-
1
-
-
0034914206
-
A molecular chaperone complex at the lysosomal membrane is required for protein translocation
-
Agarraberes F. A. and Dice J. F. (2001) A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J. Cell Sci. 114, 2491–2499.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 2491-2499
-
-
Agarraberes, F.A.1
Dice, J.F.2
-
2
-
-
79954631518
-
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
-
Alvarez-Erviti L., Seow Y., Schapira A. H., Gardiner C., Sargent I. L., Wood M. J. A. and Cooper J. M. (2011) Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol. Dis. 42, 360–367.
-
(2011)
Neurobiol. Dis.
, vol.42
, pp. 360-367
-
-
Alvarez-Erviti, L.1
Seow, Y.2
Schapira, A.H.3
Gardiner, C.4
Sargent, I.L.5
Wood, M.J.A.6
Cooper, J.M.7
-
3
-
-
0034256042
-
Regulated secretion of conventional lysosomes
-
Andrews N. W. (2000) Regulated secretion of conventional lysosomes. Trends Cell Biol. 10, 316–321.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 316-321
-
-
Andrews, N.W.1
-
4
-
-
2442530398
-
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
-
Arighi C. N., Hartnell L. M., Aguilar R. C., Haft C. R. and Bonifacino J. S. (2004) Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J. Cell Bio. 165, 123–133.
-
(2004)
J. Cell Bio.
, vol.165
, pp. 123-133
-
-
Arighi, C.N.1
Hartnell, L.M.2
Aguilar, R.C.3
Haft, C.R.4
Bonifacino, J.S.5
-
5
-
-
0031941058
-
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
-
Baba M., Nakajo S., Tu P. H., Tomita T., Nakaya K., Lee V. M., Trojanowski J. Q. and Iwatsubo T. (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152, 879–884.
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.6
Trojanowski, J.Q.7
Iwatsubo, T.8
-
6
-
-
84907360500
-
Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein
-
Bae E.-J., Yang N.-Y., Song M., et al. (2014) Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein. Nat. Commun. 5, 4755.
-
(2014)
Nat. Commun.
, vol.5
, pp. 4755
-
-
Bae, E.-J.1
Yang, N.-Y.2
Song, M.3
-
7
-
-
80052398365
-
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
-
Bartels T., Choi J. G. and Selkoe D. J. (2011) α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 477, 107–110.
-
(2011)
Nature
, vol.477
, pp. 107-110
-
-
Bartels, T.1
Choi, J.G.2
Selkoe, D.J.3
-
8
-
-
67349279396
-
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
-
Beach T. G., Adler C. H., Lue L. F., Sue L. I., Bachalakuri J., Henry-Watson J., Sasse J., Boyer S., Shirohi S. and Brooks R. (2009) Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol. 117, 613–634.
-
(2009)
Acta Neuropathol.
, vol.117
, pp. 613-634
-
-
Beach, T.G.1
Adler, C.H.2
Lue, L.F.3
Sue, L.I.4
Bachalakuri, J.5
Henry-Watson, J.6
Sasse, J.7
Boyer, S.8
Shirohi, S.9
Brooks, R.10
-
10
-
-
33748313351
-
Retrograde transport from endosomes to the trans-Golgi network
-
Bonifacino J. S. and Rojas R. (2006) Retrograde transport from endosomes to the trans-Golgi network. Nat. Rev. Mol. Cell Biol. 7, 568–579.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 568-579
-
-
Bonifacino, J.S.1
Rojas, R.2
-
11
-
-
43649106356
-
Invited Article: nervous system pathology in sporadic Parkinson disease
-
Braak H. and del Tredici K. (2008) Invited Article: nervous system pathology in sporadic Parkinson disease. Neurology 70, 1916–1925.
-
(2008)
Neurology
, vol.70
, pp. 1916-1925
-
-
Braak, H.1
del Tredici, K.2
-
12
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H., Del Tredici K., Rub U., de Vos R. A. I., Steur E. and Braak E. (2003a) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24, 197–211.
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rub, U.3
de Vos, R.A.I.4
Steur, E.5
Braak, E.6
-
13
-
-
0038748401
-
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
-
Braak H., R b U., Gai W. P. and Del Tredici K. (2003b) Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J. Neural. Transm. 110, 517–536.
-
(2003)
J. Neural. Transm.
, vol.110
, pp. 517-536
-
-
Braak, H.1
R b, U.2
Gai, W.P.3
Del Tredici, K.4
-
14
-
-
5444255434
-
Stages in the development of Parkinson's disease-related pathology
-
Braak H., Ghebremedhin E., Rüb U., Bratzke H. and del Tredici K. (2004) Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res. 318, 121–134.
-
(2004)
Cell Tissue Res.
, vol.318
, pp. 121-134
-
-
Braak, H.1
Ghebremedhin, E.2
Rüb, U.3
Bratzke, H.4
del Tredici, K.5
-
15
-
-
34547727312
-
Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease
-
Braak H., Sastre M. and del Tredici K. (2007) Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol. 114, 231–241.
-
(2007)
Acta Neuropathol.
, vol.114
, pp. 231-241
-
-
Braak, H.1
Sastre, M.2
del Tredici, K.3
-
16
-
-
84855490021
-
Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion
-
Bruns C., McCaffery J. M., Curwin A. J., Duran J. M. and Malhotra V. (2011) Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion. J. Cell Biol. 195, 979–992.
-
(2011)
J. Cell Biol.
, vol.195
, pp. 979-992
-
-
Bruns, C.1
McCaffery, J.M.2
Curwin, A.J.3
Duran, J.M.4
Malhotra, V.5
-
17
-
-
84952645933
-
The synaptic function of a-synuclein
-
Burré J. (2015) The synaptic function of a-synuclein. J Parkinsons Dis. 4, 699–713.
-
(2015)
J Parkinsons Dis.
, vol.4
, pp. 699-713
-
-
Burré, J.1
-
18
-
-
77957347060
-
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro
-
Burré J., Sharma M., Tsetsenis T., Buchman V., Etherton M. R. and Südhof T. C. (2010) Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 329, 1663–1667.
-
(2010)
Science
, vol.329
, pp. 1663-1667
-
-
Burré, J.1
Sharma, M.2
Tsetsenis, T.3
Buchman, V.4
Etherton, M.R.5
Südhof, T.C.6
-
19
-
-
84919449363
-
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
-
Burré J., Sharma M. and Südhof T. C. (2014) α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proc. Natl Acad. Sci. USA 111, E4274–E4283.
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E4274-E4283
-
-
Burré, J.1
Sharma, M.2
Südhof, T.C.3
-
20
-
-
27544507306
-
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
-
Chandra S., Gallardo G., Fernández-Chacón R., Schlüter O. M. and Südhof T. C. (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123, 383–396.
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernández-Chacón, R.3
Schlüter, O.M.4
Südhof, T.C.5
-
21
-
-
23844434211
-
The non-motor symptom complex of Parkinson's disease: a comprehensive assessment is essential
-
Chaudhuri K. R., Yates L. and Martinez-Martin P. (2005) The non-motor symptom complex of Parkinson's disease: a comprehensive assessment is essential. Curr. Neurol. Neurosci. Rep. 5, 275–283.
-
(2005)
Curr. Neurol. Neurosci. Rep.
, vol.5
, pp. 275-283
-
-
Chaudhuri, K.R.1
Yates, L.2
Martinez-Martin, P.3
-
22
-
-
0024975155
-
A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins
-
Chiang H. L., Terlecky S. R., Plant C. P. and Dice J. F. (1989) A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 246, 382–385.
-
(1989)
Science
, vol.246
, pp. 382-385
-
-
Chiang, H.L.1
Terlecky, S.R.2
Plant, C.P.3
Dice, J.F.4
-
23
-
-
68149123529
-
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions
-
Chu Y., Dodiya H., Aebischer P., Olanow C. W. and Kordower J. H. (2009) Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol. Dis. 35, 385–398.
-
(2009)
Neurobiol. Dis.
, vol.35
, pp. 385-398
-
-
Chu, Y.1
Dodiya, H.2
Aebischer, P.3
Olanow, C.W.4
Kordower, J.H.5
-
24
-
-
0029837453
-
A receptor for the selective uptake and degradation of proteins by lysosomes
-
Cuervo A. M. and Dice J. F. (1996) A receptor for the selective uptake and degradation of proteins by lysosomes. Science 273, 501–503.
-
(1996)
Science
, vol.273
, pp. 501-503
-
-
Cuervo, A.M.1
Dice, J.F.2
-
25
-
-
4344659685
-
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
-
Cuervo A. M., Stefanis L., Fredenburg R., Lansbury P. T. and Sulzer D. (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305, 1292–1295.
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
26
-
-
77953463398
-
Protein degradation, aggregation, and misfolding
-
Cuervo A. M., Wong E. S. P. and Martinez-Vicente M. (2010) Protein degradation, aggregation, and misfolding. Mov. Disord. 25, S49–S54.
-
(2010)
Mov. Disord.
, vol.25
, pp. S49-S54
-
-
Cuervo, A.M.1
Wong, E.S.P.2
Martinez-Vicente, M.3
-
27
-
-
64949185378
-
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
-
Cullen V., Lindfors M., Ng J. et al. (2009) Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Mol. Brain 2, 5.
