-
1
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840-846 (2006
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
2
-
-
33845886915
-
Abdominal obesity and metabolic syndrome
-
Despres, J. P., & Lemieux, I. Abdominal obesity and metabolic syndrome. Nature 444, 881-887 (2006
-
(2006)
Nature
, vol.444
, pp. 881-887
-
-
Despres, J.P.1
Lemieux, I.2
-
4
-
-
47149096915
-
Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
-
Heilbronn, L. K., & Campbell, L. V. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr. Pharm. Des. 14, 1225-1230 (2008
-
(2008)
Curr. Pharm. des
, vol.14
, pp. 1225-1230
-
-
Heilbronn, L.K.1
Campbell, L.V.2
-
5
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
Lumeng, C. N., & Saltiel, A. R. Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121, 2111-2117 (2011
-
(2011)
J. Clin. Invest
, vol.121
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
6
-
-
84857985148
-
The cellular and signaling networks linking the immune system and metabolism in disease
-
Osborn, O., & Olefsky, J. M. The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med. 18, 363-374 (2012
-
(2012)
Nat. Med
, vol.18
, pp. 363-374
-
-
Osborn, O.1
Olefsky, J.M.2
-
7
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg, S. P., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808 (2003
-
(2003)
J. Clin. Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
-
8
-
-
84925873107
-
Immune regulation of metabolic homeostasis in health and disease
-
Brestoff, J. R., & Artis, D. Immune regulation of metabolic homeostasis in health and disease. Cell 161, 146-160 (2015
-
(2015)
Cell
, vol.161
, pp. 146-160
-
-
Brestoff, J.R.1
Artis, D.2
-
9
-
-
84904392112
-
Macrophages immunity, and metabolic disease
-
McNelis, J. C., & Olefsky, J. M. Macrophages, immunity, and metabolic disease. Immunity 41, 36-48 (2014
-
(2014)
Immunity
, vol.41
, pp. 36-48
-
-
McNelis, J.C.1
Olefsky, J.M.2
-
10
-
-
84870058819
-
Adaptive immunity in obesity and insulin resistance
-
Sell, H., Habich, C., & Eckel, J. Adaptive immunity in obesity and insulin resistance. Nat. Rev. Endocrinol. 8, 709-716 (2012
-
(2012)
Nat. Rev. Endocrinol
, vol.8
, pp. 709-716
-
-
Sell, H.1
Habich, C.2
Eckel, J.3
-
11
-
-
84878785347
-
Immunological goings-on in visceral adipose tissue
-
Mathis, D. Immunological goings-on in visceral adipose tissue. Cell Metab. 17, 851-859 (2013
-
(2013)
Cell Metab
, vol.17
, pp. 851-859
-
-
Mathis, D.1
-
12
-
-
84904035279
-
Adipose tissue-resident regulatory T cells: Phenotypic specialization, functions and therapeutic potential
-
Cipolletta, D. Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential. Immunology 142, 517-525 (2014
-
(2014)
Immunology
, vol.142
, pp. 517-525
-
-
Cipolletta, D.1
-
13
-
-
0027459878
-
Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
-
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259, 87-91 (1993
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
14
-
-
78650878363
-
NF ?B, inflammation, and metabolic disease
-
Baker, R. G., Hayden, M. S., & Ghosh, S. NF ?B, inflammation, and metabolic disease. Cell Metab. 13, 11-22 (2011
-
(2011)
Cell Metab
, vol.13
, pp. 11-22
-
-
Baker, R.G.1
Hayden, M.S.2
Ghosh, S.3
-
15
-
-
84867867477
-
The nuclear factor ? B signaling pathway: Integrating metabolism with inflammation
-
Tornatore, L., Thotakura, A. K., Bennett, J., Moretti, M., & Franzoso, G. The nuclear factor ? B signaling pathway: integrating metabolism with inflammation. Trends Cell Biol. 22, 557-566 (2012
-
(2012)
Trends Cell Biol
, vol.22
, pp. 557-566
-
-
Tornatore, L.1
Thotakura, A.K.2
Bennett, J.3
Moretti, M.4
Franzoso, G.5
-
16
-
-
0032487857
-
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I?B kinase β
-
Yin, M J., Yamamoto, Y., & Gaynor, R. B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I?B kinase β. Nature 396, 77-80 (1998
-
(1998)
Nature
, vol.396
, pp. 77-80
-
-
Yin, M.J.1
Yamamoto, Y.2
Gaynor, R.B.3
-
17
-
-
0035979775
-
Reversal of obesity-And diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
-
Yuan, M., et al. Reversal of obesity-And diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 293, 1673-1677 (2001
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
-
18
-
-
0346880505
-
Inflammation and the IKKβ/I?B/NF ?B axis in obesity-And diet-induced insulin resistance
-
Shoelson, S. E., Lee, J., & Yuan, M. Inflammation and the IKKβ/I?B/NF ?B axis in obesity-And diet-induced insulin resistance. Int. J. Obes. Relat. Metab. Disord. 27, S49-S52 (2003
-
(2003)
Int. J. Obes. Relat. Metab. Disord
, vol.27
, pp. S49-S52
-
-
Shoelson, S.E.1
Lee, J.2
Yuan, M.3
-
19
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi, J., et al. A central role for JNK in obesity and insulin resistance. Nature 420, 333-336 (2002
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
-
20
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio, G., et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322, 1539-1543 (2008
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
-
21
-
-
35548943962
-
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
-
Solinas, G., et al. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 6, 386-397 (2007
-
(2007)
Cell Metab
, vol.6
, pp. 386-397
-
-
Solinas, G.1
-
22
-
-
77955806634
-
JNK1 and IKKβ: Molecular links between obesity and metabolic dysfunction
-
Solinas, G., & Karin, M. JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction. FASEB J. 24, 2596-2611 (2010
-
(2010)
FASEB J.
