-
1
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich A., Schmitz Y., Fariñas I., Choi-Lundberg D., Ho W.H., Castillo P.E., Shinsky N., Verdugo J.M., Armanini M., Ryan A., et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25 (2000) 239-252
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Fariñas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
-
2
-
-
0035141520
-
The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice
-
Augustin I., Korte S., Rickmann M., Kretzschmar H.A., Südhof T.C., Herms J.W., and Brose N. The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. J. Neurosci. 21 (2001) 10-17
-
(2001)
J. Neurosci.
, vol.21
, pp. 10-17
-
-
Augustin, I.1
Korte, S.2
Rickmann, M.3
Kretzschmar, H.A.4
Südhof, T.C.5
Herms, J.W.6
Brose, N.7
-
4
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H., Del Tredici K., Rüb U., de Vos R.A., Jansen Steur E.N., and Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24 (2003) 197-211
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rüb, U.3
de Vos, R.A.4
Jansen Steur, E.N.5
Braak, E.6
-
5
-
-
0038054286
-
A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins
-
Bussell Jr. R., and Eliezer D. A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins. J. Mol. Biol. 329 (2003) 763-778
-
(2003)
J. Mol. Biol.
, vol.329
, pp. 763-778
-
-
Bussell Jr., R.1
Eliezer, D.2
-
6
-
-
1942534598
-
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein
-
Bussell Jr. R., and Eliezer D. Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein. Biochemistry 43 (2004) 4810-4818
-
(2004)
Biochemistry
, vol.43
, pp. 4810-4818
-
-
Bussell Jr., R.1
Eliezer, D.2
-
7
-
-
0037109727
-
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
-
Cabin D.E., Shimazu K., Murphy D., Cole N.B., Gottschalk W., McIlwain K.L., Orrison B., Chen A., Ellis C.E., Paylor R., et al. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J. Neurosci. 22 (2002) 8797-8807
-
(2002)
J. Neurosci.
, vol.22
, pp. 8797-8807
-
-
Cabin, D.E.1
Shimazu, K.2
Murphy, D.3
Cole, N.B.4
Gottschalk, W.5
McIlwain, K.L.6
Orrison, B.7
Chen, A.8
Ellis, C.E.9
Paylor, R.10
-
8
-
-
6944227811
-
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions
-
Chandra S., Fornai F., Kwon H.B., Yazdani U., Atasoy D., Liu X., Hammer R.E., Battaglia G., German D.C., Castillo P.E., and Südhof T.C. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc. Natl. Acad. Sci. USA 101 (2004) 14966-14971
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 14966-14971
-
-
Chandra, S.1
Fornai, F.2
Kwon, H.B.3
Yazdani, U.4
Atasoy, D.5
Liu, X.6
Hammer, R.E.7
Battaglia, G.8
German, D.C.9
Castillo, P.E.10
Südhof, T.C.11
-
9
-
-
27544507306
-
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
-
Chandra S., Gallardo G., Fernández-Chacón R., Schlüter O.M., and Südhof T.C. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123 (2005) 383-396
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernández-Chacón, R.3
Schlüter, O.M.4
Südhof, T.C.5
-
10
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin M.C., Kachergus J., Roumier C., Mouroux V., Douay X., Lincoln S., Levecque C., Larvor L., Andrieux J., Hulihan M., et al. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364 (2004) 1167-1169
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
-
11
-
-
17844406856
-
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
Chen L., and Feany M.B. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat. Neurosci. 8 (2005) 657-663
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
-
12
-
-
33751019425
-
Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients
-
Chiba-Falek O., Lopez G.J., and Nussbaum R.L. Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. Mov. Disord. 21 (2006) 1703-1708
-
(2006)
Mov. Disord.
