 로고    scopus 로고
    • The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes
    • Li, Q., Hata, A., Kosugi, C., Kataoka, N. & Funaki, M. The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes. FEBS Lett. 584, 4145-4150 (2010).
    • (2010) FEBS Lett. , vol.584 , pp. 4145-4150
    • Li, Q.1    Hata, A.2    Kosugi, C.3    Kataoka, N.4    Funaki, M.5
  • 79
    • 84929152818 scopus 로고    scopus 로고
    • At the bench: Understanding group 2 innate lymphoid cells in disease
    • Doherty, T. A. At the bench: understanding group 2 innate lymphoid cells in disease. J. Leukoc. Biol. 97, 455-467 (2015).
    • (2015) J. Leukoc. Biol. , vol.97 , pp. 455-467
    • Doherty, T.A.1
  • 80
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
    • Moro, K. et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells. Nature 463, 540-544 (2010).
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1
  • 81
    • 84876746655 scopus 로고    scopus 로고
    • Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    • Molofsky, A. B. et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med. 210, 535-549 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 535-549
    • Molofsky, A.B.1
  • 82
    • 84920940721 scopus 로고    scopus 로고
    • Activated type 2 innate lymphoid cells regulate beige fat biogenesis
    • Lee, M. W. et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74-87 (2015).
    • (2015) Cell , vol.160 , pp. 74-87
    • Lee, M.W.1
  • 83
    • 84924969384 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
    • Brestoff, J. R. et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519, 242-246 (2015).
    • (2015) Nature , vol.519 , pp. 242-246
    • Brestoff, J.R.1
  • 84
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard, J. I. et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447, 1116-1120 (2007).
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1
  • 85
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang, K. et al. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 7, 485-495 (2008).
    • (2008) Cell Metab. , vol.7 , pp. 485-495
    • Kang, K.1
  • 86
    • 70350560546 scopus 로고    scopus 로고
    • Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
    • Fujisaka, S. et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58, 2574-2582 (2009).
    • (2009) Diabetes , vol.58 , pp. 2574-2582
    • Fujisaka, S.1
  • 87
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg, S. P. et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1
  • 88
    • 84949627236 scopus 로고    scopus 로고
    • Regulation of metabolism by the innate immune system
    • Lackey, D. E. & Olefsky, J. M. Regulation of metabolism by the innate immune system. Nat. Rev. Endocrinol. 12, 15-28 (2016).
    • (2016) Nat. Rev. Endocrinol. , vol.12 , pp. 15-28
    • Lackey, D.E.1    Olefsky, J.M.2
  • 89
    • 84889663497 scopus 로고    scopus 로고
    • Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation
    • Xu, X. et al. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab. 18, 816-830 (2013).
    • (2013) Cell Metab. , vol.18 , pp. 816-830
    • Xu, X.1
  • 90
    • 84907991703 scopus 로고    scopus 로고
    • Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
    • Kratz, M. et al. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab. 20, 614-625 (2014).
    • (2014) Cell Metab. , vol.20 , pp. 614-625
    • Kratz, M.1
  • 91
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    • Odegaard, J. I. et al. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 7, 496-507 (2008).
    • (2008) Cell Metab. , vol.7 , pp. 496-507
    • Odegaard, J.I.1
  • 92
    • 84918593760 scopus 로고    scopus 로고
    • T-Cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans.
    • McLaughlin, T. et al. T-Cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans. Arterioscler. Thromb. Vasc. Biol. 34, 2637-2643 (2014).
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , pp. 2637-2643
    • McLaughlin, T.1
  • 93
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura, S. et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15, 914-920 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 914-920
    • Nishimura, S.1
  • 94
    • 77956396699 scopus 로고    scopus 로고
    • Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance
    • Yang, H. et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol. 185, 1836-1845 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1836-1845
    • Yang, H.1
  • 95
    • 84928924352 scopus 로고    scopus 로고
    • The impact of adiposity on adipose tissue-resident lymphocyte activation in humans
    • Travers, R. L., Motta, A. C., Betts, J. A., Bouloumie, A. & Thompson, D. The impact of adiposity on adipose tissue-resident lymphocyte activation in humans. Int. J. Obes. (Lond.) 39, 762-769 (2015).