, vol.24
, pp. 2596-2611
-
-
Solinas, G.1
Karin, M.2
-
23
-
-
84923668958
-
Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation
-
Yin, J., et al. Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: implications for apoptosis and inflammation. Int. J. Mol. Med. 35, 932-940 (2015
-
(2015)
Int. J. Mol. Med
, vol.35
, pp. 932-940
-
-
Yin, J.1
-
24
-
-
84892152979
-
Palmitate induces autophagy in pancreatic β cells via endoplasmic reticulum stress and its downstream JNK pathway
-
Chen, Y. Y., et al. Palmitate induces autophagy in pancreatic β cells via endoplasmic reticulum stress and its downstream JNK pathway. Int. J. Mol. Med. 32, 1401-1406 (2013
-
(2013)
Int. J. Mol. Med
, vol.32
, pp. 1401-1406
-
-
Chen, Y.Y.1
-
25
-
-
14544271905
-
Positive and negative regulation of insulin signaling through IRS 1 phosphorylation
-
Gual, P., Le Marchand-Brustel, Y., & Tanti, J. F. Positive and negative regulation of insulin signaling through IRS 1 phosphorylation. Biochimie 87, 99-109 (2005
-
(2005)
Biochimie
, vol.87
, pp. 99-109
-
-
Gual, P.1
Le Marchand-Brustel, Y.2
Tanti, J.F.3
-
26
-
-
84899425498
-
Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes
-
Westwell-Roper, C., Nackiewicz, D., Dan, M., & Ehses, J. A. Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes. Immunol. Cell Biol. 92, 314-323 (2014
-
(2014)
Immunol. Cell Biol
, vol.92
, pp. 314-323
-
-
Westwell-Roper, C.1
Nackiewicz, D.2
Dan, M.3
Ehses, J.A.4
-
27
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL 1β in type 2 diabetes
-
Masters, S. L., et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL 1β in type 2 diabetes. Nat. Immunol. 11, 897-904 (2010
-
(2010)
Nat. Immunol
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
-
28
-
-
84927779736
-
NLRP3 at the interface of metabolism and inflammation
-
Haneklaus, M., & O'Neill, L. A. NLRP3 at the interface of metabolism and inflammation. Immunol. Rev. 265, 53-62 (2015
-
(2015)
Immunol. Rev
, vol.265
, pp. 53-62
-
-
Haneklaus, M.1
O'Neill, L.A.2
-
29
-
-
80053087484
-
Inflammasome is a central player in the induction of obesity and insulin resistance
-
Stienstra, R., et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc. Natl Acad. Sci. USA 108, 15324-15329 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 15324-15329
-
-
Stienstra, R.1
-
30
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar, B., et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188 (2011
-
(2011)
Nat. Med
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
-
31
-
-
84924356420
-
The ketone metabolite β hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
-
Youm, Y. H., et al. The ketone metabolite β hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med. 21, 263-269 (2015
-
(2015)
Nat. Med
, vol.21
, pp. 263-269
-
-
Youm, Y.H.1
-
32
-
-
84934921383
-
Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL 1β secretion and insulin resistance despite obesity
-
Finucane, O. M., et al. Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL 1β secretion and insulin resistance despite obesity. Diabetes 64, 2116-2128 (2015
-
(2015)
Diabetes
, vol.64
, pp. 2116-2128
-
-
Finucane, O.M.1
-
33
-
-
33746736936
-
Long-Term treatment with interleukin 1β induces insulin resistance in murine and human adipocytes
-
Lagathu, C., et al. Long-Term treatment with interleukin 1β induces insulin resistance in murine and human adipocytes. Diabetologia 49, 2162-2173 (2006
-
(2006)
Diabetologia
, vol.49
, pp. 2162-2173
-
-
Lagathu, C.1
-
34
-
-
42449091550
-
The antiinflammatory cytokine interleukin 1 receptor antagonist protects from high-fat diet-induced hyperglycemia
-
Sauter, N. S., Schulthess, F. T., Galasso, R., Castellani, L. W., & Maedler, K. The antiinflammatory cytokine interleukin 1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology 149, 2208-2218 (2008
-
(2008)
Endocrinology
, vol.149
, pp. 2208-2218
-
-
Sauter, N.S.1
Schulthess, F.T.2
Galasso, R.3
Castellani, L.W.4
Maedler, K.5
-
35
-
-
34247170807
-
Interleukin 1 receptor antagonist in type 2 diabetes mellitus
-
Larsen, C. M., et al. Interleukin 1 receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356, 1517-1526 (2007
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
-
36
-
-
84907193701
-
Interleukin 1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes
-
Gao, D., et al. Interleukin 1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes. Am. J. Physiol. Endocrinol. Metab. 307, E289-E304 (2014
-
(2014)
Am. J. Physiol. Endocrinol. Metab
, vol.307
, pp. E289-E304
-
-
Gao, D.1
-
37
-
-
80053165080
-
The inflammasome and caspase 1 activation: A new mechanism underlying increased inflammatory activity in human visceral adipose tissue
-
Koenen, T. B., et al. The inflammasome and caspase 1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue. Endocrinology 152, 3769-3778 (2011
-
(2011)
Endocrinology
, vol.152
, pp. 3769-3778
-
-
Koenen, T.B.1
-
38
-
-
0035907302
-
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase 2 mediated through Toll-like receptor 4
-
Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase 2 mediated through Toll-like receptor 4. J. Biol. Chem. 276, 16683-16689 (2001
-
(2001)
J. Biol. Chem
, vol.276
, pp. 16683-16689
-
-
Lee, J.Y.1
Sohn, K.H.2
Rhee, S.H.3
Hwang, D.4
-
39
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi, H., et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116, 3015-3025 (2006
-
(2006)
J. Clin. Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
-
40
-
-
84864657351
-
Fetuin A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
Pal, D., et al. Fetuin A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med. 18, 1279-1285 (2012
-
(2012)
Nat. Med
, vol.18
, pp. 1279-1285
-
-
Pal, D.1
-
41
-
-
84893051766
-
Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms
-
Guo, S. Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J. Endocrinol. 220, T1-T23 (2014
-
(2014)
J. Endocrinol
, vol.220
, pp. T1-T23
-
-
Guo, S.1
-
42
-
-
4143050204
-
Insulin resistance due to phosphorylation of insulin receptor substrate 1 at serine 302
-
Werner, E. D., Lee, J., Hansen, L., Yuan, M., & Shoelson, S. E. Insulin resistance due to phosphorylation of insulin receptor substrate 1 at serine 302. J. Biol. Chem. 279, 35298-35305 (2004
-
(2004)
J. Biol. Chem
, vol.279
, pp. 35298-35305
-
-
Werner, E.D.1
Lee, J.2
Hansen, L.3
Yuan, M.4
Shoelson, S.E.5
-
43
-
-
67049132971
-
High-fat feeding increases insulin receptor and IRS 1 coimmunoprecipitation with SOCS 3 IKKα/β phosphorylation and decreases PI 3 kinase activity in muscle
-
Yaspelkis, B. B. 3rd, Kvasha, I. A., & Figueroa, T. Y. High-fat feeding increases insulin receptor and IRS 1 coimmunoprecipitation with SOCS 3, IKKα/β phosphorylation and decreases PI 3 kinase activity in muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296, R1709-R1715 (2009
-
(2009)
Am. J. Physiol. Regul. Integr. Comp. Physiol
, vol.296
, pp. R1709-R1715
-
-
Yaspelkis, B.B.1
Kvasha, I.A.2
Figueroa, T.Y.3
-
44
-
-
84867334372
-
Insulin receptor and IRS 1 co-immunoprecipitation with SOCS 3, and IKKα/β phosphorylation are increased in obese Zucker rat skeletal muscle
-
Zolotnik, I. A., Figueroa, T. Y., & Yaspelkis, B. B. 3rd. Insulin receptor and IRS 1 co-immunoprecipitation with SOCS 3, and IKKα/β phosphorylation are increased in obese Zucker rat skeletal muscle. Life Sci. 91, 816-822 (2012
-
(2012)
Life Sci
, vol.91
, pp. 816-822
-
-
Zolotnik, I.A.1
Figueroa, T.Y.2
Yaspelkis, B.B.3
-
45
-
-
84919884648
-
Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells
-
Poletto, A. C., et al. Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells. Mol. Cell. Endocrinol. 401, 65-72 (2015
-
(2015)
Mol. Cell. Endocrinol
, vol.401
, pp. 65-72
-
-
Poletto, A.C.1
-
46
-
-
0036313033
-
Tumor necrosis factor α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3 L1 adipocytes: Nuclear factor-?B activation by TNF α is obligatory
