Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

Cell

Volumn 157, Issue 6, 2014, Pages 1339-1352

  Lee, Yun Sok ^a   Kim, Jung Whan ^b   Osborne, Olivia ^a   Oh, Da Young ^a   Sasik, Roman ^a   Schenk, Simon ^b   Chen, Ai ^a   Chung, Heekyung ^a   Murphy, Anne ^b   Watkins, Steven M ^c   Quehenberger, Oswald ^a   Johnson, Randall S ^b,d,e   Olefsky, Jerrold M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Lipomics Technologies   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ADENINE NUCLEOTIDE TRANSLOCASE 2; INNER MITOCHONDRIAL MEMBRANE PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; FATTY ACID; HIF1A PROTEIN, MOUSE; LACTIC ACID; NITRIC OXIDE; OXYGEN;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL RESPIRATION; FEEDING; GLUCOSE TOLERANCE; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; CELL HYPOXIA; CONTROLLED STUDY; ANIMAL; GENETICS; KNOCKOUT MOUSE; METABOLISM;

ADENINE NUCLEOTIDE TRANSLOCATOR 2; ADIPOCYTES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; DIET, HIGH-FAT; FATTY ACIDS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; INSULIN RESISTANCE; LACTIC ACID; MICE; MICE, KNOCKOUT; NITRIC OXIDE; OBESITY; OXYGEN;

EID: 84902075318     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.05.012     Document Type: Article

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