CHIP targets toxic α-synuclein oligomers for degradation

Journal of Biological Chemistry

Volumn 283, Issue 26, 2008, Pages 17962-17968

  Tetzlaff, Julie E ^a   Putcha, Preeti ^a   Outeiro, Tiago F ^a   Ivanov, Alexander ^a   Berezovska, Oksana ^a   Hyman, Bradley T ^a   McLean, Pamela J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG THERAPY; OLIGOMERIZATION; OLIGOMERS; POLYMERS; PROTEINS; TOXIC MATERIALS;

BIMOLECULAR FLUORESCENCE COMPLEMENTATION; BINDING DOMAINS; CARBOXYL TERMINUSES; DO-MAINS; INDUCED DEGRADATIONS; LEWY BODIES; MISFOLDED PROTEINS; MOLECULAR CHAPERONES; MULTI DOMAINS; PARKINSON DISEASES; SYNUCLEIN;

DEGRADATION;

ALPHA SYNUCLEIN; CHAPERONE; CHIP PROTEIN; HEAT SHOCK PROTEIN 70; OLIGOMER; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; DETERGENT; GREEN FLUORESCENT PROTEIN; STUB1 PROTEIN, HUMAN;

ARTICLE; BIMOLECULAR FLUORESCENCE COMPLEMENTATION ASSAY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FIBER; FLUORESCENCE; HUMAN; HUMAN CELL; LEWY BODY; NEUROTOXICITY; OLIGOMERIZATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; TETRATRICOPEPTIDE REPEAT; CELL FRACTIONATION; CHEMISTRY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; METABOLISM; MOLECULAR WEIGHT; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TEMPERATURE; TUMOR CELL LINE;

ALPHA-SYNUCLEIN; CELL LINE, TUMOR; DETERGENTS; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR WEIGHT; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBCELLULAR FRACTIONS; TEMPERATURE; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

EID: 49649125680     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802283200     Document Type: Article

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