, vol.21
, pp. 1703-1708
-
-
Chiba-Falek, O.1
Lopez, G.J.2
Nussbaum, R.L.3
-
13
-
-
33746533924
-
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
Cooper A.A., Gitler A.D., Cashikar A., Haynes C.M., Hill K.J., Bhullar B., Liu K., Xu K., Strathearn K.E., Liu F., et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313 (2006) 324-328
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
-
14
-
-
1642309655
-
Dopamine neurons in culture express VGLUT2 explaining their capacity to release glutamate at synapses in addition to dopamine
-
Dal Bo G., St-Gelais F., Danik M., Williams S., Cotton M., and Trudeau L.E. Dopamine neurons in culture express VGLUT2 explaining their capacity to release glutamate at synapses in addition to dopamine. J. Neurochem. 88 (2004) 1398-1405
-
(2004)
J. Neurochem.
, vol.88
, pp. 1398-1405
-
-
Dal Bo, G.1
St-Gelais, F.2
Danik, M.3
Williams, S.4
Cotton, M.5
Trudeau, L.E.6
-
15
-
-
0032540327
-
Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
-
Davidson W.S., Jonas A., Clayton D.F., and George J.M. Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 273 (1998) 9443-9449
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
George, J.M.4
-
16
-
-
84940364788
-
Alpha-synuclein and the Lewy body disorders
-
Dickson D.W. Alpha-synuclein and the Lewy body disorders. Curr. Opin. Neurol. 14 (2001) 423-432
-
(2001)
Curr. Opin. Neurol.
, vol.14
, pp. 423-432
-
-
Dickson, D.W.1
-
17
-
-
0035830913
-
alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases
-
Ellis C.E., Schwartzberg P.L., Grider T.L., Fink D.W., and Nussbaum R.L. alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases. J. Biol. Chem. 276 (2001) 3879-3884
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3879-3884
-
-
Ellis, C.E.1
Schwartzberg, P.L.2
Grider, T.L.3
Fink, D.W.4
Nussbaum, R.L.5
-
18
-
-
34247583278
-
A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis
-
Ferguson S.M., Brasnjo G., Hayashi M., Wolfel M., Collesi C., Giovedi S., Raimondi A., Gong L.W., Ariel P., Paradise S., et al. A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science 316 (2007) 570-574
-
(2007)
Science
, vol.316
, pp. 570-574
-
-
Ferguson, S.M.1
Brasnjo, G.2
Hayashi, M.3
Wolfel, M.4
Collesi, C.5
Giovedi, S.6
Raimondi, A.7
Gong, L.W.8
Ariel, P.9
Paradise, S.10
-
19
-
-
14644415031
-
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
-
Fernández-Chacón R., Wölfel M., Nishimune H., Tabares L., Schmitz F., Castellano-Muñoz M., Rosenmund C., Montesinos M.L., Sanes J.R., Schneggenburger R., and Südhof T.C. The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron 42 (2004) 237-251
-
(2004)
Neuron
, vol.42
, pp. 237-251
-
-
Fernández-Chacón, R.1
Wölfel, M.2
Nishimune, H.3
Tabares, L.4
Schmitz, F.5
Castellano-Muñoz, M.6
Rosenmund, C.7
Montesinos, M.L.8
Sanes, J.R.9
Schneggenburger, R.10
Südhof, T.C.11
-
20
-
-
3342951965
-
Lipid rafts mediate the synaptic localization of alpha-synuclein
-
Fortin D.L., Troyer M.D., Nakamura K., Kubo S., Anthony M.D., and Edwards R.H. Lipid rafts mediate the synaptic localization of alpha-synuclein. J. Neurosci. 24 (2004) 6715-6723
-
(2004)
J. Neurosci.
, vol.24
, pp. 6715-6723
-
-
Fortin, D.L.1
Troyer, M.D.2
Nakamura, K.3
Kubo, S.4
Anthony, M.D.5
Edwards, R.H.6
-
21
-
-
28044461467
-
Neural activity controls the synaptic accumulation of alpha-synuclein
-
Fortin D.L., Nemani V.M., Voglmaier S.M., Anthony M.D., Ryan T.A., and Edwards R.H. Neural activity controls the synaptic accumulation of alpha-synuclein. J. Neurosci. 25 (2005) 10913-10921
-
(2005)