-
Ruan, H., Hacohen, N., Golub, T. R., Van Parijs, L., & Lodish, H. F. Tumor necrosis factor α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3 L1 adipocytes: nuclear factor-?B activation by TNF α is obligatory. Diabetes 51, 1319-1336 (2002
-
(2002)
Diabetes
, vol.51
, pp. 1319-1336
-
-
Ruan, H.1
Hacohen, N.2
Golub, T.R.3
Van Parijs, L.4
Lodish, H.F.5
-
47
-
-
0025837140
-
Transcriptional repression of the GLUT4 and C/EBP genes in 3T3 L1 adipocytes by tumor necrosis factor α
-
Stephens, J. M., & Pekala, P. H. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3 L1 adipocytes by tumor necrosis factor α. J. Biol. Chem. 266, 21839-21845 (1991
-
(1991)
J. Biol. Chem
, vol.266
, pp. 21839-21845
-
-
Stephens, J.M.1
Pekala, P.H.2
-
48
-
-
84929965189
-
MicroRNA regulatory networks in human adipose tissue and obesity
-
Arner, P., & Kulyte, A. MicroRNA regulatory networks in human adipose tissue and obesity. Nat. Rev. Endocrinol. 11, 276-288 (2015
-
(2015)
Nat. Rev. Endocrinol
, vol.11
, pp. 276-288
-
-
Arner, P.1
Kulyte, A.2
-
49
-
-
84865304885
-
Inducible microRNA 223 down-regulation promotes TLR-Triggered IL 6 and IL 1β production in macrophages by targeting STAT3
-
Chen, Q., et al Inducible microRNA 223 down-regulation promotes TLR-Triggered IL 6 and IL 1β production in macrophages by targeting STAT3. PLoS ONE 7, e42971 (2012
-
(2012)
PLoS ONE
, vol.7
, pp. e42971
-
-
Chen, Q.1
-
50
-
-
80054918892
-
TNFα-induced up-regulation of miR 155 inhibits adipogenesis by down-regulating early adipogenic transcription factors
-
Liu, S., Yang, Y., & Wu, J. TNFα-induced up-regulation of miR 155 inhibits adipogenesis by down-regulating early adipogenic transcription factors. Biochem. Biophys. Res. Commun. 414, 618-624 (2011
-
(2011)
Biochem. Biophys. Res. Commun
, vol.414
, pp. 618-624
-
-
Liu, S.1
Yang, Y.2
Wu, J.3
-
51
-
-
84899500112
-
MicroRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome
-
Ge, Q., Brichard, S., Yi, X., & Li, Q. MicroRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome. J. Immunol. Res. 2014, 987285 (2014
-
(2014)
J. Immunol. Res
, vol.2014
, pp. 987285
-
-
Ge, Q.1
Brichard, S.2
Yi, X.3
Li, Q.4
-
52
-
-
42449097289
-
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
-
Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 367-377 (2008
-
(2008)
Nat. Rev. Mol. Cell Biol
, vol.9
, pp. 367-377
-
-
Guilherme, A.1
Virbasius, J.V.2
Puri, V.3
Czech, M.P.4
-
53
-
-
77956022194
-
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption
-
Ussher, J. R., et al. Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. Diabetes 59, 2453-2464 (2010
-
(2010)
Diabetes
, vol.59
, pp. 2453-2464
-
-
Ussher, J.R.1
-
54
-
-
79955487247
-
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
-
Holland, W. L., et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin. Invest. 121, 1858-1870 (2011
-
(2011)
J. Clin. Invest
, vol.121
, pp. 1858-1870
-
-
Holland, W.L.1
-
55
-
-
79955037346
-
Hepatocyte-specific IKK β activation enhances VLDL-Triglyceride production in APOE 3 Leiden mice
-
van Diepen, J. A., et al. Hepatocyte-specific IKK β activation enhances VLDL-Triglyceride production in APOE 3 Leiden mice. J. Lipid Res. 52, 942-950 (2011
-
(2011)
J. Lipid Res
, vol.52
, pp. 942-950
-
-
Van Diepen, J.A.1
-
56
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu, H., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112, 1821-1830 (2003
-
(2003)
J. Clin. Invest
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
-
57
-
-
33846004396
-
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
-
Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am. J. Physiol. Endocrinol. Metab. 292, E166-E174 (2007
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.292
, pp. E166-E174
-
-
Lumeng, C.N.1
Deyoung, S.M.2
Saltiel, A.R.3
-
58
-
-
33847073149
-
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
-
Lumeng, C. N., Deyoung, S. M., Bodzin, J. L., & Saltiel, A. R. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56, 16-23 (2007
-
(2007)
Diabetes
, vol.56
, pp. 16-23
-
-
Lumeng, C.N.1
Deyoung, S.M.2
Bodzin, J.L.3
Saltiel, A.R.4
-
59
-
-
52749092267
-
Ablation of CD11c positive cells normalizes insulin sensitivity in obese insulin resistant animals
-
Patsouris, D., et al. Ablation of CD11c positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 8, 301-309 (2008
-
(2008)
Cell Metab
, vol.8
, pp. 301-309
-
-
Patsouris, D.1
-
60
-
-
84925485114
-
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
-
Li, P., et al. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat. Med. 21, 239-247 (2015
-
(2015)
Nat. Med
, vol.21
, pp. 239-247
-
-
Li, P.1
-
61
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF α function
-
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. Protection from obesity-induced insulin resistance in mice lacking TNF α function. Nature 389, 610-614 (1997
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
62
-
-
80051939276
-
Deficiency of the leukotriene B4 receptor, BLT 1, protects against systemic insulin resistance in diet-induced obesity
-
Spite, M., et al. Deficiency of the leukotriene B4 receptor, BLT 1, protects against systemic insulin resistance in diet-induced obesity. J. Immunol. 187, 1942-1949 (2011
-
(2011)
J. Immunol
, vol.187
, pp. 1942-1949
-
-
Spite, M.1
-
63
-
-
20044387026
-
IKK β links inflammation to obesity-induced insulin resistance
-
Arkan, M. C., et al. IKK β links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191-198 (2005
-
(2005)
Nat. Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
-
64
-
-
84872142459
-
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
-
Han, M. S., et al. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339, 218-222 (2013
-
(2013)
Science
, vol.339
, pp. 218-222
-
-
Han, M.S.1
-
65
-
-
84924415012
-
Blocking IL 6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance
-
Kraakman, M. J., et al. Blocking IL 6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab. 21, 403-416 (2015
-
(2015)
Cell Metab
, vol.21
, pp. 403-416
-
-
Kraakman, M.J.1
-
66
-
-
84904044334
-
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
-
Wernstedt Asterholm, I., et al. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 20, 103-118 (2014
-
(2014)
Cell Metab
, vol.20
, pp. 103-118
-
-
Wernstedt Asterholm, I.1
-
67
-
-
69449097633
-
The protein kinase IKK? Regulates energy balance in obese mice
-
Chiang, S. H., et al. The protein kinase IKK? Regulates energy balance in obese mice. Cell 138, 961-975 (2009
-
(2009)
Cell
, vol.138
, pp. 961-975
-
-
Chiang, S.H.1
-
68
-
-
84875179301
-
An inhibitor of the protein kinases TBK1 and IKK-improves obesity-related metabolic dysfunctions in mice
-
Reilly, S. M., et al. An inhibitor of the protein kinases TBK1 and IKK-improves obesity-related metabolic dysfunctions in mice. Nat. Med. 19, 313-321 (2013
-
(2013)
Nat. Med
, vol.19
, pp. 313-321
-
-
Reilly, S.M.1
-
69
-
-
84891534573
-
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKK? and TBK1
-
Mowers, J., et al. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKK? and TBK1. eLIFE 2, e01119 (2013
-
(2013)
ELife
, vol.2
, pp. e01119
-
-
Mowers, J.1
-
70
-
-
84923110854
-
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis
-
Reilly, S. M., et al. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat. Commun. 6, 6047 (2015
-
(2015)
Nat. Commun
, vol.6
, pp. 6047
-
-
Reilly, S.M.1
-
71
-
-
51349111709
-
Prolonged interleukin 6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats
-
Holmes, A. G., et al. Prolonged interleukin 6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats. J. Endocrinol. 198, 367-374 (2008
-
(2008)
J. Endocrinol
, vol.198
, pp. 367-374
-
-
Holmes, A.G.1
-
72
-
-
33750859187
-
Interleukin 6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-Activated protein kinase
-