-
(2009)
Mol. Brain
, vol.2
, pp. 5
-
-
Cullen, V.1
Lindfors, M.2
Ng, J.3
-
28
-
-
84865307818
-
Exosomal cell-to-cell transmission of alpha synuclein oligomers
-
Danzer K. M., Kranich L. R., Ruf W. P., Cagsal-Getkin O., Winslow A. R., Zhu L., Vanderburg C. R. and McLean P. J. (2012) Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol. Neurodegener. 7, 42.
-
(2012)
Mol. Neurodegener.
, vol.7
, pp. 42
-
-
Danzer, K.M.1
Kranich, L.R.2
Ruf, W.P.3
Cagsal-Getkin, O.4
Winslow, A.R.5
Zhu, L.6
Vanderburg, C.R.7
McLean, P.J.8
-
29
-
-
84855195340
-
Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways
-
Dargemont C. and Ossareh-Nazari B. (2012) Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways. Biochim. Biophys. Acta 1823, 138–144.
-
(2012)
Biochim. Biophys. Acta
, vol.1823
, pp. 138-144
-
-
Dargemont, C.1
Ossareh-Nazari, B.2
-
30
-
-
84877351078
-
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
-
Decressac M., Mattsson B., Weikop P., Lundblad M., Jakobsson J. and Björklund A. (2013) TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proc. Natl Acad. Sci. USA 110, E1817–E1826.
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. E1817-E1826
-
-
Decressac, M.1
Mattsson, B.2
Weikop, P.3
Lundblad, M.4
Jakobsson, J.5
Björklund, A.6
-
31
-
-
84919424987
-
Alpha-synuclein spreading in Parkinson's disease
-
Dehay B. (2014) Alpha-synuclein spreading in Parkinson's disease. Front. Neuroanat. 8, 159.
-
(2014)
Front. Neuroanat.
, vol.8
, pp. 159
-
-
Dehay, B.1
-
32
-
-
84941313512
-
New insights into cellular homeostasis in health and disease
-
Dettmer U., Selkoe D. and Bartels T. (2015) New insights into cellular homeostasis in health and disease. Curr. Opini. Neurobiol. 36, 15–22.
-
(2015)
Curr. Opini. Neurobiol.
, vol.36
, pp. 15-22
-
-
Dettmer, U.1
Selkoe, D.2
Bartels, T.3
-
33
-
-
0025294506
-
Peptide sequences that target cytosolic proteins for lysosomal proteolysis
-
Dice J. F. (1990) Peptide sequences that target cytosolic proteins for lysosomal proteolysis. Trends Biochem. Sci. 15, 305–309.
-
(1990)
Trends Biochem. Sci.
, vol.15
, pp. 305-309
-
-
Dice, J.F.1
-
34
-
-
84954168300
-
Alpha-synuclein expression in the oligodendrocyte lineage: an in vitro and in vivo study using rodent and human models
-
Djelloul M., Holmqvist S., Boza-Serrano A., Azevedo C., Yeung M. S., Goldwurm S., Frisén J., Deierborg T. and Roybon L. (2015). Alpha-synuclein expression in the oligodendrocyte lineage: an in vitro and in vivo study using rodent and human models. Stem Cell Reports 5, 174–184.
-
(2015)
Stem Cell Reports
, vol.5
, pp. 174-184
-
-
Djelloul, M.1
Holmqvist, S.2
Boza-Serrano, A.3
Azevedo, C.4
Yeung, M.S.5
Goldwurm, S.6
Frisén, J.7
Deierborg, T.8
Roybon, L.9
-
35
-
-
33744544785
-
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein
-
Dorval V. and Fraser P. E. (2006) Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein. J. Biol. Chem. 281, 9919–9924.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 9919-9924
-
-
Dorval, V.1
Fraser, P.E.2
-
36
-
-
34250832784
-
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation
-
Dufty B. M., Warner L. R., Hou S. T., Jiang S. X., Gomez-Isla T., Leenhouts K. M., Oxford J. T., Feany M. B., Masliah E. and Rohn T. T. (2007) Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. Am. J. Pathol. 170, 1725–1738.
-
(2007)
Am. J. Pathol.
, vol.170
, pp. 1725-1738
-
-
Dufty, B.M.1
Warner, L.R.2
Hou, S.T.3
Jiang, S.X.4
Gomez-Isla, T.5
Leenhouts, K.M.6
Oxford, J.T.7
Feany, M.B.8
Masliah, E.9
Rohn, T.T.10
-
37
-
-
84860686110
-
Can Parkinson's disease pathology be propagated from one neuron to another?
-
Dunning C. J. R., Reyes J. F., Steiner J. A. and Brundin P. (2011) Can Parkinson's disease pathology be propagated from one neuron to another? Prog. Neurobiol. 97, 205–219.
-
(2011)
Prog. Neurobiol.
, vol.97
, pp. 205-219
-
-
Dunning, C.J.R.1
Reyes, J.F.2
Steiner, J.A.3
Brundin, P.4
-
38
-
-
0032573597
-
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments
-
El-Agnaf O. M., Jakes R., Curran M. D., Middleton D., Ingenito R., Bianchi E., Pessi A., Neill D. and Wallace A. (1998) Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Lett. 440, 71–75.
-
(1998)
FEBS Lett.
, vol.440
, pp. 71-75
-
-
El-Agnaf, O.M.1
Jakes, R.2
Curran, M.D.3
Middleton, D.4
Ingenito, R.5
Bianchi, E.6
Pessi, A.7
Neill, D.8
Wallace, A.9
-
39
-
-
85109083933
-
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
-
El-Agnaf O. M. A., Salem S. A., Paleologou K. E. et al. (2003) Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J. 17, 1945–1947.
-
(2003)
FASEB J.
, vol.17
, pp. 1945-1947
-
-
El-Agnaf, O.M.A.1
Salem, S.A.2
Paleologou, K.E.3
-
40
-
-
38149044992
-
Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells
-
Fader C. M., Sánchez D., Furlán M. and Colombo M. I. (2008) Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells. Traffic 9, 230–250.
-
(2008)
Traffic
, vol.9
, pp. 230-250
-
-
Fader, C.M.1
Sánchez, D.2
Furlán, M.3
Colombo, M.I.4
-
41
-
-
0038727936
-
Description of Parkinson's disease as a clinical syndrome
-
Fahn S. (2003) Description of Parkinson's disease as a clinical syndrome. Ann. N. Y. Acad. Sci. 991, 1–14.
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.991
, pp. 1-14
-
-
Fahn, S.1
-
42
-
-
84872595532
-
Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
-
Fellner L., Irschick R., Schanda K., Reindl M., Klimaschewski L., Poewe W., Wenning G. K. and Stefanova N. (2013) Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia. Glia 61, 349–360.
-
(2013)
Glia
, vol.61
, pp. 349-360
-
-
Fellner, L.1
Irschick, R.2
Schanda, K.3
Reindl, M.4
Klimaschewski, L.5
Poewe, W.6
Wenning, G.K.7
Stefanova, N.8
-
43
-
-
84892489531
-
The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer
-
Follett J., Norwood S. J., Hamilton N. A. et al. (2014) The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer. Traffic 15, 230–244.
-
(2014)
Traffic
, vol.15
, pp. 230-244
-
-
Follett, J.1
Norwood, S.J.2
Hamilton, N.A.3
-
44
-
-
84876722731
-
Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
-
Freeman D., Cedillos R., Choyke S. et al. (2013) Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis. PLoS ONE 8, e62143.
-
(2013)
PLoS ONE
, vol.8
-
-
Freeman, D.1
Cedillos, R.2
Choyke, S.3
-
45
-
-
0036174010
-
alpha-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H., Hasegawa M., Dohmae N., Kawashima A., Masliah E., Goldberg M. S., Shen J., Takio K. and Iwatsubo T. (2002) alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 4, 160–164.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
46
-
-
84903971406
-
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models
-
Games D., Valera E., Spencer B. et al. (2014) Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models. J. Neurosci. 34, 9441–9454.
-
(2014)
J. Neurosci.
, vol.34
, pp. 9441-9454
-
-
Games, D.1
Valera, E.2
Spencer, B.3
-
47
-
-
84941779114
-
Immunotherapy in Parkinson's Disease: micromanaging Alpha-Synuclein Aggregation
-
George S. and Brundin P. (2015) Immunotherapy in Parkinson's Disease: micromanaging Alpha-Synuclein Aggregation. J. Parkinsons Dis. 5, 413–424.
-
(2015)
J. Parkinsons Dis.
, vol.5
, pp. 413-424
-
-
George, S.1
Brundin, P.2
-
48
-
-
0029127954
-
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
-
George J. M., Jin H., Woods W. S. and Clayton D. F. (1995) Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15, 361–372.
-
(1995)
Neuron
, vol.15
, pp. 361-372
-
-
George, J.M.1
Jin, H.2
Woods, W.S.3
Clayton, D.F.4
-
49
-
-
77956975355
-
α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment
-
George S., Mok S. S., Nurjono M., Ayton S., Finkelstein D. I., Masters C. L., Li Q.-X. and Culvenor J. G. (2010) α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment. J. Mol. Neurosci. 42, 243–254.
-
(2010)
J. Mol. Neurosci.
, vol.42
, pp. 243-254
-
-
George, S.1
Mok, S.S.2
Nurjono, M.3
Ayton, S.4
Finkelstein, D.I.5
Masters, C.L.6
Li, Q.-X.7
Culvenor, J.G.8
-
50
-
-
84876240395
-
α-synuclein: the long distance runner
-
George S., Rey N. L., Reichenbach N., Steiner J. A. and Brundin P. (2013) α-synuclein: the long distance runner. Brain Pathol. 23, 350–357.
