Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Arner, Peter ^a   Arner, Erik ^a   Hammarstedt, Ann ^b   Smith, Ulf ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ABDOMINAL FAT; ADIPOGENESIS; ADIPOSE TISSUE CELL; ADULT; ARTICLE; BIOPSY TECHNIQUE; CELL EXPANSION; CELL SIZE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; GENETIC PREDISPOSITION; HUMAN; HUMAN TISSUE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN BLOOD LEVEL; ADIPOSE TISSUE; GENETICS; PATHOLOGY;

ADIPOSE TISSUE; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HUMANS; OBESITY; OVERWEIGHT;

EID: 79954459509     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018284     Document Type: Article

References (22)

1. Zimmet P, Alberti KG, Shaw J, (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782-787.
2. Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, et al. (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 359: 2220-2232.
3. Despres JP, Lemieux I, (2006) Abdominal obesity and metabolic syndrome. Nature 444: 881-887.
4. Wilding J, Finer N, (2006) Obesity and risk of myocardial infarction: the INTERHEART study. Lancet 367: 1053; author reply 1054.
5. Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U, (1983) Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 72: 1150-1162.
6. Arner E, Westermark PO, Spalding KL, Britton T, Ryden M, et al. (2010) Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59: 105-109.
7. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, et al. (2008) Dynamics of fat cell turnover in humans. Nature 453: 783-787.
8. Tchoukalova YD, Votruba SB, Tchkonia T, Giorgadze N, Kirkland JL, et al. (2010) Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci U S A 107: 18226-18231.
9. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808.
10. Jansson PA, Pellme F, Hammarstedt A, Sandqvist M, Brekke H, et al. (2003) A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin. FASEB J 17: 1434-1440.
11. Carvalho E, Jansson PA, Nagaev I, Wenthzel AM, Smith U, (2001) Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport. FASEB J 15: 1101-1103.
12. Isakson P, Hammarstedt A, Gustafson B, Smith U, (2009) Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes 58: 1550-1557.
13. Shepherd PR, Kahn BB, (1999) Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus. N Engl J Med 341: 248-257.
14. Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH, et al. (1997) Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A 94: 4171-4175.
15. Smith U, (2002) Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance-is insulin resistance initiated in the adipose tissue? Int J Obes Relat Metab Disord 26: 897-904.
16. Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vanttinen M, et al. (2008) Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study. Diabetologia 51: 502-511.
17. Hellstrom L, Langin D, Reynisdottir S, Dauzats M, Arner P, (1996) Adipocyte lipolysis in normal weight subjects with obesity among first-degree relatives. Diabetologia 39: 921-928.
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
19. Weyer C, Foley JE, Bogardus C, Tataranni PA, Pratley RE, (2000) Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 43: 1498-1506.
20. Lonn M, Mehlig K, Bengtsson C, Lissner L, (2010) Adipocyte size predicts incidence of type 2 diabetes in women. FASEB J 24: 326-331.
21. Gustafson B, Smith U, (2006) Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 281: 9507-9516.
22. Serino M, Menghini R, Fiorentino L, Amoruso R, Mauriello A, et al. (2007) Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes. Diabetes 56: 2541-2546.