Carey, A. L., et al. Interleukin 6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-Activated protein kinase. Diabetes 55, 2688-2697 (2006
-
(2006)
Diabetes
, vol.55
, pp. 2688-2697
-
-
Carey, A.L.1
-
73
-
-
12144290761
-
Differential effects of interleukin 6 and 10 on skeletal muscle and liver insulin action in vivo
-
Kim, H. J., et al. Differential effects of interleukin 6 and 10 on skeletal muscle and liver insulin action in vivo. Diabetes 53, 1060-1067 (2004
-
(2004)
Diabetes
, vol.53
, pp. 1060-1067
-
-
Kim, H.J.1
-
74
-
-
8544244084
-
PKC knockout mice are protected from fat-induced insulin resistance
-
Kim, J. K., et al. PKC knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 114, 823-827 (2004
-
(2004)
J. Clin. Invest
, vol.114
, pp. 823-827
-
-
Kim, J.K.1
-
75
-
-
33947171146
-
A high-fat meal is accompanied by increased plasma interleukin 6 concentrations
-
Lundman, P., et al. A high-fat meal is accompanied by increased plasma interleukin 6 concentrations. Nutr. Metab. Cardiovasc. Dis. 17, 195-202 (2007
-
(2007)
Nutr. Metab. Cardiovasc. Dis
, vol.17
, pp. 195-202
-
-
Lundman, P.1
-
76
-
-
2142827887
-
Increase in intranuclear nuclear factor ?B and decrease in inhibitor ?B in mononuclear cells after a mixed meal: Evidence for a proinflammatory effect
-
Aljada, A., et al. Increase in intranuclear nuclear factor ?B and decrease in inhibitor ?B in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Am. J. Clin. Nutr. 79, 682-690 (2004
-
(2004)
Am. J. Clin. Nutr
, vol.79
, pp. 682-690
-
-
Aljada, A.1
-
77
-
-
5444256832
-
Activation of leukocytes by postprandial lipemia in healthy volunteers
-
van Oostrom, A. J., et al. Activation of leukocytes by postprandial lipemia in healthy volunteers. Atherosclerosis 177, 175-182 (2004
-
(2004)
Atherosclerosis
, vol.177
, pp. 175-182
-
-
Van Oostrom, A.J.1
-
78
-
-
84929223982
-
Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation
-
Kim, J. I., et al. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol. Cell. Biol. 35, 1686-1699 (2015
-
(2015)
Mol. Cell. Biol
, vol.35
, pp. 1686-1699
-
-
Kim, J.I.1
-
79
-
-
11144355563
-
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle
-
Kim, J. K., et al. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J. Clin. Invest. 113, 756-763 (2004
-
(2004)
J. Clin. Invest
, vol.113
, pp. 756-763
-
-
Kim, J.K.1
-
80
-
-
80053406579
-
Inflammation is necessary for long-Term but not short-Term high-fat diet-induced insulin resistance
-
Lee, Y. S., et al. Inflammation is necessary for long-Term but not short-Term high-fat diet-induced insulin resistance. Diabetes 60, 2474-2483 (2011
-
(2011)
Diabetes
, vol.60
, pp. 2474-2483
-
-
Lee, Y.S.1
-
81
-
-
77953268611
-
Alternative activation of macrophages: Mechanism and functions
-
Gordon, S., & Martinez, F. O. Alternative activation of macrophages: mechanism and functions. Immunity 32, 593-604 (2010
-
(2010)
Immunity
, vol.32
, pp. 593-604
-
-
Gordon, S.1
Martinez, F.O.2
-
82
-
-
84857883847
-
Macrophage plasticity and polarization: In vivo veritas
-
Sica, A., & Mantovani, A. Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 122, 787-795 (2012
-
(2012)
J. Clin. Invest
, vol.122
, pp. 787-795
-
-
Sica, A.1
Mantovani, A.2
-
83
-
-
84904394690
-
Macrophage activation and polarization: Nomenclature and experimental guidelines
-
Murray, P. J., et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20 (2014
-
(2014)
Immunity
, vol.41
, pp. 14-20
-
-
Murray, P.J.1
-
84
-
-
84889663497
-
Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation
-
Xu, X., et al. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab. 18, 816-830 (2013
-
(2013)
Cell Metab
, vol.18
, pp. 816-830
-
-
Xu, X.1
-
85
-
-
84907991703
-
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
-
Kratz, M., et al. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab. 20, 614-625 (2014
-
(2014)
Cell Metab
, vol.20
, pp. 614-625
-
-
Kratz, M.1
-
86
-
-
77952083245
-
Functional heterogeneity of CD11c positive adipose tissue macrophages in diet-induced obese mice
-
Li, P., et al. Functional heterogeneity of CD11c positive adipose tissue macrophages in diet-induced obese mice. J. Biol. Chem. 285, 15333-15345 (2010
-
(2010)
J. Biol. Chem
, vol.285
, pp. 15333-15345
-
-
Li, P.1
-
87
-
-
84938747174
-
Adiponectin enhances cold-induced browning of subcutaneous adipose tissue via promoting M2 macrophage proliferation
-
Hui, X., et al. Adiponectin enhances cold-induced browning of subcutaneous adipose tissue via promoting M2 macrophage proliferation. Cell Metab. 22, 279-290 (2015
-
(2015)
Cell Metab
, vol.22
, pp. 279-290
-
-
Hui, X.1
-
88
-
-
71449120759
-
Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment
-
Patsouris, D., et al. Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J. Biol. Chem. 284, 31223-31235 (2009
-
(2009)
J. Biol. Chem
, vol.284
, pp. 31223-31235
-
-
Patsouris, D.1
-
89
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184 (2007
-
(2007)
J. Clin. Invest
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
90
-
-
84856533216
-
Increased macrophage migration into adipose tissue in obese mice
-
Oh, D. Y., Morinaga, H., Talukdar, S., Bae, E. J., & Olefsky, J. M. Increased macrophage migration into adipose tissue in obese mice. Diabetes 61, 346-354 (2012
-
(2012)
Diabetes
, vol.61
, pp. 346-354
-
-
Oh, D.Y.1
Morinaga, H.2
Talukdar, S.3
Bae, E.J.4
Olefsky, J.M.5
-
91
-
-
34548434020
-
Absence of CC chemokine ligand 2 does not limit obesity-Associated infiltration of macrophages into adipose tissue
-
Inouye, K. E., et al. Absence of CC chemokine ligand 2 does not limit obesity-Associated infiltration of macrophages into adipose tissue. Diabetes 56, 2242-2250 (2007
-
(2007)
Diabetes
, vol.56
, pp. 2242-2250
-
-
Inouye, K.E.1
-
92
-
-
48449102722
-
Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue
-
Kirk, E. A., Sagawa, Z. K., McDonald, T. O., O'Brien, K. D., & Heinecke, J. W. Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue. Diabetes 57, 1254-1261 (2008
-
(2008)
Diabetes
, vol.57
, pp. 1254-1261
-
-
Kirk, E.A.1
Sagawa, Z.K.2
McDonald, T.O.3
O'Brien, K.D.4
Heinecke, J.W.5
-
93
-
-
84885108889
-
Semaphorin3E induced inflammation contributes to insulin resistance in dietary obesity
-
Shimizu, I., et al. Semaphorin3E induced inflammation contributes to insulin resistance in dietary obesity. Cell Metab. 18, 491-504 (2013
-
(2013)
Cell Metab
, vol.18
, pp. 491-504
-
-
Shimizu, I.1
-
94
-
-
84927624671
-
Microparticles release by adipocytes act as 'find-me' signals to promote macrophage migration
-
Eguchi, A., et al. Microparticles release by adipocytes act as 'find-me' signals to promote macrophage migration. PLoS ONE 10, e0123110 (2015
-
(2015)
PLoS ONE
, vol.10
, pp. e0123110
-
-
Eguchi, A.1
-
95
-
-
58149347227
-
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
-
Lumeng, C. N., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57, 3239-3246 (2008
-
(2008)
Diabetes
, vol.57
, pp. 3239-3246
-
-
Lumeng, C.N.1
DelProposto, J.B.2
Westcott, D.J.3
Saltiel, A.R.4
-
96
-
-
34347354309
-
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
-
Odegaard, J. I., et al. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance. Nature 447, 1116-1120 (2007
-
(2007)
Nature
, vol.447
, pp. 1116-1120
-
-
Odegaard, J.I.1
-
97
-
-
34249907880
-
Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
-
Hevener, A. L., et al. Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J. Clin. Invest. 117, 1658-1669 (2007
-
(2007)
J. Clin. Invest
, vol.117
, pp. 1658-1669
-
-
Hevener, A.L.1
-
98
-
-
70349150518
-
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN γ in inflammation in human adipose tissue
-
O'Rourke, R. W., et al. Depot-specific differences in inflammatory mediators and a role for NK cells and IFN γ in inflammation in human adipose tissue. Int. J. Obes. (Lond.) 33, 978-990 (2009
-
(2009)
Int. J. Obes. (Lond.)