-
(2013)
Brain Pathol.
, vol.23
, pp. 350-357
-
-
George, S.1
Rey, N.L.2
Reichenbach, N.3
Steiner, J.A.4
Brundin, P.5
-
51
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
-
Giasson B. I., Duda J. E., Murray I. V., Chen Q., Souza J. M., Hurtig H. I., Ischiropoulos H., Trojanowski J. Q. and Lee V. M. (2000) Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290, 985–989.
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, B.I.1
Duda, J.E.2
Murray, I.V.3
Chen, Q.4
Souza, J.M.5
Hurtig, H.I.6
Ischiropoulos, H.7
Trojanowski, J.Q.8
Lee, V.M.9
-
52
-
-
84893658332
-
Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction
-
Ginns E. I., Mak S. K.-K., Ko N. et al. (2014) Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction. Mol. Genet. Metab. 111, 152–162.
-
(2014)
Mol. Genet. Metab.
, vol.111
, pp. 152-162
-
-
Ginns, E.I.1
Mak, S.K.-K.2
Ko, N.3
-
53
-
-
0035961293
-
From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases
-
Goedert M., Spillantini M. G., Serpell L. C., Berriman J., Smith M. J., Jakes R. and Crowther R. A. (2001) From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases. Philos. T Roy. Soc. B 356, 213–227.
-
(2001)
Philos. T Roy. Soc. B
, vol.356
, pp. 213-227
-
-
Goedert, M.1
Spillantini, M.G.2
Serpell, L.C.3
Berriman, J.4
Smith, M.J.5
Jakes, R.6
Crowther, R.A.7
-
54
-
-
71549167371
-
A FAM21-containing WASH complex regulates retromer-dependent sorting
-
Gomez T. S. and Billadeau D. D. (2009) A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev. Cell 17, 699–711.
-
(2009)
Dev. Cell
, vol.17
, pp. 699-711
-
-
Gomez, T.S.1
Billadeau, D.D.2
-
55
-
-
61849178720
-
Prions hijack tunnelling nanotubes for intercellular spread
-
Gousset K., Schiff E., Langevin C. et al. (2009) Prions hijack tunnelling nanotubes for intercellular spread. Nat. Cell Biol. 11, 328–336.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 328-336
-
-
Gousset, K.1
Schiff, E.2
Langevin, C.3
-
56
-
-
41149177434
-
The progression of pathology in longitudinally followed patients with Parkinson's disease
-
Halliday G., Hely M., Reid W. and Morris J. (2008) The progression of pathology in longitudinally followed patients with Parkinson's disease. Acta Neuropathol. 115, 409–415.
-
(2008)
Acta Neuropathol.
, vol.115
, pp. 409-415
-
-
Halliday, G.1
Hely, M.2
Reid, W.3
Morris, J.4
-
57
-
-
79551519276
-
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
-
Hansen C., Angot E., Bergström A.-L. et al. (2011) α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J. Clin. Invest. 121, 715–725.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 715-725
-
-
Hansen, C.1
Angot, E.2
Bergström, A.-L.3
-
59
-
-
71649087199
-
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
-
Hayashi-Nishino M., Fujita N., Noda T., Yamaguchi A., Yoshimori T. and Yamamoto A. (2009) A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat. Cell Biol. 11, 1433–1437.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1433-1437
-
-
Hayashi-Nishino, M.1
Fujita, N.2
Noda, T.3
Yamaguchi, A.4
Yoshimori, T.5
Yamamoto, A.6
-
61
-
-
9144229591
-
Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation
-
Hodara R., Norris E. H., Giasson B. I., Mishizen-Eberz A. J., Lynch D. R., Lee V. M. Y. and Ischiropoulos H. (2004) Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. J. Biol. Chem. 279, 47746–47753.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47746-47753
-
-
Hodara, R.1
Norris, E.H.2
Giasson, B.I.3
Mishizen-Eberz, A.J.4
Lynch, D.R.5
Lee, V.M.Y.6
Ischiropoulos, H.7
-
62
-
-
84882306577
-
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
-
Holmes B. B., Devos S. L., Kfoury N. et al. (2013) Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc. Natl Acad. Sci. USA 110, 3138–3147.
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 3138-3147
-
-
Holmes, B.B.1
Devos, S.L.2
Kfoury, N.3
-
63
-
-
42949118684
-
Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)
-
Hruska K. S., LaMarca M. E., Scott C. R. and Sidransky E. (2008) Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA). Hum. Mutat. 29, 567–583.
-
(2008)
Hum. Mutat.
, vol.29
, pp. 567-583
-
-
Hruska, K.S.1
LaMarca, M.E.2
Scott, C.R.3
Sidransky, E.4
-
64
-
-
0344444234
-
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
-
Imamura K., Hishikawa N., Sawada M., Nagatsu T., Yoshida M. and Hashizume Y. (2003) Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains. Acta Neuropathol. 106, 518–526.
-
(2003)
Acta Neuropathol.
, vol.106
, pp. 518-526
-
-
Imamura, K.1
Hishikawa, N.2
Sawada, M.3
Nagatsu, T.4
Yoshida, M.5
Hashizume, Y.6
-
65
-
-
59149090357
-
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system
-
Inglis K. J., Chereau D., Brigham E. F. et al. (2009) Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J. Biol. Chem. 284, 2598–2602.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 2598-2602
-
-
Inglis, K.J.1
Chereau, D.2
Brigham, E.F.3
-
66
-
-
0028985267
-
The precursor protein of non-Aß component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai A., Masliah E., Yoshimoto M., Ge N. and Flanagan L. (1995) The precursor protein of non-Aß component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14, 467–475.
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
Masliah, E.2
Yoshimoto, M.3
Ge, N.4
Flanagan, L.5
-
67
-
-
0142154275
-
Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies
-
Iwata A., Maruyama M., Akagi T., Hashikawa T., Kanazawa I., Tsuji S. and Nukina N. (2003) Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Hum. Mol. Gen. 12, 2625–2635.
-
(2003)
Hum. Mol. Gen.
, vol.12
, pp. 2625-2635
-
-
Iwata, A.1
Maruyama, M.2
Akagi, T.3
Hashikawa, T.4
Kanazawa, I.5
Tsuji, S.6
Nukina, N.7
-
68
-
-
77951885732
-
Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions
-
Jang A., Lee H.-J., Suk J.-E., Jung J.-W., Kim K. P. and Lee S.-J. (2010) Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J. Neurochem. 113, 1263–1274.
-
(2010)
J. Neurochem.
, vol.113
, pp. 1263-1274
-
-
Jang, A.1
Lee, H.-J.2
Suk, J.-E.3
Jung, J.-W.4
Kim, K.P.5
Lee, S.-J.6
-
69
-
-
45749155306
-
A critical reappraisal of current staging of Lewy-related pathology in human brain
-
Jellinger K. A. (2008) A critical reappraisal of current staging of Lewy-related pathology in human brain. Acta Neuropathol. 116, 1–16.
-
(2008)
Acta Neuropathol.
, vol.116
, pp. 1-16
-
-
Jellinger, K.A.1
-
70
-
-
0032492689
-
Regulation of phospholipase D2:? selective inhibition of mammalian phospholipase D isoenzymes by a- and ß-synucleins†
-
Jenco J. M., Andrew R., Brenda Daniels A. and Morris A. J. (1998) Regulation of phospholipase D2:? selective inhibition of mammalian phospholipase D isoenzymes by a- and ß-synucleins†. Biochemistry 37, 4901–4909.
-
(1998)
Biochemistry
, vol.37
, pp. 4901-4909
-
-
Jenco, J.M.1
Andrew, R.2
Brenda Daniels, A.3
Morris, A.J.4
-
71
-
-
73649117089
-
Regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by alpha-synuclein in rat primary glial cells
-
Joo S. H., Kwon K. J., Kim J. W., Kim J. W., Hasan M. R., Lee H.-J., Han S.-H. and Shin C. Y. (2010) Regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by alpha-synuclein in rat primary glial cells. Neurosci. Lett. 469, 352–356.
-
(2010)
Neurosci. Lett.
, vol.469
, pp. 352-356
-
-
Joo, S.H.1
Kwon, K.J.2
Kim, J.W.3
Kim, J.W.4
Hasan, M.R.5
Lee, H.-J.6
Han, S.-H.7
Shin, C.Y.8
-
72
-
-
79959855550
-
Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation
-
Kim Y. M., Jang W. H., Quezado M. M., Oh Y., Chung K. C., Junn E. and Mouradian M. M. (2011) Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation. J. Neurol. Sci. 307, 157–161.
-
(2011)
J. Neurol. Sci.
, vol.307
, pp. 157-161
-
-
Kim, Y.M.1
Jang, W.H.2
Quezado, M.M.3
Oh, Y.4
Chung, K.C.5
Junn, E.6
Mouradian, M.M.7
-
73
-
-
84864082521
-
Proteolytic cleavage of extracellular a-synuclein by plasmin: implications for Parkinson's disease
-
Kim K. S., Choi Y. R., Park J. Y., Lee J. H., Kim D. K., Lee S. J., Paik S. R., Jou I. and Park S. M. (2012) Proteolytic cleavage of extracellular a-synuclein by plasmin: implications for Parkinson's disease. J. Biol. Chem. 287, 24862–24872.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 24862-24872
-
-
Kim, K.S.1
Choi, Y.R.2
Park, J.Y.3
Lee, J.H.4
Kim, D.K.5
Lee, S.J.6
Paik, S.R.7
Jou, I.8
Park, S.M.9
-
74
-
-
84875898265
-
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
-
Kim C., Ho D.-H., Suk J.-E. et al. (2013) Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat. Commun. 4, 1562.
