Thermogenic activation induces FGF21 expression and release in brown adipose tissue

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 12983-12990

  Hondares, Elayne ^a   Iglesias, Roser ^a   Giralt, Albert ^a   Gonzalez, Frank J ^b   Giralt, Marta ^a   Mampel, Teresa ^a   Villarroya, Francesc ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTES; ADIPOSE TISSUE; BLOOD FLOW; GENE PROMOTER; GENE TRANSCRIPTIONS; GLUCOSE HOMEOSTASIS; IN-VIVO; INSULIN SENSITIVITY; P38 MAPK; PROTEIN KINASE A; THERMOGENIC ACTIVITY;

BLOOD; FETAL MONITORING; GENES; GLUCOSE; TISSUE;

TRANSCRIPTION;

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; 2 CHLORO 5 NITROBENZANILIDE; ACTIVATING TRANSCRIPTION FACTOR 2; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FIBROBLAST GROWTH FACTOR 21; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; GENE CONTROL; GENETIC TRANSCRIPTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; THERMOGENESIS; TRANSCRIPTION REGULATION;

ADIPOSE TISSUE, BROWN; ANIMALS; CELLS, CULTURED; COLD TEMPERATURE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOCRINE GLANDS; ENZYME ACTIVATION; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; MALE; MICE; MICE, MUTANT STRAINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; THERMOGENESIS; TRANSCRIPTION, GENETIC;

RATTUS;

EID: 79953886306     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.215889     Document Type: Article

References (33)

1. Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., Gromada, J., Brozinick, J. T., Hawkins, E. D., Wroblewski, V. J., Li, D. S., Mehrbod, F., Jaskunas, S. R., and Shanafelt, A. B. (2005) J. Clin. Invest. 115, 1627-1635
2. Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J. K., Gerard, R. D., Burgess, S. C., Hammer, R. E., Mangelsdorf, D. J., and Kliewer, S. A. (2007) Cell Metab. 5, 415-425
3. Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., and Maratos-Flier, E. (2007) Cell Metab. 5, 426-437
4. Gälman, C., Lundåsen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafström, I., Dahlin, M., Amark, P., Angelin, B., and Rudling, M. (2008) Cell Metab. 8, 169-174
5. Berglund, E. D., Li, C. Y., Bina, H. A., Lynes, S. E., Michael, M. D., Shanafelt, A. B., Kharitonenkov, A., and Wasserman, D. H. (2009) Endocrinology 150, 4084-4093
6. Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., and Kharitonenkov, A. (2008) Endocrinology 149, 6018-6027
7. Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y. S., Lindberg, R. A., Chen, J. L., Jung, D. Y., Zhang, Z., Ko, H. J., Kim, J. K., and Véniant, M. M. (2009) Diabetes 58, 250-259
8. Badman, M. K., Koester, A., Flier, J. S., Kharitonenkov, A., and Maratos-Flier, E. (2009) Endocrinology 150, 4931-4940
9. Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi,M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., and Burgess, S. C. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 10853-10858
10. Hotta, Y., Nakamura, H., Konishi, M., Murata, Y., Takagi, H., Matsumura, S., Inoue, K., Fushiki, T., and Itoh, N. (2009) Endocrinology 150, 4625-4633
11. Arner, P., Pettersson, A., Mitchell, P. J., Dunbar, J. D., Kharitonenkov, A., and Rydén, M. (2008) FEBS Lett. 582, 1725-1730
12. Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., and Villarroya, F. (2010) Cell Metab. 11, 206-212
13. Mai, K., Andres, J., Biedasek, K., Weicht, J., Bobbert, T., Sabath, M., Meinus, S., Reinecke, F., Möhlig, M., Weickert, M. O., Clemenz, M., Pfeiffer, A. F., Kintscher, U., Spuler, S., and Spranger, J. (2009) Diabetes 58, 1532-1538
14. Muise, E. S., Azzolina, B., Kuo, D. W., El-Sherbeini, M., Tan, Y., Yuan, X., Mu, J., Thompson, J. R., Berger, J. P., and Wong, K. K. (2008) Mol. Pharmacol. 74, 403-412
15. Moyers, J. S., Shiyanova, T. L., Mehrbod, F., Dunbar, J. D., Noblitt, T. W., Otto, K. A., Reifel-Miller, A., and Kharitonenkov, A. (2007) J. Cell Physiol. 210, 1-6
16. Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., and Walsh, K. (2008) FEBS Lett. 582, 3805-3810
17. Enerbäck, S. (2010) Cell Metab. 11, 248-252
18. Fernandez, J. A., Mampel, T., Villarroya, F., and Iglesias, R. (1987) Biochem. J. 243, 281-284
19. Foster, D. O., and Frydman, M. L. (1979) Can J. Physiol. Pharmacol. 57, 257-270
20. Jones, R. G., and Williamson, D. H. (1984) Biosci. Rep. 4, 421-426
21. Carmona, M. C., Hondares, E., Rodríguez de la Concepción, M. L., Rodríguez-Sureda, V., Peinado-Onsurbe, J., Poli, V., Iglesias, R., Villarroya, F., and Giralt, M. (2005) Biochem. J. 389, 47-56
22. Muramatsu, M., Kaibuchi, K., and Arai, K. (1989) Mol. Cell Biol. 9, 831-836
23. Raingeaud, J., Whitmarsh, A. J., Barrett, T., Dérijard, B., and Davis, R. J. (1996) Mol. Cell Biol. 16, 1247-1255
24. Villena, J. A., Hock, M. B., Chang, W. Y., Barcas, J. E., Giguère, V., and Kralli, A. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 1418-1423
25. Cannon, B., and Nedergaard, J. (2004) Physiol. Rev. 84, 277-359
26. Petrovic, N., Shabalina, I. G., Timmons, J. A., Cannon, B., and Nedergaard, J. (2008) Am. J. Physiol. Endocrinol. Metab. 295, E287-296
27. Collins, S., Cao, W., and Robidoux, J. (2004) Mol. Endocrinol. 18, 2123-2131
28. Xu, J., Stanislaus, S., Chinookoswong, N., Lau, Y. Y., Hager, T., Patel, J., Ge, H., Weiszmann, J., Lu, S. C., Graham, M., Busby, J., Hecht, R., Li, Y. S., Li, Y., Lindberg, R. A., and Véniant, M. M. (2009) Am. J. Physiol. Endocrinol. Metab. 297, E1105-1114
29. Silva, J. E., and Larsen, P. R. (1985) J. Clin. Invest. 76, 2296-2305
30. Bukowiecki, L. J. (1989) Can J. Physiol. Pharmacol. 67, 382-393
31. Lansberg, L., and Young, J. B. (1983) in Autonomic Regulation of Thermogenesis: Mammalian Thermogenesis (Girardier, L., and Stock, M. J., eds) pp. 99-140, Champan and Hall, New York
32. Sarruf, D. A., Thaler, J. P., Morton, G. J., German, J., Fischer, J. D., Ogimoto, K., and Schwartz, M. W. (2010) Diabetes 59, 1817-1824
33. Seale, P., Kajimura, S., and Spiegelman, B. M. (2009) Genes Dev. 23, 788-797