, vol.33
, pp. 978-990
-
-
O'Rourke, R.W.1
-
99
-
-
84920034829
-
Perforin is a novel immune regulator of obesity-related insulin resistance
-
Revelo, X. S., et al. Perforin is a novel immune regulator of obesity-related insulin resistance. Diabetes 64, 90-103 (2015
-
(2015)
Diabetes
, vol.64
, pp. 90-103
-
-
Revelo, X.S.1
-
100
-
-
84907672655
-
Systemic NK cell ablation attenuates intra-Abdominal adipose tissue macrophage infiltration in murine obesity
-
O'Rourke, R. W., et al. Systemic NK cell ablation attenuates intra-Abdominal adipose tissue macrophage infiltration in murine obesity. Obesity (Silver Spring) 22, 2109-2114 (2014
-
(2014)
Obesity (Silver Spring)
, vol.22
, pp. 2109-2114
-
-
O'Rourke, R.W.1
-
101
-
-
84925627014
-
NK cells link obesity-induced adipose stress to inflammation and insulin resistance
-
Wensveen, F. M., et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat. Immunol. 16, 376-385 (2015
-
(2015)
Nat. Immunol
, vol.16
, pp. 376-385
-
-
Wensveen, F.M.1
-
102
-
-
68349160704
-
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
-
Liu, J., et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat. Med. 15, 940-945 (2009
-
(2009)
Nat. Med
, vol.15
, pp. 940-945
-
-
Liu, J.1
-
103
-
-
84866166644
-
Mast cells in human adipose tissue: Link with morbid obesity, inflammatory status, and diabetes
-
Divoux, A., et al. Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes. J. Clin. Endocrinol. Metab. 97, E1677-E1685 (2012
-
(2012)
J. Clin. Endocrinol. Metab
, vol.97
, pp. E1677-E1685
-
-
Divoux, A.1
-
104
-
-
84940197047
-
Hematopoietic Kit deficiency, rather than lack of mast cells, protects mice from obesity and insulin resistance
-
Gutierrez, D. A., Muralidhar, S., Feyerabend, T. B., Herzig, S., & Rodewald, H. R. Hematopoietic Kit deficiency, rather than lack of mast cells, protects mice from obesity and insulin resistance. Cell Metab. 21, 678-691 (2015
-
(2015)
Cell Metab
, vol.21
, pp. 678-691
-
-
Gutierrez, D.A.1
Muralidhar, S.2
Feyerabend, T.B.3
Herzig, S.4
Rodewald, H.R.5
-
105
-
-
79953815551
-
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
-
Wu, D., et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332, 243-247 (2011
-
(2011)
Science
, vol.332
, pp. 243-247
-
-
Wu, D.1
-
106
-
-
84940426553
-
Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice
-
Hussaarts, L., et al. Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice. FASEB J. 29, 3027-3039 (2015
-
(2015)
FASEB J.
, vol.29
, pp. 3027-3039
-
-
Hussaarts, L.1
-
108
-
-
84885572626
-
Type 2 innate lymphoid cells control eosinophil homeostasis
-
Nussbaum, J. C., et al. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 502, 245-248 (2013
-
(2013)
Nature
, vol.502
, pp. 245-248
-
-
Nussbaum, J.C.1
-
109
-
-
84876746655
-
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
-
Molofsky, A. B., et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med. 210, 535-549 (2013
-
(2013)
J. Exp. Med
, vol.210
, pp. 535-549
-
-
Molofsky, A.B.1
-
110
-
-
84888346690
-
Cutting edge: IL 25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice
-
Hams, E., Locksley, R. M., McKenzie, A. N., & Fallon, P. G. Cutting edge: IL 25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J. Immunol. 191, 5349-5353 (2013
-
(2013)
J. Immunol
, vol.191
, pp. 5349-5353
-
-
Hams, E.1
Locksley, R.M.2
McKenzie, A.N.3
Fallon, P.G.4
-
111
-
-
84887431711
-
Brown and beige fat: Development, function and therapeutic potential
-
Harms, M., & Seale, P. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19, 1252-1263 (2013
-
(2013)
Nat. Med
, vol.19
, pp. 1252-1263
-
-
Harms, M.1
Seale, P.2
-
112
-
-
84873518501
-
Adaptive thermogenesis in adipocytes: Is beige the new brown
-
Wu, J., Cohen, P., & Spiegelman, B. M. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 27, 234-250 (2013
-
(2013)
Genes Dev
, vol.27
, pp. 234-250
-
-
Wu, J.1
Cohen, P.2
Spiegelman, B.M.3
-
113
-
-
85027909934
-
Adipose tissue browning and metabolic health
-
Bartelt, A., & Heeren, J. Adipose tissue browning and metabolic health. Nat. Rev. Endocrinol. 10, 24-36 (2014
-
(2014)
Nat. Rev. Endocrinol
, vol.10
, pp. 24-36
-
-
Bartelt, A.1
Heeren, J.2
-
114
-
-
82555186955
-
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
-
Nguyen, K. D., et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480, 104-108 (2011
-
(2011)
Nature
, vol.480
, pp. 104-108
-
-
Nguyen, K.D.1
-
115
-
-
84902094655
-
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
-
Qiu, Y., et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157, 1292-1308 (2014
-
(2014)
Cell
, vol.157
, pp. 1292-1308
-
-
Qiu, Y.1
-
116
-
-
84924969384
-
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
-
Brestoff, J. R., et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519, 242-246 (2015
-
(2015)
Nature
, vol.519
, pp. 242-246
-
-
Brestoff, J.R.1
-
117
-
-
84872943896
-
Invariant natural killer T cells: An innate activation scheme linked to diverse effector functions
-
Brennan, P. J., Brigl, M., & Brenner, M. B. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat. Rev. Immunol. 13, 101-117 (2013
-
(2013)
Nat. Rev. Immunol
, vol.13
, pp. 101-117
-
-
Brennan, P.J.1
Brigl, M.2
Brenner, M.B.3
-
118
-
-
84859997837
-
Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin 4 (IL 4)/STAT6 protein signaling axis in obesity
-
Ji, Y., et al. Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin 4 (IL 4)/STAT6 protein signaling axis in obesity. J. Biol. Chem. 287, 13561-13571 (2012
-
(2012)
J. Biol. Chem
, vol.287
, pp. 13561-13571
-
-
Ji, Y.1
-
119
-
-
69249155107
-
Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity
-
Lynch, L., et al. Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity. Eur. J. Immunol. 39, 1893-1901 (2009
-
(2009)
Eur. J. Immunol
, vol.39
, pp. 1893-1901
-
-
Lynch, L.1
-
120
-
-
84866520055
-
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
-
Lynch, L., et al. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 37, 574-587 (2012
-
(2012)
Immunity
, vol.37
, pp. 574-587
-
-
Lynch, L.1
-
121
-
-
84871871453
-
A novel function of adipocytes in lipid antigen presentation to iNKT cells
-
Huh, J. Y., et al. A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol. Cell. Biol. 33, 328-339 (2013
-
(2013)
Mol. Cell. Biol
, vol.33
, pp. 328-339
-
-
Huh, J.Y.1
-
122
-
-
84923384136
-
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of TReg cells and macrophages in adipose tissue
-
Lynch, L., et al. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of TReg cells and macrophages in adipose tissue. Nat. Immunol. 16, 85-95 (2015
-
(2015)
Nat. Immunol
, vol.16
, pp. 85-95
-
-
Lynch, L.1
-
123
-
-
