메뉴 건너뛰기




Volumn 13, Issue 1, 2011, Pages 11-22

NF-κB, inflammation, and metabolic disease

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA RECEPTOR ANTAGONIST; SALICYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

EID: 78650878363     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2010.12.008     Document Type: Review
Times cited : (1605)

References (89)
  • 1
    • 33748756170 scopus 로고    scopus 로고
    • IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation
    • M. Adli, and A.S. Baldwin IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation J. Biol. Chem. 281 2006 26976 26984
    • (2006) J. Biol. Chem. , vol.281 , pp. 26976-26984
    • Adli, M.1    Baldwin, A.S.2
  • 8
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • D. Cai, M. Yuan, D.F. Frantz, P.A. Melendez, L. Hansen, J. Lee, and S.E. Shoelson Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat. Med. 11 2005 183 190
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 9
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • E.E. Calle, C. Rodriguez, K. Walker-Thurmond, and M.J. Thun Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N. Engl. J. Med. 348 2003 1625 1638
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 10
    • 0038142707 scopus 로고    scopus 로고
    • Nuclear factor kappaB protects pancreatic beta-cells from tumor necrosis factor-alpha-mediated apoptosis
    • I. Chang, S. Kim, J.Y. Kim, N. Cho, Y.H. Kim, H.S. Kim, M.K. Lee, K.W. Kim, and M.S. Lee Nuclear factor kappaB protects pancreatic beta-cells from tumor necrosis factor-alpha-mediated apoptosis Diabetes 52 2003 1169 1175
    • (2003) Diabetes , vol.52 , pp. 1169-1175
    • Chang, I.1    Kim, S.2    Kim, J.Y.3    Cho, N.4    Kim, Y.H.5    Kim, H.S.6    Lee, M.K.7    Kim, K.W.8    Lee, M.S.9
  • 13
    • 44449110675 scopus 로고    scopus 로고
    • Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
    • J.E. Davis, N.K. Gabler, J. Walker-Daniels, and M.E. Spurlock Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat Obesity (Silver Spring) 16 2008 1248 1255
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1248-1255
    • Davis, J.E.1    Gabler, N.K.2    Walker-Daniels, J.3    Spurlock, M.E.4
  • 14
    • 78650762257 scopus 로고    scopus 로고
    • Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes
    • 10.1016/j.jnutbio.2009.12.008 in press. Published online April 29, 2010
    • J.E. Davis, D.R. Braucher, J. Walker-Daniels, and M.E. Spurlock Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes J. Nutr. Biochem. 2010 10.1016/j.jnutbio.2009.12.008 in press. Published online April 29, 2010
    • (2010) J. Nutr. Biochem.
    • Davis, J.E.1    Braucher, D.R.2    Walker-Daniels, J.3    Spurlock, M.E.4
  • 15
    • 0030699420 scopus 로고    scopus 로고
    • Metabolic costs of mounting an antigen-stimulated immune response in adult and aged C57BL/6J mice
    • G.E. Demas, V. Chefer, M.I. Talan, and R.J. Nelson Metabolic costs of mounting an antigen-stimulated immune response in adult and aged C57BL/6J mice Am. J. Physiol. 273 1997 R1631 R1637
    • (1997) Am. J. Physiol. , vol.273
    • Demas, G.E.1    Chefer, V.2    Talan, M.I.3    Nelson, R.J.4
  • 22
    • 38949119419 scopus 로고    scopus 로고
    • Salsalate improves glycemia and inflammatory parameters in obese young adults
    • A. Fleischman, S.E. Shoelson, R. Bernier, and A.B. Goldfine Salsalate improves glycemia and inflammatory parameters in obese young adults Diabetes Care 31 2008 289 294
    • (2008) Diabetes Care , vol.31 , pp. 289-294
    • Fleischman, A.1    Shoelson, S.E.2    Bernier, R.3    Goldfine, A.B.4
  • 23
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications
    • S.L. Foster, D.C. Hargreaves, and R. Medzhitov Gene-specific control of inflammation by TLR-induced chromatin modifications Nature 447 2007 972 978
    • (2007) Nature , vol.447 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 25
    • 0034711250 scopus 로고    scopus 로고
    • Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor
    • N. Giannoukakis, W.A. Rudert, M. Trucco, and P.D. Robbins Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor J. Biol. Chem. 275 2000 36509 36513
    • (2000) J. Biol. Chem. , vol.275 , pp. 36509-36513
    • Giannoukakis, N.1    Rudert, W.A.2    Trucco, M.3    Robbins, P.D.4
  • 26
  • 28
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • M.S. Hayden, and S. Ghosh Shared principles in NF-kappaB signaling Cell 132 2008 344 362
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 30
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 2010 900 917
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 31
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • G.S. Hotamisligil, and E. Erbay Nutrient sensing and inflammation in metabolic diseases Nat. Rev. Immunol. 8 2008 923 934
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 32
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87 91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 33
    • 0345060875 scopus 로고    scopus 로고
    • A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains
    • S. Idel, H.M. Dansky, and J.L. Breslow A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains Proc. Natl. Acad. Sci. USA 100 2003 14235 14240
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 14235-14240
    • Idel, S.1    Dansky, H.M.2    Breslow, J.L.3
  • 35
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • S. Ishibashi, M.S. Brown, J.L. Goldstein, R.D. Gerard, R.E. Hammer, and J. Herz Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery J. Clin. Invest. 92 1993 883 893 (Pubitemid 23262411)
    • (1993) Journal of Clinical Investigation , vol.92 , Issue.2 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.E.5    Herz, J.6
  • 42
    • 0028167846 scopus 로고
    • Inhibition of NF-kappa B by sodium salicylate and aspirin
    • E. Kopp, and S. Ghosh Inhibition of NF-kappa B by sodium salicylate and aspirin Science 265 1994 956 959
    • (1994) Science , vol.265 , pp. 956-959
    • Kopp, E.1    Ghosh, S.2
  • 44
    • 0034730713 scopus 로고    scopus 로고
    • Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    • E.G. Lee, D.L. Boone, S. Chai, S.L. Libby, M. Chien, J.P. Lodolce, and A. Ma Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice Science 289 2000 2350 2354
    • (2000) Science , vol.289 , pp. 2350-2354
    • Lee, E.G.1    Boone, D.L.2    Chai, S.3    Libby, S.L.4    Chien, M.5    Lodolce, J.P.6    Ma, A.7
  • 45
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • R.E. Ley, P.J. Turnbaugh, S. Klein, and J.I. Gordon Microbial ecology: human gut microbes associated with obesity Nature 444 2006 1022 1023
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 46
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • C.N. Lumeng, J.L. Bodzin, and A.R. Saltiel Obesity induces a phenotypic switch in adipose tissue macrophage polarization J. Clin. Invest. 117 2007 175 184
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 47
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • C.N. Lumeng, S.M. Deyoung, J.L. Bodzin, and A.R. Saltiel Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity Diabetes 56 2007 16 23
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 48
    • 29444453188 scopus 로고    scopus 로고
    • The anti-death machinery in IKK/NF-kappaB signaling
    • J.L. Luo, H. Kamata, and M. Karin The anti-death machinery in IKK/NF-kappaB signaling J. Clin. Immunol. 25 2005 541 550
    • (2005) J. Clin. Immunol. , vol.25 , pp. 541-550
    • Luo, J.L.1    Kamata, H.2    Karin, M.3
  • 49
    • 26644452073 scopus 로고    scopus 로고
    • Macrophage polarization comes of age
    • A. Mantovani, A. Sica, and M. Locati Macrophage polarization comes of age Immunity 23 2005 344 346
    • (2005) Immunity , vol.23 , pp. 344-346
    • Mantovani, A.1    Sica, A.2    Locati, M.3
  • 50
    • 35148818401 scopus 로고    scopus 로고
