Monoubiquitylation of α-Synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells

Journal of Biological Chemistry

Volumn 283, Issue 6, 2008, Pages 3316-3328

  Rott, Ruth ^a   Szargel, Raymonde ^a   Haskin, Joseph ^a   Shani, Vered ^a   Shainskaya, Alla ^b   Manov, Irena ^a   Liani, Esti ^a   Avraham, Eyal ^a   Engelender, Simone ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN EXTRACTS; DOPAMINERGIC CELLS; IN VITRO; IN-VIVO; INCLUSION BODIES; ISOPEPTIDE LIGASE; LEWY BODIES; MASS SPECTROMETRY ANALYSIS; OVEREXPRESSION; PARKINSON DISEASES; SHORT HAIRPIN RNAS; SYNUCLEIN; SYNUCLEIN AGGREGATIONS; UBIQUITIN; UBIQUITYLATION;

AMINO ACIDS; CELL DEATH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCLUSIONS; MASS SPECTROMETRY; NUCLEIC ACIDS; PROTEINS; RNA; TOXIC MATERIALS;

AGGLOMERATION;

ALPHA SYNUCLEIN; LYSINE; PROTEIN SIAH; SHORT HAIRPIN RNA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; DOPAMINE; NUCLEAR PROTEIN; SEVEN IN ABSENTIA PROTEINS; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HUMAN; HUMAN CELL; LEWY BODY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; UBIQUITINATION; CELL INCLUSION; CHEMISTRY; MASS SPECTROMETRY; METABOLISM; NERVE CELL; PHYSIOLOGY; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE;

ALPHA-SYNUCLEIN; CELL LINE, TUMOR; DOPAMINE; HUMANS; INCLUSION BODIES; LEWY BODIES; LYSINE; MASS SPECTROMETRY; MICROSCOPY, ELECTRON, TRANSMISSION; MUTAGENESIS, SITE-DIRECTED; NEURONS; NUCLEAR PROTEINS; PROTEIN BINDING; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 41249090880     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704809200     Document Type: Article

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