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Volumn 113, Issue 5, 2010, Pages 1263-1274

Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions

Author keywords

Misfolding; Neurodegenerative disease; Parkinson's disease; Protein aggregation; Secretion

Indexed keywords

ALPHA SYNUCLEIN; GLOBULAR PROTEIN;

EID: 77951885732     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06695.x     Document Type: Article
Times cited : (233)

References (49)
  • 1
    • 0037387147 scopus 로고    scopus 로고
    • A cell surface receptor complex for fibrillar β-amyloid mediates microglial activation
    • Bamberger M. E., Harris M. E., McDonald D. R., Husemann J. Landreth G. E. (2003) A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci 23, 2665 2674. (Pubitemid 36418601)
    • (2003) Journal of Neuroscience , vol.23 , Issue.7 , pp. 2665-2674
    • Bamberger, M.E.1    Harris, M.E.2    McDonald, D.R.3    Husemann, J.4    Landreth, G.E.5
  • 3
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • DOI 10.1016/S0197-4580(02)00065-9, PII S0197458002000659
    • Braak H., Del Tredici K., Rub U., de Vos R. A., Jansen Steur E. N. Braak E. (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24, 197 211. (Pubitemid 36007810)
    • (2003) Neurobiology of Aging , vol.24 , Issue.2 , pp. 197-211
    • Braak, H.1    Del Tredici, K.2    Rub, U.3    De Vos, R.A.I.4    Jansen Steur, E.N.H.5    Braak, E.6
  • 4
    • 0034646391 scopus 로고    scopus 로고
    • Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
    • Conway K. A., Harper J. D. Lansbury Jr. P. T. (2000) Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 39, 2552 2563.
    • (2000) Biochemistry , vol.39 , pp. 2552-2563
    • Conway, K.A.1    Harper, J.D.2    Lansbury Jr., P.T.3
  • 5
    • 22244442489 scopus 로고    scopus 로고
    • The biochemistry of Parkinson's disease
    • Cookson M. R. (2005) The biochemistry of Parkinson's disease. Annu Rev Biochem 74, 29 52.
    • (2005) Annu Rev Biochem , vol.74 , pp. 29-52
    • Cookson, M.R.1
  • 6
    • 0347481133 scopus 로고    scopus 로고
    • 'Nonclassical' Secretion of Annexin A2 to the Lumenal Side of the Enterocyte Brush Border Membrane
    • DOI 10.1021/bi0355239
    • Danielsen E. M., van Deurs B. Hansen G. H. (2003) " Nonclassical" secretion of annexin A2 to the lumenal side of the enterocyte brush border membrane. Biochemistry 42, 14670 14676. (Pubitemid 37532014)
    • (2003) Biochemistry , vol.42 , Issue.49 , pp. 14670-14676
    • Danielsen, E.M.1    Van Deurs, B.2    Hansen, G.H.3
  • 7
    • 0032540327 scopus 로고    scopus 로고
    • Stabilization of α-Synuclein secondary structure upon binding to synthetic membranes
    • DOI 10.1074/jbc.273.16.9443
    • Davidson W. S., Jonas A., Clayton D. F. George J. M. (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J Biol Chem 273, 9443 9449. (Pubitemid 28183026)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.16 , pp. 9443-9449
    • Davidson, W.S.1    Jonas, A.2    Clayton, D.F.3    George, J.M.4
  • 9
    • 85109083933 scopus 로고    scopus 로고
    • Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
    • El-Agnaf O. M., Salem S. A., Paleologou K. E., et al. (2003) Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J 17, 1945 1947.
    • (2003) FASEB J , vol.17 , pp. 1945-1947
    • El-Agnaf, O.M.1    Salem, S.A.2    Paleologou, K.E.3
  • 10
    • 33645833848 scopus 로고    scopus 로고
    • Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
    • DOI 10.1096/fj.03-1449com
    • El-Agnaf O. M., Salem S. A., Paleologou K. E., Curran M. D., Gibson M. J., Court J. A., Schlossmacher M. G. Allsop D. (2006) Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J. 20, 419 425. (Pubitemid 44933318)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 419-425
    • El-Agnaf, O.M.A.1    Salem, S.A.2    Paleologou, K.E.3    Curran, M.D.4    Gibson, M.J.5    Court, J.A.6    Schlossmacher, M.G.7    Allsop, D.8