84863808516
-
Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin 4
-
Ji, Y., et al. Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin 4. J. Biol. Chem. 287, 24378-24386 (2012
-
(2012)
J. Biol. Chem
, vol.287
, pp. 24378-24386
-
-
Ji, Y.1
-
124
-
-
79958022995
-
Mice lacking NKT cells but with a complete complement of CD8+ T cells are not protected against the metabolic abnormalities of diet-induced obesity
-
Mantell, B. S., et al. Mice lacking NKT cells but with a complete complement of CD8+ T cells are not protected against the metabolic abnormalities of diet-induced obesity. PLoS ONE 6, e19831 (2011
-
(2011)
PLoS ONE
, vol.6
, pp. e19831
-
-
Mantell, B.S.1
-
125
-
-
80053324882
-
Impact of CD1d deficiency on metabolism
-
Kotas, M. E., et al. Impact of CD1d deficiency on metabolism. PLoS ONE 6, e25478 (2011
-
(2011)
PLoS ONE
, vol.6
, pp. e25478
-
-
Kotas, M.E.1
-
126
-
-
84860794660
-
Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
-
Wu, L., et al. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc. Natl Acad. Sci. USA 109, E1143-E1152 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. E1143-E1152
-
-
Wu, L.1
-
127
-
-
84879120134
-
Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice
-
Strodthoff, D., et al. Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice. Arterioscler. Thromb. Vasc. Biol. 33, 1189-1196 (2013
-
(2013)
Arterioscler. Thromb. Vasc. Biol
, vol.33
, pp. 1189-1196
-
-
Strodthoff, D.1
-
128
-
-
84901992453
-
Adipose invariant natural killer T cells
-
Lynch, L. Adipose invariant natural killer T cells. Immunology 142, 337-346 (2014
-
(2014)
Immunology
, vol.142
, pp. 337-346
-
-
Lynch, L.1
-
129
-
-
84940417328
-
Activated Kupffer cells inhibit insulin sensitivity in obese mice
-
Tencerova, M., et al. Activated Kupffer cells inhibit insulin sensitivity in obese mice. FASEB J. 29, 2959-2969 (2015
-
(2015)
FASEB J.
, vol.29
, pp. 2959-2969
-
-
Tencerova, M.1
-
130
-
-
84929483898
-
Opposite cross-Talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation
-
Pardo, V., Gonzalez-Rodriguez, A., Guijas, C., Balsinde, J., & Valverde, A. M. Opposite cross-Talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation. J. Biol. Chem. 290, 11663-11677 (2015
-
(2015)
J. Biol. Chem
, vol.290
, pp. 11663-11677
-
-
Pardo, V.1
Gonzalez-Rodriguez, A.2
Guijas, C.3
Balsinde, J.4
Valverde, A.M.5
-
131
-
-
85015352880
-
Ontogeny and polarization of macrophages in inflammation: Blood monocytes versus tissue macrophages
-
Dey, A., Allen, J., & Hankey-Giblin, P. A. Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages. Front. Immunol. 5, 683 (2014
-
(2014)
Front. Immunol
, vol.5
, pp. 683
-
-
Dey, A.1
Allen, J.2
Hankey-Giblin, P.A.3
-
132
-
-
77951146612
-
C C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
-
Obstfeld, A. E., et al. C C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 59, 916-925 (2010
-
(2010)
Diabetes
, vol.59
, pp. 916-925
-
-
Obstfeld, A.E.1
-
133
-
-
84962026512
-
Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice
-
Morinaga, H., et al. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes 64, 1120-1130 (2015
-
(2015)
Diabetes
, vol.64
, pp. 1120-1130
-
-
Morinaga, H.1
-
134
-
-
84869208905
-
Differential Ly 6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
-
Ramachandran, P., et al. Differential Ly 6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc. Natl Acad. Sci. USA 109, E3186-E3195 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. E3186-E3195
-
-
Ramachandran, P.1
-
135
-
-
84903625203
-
Infiltrating monocyte-derived macrophages and resident Kupffer cells display different ontogeny and functions in acute liver injury
-
Zigmond, E., et al. Infiltrating monocyte-derived macrophages and resident Kupffer cells display different ontogeny and functions in acute liver injury. J. Immunol. 193, 344-353 (2014
-
(2014)
J. Immunol
, vol.193
, pp. 344-353
-
-
Zigmond, E.1
-
136
-
-
77449117735
-
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
-
Huang, W., et al. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 59, 347-357 (2010
-
(2010)
Diabetes
, vol.59
, pp. 347-357
-
-
Huang, W.1
-
137
-
-
73549090090
-
Kupffer cell activation is a causal factor for hepatic insulin resistance
-
Lanthier, N., et al. Kupffer cell activation is a causal factor for hepatic insulin resistance. Am. J. Physiol. Gastrointest. Liver Physiol. 298, G107-G116 (2010
-
(2010)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.298
, pp. G107-G116
-
-
Lanthier, N.1
-
138
-
-
80555124939
-
Ceramides as modulators of cellular and whole-body metabolism
-
Bikman, B. T., & Summers, S. A. Ceramides as modulators of cellular and whole-body metabolism. J. Clin. Invest. 121, 4222-4230 (2011
-
(2011)
J. Clin. Invest
, vol.121
, pp. 4222-4230
-
-
Bikman, B.T.1
Summers, S.A.2
-
139
-
-
0034607914
-
Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473
-
Schubert, K. M., Scheid, M. P., & Duronio, V. Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. J. Biol. Chem. 275, 13330-13335 (2000
-
(2000)
J. Biol. Chem
, vol.275
, pp. 13330-13335
-
-
Schubert, K.M.1
Scheid, M.P.2
Duronio, V.3
-
140
-
-
84895820360
-
Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans
-
Fink, L. N., et al. Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans. Obesity (Silver Spring) 22, 747-757 (2014
-
(2014)
Obesity (Silver Spring)
, vol.22
, pp. 747-757
-
-
Fink, L.N.1
-
141
-
-
84878833173
-
Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes
-
Fink, L. N., et al. Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes. Diabetologia 56, 1623-1628 (2013
-
(2013)
Diabetologia
, vol.56
, pp. 1623-1628
-
-
Fink, L.N.1
-
142
-
-
66849093697
-
Muscle inflammatory response and insulin resistance: Synergistic interaction between macrophages and fatty acids leads to impaired insulin action
-
Varma, V., et al. Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. Am. J. Physiol. Endocrinol. Metab. 296, E1300-E1310 (2009
-
(2009)
Am. J. Physiol. Endocrinol. Metab
, vol.296
, pp. E1300-E1310
-
-
Varma, V.1
-
143
-
-
84908432350
-
Insulin resistance is associated with MCP1 mediated macrophage accumulation in skeletal muscle in mice and humans
-
Patsouris, D., et al. Insulin resistance is associated with MCP1 mediated macrophage accumulation in skeletal muscle in mice and humans. PLoS ONE 9, e110653 (2014
-
(2014)
PLoS ONE
, vol.9
, pp. e110653
-
-
Patsouris, D.1
-
144
-
-
84921695002
-
Short-Term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects
-
Boon, M. R., et al. Short-Term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects. Clin. Sci. (Lond.) 128, 143-151 (2015
-
(2015)
Clin. Sci. (Lond.)
