Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

eLife

Volumn 2013, Issue 2, 2013, Pages

  Mowers, Jonathan ^a,b   Uhm, Maeran ^a,b   Reilly, Shannon M ^a   Simon, Joshua ^a   Leto, Dara ^a,c   Chiang, Shian Huey ^a,d   Chang, Louise ^a   Saltiel, Alan R ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c STANFORD UNIVERSITY   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMLEXANOX; CATECHOLAMINE; CYCLIC AMP; I KAPPA B KINASE EPSILON; PHOSPHODIESTERASE; PROTEIN KINASE; TBK1 KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; AMINOPYRIDINE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR; CHOLESTEROL ESTERASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DISODIUM (R,R)-5-(2-((2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)-AMINO)PROPYL)-1,3-BENZODIOXOLE-2,3-DICARBOXYLATE; I KAPPA B KINASE; IKBKE PROTEIN, MOUSE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; PDE3B PROTEIN, HUMAN; PDE3B PROTEIN, MOUSE; PHOSPHODIESTERASE III; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME IMMUNOASSAY; GENE EXPRESSION; INFLAMMATION; LIPOLYSIS; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; OBESITY; PHOSPHORYLATION; PROTEIN PURIFICATION; WESTERN BLOTTING; 3T3 CELL LINE; ADIPOCYTE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DISEASE MODEL; DRUG EFFECTS; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; TIME; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE, WHITE; ADRENERGIC BETA-3 RECEPTOR AGONISTS; AMINOPYRIDINES; ANIMALS; CATECHOLAMINES; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DIOXOLES; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; INFLAMMATION; ION CHANNELS; LIPOLYSIS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; OBESITY; PHOSPHORYLATION; POLY I-C; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; STEROL ESTERASE; TIME FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84891534573     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.01119     Document Type: Article

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