J. Neurosci.
, vol.25
, pp. 10913-10921
-
-
Fortin, D.L.1
Nemani, V.M.2
Voglmaier, S.M.3
Anthony, M.D.4
Ryan, T.A.5
Edwards, R.H.6
-
22
-
-
34250796802
-
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states
-
Fredenburg R.A., Rospigliosi C., Meray R.K., Kessler J.C., Lashuel H.A., Eliezer D., and Lansbury Jr. P.T. The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry 46 (2007) 7107-7118
-
(2007)
Biochemistry
, vol.46
, pp. 7107-7118
-
-
Fredenburg, R.A.1
Rospigliosi, C.2
Meray, R.K.3
Kessler, J.C.4
Lashuel, H.A.5
Eliezer, D.6
Lansbury Jr., P.T.7
-
23
-
-
0036174010
-
alpha-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H., Hasegawa M., Dohmae N., Kawashima A., Masliah E., Goldberg M.S., Shen J., Takio K., and Iwatsubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 4 (2002) 160-164
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
24
-
-
0029127954
-
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
-
George J.M., Jin H., Woods W.S., and Clayton D.F. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15 (1995) 361-372
-
(1995)
Neuron
, vol.15
, pp. 361-372
-
-
George, J.M.1
Jin, H.2
Woods, W.S.3
Clayton, D.F.4
-
25
-
-
0037118259
-
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
-
Giasson B.I., Duda J.E., Quinn S.M., Zhang B., Trojanowski J.Q., and Lee V.M. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34 (2002) 521-533
-
(2002)
Neuron
, vol.34
, pp. 521-533
-
-
Giasson, B.I.1
Duda, J.E.2
Quinn, S.M.3
Zhang, B.4
Trojanowski, J.Q.5
Lee, V.M.6
-
26
-
-
38349160161
-
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
-
Gitler A.D., Bevis B.J., Shorter J., Strathearn K.E., Hamamichi S., Su L.J., Caldwell K.A., Caldwell G.A., Rochet J.C., McCaffery J.M., et al. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc. Natl. Acad. Sci. USA 105 (2008) 145-150
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 145-150
-
-
Gitler, A.D.1
Bevis, B.J.2
Shorter, J.3
Strathearn, K.E.4
Hamamichi, S.5
Su, L.J.6
Caldwell, K.A.7
Caldwell, G.A.8
Rochet, J.C.9
McCaffery, J.M.10
-
27
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
-
Haass C., and Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 8 (2007) 101-112
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
28
-
-
0035950270
-
beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor
-
Hashimoto M., Rockenstein E., Mante M., Mallory M., and Masliah E. beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor. Neuron 32 (2001) 213-223
-
(2001)
Neuron
, vol.32
, pp. 213-223
-
-
Hashimoto, M.1
Rockenstein, E.2
Mante, M.3
Mallory, M.4
Masliah, E.5
-
29
-
-
0033611685
-
Synapsins as regulators of neurotransmitter release
-
Hilfiker S., Pieribone V.A., Czernik A.J., Kao H.T., Augustine G.J., and Greengard P. Synapsins as regulators of neurotransmitter release. Philos. Trans. R. Soc. Lond. B Biol. Sci. 354 (1999) 269-279
-
(1999)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.354
, pp. 269-279
-
-
Hilfiker, S.1
Pieribone, V.A.2
Czernik, A.J.3
Kao, H.T.4
Augustine, G.J.5
Greengard, P.6
-
30
-
-
0028985267
-
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai A., Masliah E., Yoshimoto M., Ge N., Flanagan L., de Silva H.A., Kittel A., and Saitoh T. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14 (1995) 467-475
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
Masliah, E.2
Yoshimoto, M.3
Ge, N.4
Flanagan, L.5
de Silva, H.A.6
Kittel, A.7
Saitoh, T.8
-
31
-
-
0036307753
-
Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein
-
Jo E., Fuller N., Rand R.P., St George-Hyslop P., and Fraser P.E. Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein. J. Mol. Biol. 315 (2002) 799-807
-
(2002)
J. Mol. Biol.
, vol.315
, pp. 799-807
-
-
Jo, E.1
Fuller, N.2
Rand, R.P.3
St George-Hyslop, P.4
Fraser, P.E.5
-
32
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Krüger R., Kuhn W., Müller T., Woitalla D., Graeber M., Kösel S., Przuntek H., Epplen J.T., Schöls L., and Riess O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18 (1998) 106-108
-
(1998)
Nat. Genet.