    • (2015) Int. J. Obes. (Lond.) , vol.39 , pp. 762-769
    • Travers, R.L.1    Motta, A.C.2    Betts, J.A.3    Bouloumie, A.4    Thompson, D.5
  • 96
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer, S. et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15, 921-929 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 921-929
    • Winer, S.1
  • 97
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930-939 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 930-939
    • Feuerer, M.1
  • 98
    • 84949257630 scopus 로고    scopus 로고
    • Depletion of fat-resident Treg cells prevents age-associated insulin resistance
    • Bapat, S. P. et al. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528, 137-141 (2015).
    • (2015) Nature , vol.528 , pp. 137-141
    • Bapat, S.P.1
  • 99
    • 65649117802 scopus 로고    scopus 로고
    • Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    • Duffaut, C., Galitzky, J., Lafontan, M. & Bouloumie, A. Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem. Biophys. Res. Commun. 384, 482-485 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.384 , pp. 482-485
    • Duffaut, C.1    Galitzky, J.2    Lafontan, M.3    Bouloumie, A.4
  • 100
    • 0025852445 scopus 로고
    • B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.
    • Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K. A. B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350, 423-426 (1991).
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kuhn, R.3    Rajewsky, K.A.4
  • 101
    • 85027938385 scopus 로고    scopus 로고
    • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
    • Winer, D. A. et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med. 17, 610-617 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 610-617
    • Winer, D.A.1
  • 102
    • 84875548030 scopus 로고    scopus 로고
    • B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile.
    • DeFuria, J. et al. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc. Natl Acad. Sci. USA 110, 5133-5138 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 5133-5138
    • DeFuria, J.1
  • 103
    • 84921933757 scopus 로고    scopus 로고
    • B-1a lymphocytes attenuate insulin resistance.
    • Shen, L. et al. B-1a lymphocytes attenuate insulin resistance. Diabetes 64, 593-603 (2015).
    • (2015) Diabetes , vol.64 , pp. 593-603
    • Shen, L.1
  • 104
    • 84875280888 scopus 로고    scopus 로고
    • Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
    • Deng, T. et al. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab. 17, 411-422 (2013).
    • (2013) Cell Metab. , vol.17 , pp. 411-422
    • Deng, T.1
  • 105
    • 85019606361 scopus 로고    scopus 로고
    • Deletion of CD1d in adipocytes aggravates adipose tissue inflammation and insulin resistance in obesity
    • Huh, J. Y. et al. Deletion of CD1d in adipocytes aggravates adipose tissue inflammation and insulin resistance in obesity. Diabetes 66, 835-847 (2017).
    • (2017) Diabetes , vol.66 , pp. 835-847
    • Huh, J.Y.1
  • 106
    • 84959506635 scopus 로고    scopus 로고
    • Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss
    • Schmitz, J. et al. Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss. Mol. Metab. 5, 328-339 (2016).
    • (2016) Mol. Metab. , vol.5 , pp. 328-339
    • Schmitz, J.1
  • 108
    • 84960810832 scopus 로고    scopus 로고
    • The intestinal immune system in obesity and insulin resistance
    • Winer, D. A., Luck, H., Tsai, S. & Winer, S. The intestinal immune system in obesity and insulin resistance. Cell Metab. 23, 413-426 (2016).
    • (2016) Cell Metab. , vol.23 , pp. 413-426
    • Winer, D.A.1    Luck, H.2    Tsai, S.3    Winer, S.4
  • 109
    • 85017123656 scopus 로고    scopus 로고
    • Weight history and all-cause and cause-specific mortality in three prospective cohort studies
    • Yu, E. et al. Weight history and all-cause and cause-specific mortality in three prospective cohort studies. Ann. Intern. Med. 166, 613-620 (2017).
