The ancient drug salicylate directly activates AMP-activated protein kinase

Science

Volumn 336, Issue 6083, 2012, Pages 918-922

  Hawley, Simon A ^a   Fullerton, Morgan D ^b   Ross, Fiona A ^a   Schertzer, Jonathan D ^b   Chevtzoff, Cyrille ^a   Walker, Katherine J ^a   Peggie, Mark W ^a   Zibrova, Darya ^a   Green, Kevin A ^a   Mustard, Kirsty J ^a   Kemp, Bruce E ^c   Sakamoto, Kei ^a,d   Steinberg, Gregory R ^b,c   Hardie, D Grahame ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ACETYL COENZYME A CARBOXYLASE; ACETYLSALICYLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SALICYLIC ACID;

CONCENTRATION (COMPOSITION); DRUG; ENZYME ACTIVITY; GROWTH; METABOLISM; MOLECULAR ANALYSIS; PROTEIN; PUBLIC HEALTH; SALICYLATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG BINDING; DRUG MEGADOSE; EMBRYO; ENZYME ACTIVATION; ENZYME METABOLISM; FATTY ACID BLOOD LEVEL; HUMAN; HUMAN CELL; KIDNEY CELL; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

MUS;

EID: 84861222690     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1215327     Document Type: Article

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