-
(2013)
Nat. Commun.
, vol.4
, pp. 1562
-
-
Kim, C.1
Ho, D.-H.2
Suk, J.-E.3
-
75
-
-
40849118624
-
α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia
-
Klegeris A., Pelech S., Giasson B. I., Maguire J., Zhang H., McGeer E. G. and McGeer P. L. (2008) α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiol. Aging 29, 739–752.
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 739-752
-
-
Klegeris, A.1
Pelech, S.2
Giasson, B.I.3
Maguire, J.4
Zhang, H.5
McGeer, E.G.6
McGeer, P.L.7
-
76
-
-
84937401553
-
Retromer-mediated trafficking of transmembrane receptors and transporters
-
Klinger S., Siupka P. and Nielsen M. (2015) Retromer-mediated trafficking of transmembrane receptors and transporters. Membranes 5, 288–306.
-
(2015)
Membranes
, vol.5
, pp. 288-306
-
-
Klinger, S.1
Siupka, P.2
Nielsen, M.3
-
77
-
-
84899964982
-
Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes
-
Kong S. M. Y., Chan B. K. K., Park J.-S. et al. (2014) Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes. Hum. Mol. Gen. 23, 2816–2833.
-
(2014)
Hum. Mol. Gen.
, vol.23
, pp. 2816-2833
-
-
Kong, S.M.Y.1
Chan, B.K.K.2
Park, J.-S.3
-
78
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower J. H., Chu Y., Hauser R. A., Freeman T. B. and Olanow C. W. (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat. Med. 14, 504–506.
-
(2008)
Nat. Med.
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
79
-
-
84865302358
-
Mechanisms and regulation of autophagosome formation
-
Kraft C. and Martens S. (2012) Mechanisms and regulation of autophagosome formation. Curr. Opin. Cell Biol. 24, 496–501.
-
(2012)
Curr. Opin. Cell Biol.
, vol.24
, pp. 496-501
-
-
Kraft, C.1
Martens, S.2
-
80
-
-
33846997878
-
Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
-
Kramer M. L. and Schulz-Schaeffer W. J. (2007) Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J. Neurosci. 27, 1405–1410.
-
(2007)
J. Neurosci.
, vol.27
, pp. 1405-1410
-
-
Kramer, M.L.1
Schulz-Schaeffer, W.J.2
-
81
-
-
79960261026
-
Sumoylation inhibits α-synuclein aggregation and toxicity
-
Krumova P., Meulmeester E., Garrido M. et al. (2011) Sumoylation inhibits α-synuclein aggregation and toxicity. J. Cell Biol. 194, 49–60.
-
(2011)
J. Cell Biol.
, vol.194
, pp. 49-60
-
-
Krumova, P.1
Meulmeester, E.2
Garrido, M.3
-
82
-
-
79958227103
-
Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease
-
Kurowska Z., Englund E., Widner H., Lindvall O., Li J.-Y. and Brundin P. (2011) Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. J. Parkinsons Dis. 1, 83–92.
-
(2011)
J. Parkinsons Dis.
, vol.1
, pp. 83-92
-
-
Kurowska, Z.1
Englund, E.2
Widner, H.3
Lindvall, O.4
Li, J.-Y.5
Brundin, P.6
-
83
-
-
21344456506
-
Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
-
Lee H.-J., Patel S. and Lee S.-J. (2005) Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J. Neurosci. 25, 6016–6024.
-
(2005)
J. Neurosci.
, vol.25
, pp. 6016-6024
-
-
Lee, H.-J.1
Patel, S.2
Lee, S.-J.3
-
84
-
-
44749083979
-
Assembly-dependent endocytosis and clearance of extracellular α-synuclein
-
Lee H.-J., Suk J.-E., Bae E.-J., Lee J.-H., Paik S. R. and Lee S.-J. (2008a) Assembly-dependent endocytosis and clearance of extracellular α-synuclein. Int. J. Biochem. Cell Biol. 40, 1835–1849.
-
(2008)
Int. J. Biochem. Cell Biol.
, vol.40
, pp. 1835-1849
-
-
Lee, H.-J.1
Suk, J.-E.2
Bae, E.-J.3
Lee, J.-H.4
Paik, S.R.5
Lee, S.-J.6
-
85
-
-
44749090147
-
Clearance and deposition of extracellular alpha-synuclein aggregates in microglia
-
Lee H.-J., Suk J.-E., Bae E.-J. and Lee S.-J. (2008b) Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. Biochem. Biophys. Res. Commun. 372, 423–428.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.372
, pp. 423-428
-
-
Lee, H.-J.1
Suk, J.-E.2
Bae, E.-J.3
Lee, S.-J.4
-
86
-
-
77950571596
-
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
-
Lee H.-J., Suk J.-E., Patrick C., Bae E.-J., Cho J.-H., Rho S., Hwang D., Masliah E. and Lee S.-J. (2010) Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J. Biol. Chem. 285, 9262–9272.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 9262-9272
-
-
Lee, H.-J.1
Suk, J.-E.2
Patrick, C.3
Bae, E.-J.4
Cho, J.-H.5
Rho, S.6
Hwang, D.7
Masliah, E.8
Lee, S.-J.9
-
87
-
-
84881147729
-
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein
-
Lee H.-J., Cho E.-D., Lee K.-W., Kim J.-H., Cho S.-G. and Lee S.-J. (2013) Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp. Mol. Med. 45, e22–e29.
-
(2013)
Exp. Mol. Med.
, vol.45
, pp. e22-e29
-
-
Lee, H.-J.1
Cho, E.-D.2
Lee, K.-W.3
Kim, J.-H.4
Cho, S.-G.5
Lee, S.-J.6
-
88
-
-
84888394934
-
Inflammation and a-synuclein's prion-like behavior in Parkinson's disease—Is there a link?
-
Lema Tomé C. M., Tyson T., Rey N. L., Grathwohl S., Britschgi M. and Brundin P. (2012) Inflammation and a-synuclein's prion-like behavior in Parkinson's disease—Is there a link? Mol. Neurobiol. 47, 561–574.
-
(2012)
Mol. Neurobiol.
, vol.47
, pp. 561-574
-
-
Lema Tomé, C.M.1
Tyson, T.2
Rey, N.L.3
Grathwohl, S.4
Britschgi, M.5
Brundin, P.6
-
89
-
-
51649109607
-
Olfactory pathogenesis of idiopathic Parkinson disease revisited
-
Lerner A. and Bagic A. (2008) Olfactory pathogenesis of idiopathic Parkinson disease revisited. Mov. Disord. 23, 1076–1084.
-
(2008)
Mov. Disord.
, vol.23
, pp. 1076-1084
-
-
Lerner, A.1
Bagic, A.2
-
90
-
-
84925500787
-
Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance
-
Leyk J., Goldbaum O., Noack M. and Richter-Landsberg C. (2015) Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance. J. Mol. Neurosci. 55, 1031–1046.
-
(2015)
J. Mol. Neurosci.
, vol.55
, pp. 1031-1046
-
-
Leyk, J.1
Goldbaum, O.2
Noack, M.3
Richter-Landsberg, C.4
-
91
-
-
13844320376
-
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
-
Li W., West N., Colla E. et al. (2005) Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc. Natl Acad. Sci. USA 102, 2162–2167.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 2162-2167
-
-
Li, W.1
West, N.2
Colla, E.3
-
92
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li J.-Y., Englund E., Holton J. L. et al. (2008) Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat. Med. 14, 501–503.
-
(2008)
Nat. Med.
, vol.14
, pp. 501-503
-
-
Li, J.-Y.1
Englund, E.2
Holton, J.L.3
-
93
-
-
77949820437
-
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
-
Li J.-Y., Englund E., Widner H., Rehncrona S., Björklund A., Lindvall O. and Brundin P. (2010) Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease. Mov. Disord. 25, 1091–1096.
-
(2010)
Mov. Disord.
, vol.25
, pp. 1091-1096
-
-
Li, J.-Y.1
Englund, E.2
Widner, H.3
Rehncrona, S.4
Björklund, A.5
Lindvall, O.6
Brundin, P.7
-
94
-
-
20844456402
-
alpha-Synuclein produces a long-lasting increase in neurotransmitter release
-
Liu S., Ninan I., Antonova I., Battaglia F., Trinchese F., Narasanna A., Kolodilov N., Dauer W., Hawkins R. D. and Arancio O. (2004) alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J. 23, 4506–4516.
-
(2004)
EMBO J.
, vol.23
, pp. 4506-4516
-
-
Liu, S.1
Ninan, I.2
Antonova, I.3
Battaglia, F.4
Trinchese, F.5
Narasanna, A.6
Kolodilov, N.7
Dauer, W.8
Hawkins, R.D.9
Arancio, O.10
-
95
-
-
84862609075
-
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative -synucleinopathy in mice
-
Luk K. C., Kehm V. M., Zhang B., O'Brien P., Trojanowski J. Q. and Lee V. M. Y. (2012a) Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative -synucleinopathy in mice. J. Exp. Med. 209, 975–986.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 975-986
-
-
Luk, K.C.1
Kehm, V.M.2
Zhang, B.3
O'Brien, P.4
Trojanowski, J.Q.5
Lee, V.M.Y.6
-
96
-
-
84869109864
-
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
Luk K. C., Kehm V., Carroll J., Zhang B., O'Brien P., Trojanowski J. Q. and Lee V. M. Y. (2012b) Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338, 949–953.