    • (2017) Ann. Intern. Med. , vol.166 , pp. 613-620
    • Yu, E.1
  • 110
    • 78751649211 scopus 로고    scopus 로고
    • Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity
    • Hardy, O. T. et al. Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg. Obes. Relat. Dis. 7, 60-67 (2011).
    • (2011) Surg. Obes. Relat. Dis. , vol.7 , pp. 60-67
    • Hardy, O.T.1
  • 112
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan, M. C. et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191-198 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 191-198
    • Arkan, M.C.1
  • 113
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance.
    • Hirosumi, J. et al. A central role for JNK in obesity and insulin resistance. Nature 420, 333-336 (2002).
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1
  • 114
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • Holland, W. L. et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5, 167-179 (2007).
    • (2007) Cell Metab. , vol.5 , pp. 167-179
    • Holland, W.L.1
  • 115
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi, H. et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116, 3015-3025 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 3015-3025
    • Shi, H.1
  • 116
    • 75749108288 scopus 로고    scopus 로고
    • Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
    • Nakamura, T. et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 140, 338-348 (2010).
    • (2010) Cell , vol.140 , pp. 338-348
    • Nakamura, T.1
  • 117
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil, G. S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140, 900-917 (2010).
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 118
    • 77957348390 scopus 로고    scopus 로고
    • Sphingolipids and insulin resistance: The five Ws
    • Summers, S. A. Sphingolipids and insulin resistance: the five Ws. Curr. Opin. Lipidol. 21, 128-135 (2010).
    • (2010) Curr. Opin. Lipidol. , vol.21 , pp. 128-135
    • Summers, S.A.1
  • 119
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    • Saberi, M. et al. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 10, 419-429 (2009).
    • (2009) Cell Metab. , vol.10 , pp. 419-429
    • Saberi, M.1
  • 120
    • 34247511496 scopus 로고    scopus 로고
    • Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis
    • Wellen, K. E. et al. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 129, 537-548 (2007).
    • (2007) Cell , vol.129 , pp. 537-548
    • Wellen, K.E.1
  • 121
    • 34147122535 scopus 로고    scopus 로고
    • Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance
    • Lesniewski, L. A. et al. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat. Med. 13, 455-462 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 455-462
    • Lesniewski, L.A.1
  • 122
    • 84925485114 scopus 로고    scopus 로고
    • LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
    • Li, P. et al. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat. Med. 21, 239-247 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 239-247
    • Li, P.1
  • 123
    • 84995554134 scopus 로고    scopus 로고
    • Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance
    • Li, P. et al. Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance. Cell 167, 973-984. e12 (2016).
    • (2016) Cell , vol.167 , pp. 973-984e12
    • Li, P.1
  • 124
    • 77952315676 scopus 로고    scopus 로고
    • Tlr2 is critical for diet-induced metabolic syndrome in a murine model
    • Himes, R. W. & Smith, C. W. Tlr2 is critical for diet-induced metabolic syndrome in a murine model. FASEB J. 24, 731-739 (2010).
    • (2010) FASEB J. , vol.24 , pp. 731-739
    • Himes, R.W.1    Smith, C.W.2
  • 125
    • 79952206109 scopus 로고    scopus 로고
    • DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells
    • Avota, E., Gulbins, E. & Schneider-Schaulies, S. DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells. PLoS Pathog. 7, e1001290 (2011).
    • (2011) PLoS Pathog. , vol.7 , pp. e1001290
    • Avota, E.1    Gulbins, E.2    Schneider-Schaulies, S.3
  • 126
    • 0031841949 scopus 로고    scopus 로고
    • Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
    • Summers, S. A., Garza, L. A., Zhou, H. & Birnbaum, M. J. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18, 5457-5464 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5457-5464
    • Summers, S.A.1    Garza, L.A.2    Zhou, H.3    Birnbaum, M.J.4
  • 127
    • 0035513703 scopus 로고    scopus 로고
    • Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
    • Teruel, T., Hernandez, R. & Lorenzo, M. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 50, 2563-2571 (2001).