, vol.18
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Müller, T.3
Woitalla, D.4
Graeber, M.5
Kösel, S.6
Przuntek, H.7
Epplen, J.T.8
Schöls, L.9
Riess, O.10
-
33
-
-
0035932936
-
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers
-
Krüger R., Kuhn W., Leenders K.L., Sprengelmeyer R., Müller T., Woitalla D., Portman A.T., Maguire R.P., Veenma L., Schröder U., et al. Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers. Neurology 56 (2001) 1355-1362
-
(2001)
Neurology
, vol.56
, pp. 1355-1362
-
-
Krüger, R.1
Kuhn, W.2
Leenders, K.L.3
Sprengelmeyer, R.4
Müller, T.5
Woitalla, D.6
Portman, A.T.7
Maguire, R.P.8
Veenma, L.9
Schröder, U.10
-
34
-
-
24744432079
-
A combinatorial code for the interaction of alpha-synuclein with membranes
-
Kubo S., Nemani V.M., Chalkley R.J., Anthony M.D., Hattori N., Mizuno Y., Edwards R.H., and Fortin D.L. A combinatorial code for the interaction of alpha-synuclein with membranes. J. Biol. Chem. 280 (2005) 31664-31672
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31664-31672
-
-
Kubo, S.1
Nemani, V.M.2
Chalkley, R.J.3
Anthony, M.D.4
Hattori, N.5
Mizuno, Y.6
Edwards, R.H.7
Fortin, D.L.8
-
35
-
-
33751113009
-
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis
-
Larsen K.E., Schmitz Y., Troyer M.D., Mosharov E., Dietrich P., Quazi A.Z., Savalle M., Nemani V., Chaudhry F.A., Edwards R.H., et al. Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J. Neurosci. 26 (2006) 11915-11922
-
(2006)
J. Neurosci.
, vol.26
, pp. 11915-11922
-
-
Larsen, K.E.1
Schmitz, Y.2
Troyer, M.D.3
Mosharov, E.4
Dietrich, P.5
Quazi, A.Z.6
Savalle, M.7
Nemani, V.8
Chaudhry, F.A.9
Edwards, R.H.10
-
36
-
-
0037173006
-
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 -> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
-
Lee M.K., Stirling W., Xu Y., Xu X., Qui D., Mandir A.S., Dawson T.M., Copeland N.G., Jenkins N.A., and Price D.L. Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 -> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc. Natl. Acad. Sci. USA 99 (2002) 8968-8973
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8968-8973
-
-
Lee, M.K.1
Stirling, W.2
Xu, Y.3
Xu, X.4
Qui, D.5
Mandir, A.S.6
Dawson, T.M.7
Copeland, N.G.8
Jenkins, N.A.9
Price, D.L.10
-
37
-
-
27844525509
-
Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines
-
Li H., Waites C.L., Staal R.G., Dobryy Y., Park J., Sulzer D.L., and Edwards R.H. Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron 48 (2005) 619-633
-
(2005)
Neuron
, vol.48
, pp. 619-633
-
-
Li, H.1
Waites, C.L.2
Staal, R.G.3
Dobryy, Y.4
Park, J.5
Sulzer, D.L.6
Edwards, R.H.7
-
38
-
-
65249185511
-
Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach
-
Lu W., Shi Y., Jackson A.C., Bjorgan K., During M.J., Sprengel R., Seeburg P.H., and Nicoll R.A. Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron 62 (2009) 254-268
-
(2009)
Neuron
, vol.62
, pp. 254-268
-
-
Lu, W.1
Shi, Y.2
Jackson, A.C.3
Bjorgan, K.4
During, M.J.5
Sprengel, R.6
Seeburg, P.H.7
Nicoll, R.A.8
-
39
-
-
0038334899
-
Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration
-
Manning-Bog A.B., McCormack A.L., Purisai M.G., Bolin L.M., and Di Monte D.A. Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration. J. Neurosci. 23 (2003) 3095-3099
-
(2003)