, vol.128
, pp. 143-151
-
-
Boon, M.R.1
-
145
-
-
84870941378
-
Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages
-
Pillon, N. J., Arane, K., Bilan, P. J., Chiu, T. T., & Klip, A. Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages. Cell Commun. Signal. 10, 30 (2012
-
(2012)
Cell Commun. Signal
, vol.10
, pp. 30
-
-
Pillon, N.J.1
Arane, K.2
Bilan, P.J.3
Chiu, T.T.4
Klip, A.5
-
146
-
-
67650685521
-
Islet-Associated macrophages in type 2 diabetes
-
Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K., & Morgan, N. G. Islet-Associated macrophages in type 2 diabetes. Diabetologia 52, 1686-1688 (2009
-
(2009)
Diabetologia
, vol.52
, pp. 1686-1688
-
-
Richardson, S.J.1
Willcox, A.2
Bone, A.J.3
Foulis, A.K.4
Morgan, N.G.5
-
147
-
-
34548431826
-
Increased number of islet-Associated macrophages in type 2 diabetes
-
Ehses, J. A., et al. Increased number of islet-Associated macrophages in type 2 diabetes. Diabetes 56, 2356-2370 (2007
-
(2007)
Diabetes
, vol.56
, pp. 2356-2370
-
-
Ehses, J.A.1
-
148
-
-
84883784100
-
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates β cell loss in type 2 diabetes
-
Jourdan, T., et al. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates β cell loss in type 2 diabetes. Nat. Med. 19, 1132-1140 (2013
-
(2013)
Nat. Med
, vol.19
, pp. 1132-1140
-
-
Jourdan, T.1
-
149
-
-
84859449180
-
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation
-
Eguchi, K., et al. Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metab. 15, 518-533 (2012
-
(2012)
Cell Metab
, vol.15
, pp. 518-533
-
-
Eguchi, K.1
-
150
-
-
84936095407
-
Minireview: Emerging concepts in islet macrophage biology in type 2 diabetes
-
Morris, D. L. Minireview: emerging concepts in islet macrophage biology in type 2 diabetes. Mol. Endocrinol. 29, 946-962 (2015
-
(2015)
Mol. Endocrinol
, vol.29
, pp. 946-962
-
-
Morris, D.L.1
-
151
-
-
79151478555
-
Type 2 diabetes as an inflammatory disease
-
Donath, M. Y., & Shoelson, S. E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 11, 98-107 (2011
-
(2011)
Nat. Rev. Immunol
, vol.11
, pp. 98-107
-
-
Donath, M.Y.1
Shoelson, S.E.2
-
152
-
-
71949118923
-
Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin 1 receptor I
-
Boni-Schnetzler, M., et al Free Fatty Acids Induce A Proinflammatory Response in Islets Via the Abundantly Expressed Interleukin 1 Receptor I. Endocrinology 150, 5218-5229 (2009
-
(2009)
Endocrinology
, vol.150
, pp. 5218-5229
-
-
Boni-Schnetzler, M.1
-
153
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136-140 (2010
-
(2010)
Nat. Immunol
, vol.11
, pp. 136-140
-
-
Zhou, R.1
Tardivel, A.2
Thorens, B.3
Choi, I.4
Tschopp, J.5
-
154
-
-
84925581887
-
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate β cell stress
-
Hasnain, S. Z., et al. Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate β cell stress. Nat. Med. 20, 1417-1426 (2014
-
(2014)
Nat. Med
, vol.20
, pp. 1417-1426
-
-
Hasnain, S.Z.1
-
155
-
-
84929504321
-
Angiotensin II induces interleukin 1β mediated islet inflammation and β cell dysfunction independently of vasoconstrictive effects
-
Sauter, N. S., et al. Angiotensin II induces interleukin 1β mediated islet inflammation and β cell dysfunction independently of vasoconstrictive effects. Diabetes 64, 1273-1283 (2015
-
(2015)
Diabetes
, vol.64
, pp. 1273-1283
-
-
Sauter, N.S.1
-
156
-
-
84866168894
-
Functional interactions between the gut microbiota and host metabolism
-
Tremaroli, V., & Backhed, F. Functional interactions between the gut microbiota and host metabolism. Nature 489, 242-249 (2012
-
(2012)
Nature
, vol.489
, pp. 242-249
-
-
Tremaroli, V.1
Backhed, F.2
-
157
-
-
33845901507
-
Microbial ecology: Human gut microbes associated with obesity
-
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023 (2006
-
(2006)
Nature
, vol.444
, pp. 1022-1023
-
-
Ley, R.E.1
Turnbaugh, P.J.2
Klein, S.3
Gordon, J.I.4
-
158
-
-
33845874101
-
An obesity-Associated gut microbiome with increased capacity for energy harvest
-
Turnbaugh, P. J., et al. An obesity-Associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006
-
(2006)
Nature
, vol.444
, pp. 1027-1031
-
-
Turnbaugh, P.J.1
-
159
-
-
41849127118
-
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
-
Turnbaugh, P. J., Backhed, F., Fulton, L., & Gordon, J. I. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3, 213-223 (2008
-
(2008)
Cell Host Microbe
, vol.3
, pp. 213-223
-
-
Turnbaugh, P.J.1
Backhed, F.2
Fulton, L.3
Gordon, J.I.4
-
160
-
-
84868687011
-
Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
-
Caesar, R., et al. Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice. Gut 61, 1701-1707 (2012
-
(2012)
Gut
, vol.61
, pp. 1701-1707
-
-
Caesar, R.1
-
161
-
-
84866604327
-
Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors
-
Teixeira, T. F., et al. Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors. Clin. Nutr. 31, 735-740 (2012
-
(2012)
Clin. Nutr
, vol.31
, pp. 735-740
-
-
Teixeira, T.F.1
-
162
-
-
80052278497
-
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: Molecular mechanisms and probiotic treatment
-
Amar, J., et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol. Med. 3, 559-572 (2011
-
(2011)
EMBO Mol. Med
, vol.3
, pp. 559-572
-
-
Amar, J.1
-
163
-
-
48249125862
-
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
-
Cani, P. D., et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57, 1470-1481 (2008
-
(2008)
Diabetes
, vol.57
, pp. 1470-1481
-
-
Cani, P.D.1
-
164
-
-
84926678423
-
High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability
-
Johnson, A. M., et al. High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. PLoS ONE 10, e0122195 (2015
-
(2015)
PLoS ONE
, vol.10
, pp. e0122195
-
-
Johnson, A.M.1
-
165
-
-
84908311821
-
Interleukin 22 alleviates metabolic disorders and restores mucosal immunity in diabetes
-
Wang, X., et al. Interleukin 22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature 514, 237-241 (2014
-
(2014)
Nature
, vol.514
, pp. 237-241
-
-
Wang, X.1
-
166
-
-
64149121817
-
Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes
-
Goldfine, A. B., et al. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin. Transl. Sci. 1, 36-43 (2008
-
(2008)
Clin. Transl. Sci
, vol.1
, pp. 36-43
-
-
Goldfine, A.B.1
-
167
-
-
77950885686
-
The effects of salsalate on glycemic control in patients with type 2 diabetes: A randomized trial
-
Goldfine, A. B., et al. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann. Intern. Med. 152, 346-357 (2010
-
(2010)
Ann. Intern. Med
, vol.152
, pp. 346-357
-
-
Goldfine, A.B.1
-
168
-
-
84876485218
-
A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance
-
Goldfine, A. B., et al. A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia 56, 714-723 (2013
-
(2013)
Diabetologia
, vol.56
, pp. 714-723
-
-
Goldfine, A.B.1
-
169
-
-
84897894108
-
The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes
-
Barzilay, J. I., et al. The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes. Diabetes Care 37, 1083-1091 (2014
-
(2014)
Diabetes Care
, vol.37
, pp. 1083-1091
-
-
Barzilay, J.I.1
-
170
-
-
84893646664
-