    • (2001) Diabetes , vol.50 , pp. 2563-2571
    • Teruel, T.1    Hernandez, R.2    Lorenzo, M.3
  • 128
    • 4344614649 scopus 로고    scopus 로고
    • Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
    • Stratford, S., Hoehn, K. L., Liu, F. & Summers, S. A. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J. Biol. Chem. 279, 36608-36615 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 36608-36615
    • Stratford, S.1    Hoehn, K.L.2    Liu, F.3    Summers, S.A.4
  • 129
    • 35548943962 scopus 로고    scopus 로고
    • JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
    • Solinas, G. et al. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 6, 386-397 (2007).
    • (2007) Cell Metab. , vol.6 , pp. 386-397
    • Solinas, G.1
  • 130
    • 33751002634 scopus 로고    scopus 로고
    • JNK1 deficiency does not enhance muscle glucose metabolism in lean mice
    • Witczak, C. A. et al. JNK1 deficiency does not enhance muscle glucose metabolism in lean mice. Biochem. Biophys. Res. Commun. 350, 1063-1068 (2006).
    • (2006) Biochem. Biophys. Res. Commun. , vol.350 , pp. 1063-1068
    • Witczak, C.A.1
  • 131
    • 69449097633 scopus 로고    scopus 로고
    • The protein kinase IKKepsilon regulates energy balance in obese mice
    • Chiang, S. H. et al. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell 138, 961-975 (2009).
    • (2009) Cell , vol.138 , pp. 961-975
    • Chiang, S.H.1
  • 132
    • 78650878363 scopus 로고    scopus 로고
    • NF-kappaB, inflammation, and metabolic disease
    • Baker, R. G., Hayden, M. S. & Ghosh, S. NF-kappaB, inflammation, and metabolic disease. Cell Metab. 13, 11-22 (2011).
    • (2011) Cell Metab. , vol.13 , pp. 11-22
    • Baker, R.G.1    Hayden, M.S.2    Ghosh, S.3
  • 133
    • 33244481462 scopus 로고    scopus 로고
    • Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance
    • Zick, Y. Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci. STKE 2005, pe4 (2005).
    • (2005) Sci. STKE , vol.2005 , pp. pe4
    • Zick, Y.1
  • 134
    • 79954459509 scopus 로고    scopus 로고
    • Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis
    • Arner, P., Arner, E., Hammarstedt, A. & Smith, U. Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. PLoS ONE 6, e18284 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e18284
    • Arner, P.1    Arner, E.2    Hammarstedt, A.3    Smith, U.4
  • 135
    • 84877580638 scopus 로고    scopus 로고
    • Mechanisms and metabolic implications of regional differences among fat depots
    • Tchkonia, T. et al. Mechanisms and metabolic implications of regional differences among fat depots. Cell Metab. 17, 644-656 (2013).
    • (2013) Cell Metab. , vol.17 , pp. 644-656
    • Tchkonia, T.1
  • 136
    • 33751235259 scopus 로고    scopus 로고
    • Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes
    • Chung, S. et al. Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147, 5340-5351 (2006).
    • (2006) Endocrinology , vol.147 , pp. 5340-5351
    • Chung, S.1
  • 137
    • 84862001089 scopus 로고    scopus 로고
    • Insulin resistance in the defense against obesity
    • Saltiel, A. R. Insulin resistance in the defense against obesity. Cell Metab. 15, 798-804 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 798-804
    • Saltiel, A.R.1
  • 138
    • 84903523582 scopus 로고    scopus 로고
    • Induction of adipocyte hyperplasia in subcutaneous fat depot alleviated type 2 diabetes symptoms in obese mice
    • Lu, Q., Li, M., Zou, Y. & Cao, T. Induction of adipocyte hyperplasia in subcutaneous fat depot alleviated type 2 diabetes symptoms in obese mice. Obesity (Silver Spring) 22, 1623-1631 (2014).