J. Neurosci.
, vol.23
, pp. 3095-3099
-
-
Manning-Bog, A.B.1
McCormack, A.L.2
Purisai, M.G.3
Bolin, L.M.4
Di Monte, D.A.5
-
40
-
-
33746869343
-
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease
-
Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium
-
Maraganore D.M., de Andrade M., Elbaz A., Farrer M.J., Ioannidis J.P., Krüger R., Rocca W.A., Schneider N.K., Lesnick T.G., Lincoln S.J., et al., Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. JAMA 296 (2006) 661-670
-
(2006)
JAMA
, vol.296
, pp. 661-670
-
-
Maraganore, D.M.1
de Andrade, M.2
Elbaz, A.3
Farrer, M.J.4
Ioannidis, J.P.5
Krüger, R.6
Rocca, W.A.7
Schneider, N.K.8
Lesnick, T.G.9
Lincoln, S.J.10
-
41
-
-
0023722437
-
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
-
Maroteaux L., Campanelli J.T., and Scheller R.H. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8 (1988) 2804-2815
-
(1988)
J. Neurosci.
, vol.8
, pp. 2804-2815
-
-
Maroteaux, L.1
Campanelli, J.T.2
Scheller, R.H.3
-
42
-
-
0034979314
-
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter
-
Matsuoka Y., Vila M., Lincoln S., McCormack A., Picciano M., LaFrancois J., Yu X., Dickson D., Langston W.J., McGowan E., et al. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiol. Dis. 8 (2001) 535-539
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 535-539
-
-
Matsuoka, Y.1
Vila, M.2
Lincoln, S.3
McCormack, A.4
Picciano, M.5
LaFrancois, J.6
Yu, X.7
Dickson, D.8
Langston, W.J.9
McGowan, E.10
-
43
-
-
57049151865
-
Proteomic analysis identifies phosphorylation-dependent a-synuclein protein interactions
-
McFarland M.A., Ellis C.E., Markey S.P., and Nussbaum R.L. Proteomic analysis identifies phosphorylation-dependent a-synuclein protein interactions. Mol. Cell Proteomics. 7 (2008) 2123-2137
-
(2008)
Mol. Cell Proteomics.
, vol.7
, pp. 2123-2137
-
-
McFarland, M.A.1
Ellis, C.E.2
Markey, S.P.3
Nussbaum, R.L.4
-
44
-
-
0030943110
-
Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture
-
Mena M.A., Khan U., Togasaki D.M., Sulzer D., Epstein C.J., and Przedborski S. Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture. J. Neurochem. 69 (1997) 21-33
-
(1997)
J. Neurochem.
, vol.69
, pp. 21-33
-
-
Mena, M.A.1
Khan, U.2
Togasaki, D.M.3
Sulzer, D.4
Epstein, C.J.5
Przedborski, S.6
-
45
-
-
0032500053
-
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
-
Miesenböck G., De Angelis D.A., and Rothman J.E. Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature 394 (1998) 192-195
-
(1998)
Nature
, vol.394
, pp. 192-195
-
-
Miesenböck, G.1
De Angelis, D.A.2
Rothman, J.E.3
-
46
-
-
2442700253
-
Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication
-
Miller D.W., Hague S.M., Clarimon J., Baptista M., Gwinn-Hardy K., Cookson M.R., and Singleton A.B. Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology 62 (2004) 1835-1838
-
(2004)
Neurology
, vol.62
, pp. 1835-1838
-
-
Miller, D.W.1
Hague, S.M.2
Clarimon, J.3
Baptista, M.4
Gwinn-Hardy, K.5
Cookson, M.R.6
Singleton, A.B.7
-
47
-
-
0036469387
-
Development of vesicle pools during maturation of hippocampal synapses
-
Mozhayeva M.G., Sara Y., Liu X., and Kavalali E.T. Development of vesicle pools during maturation of hippocampal synapses. J. Neurosci. 22 (2002) 654-665
-
(2002)