-
(2012)
Science
, vol.338
, pp. 949-953
-
-
Luk, K.C.1
Kehm, V.2
Carroll, J.3
Zhang, B.4
O'Brien, P.5
Trojanowski, J.Q.6
Lee, V.M.Y.7
-
97
-
-
84873281274
-
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
-
MacLeod D. A., Rhinn H., Kuwahara T. et al. (2013) RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 77, 425–439.
-
(2013)
Neuron
, vol.77
, pp. 425-439
-
-
MacLeod, D.A.1
Rhinn, H.2
Kuwahara, T.3
-
98
-
-
84899894003
-
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
-
Mahul-Mellier A.-L., Fauvet B., Gysbers A. et al. (2014) c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum. Mol. Gen. 23, 2858–2879.
-
(2014)
Hum. Mol. Gen.
, vol.23
, pp. 2858-2879
-
-
Mahul-Mellier, A.-L.1
Fauvet, B.2
Gysbers, A.3
-
99
-
-
77951541740
-
Lysosomal degradation of alpha-synuclein in vivo
-
Mak S. K., McCormack A. L., Manning-Bog A. B., Cuervo A. M. and Di Monte D. A. (2010) Lysosomal degradation of alpha-synuclein in vivo. J. Biol. Chem. 285, 13621–13629.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 13621-13629
-
-
Mak, S.K.1
McCormack, A.L.2
Manning-Bog, A.B.3
Cuervo, A.M.4
Di Monte, D.A.5
-
100
-
-
0037127197
-
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein
-
Manning-Bog A. B., McCormack A. L., Li J., Uversky V. N., Fink A. L. and Di Monte D. A. (2002) The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J. Biol. Chem. 277, 1641–1644.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1641-1644
-
-
Manning-Bog, A.B.1
McCormack, A.L.2
Li, J.3
Uversky, V.N.4
Fink, A.L.5
Di Monte, D.A.6
-
101
-
-
79953276342
-
The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease
-
Martinez-Martin P., Rodriguez-Blazquez C., Kurtis M. M. and Chaudhuri K. R., on Behalf of the NMSS Validation Group (2011) The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease. Mov. Disord. 26, 399–406.
-
(2011)
Mov. Disord.
, vol.26
, pp. 399-406
-
-
Martinez-Martin, P.1
Rodriguez-Blazquez, C.2
Kurtis, M.M.3
Chaudhuri, K.R.4
-
102
-
-
38849174979
-
Dopamine-modified a-synuclein blocks chaperone-mediated autophagy
-
Martinez-Vicente M., Talloczy Z., Kaushik S. et al. (2008) Dopamine-modified a-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118, 777–788.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 777-788
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Kaushik, S.3
-
103
-
-
84866521159
-
Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?
-
Martins-Branco D., Esteves A. R., Santos D., Arduino D. M., Swerdlow R. H., Oliveira C. R., Januario C. and Cardoso S. M. (2012) Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness? Exp. Neurol. 238, 89–99.
-
(2012)
Exp. Neurol.
, vol.238
, pp. 89-99
-
-
Martins-Branco, D.1
Esteves, A.R.2
Santos, D.3
Arduino, D.M.4
Swerdlow, R.H.5
Oliveira, C.R.6
Januario, C.7
Cardoso, S.M.8
-
104
-
-
79955757052
-
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of lewy body disease
-
Masliah E., Rockenstein E., Mante M. et al. (2011) Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of lewy body disease. PLoS ONE 6, e19338.
-
(2011)
PLoS ONE
, vol.6
-
-
Masliah, E.1
Rockenstein, E.2
Mante, M.3
-
105
-
-
85048243758
-
Pathological alpha-synuclein propagates through neural networks
-
Masuda-Suzukake M., Nonaka T., Hosokawa M., Kubo M., Shimozawa A., Akiyama H. and Hasegawa M. (2014) Pathological alpha-synuclein propagates through neural networks. Acta. Neuropathol. Commun. 2, 492.
-
(2014)
Acta. Neuropathol. Commun.
, vol.2
, pp. 492
-
-
Masuda-Suzukake, M.1
Nonaka, T.2
Hosokawa, M.3
Kubo, M.4
Shimozawa, A.5
Akiyama, H.6
Hasegawa, M.7
-
106
-
-
77449113371
-
Phosphorylation of synucleins by members of the Polo-like kinase family
-
Mbefo M. K., Paleologou K. E., Boucharaba A. et al. (2010) Phosphorylation of synucleins by members of the Polo-like kinase family. J. Biol. Chem. 285, 2807–2822.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2807-2822
-
-
Mbefo, M.K.1
Paleologou, K.E.2
Boucharaba, A.3
-
107
-
-
84938118051
-
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
-
McGlinchey R. P. and Lee J. C. (2015) Cysteine cathepsins are essential in lysosomal degradation of α-synuclein. Proc. Natl Acad. Sci. USA 112, 9322–9327.
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 9322-9327
-
-
McGlinchey, R.P.1
Lee, J.C.2
-
108
-
-
84919772780
-
The structure of fibrils from “misfolded” proteins
-
Meier B. H. and Böckmann A. (2015) The structure of fibrils from “misfolded” proteins. Curr. Opin. Struct. Biol. 30, 43–49.
-
(2015)
Curr. Opin. Struct. Biol.
, vol.30
, pp. 43-49
-
-
Meier, B.H.1
Böckmann, A.2
-
109
-
-
0043233011
-
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro
-
Mishizen-Eberz A. J., Guttmann R. P., Giasson B. I., Day G. A., Hodara R., Ischiropoulos H., Lee V. M. Y., Trojanowski J. Q. and Lynch D. R. (2003) Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. J. Neurochem. 86, 836–847.
-
(2003)
J. Neurochem.
, vol.86
, pp. 836-847
-
-
Mishizen-Eberz, A.J.1
Guttmann, R.P.2
Giasson, B.I.3
Day, G.A.4
Hodara, R.5
Ischiropoulos, H.6
Lee, V.M.Y.7
Trojanowski, J.Q.8
Lynch, D.R.9
-
110
-
-
84863425120
-
α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system
-
Mollenhauer B., Trautmann E., Otte B. et al. (2012) α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system. J. Neural. Transm. 119, 739–746.
-
(2012)
J. Neural. Transm.
, vol.119
, pp. 739-746
-
-
Mollenhauer, B.1
Trautmann, E.2
Otte, B.3
-
111
-
-
0037150773
-
Immunohistochemical comparison of alpha- and beta-synuclein in adult rat central nervous system
-
Mori F., Tanji K., Yoshimoto M., Takahashi H. and Wakabayashi K. (2002) Immunohistochemical comparison of alpha- and beta-synuclein in adult rat central nervous system. Brain Res. 941, 118–126.
-
(2002)
Brain Res.
, vol.941
, pp. 118-126
-
-
Mori, F.1
Tanji, K.2
Yoshimoto, M.3
Takahashi, H.4
Wakabayashi, K.5
-
112
-
-
84863433677
-
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
-
Mougenot A.-L., Nicot S., Bencsik A., Morignat E., Verchère J., Lakhdar L., Legastelois S. and Baron T. (2012) Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol. Aging 33, 2225–2228.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 2225-2228
-
-
Mougenot, A.-L.1
Nicot, S.2
Bencsik, A.3
Morignat, E.4
Verchère, J.5
Lakhdar, L.6
Legastelois, S.7
Baron, T.8
-
113
-
-
0038116620
-
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro
-
Murray I. V. J., Giasson B. I., Quinn S. M., Koppaka V., Axelsen P. H., Ischiropoulos H., Trojanowski J. Q. and Lee V. M. Y. (2003) Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry 42, 8530–8540.
-
(2003)
Biochemistry
, vol.42
, pp. 8530-8540
-
-
Murray, I.V.J.1
Giasson, B.I.2
Quinn, S.M.3
Koppaka, V.4
Axelsen, P.H.5
Ischiropoulos, H.6
Trojanowski, J.Q.7
Lee, V.M.Y.8
-
114
-
-
73549085595
-
Increased expression of α-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
-
Nemani V. M., Lu W., Berge V., Nakamura K., Onoa B., Lee M. K., Chaudhry F. A., Nicoll R. A. and Edwards R. H. (2010) Increased expression of α-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 65, 66–79.
-
(2010)
Neuron
, vol.65
, pp. 66-79
-
-
Nemani, V.M.1
Lu, W.2
Berge, V.3
Nakamura, K.4
Onoa, B.5
Lee, M.K.6
Chaudhry, F.A.7
Nicoll, R.A.8
Edwards, R.H.9
-
115
-
-
84885864424
-
Aβ secretion and plaque formation depend on autophagy
-
Nilsson P., Loganathan K., Sekiguchi M., Matsuba Y., Hui K., Tsubuki S., Tanaka M., Iwata N., Saito T. and Saido T. C. (2013) Aβ secretion and plaque formation depend on autophagy. Cell Rep. 5, 61–69.
-
(2013)
Cell Rep.