Aspirin in type 2 diabetes, a randomised controlled study: Effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function
-
Raghavan, R. P., Laight, D. W., & Cummings, M. H. Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function. Int. J. Clin. Pract. 68, 271-277 (2014
-
(2014)
Int. J. Clin. Pract
, vol.68
, pp. 271-277
-
-
Raghavan, R.P.1
Laight, D.W.2
Cummings, M.H.3
-
171
-
-
70350436088
-
The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β cell dysfunction in overweight and obese nondiabetic men
-
Xiao, C., Giacca, A., & Lewis, G. F. The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β cell dysfunction in overweight and obese nondiabetic men. Am. J. Physiol. Endocrinol. Metab. 297, E1205-E1211 (2009
-
(2009)
Am. J. Physiol. Endocrinol. Metab
, vol.297
, pp. E1205-E1211
-
-
Xiao, C.1
Giacca, A.2
Lewis, G.F.3
-
172
-
-
47549104496
-
Salicylates increase insulin secretion in healthy obese subjects
-
Fernandez-Real, J. M., et al. Salicylates increase insulin secretion in healthy obese subjects. J. Clin. Endocrinol. Metab. 93, 2523-2530 (2008
-
(2008)
J. Clin. Endocrinol. Metab
, vol.93
, pp. 2523-2530
-
-
Fernandez-Real, J.M.1
-
173
-
-
79952856377
-
Chronic TNF α neutralization does not improve insulin resistance or endothelial function in 'healthy' men with metabolic syndrome
-
Wascher, T. C., et al. Chronic TNF α neutralization does not improve insulin resistance or endothelial function in 'healthy' men with metabolic syndrome. Mol. Med. 17, 189-193 (2011
-
(2011)
Mol. Med
, vol.17
, pp. 189-193
-
-
Wascher, T.C.1
-
174
-
-
78650917112
-
TNF α antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome
-
Stanley, T. L., et al. TNF α antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. J. Clin. Endocrinol. Metab. 96, E146-E150 (2011
-
(2011)
J. Clin. Endocrinol. Metab
, vol.96
, pp. E146-E150
-
-
Stanley, T.L.1
-
175
-
-
79959426992
-
Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis
-
Solomon, D. H., et al. Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA 305, 2525-2531 (2011
-
(2011)
JAMA
, vol.305
, pp. 2525-2531
-
-
Solomon, D.H.1
-
176
-
-
84887618957
-
Impact of interleukin 1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: Results of secondary endpoints from a randomized, placebo-controlled trial
-
Hensen, J., Howard, C. P., Walter, V., & Thuren, T. Impact of interleukin 1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: results of secondary endpoints from a randomized, placebo-controlled trial. Diabetes Metab. 39, 524-531 (2013
-
(2013)
Diabetes Metab
, vol.39
, pp. 524-531
-
-
Hensen, J.1
Howard, C.P.2
Walter, V.3
Thuren, T.4
-
177
-
-
84864386088
-
Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes
-
Cavelti-Weder, C., et al. Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care 35, 1654-1662 (2012
-
(2012)
Diabetes Care
, vol.35
, pp. 1654-1662
-
-
Cavelti-Weder, C.1
-
178
-
-
84878774925
-
Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL 1β antibody, in patients with type 2 diabetes
-
Sloan-Lancaster, J., et al. Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL 1β antibody, in patients with type 2 diabetes. Diabetes Care 36, 2239-2246 (2013
-
(2013)
Diabetes Care
, vol.36
, pp. 2239-2246
-
-
Sloan-Lancaster, J.1
-
179
-
-
84896799696
-
Insulin sensitizing and anti-inflammatory effects of thiazolidinediones are heightened in obese patients
-
Esterson, Y. B., et al. Insulin sensitizing and anti-inflammatory effects of thiazolidinediones are heightened in obese patients. J. Investig. Med. 61, 1152-1160 (2013
-
(2013)
J. Investig. Med
, vol.61
, pp. 1152-1160
-
-
Esterson, Y.B.1
-
180
-
-
84878221256
-
Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-Treated diabetic humans
-
Koppaka, S., et al. Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-Treated diabetic humans. Diabetes 62, 1843-1854 (2013
-
(2013)
Diabetes
, vol.62
, pp. 1843-1854
-
-
Koppaka, S.1
-
181
-
-
84862986986
-
PPAR γ is a major driver of the accumulation and phenotype of adipose tissue TReg cells
-
Cipolletta, D., et al. PPAR γ is a major driver of the accumulation and phenotype of adipose tissue TReg cells. Nature 486, 549-553 (2012
-
(2012)
Nature
, vol.486
, pp. 549-553
-
-
Cipolletta, D.1
-
182
-
-
84877329207
-
PPARγ signaling and metabolism: The good, the bad and the future
-
Ahmadian, M., et al. PPARγ signaling and metabolism: the good, the bad and the future. Nat. Med. 19, 557-566 (2013
-
(2013)
Nat. Med
, vol.19
, pp. 557-566
-
-
Ahmadian, M.1
-
183
-
-
84863012459
-
Fibroblast growth factor 21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
-
Dutchak, P. A., et al. Fibroblast growth factor 21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 148, 556-567 (2012
-
(2012)
Cell
, vol.148
, pp. 556-567
-
-
Dutchak, P.A.1
-
184
-
-
77956165390
-
GPR120 is an ? 3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
-
Oh, D. Y., et al. GPR120 is an ? 3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142, 687-698 (2010
-
(2010)
Cell
, vol.142
, pp. 687-698
-
-
Oh, D.Y.1
-
185
-
-
84876580724
-
3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance
-
Spencer, M., et al. 3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Diabetes 62, 1709-1717 (2013
-
(2013)
Diabetes
, vol.62
, pp. 1709-1717
-
-
Spencer, M.1
-
186
-
-
84891596777
-
3 PUFAs improved endothelial function and arterial stiffness with a parallel anti-inflammatory effect in adults with metabolic syndrome
-
Tousoulis, D., et al. 3 PUFAs improved endothelial function and arterial stiffness with a parallel anti-inflammatory effect in adults with metabolic syndrome. Atherosclerosis 232, 10-16 (2014
-
(2014)
Atherosclerosis
, vol.232
, pp. 10-16
-
-
Tousoulis, D.1
-
187
-
-
84907612482
-
A Gpr120 selective agonist improves insulin resistance and chronic inflammation in obese mice
-
Oh, D. Y., et al. A Gpr120 selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat. Med. 20, 942-947 (2014
-
(2014)
Nat. Med
, vol.20
, pp. 942-947
-
-
Oh, D.Y.1
-
188
-
-
84878002397
-
Orally-Administered chemokine receptor CCR2 antagonist CCX140 B in type 2 diabetes: A pilot double-blind, randomized clinical trial
-
Hanefeld, M., et al. Orally-Administered chemokine receptor CCR2 antagonist CCX140 B in type 2 diabetes: a pilot double-blind, randomized clinical trial. J. Diabetes Metab. 3, 225 (2012
-
(2012)
J. Diabetes Metab
, vol.3
, pp. 225
-
-
Hanefeld, M.1
-
189
-
-
84913543785
-
CCR2 antagonism in patients with type 2 diabetes mellitus: A randomized, placebo-controlled study
-
Di Prospero, N. A., et al. CCR2 antagonism in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study. Diabetes Obes. Metab. 16, 1055-1064 (2014
-
(2014)
Diabetes Obes. Metab
, vol.16
, pp. 1055-1064
-
-
Di Prospero, N.A.1
-
190
-
-
84929147898
-
Roux en y gastric bypass surgery induces early plasma metabolomic and lipidomic alterations in humans associated with diabetes remission
-
Arora, T., et al. Roux en Y gastric bypass surgery induces early plasma metabolomic and lipidomic alterations in humans associated with diabetes remission. PLoS ONE 10, e0126401 (2015
-
(2015)
PLoS ONE
, vol.10
, pp. e0126401
-
-
Arora, T.1
|