J. Neurosci.
, vol.22
, pp. 654-665
-
-
Mozhayeva, M.G.1
Sara, Y.2
Liu, X.3
Kavalali, E.T.4
-
48
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
-
Okochi M., Walter J., Koyama A., Nakajo S., Baba M., Iwatsubo T., Meijer L., Kahle P.J., and Haass C. Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J. Biol. Chem. 275 (2000) 390-397
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
49
-
-
0345189364
-
Yeast cells provide insight into alpha-synuclein biology and pathobiology
-
Outeiro T.F., and Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302 (2003) 1772-1775
-
(2003)
Science
, vol.302
, pp. 1772-1775
-
-
Outeiro, T.F.1
Lindquist, S.2
-
50
-
-
0037426346
-
Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease
-
Park J.Y., and Lansbury Jr. P.T. Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease. Biochemistry 42 (2003) 3696-3700
-
(2003)
Biochemistry
, vol.42
, pp. 3696-3700
-
-
Park, J.Y.1
Lansbury Jr., P.T.2
-
51
-
-
0036786216
-
Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets
-
Park S.M., Jung H.Y., Kim H.O., Rhim H., Paik S.R., Chung K.C., Park J.H., and Kim J. Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets. Blood 100 (2002) 2506-2514
-
(2002)
Blood
, vol.100
, pp. 2506-2514
-
-
Park, S.M.1
Jung, H.Y.2
Kim, H.O.3
Rhim, H.4
Paik, S.R.5
Chung, K.C.6
Park, J.H.7
Kim, J.8
-
52
-
-
1642264194
-
Structural determinants of PLD2 inhibition by alpha-synuclein
-
Payton J.E., Perrin R.J., Woods W.S., and George J.M. Structural determinants of PLD2 inhibition by alpha-synuclein. J. Mol. Biol. 337 (2004) 1001-1009
-
(2004)
J. Mol. Biol.
, vol.337
, pp. 1001-1009
-
-
Payton, J.E.1
Perrin, R.J.2
Woods, W.S.3
George, J.M.4
-
53
-
-
0037137702
-
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
-
Petrucelli L., O'Farrell C., Lockhart P.J., Baptista M., Kehoe K., Vink L., Choi P., Wolozin B., Farrer M., Hardy J., and Cookson M.R. Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron 36 (2002) 1007-1019
-
(2002)
Neuron
, vol.36
, pp. 1007-1019
-
-
Petrucelli, L.1
O'Farrell, C.2
Lockhart, P.J.3
Baptista, M.4
Kehoe, K.5
Vink, L.6
Choi, P.7
Wolozin, B.8
Farrer, M.9
Hardy, J.10
Cookson, M.R.11
-
54
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
-
55
-
-
0033635239
-
Rapid reuse of readily releasable pool vesicles at hippocampal synapses
-
Pyle J.L., Kavalali E.T., Piedras-Rentería E.S., and Tsien R.W. Rapid reuse of readily releasable pool vesicles at hippocampal synapses. Neuron 28 (2000) 221-231
-
(2000)
Neuron
, vol.28
, pp. 221-231
-
-
Pyle, J.L.1
Kavalali, E.T.2
Piedras-Rentería, E.S.3
Tsien, R.W.4
-
56
-
-
33745259502
-
Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection
-
Quilty M.C., King A.E., Gai W.P., Pountney D.L., West A.K., Vickers J.C., and Dickson T.C. Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection. Exp. Neurol. 199 (2006) 249-256
-
(2006)
Exp. Neurol.