, vol.5
, pp. 61-69
-
-
Nilsson, P.1
Loganathan, K.2
Sekiguchi, M.3
Matsuba, Y.4
Hui, K.5
Tsubuki, S.6
Tanaka, M.7
Iwata, N.8
Saito, T.9
Saido, T.C.10
-
116
-
-
84871745200
-
Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses
-
Ninkina N., Peters O. M., Connor-Robson N., Lytkina O., Sharfeddin E. and Buchman V. L. (2012) Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses. J. Biol. Chem. 287, 44471–44477.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 44471-44477
-
-
Ninkina, N.1
Peters, O.M.2
Connor-Robson, N.3
Lytkina, O.4
Sharfeddin, E.5
Buchman, V.L.6
-
117
-
-
0033828258
-
Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer”s disease and Parkinson”s disease
-
Ogawa K., Yamada T., Tsujioka Y. et al. (2000) Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer”s disease and Parkinson”s disease. Psychiatry Clin. Neurosci. 54, 419–426.
-
(2000)
Psychiatry Clin. Neurosci.
, vol.54
, pp. 419-426
-
-
Ogawa, K.1
Yamada, T.2
Tsujioka, Y.3
-
118
-
-
79952283388
-
Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation
-
Oh Y., Kim Y. M., Mouradian M. M. and Chung K. C. (2011) Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation. Brain Res. 1381, 78–89.
-
(2011)
Brain Res.
, vol.1381
, pp. 78-89
-
-
Oh, Y.1
Kim, Y.M.2
Mouradian, M.M.3
Chung, K.C.4
-
119
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
-
Okochi M., Walter J., Koyama A., Nakajo S., Baba M., Iwatsubo T., Meijer L., Kahle P. J. and Haass C. (2000) Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J. Biol. Chem. 275, 390–397.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
121
-
-
84885363886
-
Polo-like kinase 2 regulates selective autophagic a-synuclein clearance and suppresses its toxicity in vivo
-
Oueslati A., Schneider B. L., Aebischer P. and Lashuel H. A. (2013) Polo-like kinase 2 regulates selective autophagic a-synuclein clearance and suppresses its toxicity in vivo. Proc. Natl Acad. Sci. USA 1, 3945–3954.
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.1
, pp. 3945-3954
-
-
Oueslati, A.1
Schneider, B.L.2
Aebischer, P.3
Lashuel, H.A.4
-
122
-
-
51349105921
-
Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease
-
Park J.-Y., Paik S. R., Jou I. and Park S. M. (2008) Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease. Glia 56, 1215–1223.
-
(2008)
Glia
, vol.56
, pp. 1215-1223
-
-
Park, J.-Y.1
Paik, S.R.2
Jou, I.3
Park, S.M.4
-
123
-
-
41149141259
-
Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance
-
Parkkinen L., Pirttila T. and Alafuzoff I. (2008) Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol. 115, 399–407.
-
(2008)
Acta Neuropathol.
, vol.115
, pp. 399-407
-
-
Parkkinen, L.1
Pirttila, T.2
Alafuzoff, I.3
-
124
-
-
0035887860
-
Induction of alpha-synuclein aggregation by intracellular nitrative insult
-
Paxinou E., Chen Q., Weisse M., Giasson B. I., Norris E. H., Rueter S. M., Trojanowski J. Q., Lee V. M. and Ischiropoulos H. (2001) Induction of alpha-synuclein aggregation by intracellular nitrative insult. J. Neurosci. 21, 8053–8061.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8053-8061
-
-
Paxinou, E.1
Chen, Q.2
Weisse, M.3
Giasson, B.I.4
Norris, E.H.5
Rueter, S.M.6
Trojanowski, J.Q.7
Lee, V.M.8
Ischiropoulos, H.9
-
125
-
-
84934983329
-
a-Synuclein strains cause distinct synucleinopathies after local and systemic administration
-
Peelaerts W., Bousset L., derVan Perren A., Moskalyuk A., Pulizzi R., Giugliano M., Van den Haute C., Melki R. and Baekelandt V. (2015) a-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature 522, 340–344.
-
(2015)
Nature
, vol.522
, pp. 340-344
-
-
Peelaerts, W.1
Bousset, L.2
Van Perren, A.3
Moskalyuk, A.4
Pulizzi, R.5
Giugliano, M.6
Van den Haute, C.7
Melki, R.8
Baekelandt, V.9
-
126
-
-
37749018903
-
Biogenesis and function of multivesicular bodies
-
Piper R. C. and Katzmann D. J. (2007) Biogenesis and function of multivesicular bodies. Annu. Rev. Cell Dev. Biol. 23, 519–547.
-
(2007)
Annu. Rev. Cell Dev. Biol.
, vol.23
, pp. 519-547
-
-
Piper, R.C.1
Katzmann, D.J.2
-
127
-
-
84922364789
-
Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment
-
Poehler A.-M., Xiang W., Spitzer P. et al. (2015) Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment. Autophagy 10, 2171–2192.
-
(2015)
Autophagy
, vol.10
, pp. 2171-2192
-
-
Poehler, A.-M.1
Xiang, W.2
Spitzer, P.3
-
128
-
-
84942860108
-
Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism
-
Prusiner S. B., Woerman A. L., Mordes D. A. et al. (2015) Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc. Natl Acad. Sci. USA 112, 5308–5317.
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 5308-5317
-
-
Prusiner, S.B.1
Woerman, A.L.2
Mordes, D.A.3
-
129
-
-
79955694568
-
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
-
Qiao L., Hamamichi S., Caldwell K. A. et al. (2008) Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol. Brain 1, 17.
-
(2008)
Mol. Brain
, vol.1
, pp. 17
-
-
Qiao, L.1
Hamamichi, S.2
Caldwell, K.A.3
-
130
-
-
84924244777
-
The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to a-synuclein inclusions
-
Radford R., Rcom-H'cheo-Gauthier A., Wong M. B. et al. (2015) The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to a-synuclein inclusions. Mol. Cell Neurosci. 65, 68–81.
-
(2015)
Mol. Cell Neurosci.
, vol.65
, pp. 68-81
-
-
Radford, R.1
Rcom-H'cheo-Gauthier, A.2
Wong, M.B.3
-
131
-
-
84897977607
-
Lewy body extracts from parkinson's disease brains trigger a-synuclein pathology and neurodegeneration in mice and monkeys
-
Recasens A., Dehay B., Bové J. et al. (2013) Lewy body extracts from parkinson's disease brains trigger a-synuclein pathology and neurodegeneration in mice and monkeys. Ann. Neurol. 75, 351–362.
-
(2013)
Ann. Neurol.
, vol.75
, pp. 351-362
-
-
Recasens, A.1
Dehay, B.2
Bové, J.3
-
132
-
-
84892538035
-
Alpha-synuclein transfers from neurons to oligodendrocytes
-
Reyes J. F., Rey N. L., Bousset L., Melki R., Brundin P. and Angot E. (2014) Alpha-synuclein transfers from neurons to oligodendrocytes. Glia 62, 387–398.
-
(2014)
Glia
, vol.62
, pp. 387-398
-
-
Reyes, J.F.1
Rey, N.L.2
Bousset, L.3
Melki, R.4
Brundin, P.5
Angot, E.6
-
133
-
-
84939884559
-
A cell culture model for monitoring α-synuclein cell-to-cell transfer
-
Reyes J. F., Olsson T. T., Lamberts J. T., Devine M. J., Kunath T. and Brundin P. (2015) A cell culture model for monitoring α-synuclein cell-to-cell transfer. Neurobiol. Disease 77, 266–275.
-
(2015)
Neurobiol. Disease
, vol.77
, pp. 266-275
-
-
Reyes, J.F.1
Olsson, T.T.2
Lamberts, J.T.3
Devine, M.J.4
Kunath, T.5
Brundin, P.6
-
134
-
-
41249090880
-
Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells
-
Rott R., Szargel R., Haskin J., Shani V., Shainskaya A., Manov I., Liani E., Avraham E. and Engelender S. (2008) Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells. J. Biol. Chem. 283, 3316–3328.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3316-3328
-
-
Rott, R.1
Szargel, R.2
Haskin, J.3
Shani, V.4
Shainskaya, A.5
Manov, I.6
Liani, E.7
Avraham, E.8
Engelender, S.9
-
135
-
-
84904636970
-
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
-
Sacino A. N., Brooks M., Thomas M. A. et al. (2014) Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc. Natl Acad. Sci. USA 111, 10732–10737.
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 10732-10737
-
-
Sacino, A.N.1
Brooks, M.2
Thomas, M.A.3
-
136
-
-
84879934105
-
α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model
-
Sanchez-Guajardo V., Annibali A., Jensen P. H. and Romero-Ramos M. (2013) α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model. J. Neuropathol. Exp. Neurol. 72, 624–645.
-
(2013)
J. Neuropathol. Exp. Neurol.
, vol.72
, pp. 624-645
-
-
Sanchez-Guajardo, V.1
Annibali, A.2
Jensen, P.H.3
Romero-Ramos, M.4
-
138
-
-
84872183810
-
The retromer complex - endosomal protein recycling and beyond
-
Seaman M. N. J. (2012) The retromer complex - endosomal protein recycling and beyond. J. Cell Sci. 125, 4693–4702.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4693-4702
-
-
Seaman, M.N.J.1
-
139
-
-
51549106105
-
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
-
Sevlever D., Jiang P. and Yen S.-H. C. (2008) Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species. Biochemistry 47, 9678–9687.