    • Effect of etanercept on insulin secretion and insulin sensitivity in a randomized trial with psoriatic patients at risk for developing type 2 diabetes mellitus
    • E. Martínez-Abundis, C. Reynoso-von Drateln, E. Hernández-Salazar, and M. González-Ortiz Effect of etanercept on insulin secretion and insulin sensitivity in a randomized trial with psoriatic patients at risk for developing type 2 diabetes mellitus Arch. Dermatol. Res. 299 2007 461 465
    • (2007) Arch. Dermatol. Res. , vol.299 , pp. 461-465
    • Martínez-Abundis, E.1    Reynoso-Von Drateln, C.2    Hernández- Salazar, E.3    González-Ortiz, M.4
  • 52
    • 5044248763 scopus 로고    scopus 로고
    • Effect of 3,4-dihydroxyphenylalanine on Cu(2+)-induced inactivation of HDL-associated paraoxonasel and oxidation of HDL; Inactivation of paraoxonasel activity independent of HDL lipid oxidation
    • S.D. Nguyen, and D.E. Sok Effect of 3,4-dihydroxyphenylalanine on Cu(2+)-induced inactivation of HDL-associated paraoxonasel and oxidation of HDL; inactivation of paraoxonasel activity independent of HDL lipid oxidation Free Radic. Res. 38 2004 969 976
    • (2004) Free Radic. Res. , vol.38 , pp. 969-976
    • Nguyen, S.D.1    Sok, D.E.2
  • 53
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • M.T. Nguyen, S. Favelyukis, A.K. Nguyen, D. Reichart, P.A. Scott, A. Jenn, R. Liu-Bryan, C.K. Glass, J.G. Neels, and J.M. Olefsky A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways J. Biol. Chem. 282 2007 35279 35292
    • (2007) J. Biol. Chem. , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6    Liu-Bryan, R.7    Glass, C.K.8    Neels, J.G.9    Olefsky, J.M.10
  • 55
    • 12144279068 scopus 로고    scopus 로고
    • Nuclear factor-B activity in cells is required for glucose-stimulated insulin secretion
    • S. Norlin, U. Ahlgren, and H. Edlund Nuclear factor-B activity in cells is required for glucose-stimulated insulin secretion Diabetes 54 2005 125 132
    • (2005) Diabetes , vol.54 , pp. 125-132
    • Norlin, S.1    Ahlgren, U.2    Edlund, H.3
  • 61
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • D. Patsouris, P.P. Li, D. Thapar, J. Chapman, J.M. Olefsky, and J.G. Neels Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals Cell Metab. 8 2008 301 309
    • (2008) Cell Metab. , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5    Neels, J.G.6
  • 62
  • 63
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • A.S. Plump, J.D. Smith, T. Hayek, K. Aalto-Setala, A. Walsh, J.G. Verstuyft, E.M. Rubin, and J.L. Breslow Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells Cell 71 1992 343 353
    • (1992) Cell , vol.71 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3    Aalto-Setala, K.4    Walsh, A.5    Verstuyft, J.G.6    Rubin, E.M.7    Breslow, J.L.8
  • 64
    • 34247884376 scopus 로고    scopus 로고
    • C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
    • M. Poggi, D. Bastelica, P. Gual, M.A. Iglesias, T. Gremeaux, C. Knauf, F. Peiretti, M. Verdier, I. Juhan-Vague, and J.F. Tanti C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet Diabetologia 50 2007 1267 1276
    • (2007) Diabetologia , vol.50 , pp. 1267-1276
    • Poggi, M.1    Bastelica, D.2    Gual, P.3    Iglesias, M.A.4    Gremeaux, T.5    Knauf, C.6    Peiretti, F.7    Verdier, M.8    Juhan-Vague, I.9    Tanti, J.F.10
  • 65
    • 69249205739 scopus 로고    scopus 로고
    • Obesity, inflammation, and atherosclerosis
    • V.Z. Rocha, and P. Libby Obesity, inflammation, and atherosclerosis Nat. Rev. Cardiol. 6 2009 399 409
    • (2009) Nat. Rev. Cardiol. , vol.6 , pp. 399-409
    • Rocha, V.Z.1    Libby, P.2
  • 66
    • 33744547493 scopus 로고    scopus 로고
    • Energy cost of infection burden: An approach to understanding the dynamics of host-pathogen interactions
    • A.A. Romanyukha, S.G. Rudnev, and I.A. Sidorov Energy cost of infection burden: an approach to understanding the dynamics of host-pathogen interactions J. Theor. Biol. 241 2006 1 13
    • (2006) J. Theor. Biol. , vol.241 , pp. 1-13