, vol.199
, pp. 249-256
-
-
Quilty, M.C.1
King, A.E.2
Gai, W.P.3
Pountney, D.L.4
West, A.K.5
Vickers, J.C.6
Dickson, T.C.7
-
57
-
-
0027482675
-
Short-term synaptic plasticity is altered in mice lacking synapsin I
-
Rosahl T.W., Geppert M., Spillane D., Herz J., Hammer R.E., Malenka R.C., and Südhof T.C. Short-term synaptic plasticity is altered in mice lacking synapsin I. Cell 75 (1993) 661-670
-
(1993)
Cell
, vol.75
, pp. 661-670
-
-
Rosahl, T.W.1
Geppert, M.2
Spillane, D.3
Herz, J.4
Hammer, R.E.5
Malenka, R.C.6
Südhof, T.C.7
-
58
-
-
0029024135
-
Essential functions of synapsins I and II in synaptic vesicle regulation
-
Rosahl T.W., Spillane D., Missler M., Herz J., Selig D.K., Wolff J.R., Hammer R.E., Malenka R.C., and Südhof T.C. Essential functions of synapsins I and II in synaptic vesicle regulation. Nature 375 (1995) 488-493
-
(1995)
Nature
, vol.375
, pp. 488-493
-
-
Rosahl, T.W.1
Spillane, D.2
Missler, M.3
Herz, J.4
Selig, D.K.5
Wolff, J.R.6
Hammer, R.E.7
Malenka, R.C.8
Südhof, T.C.9
-
59
-
-
0030175394
-
Definition of the readily releasable pool of vesicles at hippocampal synapses
-
Rosenmund C., and Stevens C.F. Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 16 (1996) 1197-1207
-
(1996)
Neuron
, vol.16
, pp. 1197-1207
-
-
Rosenmund, C.1
Stevens, C.F.2
-
60
-
-
0029781368
-
Synaptic vesicle recycling in synapsin I knock-out mice
-
Ryan T.A., Li L., Chin L.S., Greengard P., and Smith S.J. Synaptic vesicle recycling in synapsin I knock-out mice. J. Cell Biol. 134 (1996) 1219-1227
-
(1996)
J. Cell Biol.
, vol.134
, pp. 1219-1227
-
-
Ryan, T.A.1
Li, L.2
Chin, L.S.3
Greengard, P.4
Smith, S.J.5
-
61
-
-
40549093026
-
Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
-
Senior S.L., Ninkina N., Deacon R., Bannerman D., Buchman V.L., Cragg S.J., and Wade-Martins R. Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur. J. Neurosci. 27 (2008) 947-957
-
(2008)
Eur. J. Neurosci.
, vol.27
, pp. 947-957
-
-
Senior, S.L.1
Ninkina, N.2
Deacon, R.3
Bannerman, D.4
Buchman, V.L.5
Cragg, S.J.6
Wade-Martins, R.7
-
62
-
-
0242300619
-
alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., et al. alpha-Synuclein locus triplication causes Parkinson's disease. Science 302 (2003) 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
-
63
-
-
20444416315
-
Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells
-
Smith W.W., Margolis R.L., Li X., Troncoso J.C., Lee M.K., Dawson V.L., Dawson T.M., Iwatsubo T., and Ross C.A. Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells. J. Neurosci. 25 (2005) 5544-5552
-
(2005)