    • (2014) Obesity (Silver Spring) , vol.22 , pp. 1623-1631
    • Lu, Q.1    Li, M.2    Zou, Y.3    Cao, T.4
  • 139
    • 84872480987 scopus 로고    scopus 로고
    • Interleukin-1beta regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability
    • Nov, O. et al. Interleukin-1beta regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability. PLoS ONE 8, e53626 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e53626
    • Nov, O.1
  • 140
    • 0032990467 scopus 로고    scopus 로고
    • Catecholamine-induced lipolysis in obesity
    • Arner, P. Catecholamine-induced lipolysis in obesity. Int. J. Obes. Relat. Metab. Disord. 23 (Suppl. 1), 10-13 (1999).
    • (1999) Int. J. Obes. Relat. Metab. Disord. , vol.23 , pp. 10-13
    • Arner, P.1
  • 141
    • 77955326815 scopus 로고    scopus 로고
    • Hyperleptinemia is required for the development of leptin resistance
    • Knight, Z. A., Hannan, K. S., Greenberg, M. L. & Friedman, J. M. Hyperleptinemia is required for the development of leptin resistance. PLoS ONE 5, e11376 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e11376
    • Knight, Z.A.1    Hannan, K.S.2    Greenberg, M.L.3    Friedman, J.M.4
  • 142
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
    • Caro, J. F. et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348, 159-161 (1996).
    • (1996) Lancet , vol.348 , pp. 159-161
    • Caro, J.F.1
  • 143
    • 0031821377 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity is associated with the Golgi apparatus of hypothalamic neurons and glial cells
    • Diano, S., Kalra, S. P. & Horvath, T. L. Leptin receptor immunoreactivity is associated with the Golgi apparatus of hypothalamic neurons and glial cells. J. Neuroendocrinol. 10, 647-650 (1998).
    • (1998) J. Neuroendocrinol. , vol.10 , pp. 647-650
    • Diano, S.1    Kalra, S.P.2    Horvath, T.L.3
  • 144
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • Ozcan, L. et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 9, 35-51 (2009).
    • (2009) Cell Metab. , vol.9 , pp. 35-51
    • Ozcan, L.1
  • 145
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang, X. et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135, 61-73 (2008).
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1
  • 146
    • 0031025546 scopus 로고    scopus 로고
    • Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice
    • Collins, S., Daniel, K. W., Petro, A. E. & Surwit, R. S. Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138, 405-413 (1997).
    • (1997) Endocrinology , vol.138 , pp. 405-413
    • Collins, S.1    Daniel, K.W.2    Petro, A.E.3    Surwit, R.S.4
  • 147
    • 0028985831 scopus 로고
    • Age-dependent changes in beta-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats
    • Gettys, T. W. et al. Age-dependent changes in beta-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats. Endocrinology 136, 2022-2032 (1995).
    • (1995) Endocrinology , vol.136 , pp. 2022-2032
    • Gettys, T.W.1
  • 148
    • 1842372073 scopus 로고    scopus 로고
    • In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity
    • Bougneres, P. et al. In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity. J. Clin. Invest. 99, 2568-2573 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 2568-2573
    • Bougneres, P.1
  • 150
    • 0033939021 scopus 로고    scopus 로고
    • Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women
    • Horowitz, J. F. & Klein, S. Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. Am. J. Physiol. Endocrinol. Metab. 278, E1144-E1152 (2000).
