A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance

Diabetologia

Volumn 56, Issue 4, 2013, Pages 714-723

  Goldfine, A B ^a   Conlin, P R ^b   Halperin, F ^a   Koska, J ^c   Permana, P ^c   Schwenke, D ^c   Shoelson, S E ^a   Reaven, P D ^c,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c CARL T HAYDEN VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Adipose tissue; Cardiovascular risk factors; Endothelial function; Impaired glucose tolerance; Inflammation; Insulin resistance; Salicylates

Indexed keywords

ADIPONECTIN; C PEPTIDE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; SALSALATE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIET RESTRICTION; DRUG DOSE INCREASE; DRUG TOLERABILITY; ENDOTHELIUM; FEMALE; GASTROINTESTINAL SYMPTOM; GLUCOSE BLOOD LEVEL; HEALTH CARE SYSTEM; HUMAN; HYPOGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; INSULIN CLEARANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TINNITUS; VETERAN;

ADIPONECTIN; ADIPOSE TISSUE; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD GLUCOSE; C-PEPTIDE; CARDIOVASCULAR DISEASES; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; NF-KAPPA B; RISK FACTORS; SALICYLATES; TRIGLYCERIDES;

EID: 84876485218     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2819-3     Document Type: Article

References (43)

1. Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Investig 116:1793-1801
2. Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867
3. Ebstein W (1876) Zur therapie des Diabetes mellitus, insbesondere uber die Anwendung des salicylsauren Natron bei demselben. Berliner Klinische Wochenschrift 13:337-340 [article in German]
4. Gilgore SG, Rupp JJ (1962) The long-term response of diabetes mellitus to salicylate therapy: report of a case. JAMA 180:65-66
5. Hecht A, Goldner MG (1959) Reappraisal of the hypoglycemic action of acetylsalicylate. Metabolism 8:418-428
6. Reid J, Macdougall AI, Andrews MM (1957) Aspirin and diabetes mellitus. Br Med J 2:1071-1074
7. Williamson RT (1901) On the treatment of glycosuria and diabetes mellitus with sodium salicylate. Br Med J 1:760-762
8. Kopp E, Ghosh S (1994) Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265:956-959
9. Yin MJ, Yamamoto Y, Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396:77-80
10. Yuan M, Konstantopoulos N, Lee J et al (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293:1673-1677
11. Arkan MC, Hevener AL, Greten FR et al (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191-198
12. Kim JK, Kim YJ, Fillmore JJ et al (2001) Prevention of fat-induced insulin resistance by salicylate. J Clin Investig 108:437-446
13. Cai D, Yuan M, Frantz DF et al (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183-190
14. Goldfine AB, Fonseca V, Jablonski KA, Pyle L, Staten MA, Shoelson SE (2010) The effects of salsalate on glycemic control in patients with type 2 diabetes. Ann Intern Med 152:346-357
15. Hundal RS, Petersen KF, Mayerson AB et al (2002) Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Investig 109:1321-1326
16. Goldfine AB, Silver R, Aldhahi W et al (2008) Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci 1:36-43
17. Faghihimani E, Aminorroaya A, Rezvanian H, Adibi P, Ismail-Beigi F, Amini M (2011) Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes. Acta Diabetol. doi: 10.1007/s00592-011-0329-2
18. Fleischman A, Shoelson SE, Bernier R, Goldfine AB (2008) Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 31:289-294
19. Koska J, Ortega E, Bunt JC et al (2009) The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study. Diabetologia 52:385-393
20. Bratusch-Marrain PR, Vierhapper H, Komjati M, Waldhausl WK (1985) Acetyl-salicylic acid impairs insulin-mediated glucose utilization and reduces insulin clearance in healthy and non-insulin-dependent diabetic man. Diabetologia 28:671-676
21. Fernandez-Real J-M, Lopez-Bermejo A, Ropero A-B et al (2008) Salicylates increase insulin secretion in healthy obese subjects. J Clin Endocrinol Metab 93:2523-2530
22. Newman WP, Brodows RG (1983) Aspirin causes tissue insensitivity to insulin in normal man. J Clin Endocrinol Metab 57:1102-1106
23. Faghihimani E, Aminorroaya A, Rezvanian H, Adibi P, Ismail-Beigi F, Amini M (2012) Salsalate reduces insulin resistance and plasma glucose level in persons with prediabetes. Endocr Pract 11:1-17
24. Giugliano D, Ceriello A, Saccomanno F, Quatraro A, Paolisso G, D'Onofrio F (1985) Effects of salicylate, tolbutamide, and prostaglandin E2 on insulin responses to glucose in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 61:160-166
25. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
26. Jones CNO, Pei D, Staris P, Polonsky KS, Chen YD-I, Reaven GM (1997) Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals. J Clin Endocrinol Metab 82:1834-1838
27. Koska J, Schwartz EA, Mullin MP, Schwenke DC, Reaven PD (2010) Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes. Diabetes Care 33:1028-1030
28. Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Kuvin JT, Lerman A (2004) Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol 44:2137-2141
29. Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J (2003) Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem 278:24944-24950
30. Ishihara K, Horiguchi K, Yamagishi N, Hatayama T (2003) Identification of sodium salicylate as an hsp inducer using a simple screening system for stress response modulators in mammalian cells. Eur J Biochem 270:3461-3468
31. Hawley SA, Fullerton MD, Ross FA et al (2012) The ancient drug salicylate directly activates AMP-activated protein kinase. Science 336:918-922
32. Hines WJ, Smith MJ (1964) Inhibition of dehydrogenases by salicylate. Nature 201:192
33. Jurivich DA, Sistonen L, Kroes RA, Morimoto RI (1992) Effect of sodium salicylate on the human heat shock response. Science 255:1243-1245
34. Nixon M, Wake DJ, Livingstone DE et al (2012) Salicylate downregulates 11beta-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes 61:790-796
35. van Diepen JA, Vroegrijk IO, Berbee JF et al (2011) Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet. Am J Physiol Endocrinol Metab 301:E1099-E1107
36. Kadowaki T, Yamauchi T (2005) Adiponectin and adiponectin receptors. Endocr Rev 26:439-451
37. Robertson RP, Chen M (1977) Modulation of insulin secretion in normal and diabetic humans by prostaglandin E and sodium salicylate. Trans Assoc Am Phys 90:353-365
38. Tran PO, Gleason CE, Robertson RP (2002) Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. Diabetes 51:1772-1778
39. Giugliano D, Sacca L, Scognamiglio G, Ungaro B, Torella R (1982) Influence of acetylsalicylic acid on glucose turnover in normal man. Diabetes Metabol 8:279-282
40. Mohlig M, Freudenberg M, Bobbert T et al (2006) Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men. J Clin Endocrinol Metab 91:964-967
41. van der Crabben SN, Allick G, Ackermans MT, Endert E, Romijn JA, Sauerwein HP (2008) Prolonged fasting induces peripheral insulin resistance, which is not ameliorated by high-dose salicylate. J Clin Endocrinol Metab 93:638-641
42. Xiao C, Giacca A, Lewis GF (2009) The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and beta-cell dysfunction in overweight and obese nondiabetic men. Am J Physiol Endocrinol Metab 297:E1205-E1211
43. Yki-Jarvinen H, Mott D, Young AA, Stone K, Bogardus C (1987) Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. J Clin Investig 80:95-100