Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

Autophagy

Volumn 10, Issue 12, 2014, Pages 2171-2192

  Poehler, Anne Maria ^a   Xiang, Wei ^a   Spitzer, Philipp ^a   May, Verena Elisabeth Luise ^a   Meixner, Holger ^a   Rockenstein, Edward ^b   Chutna, Oldriska ^c   Outeiro, Tiago Fleming ^c,d   Winkler, Juergen ^a,b   Masliah, Eliezer ^b   Klucken, Jochen ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^d UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Inflammation; Lysosomal degradation; Parkinson disease; Protein aggregation; Secretion; Synucleinopathies; synuclein

Indexed keywords

ALPHA SYNUCLEIN; OLIGOMER; RAB11 PROTEIN; RAB11A PROTEIN; UNCLASSIFIED DRUG; SNCA PROTEIN, HUMAN; SNCA PROTEIN, MOUSE; SNCA PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL DAMAGE; CONTROLLED STUDY; EXOSOME; GLIA CELL; GLIOSIS; MICROENVIRONMENT; MOUSE; NONHUMAN; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN SECRETION; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; HUMAN; LEWY BODY; METABOLISM; NERVE CELL; PARKINSON DISEASE; PHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

MUS MUSCULUS;

ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; CELLS, CULTURED; HUMANS; LEWY BODIES; MICE; MICE, TRANSGENIC; NEURONS; PARKINSON DISEASE; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 84922364789     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.36436     Document Type: Article

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