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278 , pp. E1144-E1152
    • Horowitz, J.F.1    Klein, S.2
  • 151
    • 0042531999 scopus 로고    scopus 로고
    • Beta-adrenergic receptors, diet-induced thermogenesis, and obesity
    • Lowell, B. B. & Bachman, E. S. Beta-adrenergic receptors, diet-induced thermogenesis, and obesity. J. Biol. Chem. 278, 29385-29388 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 29385-29388
    • Lowell, B.B.1    Bachman, E.S.2
  • 152
    • 84983756971 scopus 로고    scopus 로고
    • Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice
    • Sakamoto, T. et al. Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice. Am. J. Physiol. Endocrinol. Metab. 310, E676-E687 (2016).
    • (2016) Am. J. Physiol. Endocrinol. Metab. , vol.310 , pp. E676-E687
    • Sakamoto, T.1
  • 153
    • 84928551190 scopus 로고    scopus 로고
    • Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity
    • Guo, T. et al. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. eLife 3, e03245 (2014).
    • (2014) ELife , vol.3 , pp. e03245
    • Guo, T.1
  • 154
    • 84891534573 scopus 로고    scopus 로고
    • Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKK and TBK1
    • Mowers, J. et al. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKK and TBK1. eLife 2, e01119 (2013).
    • (2013) ELife , vol.2 , pp. e01119
    • Mowers, J.1
  • 155
    • 84875179301 scopus 로고    scopus 로고
    • An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice
    • Reilly, S. M. et al. An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice. Nat. Med. 19, 313-321 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 313-321
    • Reilly, S.M.1
  • 156
    • 0036584028 scopus 로고    scopus 로고
    • Development of anti-TNF therapy for rheumatoid arthritis
    • Feldmann, M. Development of anti-TNF therapy for rheumatoid arthritis. Nat. Rev. Immunol. 2, 364-371 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 364-371
    • Feldmann, M.1
  • 157
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNFa antibody (SDP571) on insulin sensitivity and glycemic control in pateints with NIDDM
    • Ofei, F., Hurel, S., Newkirk, J., Sopwith, M. & Taylor, R. Effects of an engineered human anti-TNFa antibody (SDP571) on insulin sensitivity and glycemic control in pateints with NIDDM. Diabetes 45, 881-885 (1996).
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 158
    • 79959426992 scopus 로고    scopus 로고
    • Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis
    • Solomon, D. H. et al. Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA 305, 2525-2531 (2011).
    • (2011) JAMA , vol.305 , pp. 2525-2531
    • Solomon, D.H.1
  • 159
    • 0033867178 scopus 로고    scopus 로고
    • Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes
    • Moller, D. E. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol. Metab. 11, 212-217 (2000).
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 212-217
    • Moller, D.E.1
  • 160
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
    • Ofei, F., Hurel, S., Newkirk, J., Sopwith, M. & Taylor, R. Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 45, 881-885 (1996).
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 161
    • 84878774925 scopus 로고    scopus 로고
    • Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1beta antibody, in patients with type 2 diabetes
    • Sloan-Lancaster, J. et al. Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1beta antibody, in patients with type 2 diabetes. Diabetes Care 36, 2239-2246 (2013).
    • (2013) Diabetes Care , vol.36 , pp. 2239-2246
    • Sloan-Lancaster, J.1
  • 162
    • 77950885686 scopus 로고    scopus 로고
    • The effects of salsalate on glycemic control in patients with type 2 diabetes: A randomized trial
    • Goldfine, A. B. et al. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann. Intern. Med. 152, 346-357 (2010).
    • (2010) Ann. Intern. Med. , vol.152 , pp. 346-357
    • Goldfine, A.B.1
  • 163
    • 84861222690 scopus 로고    scopus 로고
    • The ancient drug salicylate directly activates AMP-activated protein kinase
    • Hawley, S. A. et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 336, 918-922 (2012).
    • (2012) Science , vol.336 , pp. 918-922
    • Hawley, S.A.1
  • 164
    • 84876485218 scopus 로고    scopus 로고
    • A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance.
    • Goldfine, A. B. et al. A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia 56, 714-723 (2013).