    • Romanyukha, A.A.1    Rudnev, S.G.2    Sidorov, I.A.3
  • 67
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    • M. Saberi, N.B. Woods, C. de Luca, S. Schenk, J.C. Lu, G. Bandyopadhyay, I.M. Verma, and J.M. Olefsky Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice Cell Metab. 10 2009 419 429
    • (2009) Cell Metab. , vol.10 , pp. 419-429
    • Saberi, M.1    Woods, N.B.2    De Luca, C.3    Schenk, S.4    Lu, J.C.5    Bandyopadhyay, G.6    Verma, I.M.7    Olefsky, J.M.8
  • 69
    • 42449091550 scopus 로고    scopus 로고
    • The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia
    • N.S. Sauter, F.T. Schulthess, R. Galasso, L.W. Castellani, and K. Maedler The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia Endocrinology 149 2008 2208 2218
    • (2008) Endocrinology , vol.149 , pp. 2208-2218
    • Sauter, N.S.1    Schulthess, F.T.2    Galasso, R.3    Castellani, L.W.4    Maedler, K.5
  • 71
    • 33847687659 scopus 로고    scopus 로고
    • Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity
    • B.R. Tenoever, S.L. Ng, M.A. Chua, S.M. McWhirter, A. Garcia-Sastre, and T. Maniatis Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity Science 315 2007 1274 1278
    • (2007) Science , vol.315 , pp. 1274-1278
    • Tenoever, B.R.1    Ng, S.L.2    Chua, M.A.3    McWhirter, S.M.4    Garcia-Sastre, A.5    Maniatis, T.6
  • 73
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • K.T. Uysal, S.M. Wiesbrock, M.W. Marino, and G.S. Hotamisligil Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function Nature 389 1997 610 614
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 77
    • 14244269416 scopus 로고
    • On the treatment of glycosuria and diabetes mellitus with sodium salicylate
    • R.T. Williamson On the treatment of glycosuria and diabetes mellitus with sodium salicylate Br. Med. J. 1 1901 760 762
    • (1901) Br. Med. J. , vol.1 , pp. 760-762
    • Williamson, R.T.1
  • 79
    • 36749057932 scopus 로고    scopus 로고
    • The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes
    • S. Wolfrum, D. Teupser, M. Tan, K.Y. Chen, and J.L. Breslow The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes Proc. Natl. Acad. Sci. USA 104 2007 18601 18606
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 18601-18606
    • Wolfrum, S.1    Teupser, D.2    Tan, M.3    Chen, K.Y.4    Breslow, J.L.5
  • 84
    • 77956396699 scopus 로고    scopus 로고
    • Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance
    • H. Yang, Y.H. Youm, B. Vandanmagsar, A. Ravussin, J.M. Gimble, F. Greenway, J.M. Stephens, R.L. Mynatt, and V.D. Dixit Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance J. Immunol. 185 2010 1836 1845
    • (2010) J. Immunol. , vol.185 , pp. 1836-1845
    • Yang, H.1    Youm, Y.H.2    Vandanmagsar, B.3    Ravussin, A.4    Gimble, J.M.5    Greenway, F.6    Stephens, J.M.7    Mynatt, R.L.8    Dixit, V.D.9
  • 85
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
    • M.J. Yin, Y. Yamamoto, and R.B. Gaynor The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta Nature 396 1998 77 80
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 86
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • M. Yuan, N. Konstantopoulos, J. Lee, L. Hansen, Z.W. Li, M. Karin, and S.E. Shoelson Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta Science 293 2001 1673 1677
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6    Shoelson, S.E.7
  • 87
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein e
    • S.H. Zhang, R.L. Reddick, J.A. Piedrahita, and N. Maeda Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E Science 258 1992 468 471
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 89
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • X. Zhang, G. Zhang, H. Zhang, M. Karin, H. Bai, and D. Cai Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity Cell 135 2008 61 73
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.