-
(2008)
Biochemistry
, vol.47
, pp. 9678-9687
-
-
Sevlever, D.1
Jiang, P.2
Yen, S.-H.C.3
-
140
-
-
84909592222
-
Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions
-
Shahpasandzadeh H., Popova B., Kleinknecht A., Fraser P. E., Outeiro T. F. and Braus G. H. (2014) Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions. J. Biol. Chem. 289, 31224–31240.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 31224-31240
-
-
Shahpasandzadeh, H.1
Popova, B.2
Kleinknecht, A.3
Fraser, P.E.4
Outeiro, T.F.5
Braus, G.H.6
-
141
-
-
0035854437
-
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease
-
Shimura H., Schlossmacher M. G., Hattori N., Frosch M. P., Trockenbacher A., Schneider R., Mizuno Y., Kosik K. S. and Selkoe D. J. (2001) Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science 293, 263–269.
-
(2001)
Science
, vol.293
, pp. 263-269
-
-
Shimura, H.1
Schlossmacher, M.G.2
Hattori, N.3
Frosch, M.P.4
Trockenbacher, A.5
Schneider, R.6
Mizuno, Y.7
Kosik, K.S.8
Selkoe, D.J.9
-
142
-
-
21244499845
-
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates αlpha-synuclein degradation decisions between proteasomal and lysosomal pathways
-
Shin Y. (2005) The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates αlpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J. Biol. Chem. 280, 23727–23734.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23727-23734
-
-
Shin, Y.1
-
143
-
-
84930220496
-
The utility of a-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature
-
Simonsen A. H., Kuiperij B., Ali El-Agnaf O. M. et al. (2015) The utility of a-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature. Biomark Med.
-
(2015)
Biomark Med.
-
-
Simonsen, A.H.1
Kuiperij, B.2
Ali El-Agnaf, O.M.3
-
144
-
-
70350550208
-
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in α-synuclein models of Parkinson's and lewy body diseases
-
Spencer B., Potkar R., Trejo M., Rockenstein E., Patrick C., Gindi R., Adame A., Wyss-Coray T. and Masliah E. (2009) Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in α-synuclein models of Parkinson's and lewy body diseases. J. Neurosci. 29, 13578–13588.
-
(2009)
J. Neurosci.
, vol.29
, pp. 13578-13588
-
-
Spencer, B.1
Potkar, R.2
Trejo, M.3
Rockenstein, E.4
Patrick, C.5
Gindi, R.6
Adame, A.7
Wyss-Coray, T.8
Masliah, E.9
-
145
-
-
84871921645
-
Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD
-
Spencer B., Michael S., Shen J., Kosberg K., Rockenstein E., Patrick C., Adame A. and Masliah E. (2013) Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD. Mol. Ther. 21, 31–41.
-
(2013)
Mol. Ther.
, vol.21
, pp. 31-41
-
-
Spencer, B.1
Michael, S.2
Shen, J.3
Kosberg, K.4
Rockenstein, E.5
Patrick, C.6
Adame, A.7
Masliah, E.8
-
146
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini M. G., Schmidt M. L., Lee V. M., Trojanowski J. Q., Jakes R. and Goedert M. (1997) Alpha-synuclein in Lewy bodies. Nature 388, 839–840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
147
-
-
0032568534
-
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
Spillantini M. G., Crowther R. A., Jakes R., Hasegawa M. and Goedert M. (1998) alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl Acad. Sci. USA 95, 6469–6473.
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
148
-
-
0035894855
-
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
-
Stefanis L., Larsen K. E., Rideout H. J., Sulzer D. and Greene L. A. (2001) Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J. Neurosci. 21, 9549–9560.
-
(2001)
J. Neurosci.
, vol.21
, pp. 9549-9560
-
-
Stefanis, L.1
Larsen, K.E.2
Rideout, H.J.3
Sulzer, D.4
Greene, L.A.5
-
149
-
-
80051707299
-
A deadly spread: cellular mechanisms of α-synuclein transfer
-
Steiner J. A., Angot E. and Brundin P. (2011) A deadly spread: cellular mechanisms of α-synuclein transfer. Cell Death Differ. 18, 1425–1433.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 1425-1433
-
-
Steiner, J.A.1
Angot, E.2
Brundin, P.3
-
150
-
-
0035920226
-
Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein
-
Sung J. Y., Kim J., Paik S. R., Park J. H., Ahn Y. S. and Chung K. C. (2001) Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. J. Biol. Chem. 276, 27441–27448.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27441-27448
-
-
Sung, J.Y.1
Kim, J.2
Paik, S.R.3
Park, J.H.4
Ahn, Y.S.5
Chung, K.C.6
-
151
-
-
21644446495
-
Proteolytic cleavage of extracellular secreted alpha-synuclein via matrix metalloproteinases
-
Sung J. Y., Park S. M., Lee C. H., Um J. W., Lee H. J., Kim J., Oh Y. J., Lee S. T., Paik S. R. and Chung K. C. (2005) Proteolytic cleavage of extracellular secreted alpha-synuclein via matrix metalloproteinases. J. Biol. Chem. 280, 25216–25224.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25216-25224
-
-
Sung, J.Y.1
Park, S.M.2
Lee, C.H.3
Um, J.W.4
Lee, H.J.5
Kim, J.6
Oh, Y.J.7
Lee, S.T.8
Paik, S.R.9
Chung, K.C.10
-
152
-
-
84890146490
-
Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy
-
Tanaka K. and Matsuda N. (2014) Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy. Biochim. Biophys. Acta 1843, 197–204.
-
(2014)
Biochim. Biophys. Acta
, vol.1843
, pp. 197-204
-
-
Tanaka, K.1
Matsuda, N.2
-
153
-
-
1042266326
-
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective
-
Tanaka M., Kim Y. M., Lee G., Junn E., Iwatsubo T. and Mouradian M. M. (2004) Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective. J. Biol. Chem. 279, 4625–4631.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 4625-4631
-
-
Tanaka, M.1
Kim, Y.M.2
Lee, G.3
Junn, E.4
Iwatsubo, T.5
Mouradian, M.M.6
-
154
-
-
84878230429
-
Lewy body-like a -synuclein aggregates resist degradation and impair macroautophagy
-
Tanik S. A., Schultheiss C. E., Volpicelli-Daley L. A., Brunden K. R. and Lee V. M. Y. (2013) Lewy body-like a -synuclein aggregates resist degradation and impair macroautophagy. J. Biol. Chem. 288, 15194–15210.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 15194-15210
-
-
Tanik, S.A.1
Schultheiss, C.E.2
Volpicelli-Daley, L.A.3
Brunden, K.R.4
Lee, V.M.Y.5
-
155
-
-
77955686287
-
Extracellular neurosin degrades α-synuclein in cultured cells
-
Tatebe H., Watanabe Y., Kasai T., Mizuno T., Nakagawa M., Tanaka M. and Tokuda T. (2010) Extracellular neurosin degrades α-synuclein in cultured cells. Neurosci. Res. 67, 341–346.
-
(2010)
Neurosci. Res.
, vol.67
, pp. 341-346
-
-
Tatebe, H.1
Watanabe, Y.2
Kasai, T.3
Mizuno, T.4
Nakagawa, M.5
Tanaka, M.6
Tokuda, T.7
-
157
-
-
84901361843
-
Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease
-
Tenreiro S., Reimão-Pinto M. M., Antas P. et al. (2014b) Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease. PLoS Genet. 10, e1004302.
-
(2014)
PLoS Genet.
, vol.10
-
-
Tenreiro, S.1
Reimão-Pinto, M.M.2
Antas, P.3
-
158
-
-
49649125680
-
CHIP targets toxic α-synuclein oligomers for degradation
-
Tetzlaff J. E., Putcha P., Outeiro T. F., Ivanov A., Berezovska O., Hyman B. T. and McLean P. J. (2008) CHIP targets toxic α-synuclein oligomers for degradation. J. Biol. Chem. 283, 17962–17968.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 17962-17968
-
-
Tetzlaff, J.E.1
Putcha, P.2
Outeiro, T.F.3
Ivanov, A.4
Berezovska, O.5
Hyman, B.T.6
McLean, P.J.7
-
159
-
-
0035976835
-
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
-
Tofaris G. K., Layfield R. and Spillantini M. G. (2001) alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Lett. 509, 22–26.
-
(2001)
FEBS Lett.
, vol.509
, pp. 22-26
-
-
Tofaris, G.K.1
Layfield, R.2
Spillantini, M.G.3
-
160
-
-
0242666359
-
Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
-
Tofaris G. K., Razzaq A., Ghetti B., Lilley K. S. and Spillantini M. G. (2003) Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J. Biol. Chem. 278, 44405–44411.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 44405-44411
-
-
Tofaris, G.K.1
Razzaq, A.2
Ghetti, B.3
Lilley, K.S.4
Spillantini, M.G.5
-
161
-
-
80054732644
-
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway
-
Tofaris G. K., Kim H. T., Hourez R., Jung J.-W., Kim K. P. and Goldberg A. L. (2011) Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway. Proc. Natl Acad. Sci. USA 108, 17004–17009.
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 17004-17009
-
-
Tofaris, G.K.1
Kim, H.T.2
Hourez, R.3
Jung, J.-W.4
Kim, K.P.5
Goldberg, A.L.6
-
162
-
-
84903441419
-
a-synuclein immunotherapy blocks uptakeand templated propagation of misfolded a-synuclein and neurodegeneration
-
Tran H. T., Chung C. H.-Y., Iba M., Bin Z., Trojanowski J. Q., Luk K. C. and Lee V. M. Y. (2014) a-synuclein immunotherapy blocks uptakeand templated propagation of misfolded a-synuclein and neurodegeneration. CellReports 7, 1–29.