    • (2013) Diabetologia , vol.56 , pp. 714-723
    • Goldfine, A.B.1
  • 165
    • 84928428363 scopus 로고    scopus 로고
    • Salsalate has no effect on insulin secretion but decreases insulin clearance: A randomized, placebo-controlled trial in subjects without diabetes
    • Penesova, A. et al. Salsalate has no effect on insulin secretion but decreases insulin clearance: a randomized, placebo-controlled trial in subjects without diabetes. Diabetes Obes. Metab. 17, 608-612 (2015).
    • (2015) Diabetes Obes. Metab. , vol.17 , pp. 608-612
    • Penesova, A.1
  • 166
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta, D. et al. PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486, 549-553 (2012).
    • (2012) Nature , vol.486 , pp. 549-553
    • Cipolletta, D.1
  • 167
    • 84923110854 scopus 로고    scopus 로고
    • A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.
    • Reilly, S. M. et al. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat. Commun. 6, 6047 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6047
    • Reilly, S.M.1
  • 168
    • 85029169452 scopus 로고    scopus 로고
    • Inhibition of IKK and TBK1 improves glucose control in a subset of patients with type 2 diabetes
    • Oral, E. A. et al. Inhibition of IKK and TBK1 improves glucose control in a subset of patients with type 2 diabetes. Cell Metab. 26 157-170 (2017).
    • (2017) Cell Metab. , vol.26 , pp. 157-170
    • Oral, E.A.1
  • 169
    • 84900468450 scopus 로고    scopus 로고
    • Metformin inhibits mitochondrial complex i of cancer cells to reduce tumorigenesis
    • Wheaton, W. W. et al. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. eLife 3, e02242 (2014).
    • (2014) ELife , vol.3 , pp. e02242
    • Wheaton, W.W.1
  • 170
    • 33646105593 scopus 로고    scopus 로고
    • Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells
    • Isoda, K. et al. Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells. Arterioscler. Thromb. Vasc. Biol. 26, 611-617 (2006).
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 611-617
    • Isoda, K.1
  • 171
    • 84878221256 scopus 로고    scopus 로고
    • Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans
    • Koppaka, S. et al. Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans. Diabetes 62, 1843-1854 (2013).
    • (2013) Diabetes , vol.62 , pp. 1843-1854
    • Koppaka, S.1
  • 172
    • 0030885575 scopus 로고    scopus 로고
    • Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
    • Peraldi, P., Xu, M. & Spiegelman, B. M. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J. Clin. Invest. 100, 1863-1869 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 1863-1869
    • Peraldi, P.1    Xu, M.2    Spiegelman, B.M.3
  • 173
    • 77952997178 scopus 로고    scopus 로고
    • Control of macrophage activation and function by PPARs
    • Chawla, A. Control of macrophage activation and function by PPARs. Circ. Res. 106, 1559-1569 (2010).
    • (2010) Circ. Res. , vol.106 , pp. 1559-1569
    • Chawla, A.1
  • 174
    • 0036307159 scopus 로고    scopus 로고
    • TNF-alpha is a predictor of insulin resistance in human pregnancy
    • Kirwan, J. P. et al. TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes 51, 2207-2213 (2002).
    • (2002) Diabetes , vol.51 , pp. 2207-2213
    • Kirwan, J.P.1
  • 175
    • 33749559832 scopus 로고    scopus 로고
    • Modulation of adipokines and cytokines in gestational diabetes and macrosomia
    • Ategbo, J. M. et al. Modulation of adipokines and cytokines in gestational diabetes and macrosomia. J. Clin. Endocrinol. Metab. 91, 4137-4143 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 4137-4143
    • Ategbo, J.M.1
  • 176
    • 84907246688 scopus 로고    scopus 로고
    • Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: A systematic review and meta-analysis
    • Xu, J. et al. Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis. ScientificWorldJournal 2014, 926932 (2014).
    • (2014) ScientificWorldJournal , vol.2014 , pp. 926932
    • Xu, J.1


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