Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity

Diabetes

Volumn 64, Issue 6, 2015, Pages 2116-2128

  Finucane, Orla M ^a   Lyons, Claire L ^a   Murphy, Aoife M ^a   Reynolds, Clare M ^a   Klinger, Rut ^a   Healy, Niamh P ^a   Cooke, Aoife A ^a   Coll, Rebecca C ^b   Mcallan, Liam ^c   Nilaweera, Kanishka N ^c   O'Reilly, Marcella E ^a   Tierney, Audrey C ^d   Morine, Melissa J ^e   Alcala Diaz, Juan F ^f   Lopez Miranda, Jose ^f   O'Connor, Darran P ^a   O'Neill, Luke A ^b   Mcgillicuddy, Fiona C ^a   Roche, Helen M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c TEAGASC FOOD RESEARCH CENTRE   (Ireland)

^d LA TROBE UNIVERSITY   (Australia)

^e UNIVERSITY OF TRENTO   (Italy)

^f HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CRYOPYRIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INFLAMMASOME; INSULIN; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LENTIVIRUS VECTOR; MESSENGER RNA; MONOUNSATURATED FATTY ACID; OLEIC ACID; OLIVE OIL; SHORT HAIRPIN RNA; SIRTUIN 1; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; AMPK ALPHA1 SUBUNIT, MOUSE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; DIET RESTRICTION; DIET THERAPY; ENZYME ACTIVATION; EX VIVO STUDY; GENE SILENCING; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN CELL; HYPERINSULINEMIA; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRACELLULAR SPACE; LIPID DIET; LUNG GAS EXCHANGE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; DIET, HIGH-FAT; FATTY ACIDS, MONOUNSATURATED; HUMANS; INSULIN RESISTANCE; INTERLEUKIN-1BETA; MALE; MICE; MICE, INBRED C57BL; OBESITY;

EID: 84934921383     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1098     Document Type: Article

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