Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments

FEBS Letters

Volumn 440, Issue 1-2, 1998, Pages 71-75

  El Agnaf, Omar M A ^a   Jakes, Ross ^b   Curran, Martin D ^c   Middleton, Derek ^a,c   Ingenito, Raffaele ^d   Bianchi, Elisabetta ^d   Pessi, Antonello ^d   Neill, David ^e   Wallace, Andrew ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Med Res Cncl of Molecular Biology   (United Kingdom)

^c BELFAST CITY HOSPITAL   (United Kingdom)

^d IRBM   (Italy)

^e NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

Author keywords

Synuclein; Amyloid; Lewy body; Neurodegenerative disease; Parkinson's disease; Toxicity

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DEGENERATIVE DISEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEWY BODY; NERVE DEGENERATION; NEUROBLASTOMA; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY;

ALPHA-SYNUCLEIN; AMYLOID; APOPTOSIS; BIOPOLYMERS; CELL NUCLEUS; CELL SURVIVAL; CIRCULAR DICHROISM; HUMANS; MICROSCOPY, ELECTRON; MUTATION; NERVE TISSUE PROTEINS; NEUROBLASTOMA; NEURODEGENERATIVE DISEASES; NEURONS; PARKINSON DISEASE; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; SYNUCLEINS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0032573597     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)01418-5     Document Type: Article

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