-
(2014)
CellReports
, vol.7
, pp. 1-29
-
-
Tran, H.T.1
Chung, C.H.-Y.2
Iba, M.3
Bin, Z.4
Trojanowski, J.Q.5
Luk, K.C.6
Lee, V.M.Y.7
-
163
-
-
84908518328
-
Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils
-
Tsujimura A., Taguchi K., Watanabe Y., Tatebe H., Tokuda T., Mizuno T. and Tanaka M. (2014) Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils. Neurobiol. Disease 73C, 244–253.
-
(2014)
Neurobiol. Disease
, vol.73C
, pp. 244-253
-
-
Tsujimura, A.1
Taguchi, K.2
Watanabe, Y.3
Tatebe, H.4
Tokuda, T.5
Mizuno, T.6
Tanaka, M.7
-
164
-
-
18544410708
-
The plasmin system is induced by and degrades amyloid-beta aggregates
-
Tucker H. M., Kihiko M., Caldwell J. N. et al. (2000) The plasmin system is induced by and degrades amyloid-beta aggregates. J. Neurosci. 20, 3937–3946.
-
(2000)
J. Neurosci.
, vol.20
, pp. 3937-3946
-
-
Tucker, H.M.1
Kihiko, M.2
Caldwell, J.N.3
-
165
-
-
77955141273
-
Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
-
Ulusoy A., Febbraro F., Jensen P. H., Kirik D. and Romero-Ramos M. (2010) Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology. Eur. J. Neurosci. 32, 409–422.
-
(2010)
Eur. J. Neurosci.
, vol.32
, pp. 409-422
-
-
Ulusoy, A.1
Febbraro, F.2
Jensen, P.H.3
Kirik, D.4
Romero-Ramos, M.5
-
166
-
-
85018196378
-
Neuron-to-neuron a-synuclein propagation in vivo is independent of neuronal injury
-
Ulusoy A., Musgrove R. E., Rusconi R., Klinkenberg M., Helwig M., Schneider A. and Di Monte D. A. (2015) Neuron-to-neuron a-synuclein propagation in vivo is independent of neuronal injury. Acta Neuropathol Commun 3, 13.
-
(2015)
Acta Neuropathol Commun
, vol.3
, pp. 13
-
-
Ulusoy, A.1
Musgrove, R.E.2
Rusconi, R.3
Klinkenberg, M.4
Helwig, M.5
Schneider, A.6
Di Monte, D.A.7
-
167
-
-
0033621048
-
Plasmin cleavage of the amyloid ß-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity
-
Van Nostrand W. E. and Porter M. (1999) Plasmin cleavage of the amyloid ß-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity. Biochemistry 38, 11570–11576.
-
(1999)
Biochemistry
, vol.38
, pp. 11570-11576
-
-
Van Nostrand, W.E.1
Porter, M.2
-
168
-
-
84939641927
-
α-Synuclein and nonhuman primate models of Parkinson's disease
-
Vermilyea S. C. and Emborg M. E. (2015) α-Synuclein and nonhuman primate models of Parkinson's disease. J. NeurosciMethods 255, 38–51.
-
(2015)
J. NeurosciMethods
, vol.255
, pp. 38-51
-
-
Vermilyea, S.C.1
Emborg, M.E.2
-
170
-
-
53049098471
-
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
-
Vogiatzi T., Xilouri M., Vekrellis K. and Stefanis L. (2008) Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem. 283, 23542–23556.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 23542-23556
-
-
Vogiatzi, T.1
Xilouri, M.2
Vekrellis, K.3
Stefanis, L.4
-
171
-
-
80053613574
-
Exogenous alpha-synuclein fibrils induce lewy body pathology leading to synaptic dysfunction and neuron death
-
Volpicelli-Daley L. A., Luk K. C., Patel T. P., Tanik S. A., Riddle D. M., Stieber A., Meaney D. F., Trojanowski J. Q. and Lee V. M. Y. (2011) Exogenous alpha-synuclein fibrils induce lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72, 57–71.
-
(2011)
Neuron
, vol.72
, pp. 57-71
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Patel, T.P.3
Tanik, S.A.4
Riddle, D.M.5
Stieber, A.6
Meaney, D.F.7
Trojanowski, J.Q.8
Lee, V.M.Y.9
-
172
-
-
0033973421
-
NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains
-
Wakabayashi K., Hayashi S., Yoshimoto M., Kudo H. and Takahashi H. (2000) NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains. Acta Neuropathol. 99, 14–20.
-
(2000)
Acta Neuropathol.
, vol.99
, pp. 14-20
-
-
Wakabayashi, K.1
Hayashi, S.2
Yoshimoto, M.3
Kudo, H.4
Takahashi, H.5
-
173
-
-
80055078029
-
A soluble α-synuclein construct forms a dynamic tetramer
-
Wang W., Perovic I., Chittuluru J. et al. (2011) A soluble α-synuclein construct forms a dynamic tetramer. Proc. Natl Acad. Sci. USA 108, 17797–17802.
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 17797-17802
-
-
Wang, W.1
Perovic, I.2
Chittuluru, J.3
-
174
-
-
84888349390
-
Transmission of multiple system atrophy prions to transgenic mice
-
Watts J. C., Giles K., Oehler A., Middleton L., Dexter D. T., Gentleman S. M., Dearmond S. J. and Prusiner S. B. (2013) Transmission of multiple system atrophy prions to transgenic mice. Proc. Natl Acad. Sci. USA 110, 19555–19560.
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 19555-19560
-
-
Watts, J.C.1
Giles, K.2
Oehler, A.3
Middleton, L.4
Dexter, D.T.5
Gentleman, S.M.6
Dearmond, S.J.7
Prusiner, S.B.8
-
175
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
Weinreb P. H., Zhen W., Poon A. W., Conway K. A. and Lansbury P. T. (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35, 13709–13715.
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury, P.T.5
-
176
-
-
77957189194
-
α-Synuclein impairs macroautophagy: implications for Parkinson's disease
-
Winslow A. R., Chen C. W., Corrochano S. et al. (2010) α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J. Cell Biol. 190, 1023–1037.
-
(2010)
J. Cell Biol.
, vol.190
, pp. 1023-1037
-
-
Winslow, A.R.1
Chen, C.W.2
Corrochano, S.3
-
177
-
-
65849127844
-
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
-
Xilouri M., Vogiatzi T., Vekrellis K., Park D. and Stefanis L. (2009) Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS ONE 4, e5515.
-
(2009)
PLoS ONE
, vol.4
-
-
Xilouri, M.1
Vogiatzi, T.2
Vekrellis, K.3
Park, D.4
Stefanis, L.5
-
178
-
-
84911001724
-
Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway
-
Yan J.-Q., Yuan Y.-H., Gao Y.-N., Huang J.-Y., Ma K.-L., Gao Y., Zhang W.-Q., Guo X.-F. and Chen N.-H. (2014) Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway. Mol. Neurobiol. 50, 685–701.
-
(2014)
Mol. Neurobiol.
, vol.50
, pp. 685-701
-
-
Yan, J.-Q.1
Yuan, Y.-H.2
Gao, Y.-N.3
Huang, J.-Y.4
Ma, K.-L.5
Gao, Y.6
Zhang, W.-Q.7
Guo, X.-F.8
Chen, N.-H.9
-
179
-
-
68449089023
-
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein
-
Yu W. H., Dorado B., Figueroa H. Y., Wang L., Planel E., Cookson M. R., Clark L. N. and Duff K. E. (2009) Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. Am. J. Pathol. 175, 736–747.
-
(2009)
Am. J. Pathol.
, vol.175
, pp. 736-747
-
-
Yu, W.H.1
Dorado, B.2
Figueroa, H.Y.3
Wang, L.4
Planel, E.5
Cookson, M.R.6
Clark, L.N.7
Duff, K.E.8
-
180
-
-
77956298994
-
Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats
-
Yu Z., Xu X., Xiang Z., Zhou J., Zhang Z., Hu C. and He C. (2010) Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. PLoS ONE 5, e9956.
-
(2010)
PLoS ONE
, vol.5
-
-
Yu, Z.1
Xu, X.2
Xiang, Z.3
Zhou, J.4
Zhang, Z.5
Hu, C.6
He, C.7
-
181
-
-
41349084608
-
Patterns and stages of alpha-synucleinopathy: relevance in a population-based cohort
-
Zaccai J., Brayne C., McKeith I., Matthews F. and Ince P. G. (2008) Patterns and stages of alpha-synucleinopathy: relevance in a population-based cohort. Neurology 70, 1042–1048.
-
(2008)
Neurology
, vol.70
, pp. 1042-1048
-
-
Zaccai, J.1
Brayne, C.2
McKeith, I.3
Matthews, F.4
Ince, P.G.5
-
182
-
-
84900460616
-
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy
-
Zavodszky E., Seaman M. N. J., Moreau K., Jimenez-Sanchez M., Breusegem S. Y., Harbour M. E. and Rubinsztein D. C. (2014) Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. Nat. Commun. 5, 3828.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3828
-
-
Zavodszky, E.1
Seaman, M.N.J.2
Moreau, K.3
Jimenez-Sanchez, M.4
Breusegem, S.Y.5
Harbour, M.E.6
Rubinsztein, D.C.7
-
183
-
-
80051534540
-
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
-
Zimprich A., Benet-Pagès A., Struhal W. et al. (2011) A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am. J. Hum. Genet. 89, 168–175.
-
(2011)
Am. J. Hum. Genet.
, vol.89
, pp. 168-175
-
-
Zimprich, A.1
Benet-Pagès, A.2
Struhal, W.3
|