J. Neurosci.
, vol.25
, pp. 5544-5552
-
-
Smith, W.W.1
Margolis, R.L.2
Li, X.3
Troncoso, J.C.4
Lee, M.K.5
Dawson, V.L.6
Dawson, T.M.7
Iwatsubo, T.8
Ross, C.A.9
-
64
-
-
41649117989
-
Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae
-
Soper J.H., Roy S., Stieber A., Lee E., Wilson R.B., Trojanowski J.Q., Burd C.G., and Lee V.M. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol. Biol. Cell 19 (2008) 1093-1103
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 1093-1103
-
-
Soper, J.H.1
Roy, S.2
Stieber, A.3
Lee, E.4
Wilson, R.B.5
Trojanowski, J.Q.6
Burd, C.G.7
Lee, V.M.8
-
65
-
-
0032568534
-
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
-
Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., and Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Natl. Acad. Sci. USA 95 (1998) 6469-6473
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
66
-
-
58849092285
-
Membrane fusion: grappling with SNARE and SM proteins
-
Sudhof T.C., and Rothman J.E. Membrane fusion: grappling with SNARE and SM proteins. Science 323 (2009) 474-477
-
(2009)
Science
, vol.323
, pp. 474-477
-
-
Sudhof, T.C.1
Rothman, J.E.2
-
67
-
-
0032526981
-
Dopamine neurons make glutamatergic synapses in vitro
-
Sulzer D., Joyce M.P., Lin L., Geldwert D., Haber S.N., Hattori T., and Rayport S. Dopamine neurons make glutamatergic synapses in vitro. J. Neurosci. 18 (1998) 4588-4602
-
(1998)
J. Neurosci.
, vol.18
, pp. 4588-4602
-
-
Sulzer, D.1
Joyce, M.P.2
Lin, L.3
Geldwert, D.4
Haber, S.N.5
Hattori, T.6
Rayport, S.7
-
68
-
-
0037023699
-
Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins
-
Uversky V.N., Li J., Souillac P., Millett I.S., Doniach S., Jakes R., Goedert M., and Fink A.L. Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins. J. Biol. Chem. 277 (2002) 11970-11978
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11970-11978
-
-
Uversky, V.N.1
Li, J.2
Souillac, P.3
Millett, I.S.4
Doniach, S.5
Jakes, R.6
Goedert, M.7
Fink, A.L.8
-
69
-
-
0033966487
-
Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
-
Vila M., Vukosavic S., Jackson-Lewis V., Neystat M., Jakowec M., and Przedborski S. Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem. 74 (2000) 721-729
-
(2000)
J. Neurochem.
, vol.74
, pp. 721-729
-
-
Vila, M.1
Vukosavic, S.2
Jackson-Lewis, V.3
Neystat, M.4
Jakowec, M.5
Przedborski, S.6
-
70
-
-
33745494172
-
Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling
-
Voglmaier S.M., Kam K., Yang H., Fortin D.L., Hua Z., Nicoll R.A., and Edwards R.H. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron 51 (2006) 71-84
-
(2006)
Neuron
, vol.51
, pp. 71-84
-
-
Voglmaier, S.M.1
Kam, K.2
Yang, H.3
Fortin, D.L.4
Hua, Z.5
Nicoll, R.A.6
Edwards, R.H.7
-
71
-
-
0345189365
-
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein
-
Willingham S., Outeiro T.F., DeVit M.J., Lindquist S.L., and Muchowski P.J. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 302 (2003) 1769-1772
-
(2003)
Science
, vol.302
, pp. 1769-1772
-
-
Willingham, S.1
Outeiro, T.F.2
DeVit, M.J.3
Lindquist, S.L.4
Muchowski, P.J.5
-
72
-
-
10944243102
-
Role of alpha-synuclein in presynaptic dopamine recruitment
-
Yavich L., Tanila H., Vepsalainen S., and Jakala P. Role of alpha-synuclein in presynaptic dopamine recruitment. J. Neurosci. 24 (2004) 11165-11170
-
(2004)
J. Neurosci.
, vol.24
, pp. 11165-11170
-
-
Yavich, L.1
Tanila, H.2
Vepsalainen, S.3
Jakala, P.4
-
73
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz J.J., Alegre J., Gómez-Esteban J.C., Lezcano E., Ros R., Ampuero I., Vidal L., Hoenicka J., Rodriguez O., Atarés B., et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55 (2004) 164-173
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gómez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atarés, B.10
-
74
-
-
0034595728
-
Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells
-
Zhou W., Hurlbert M.S., Schaack J., Prasad K.N., and Freed C.R. Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. Brain Res. 866 (2000) 33-43
-
(2000)
Brain Res.
, vol.866
, pp. 33-43
-
-
Zhou, W.1
Hurlbert, M.S.2
Schaack, J.3
Prasad, K.N.4
Freed, C.R.5
|