  • 11
    • 3543056130 scopus 로고    scopus 로고
    • Neurodegeneration and Neuroprotection in Parkinson Disease
    • DOI 10.1602/neurorx.1.1.139, PII S1545534306700141
    • Fahn S. Sulzer D. (2004) Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx 1, 139 154. (Pubitemid 46589347)
    • (2004) NeuroRx , vol.1 , Issue.1 , pp. 139-154
    • Fahn, S.1    Sulzer, D.2
  • 12
    • 2942584868 scopus 로고    scopus 로고
    • NMR of α-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation
    • DOI 10.1038/sj.emboj.7600211
    • Fernandez C. O., Hoyer W., Zweckstetter M., Jares-Erijman E. A., Subramaniam V., Griesinger C. Jovin T. M. (2004) NMR of alpha-synuclein- polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO J. 23, 2039 2046. (Pubitemid 38737731)
    • (2004) EMBO Journal , vol.23 , Issue.10 , pp. 2039-2046
    • Fernandez, C.O.1    Hoyer, W.2    Zweckstetter, M.3    Jares-Erijman, E.A.4    Subramaniam, V.5    Griesinger, C.6    Jovin, T.M.7
  • 13
    • 3142630225 scopus 로고    scopus 로고
    • Exosomes: Endosomal-derived vesicles shipping extracellular messages
    • DOI 10.1016/j.ceb.2004.06.003, PII S0955067404000729
    • Fevrier B. Raposo G. (2004) Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16, 415 421. (Pubitemid 38903148)
    • (2004) Current Opinion in Cell Biology , vol.16 , Issue.4 , pp. 415-421
    • Fevrier, B.1    Raposo, G.2
  • 16
    • 0036775236 scopus 로고    scopus 로고
    • The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway
    • DOI 10.1093/embo-reports/kvf198
    • Gardella S., Andrei C., Ferrera D., Lotti L. V., Torrisi M. R., Bianchi M. E. Rubartelli A. (2002) The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep. 3, 995 1001. (Pubitemid 35256475)
    • (2002) EMBO Reports , vol.3 , Issue.10 , pp. 995-1001
    • Gardella, S.1    Andrei, C.2    Ferrera, D.3    Lotti, L.V.4    Torrisi, M.R.5    Bianchi, M.E.6    Rubartelli, A.7
  • 17
    • 36949031267 scopus 로고    scopus 로고
    • α-Synucleinopathy models and human neuropathology: Similarities and differences
    • DOI 10.1007/s00401-007-0302-x
    • Kahle P. J. (2008) alpha-Synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol. 115, 87 95. (Pubitemid 350238669)
    • (2008) Acta Neuropathologica , vol.115 , Issue.1 , pp. 87-95
    • Kahle, P.J.1
  • 18
    • 54749104651 scopus 로고    scopus 로고
    • Controlling the mass action of alpha-synuclein in Parkinson's disease
    • Kim C. Lee S.-J. (2008) Controlling the mass action of alpha-synuclein in Parkinson's disease. J. Neurochem. 107, 303 316.
    • (2008) J. Neurochem. , vol.107 , pp. 303-316
    • Kim, C.1    Lee, S.-J.2
  • 19
    • 33745279409 scopus 로고    scopus 로고
    • A Novel Mechanism of Interaction between α-Synuclein and Biological Membranes
    • DOI 10.1016/j.jmb.2006.05.004, PII S0022283606005705
    • Kim Y. S., Laurine E., Woods W. Lee S. J. (2006) A novel mechanism of interaction between alpha-synuclein and biological membranes. J. Mol. Biol. 360, 386 397. (Pubitemid 43927829)
    • (2006) Journal of Molecular Biology , vol.360 , Issue.2 , pp. 386-397
    • Kim, Y.S.1    Laurine, E.2    Woods, W.3    Lee, S.-J.4
  • 20
    • 40849118624 scopus 로고    scopus 로고
    • α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia
    • DOI 10.1016/j.neurobiolaging.2006.11.013, PII S0197458006004362
    • Klegeris A., Pelech S., Giasson B. I., Maguire J., Zhang H., McGeer E. G. McGeer P. L. (2008) Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiol. Aging 29, 739 752. (Pubitemid 351400820)
    • (2008) Neurobiology of Aging , vol.29 , Issue.5 , pp. 739-752
    • Klegeris, A.1    Pelech, S.2    Giasson, B.I.3    Maguire, J.4    Zhang, H.5    McGeer, E.G.6    McGeer, P.L.7
  • 21
    • 33750117120 scopus 로고    scopus 로고
    • Detection of novel intracellular α-synuclein oligomeric species by fluorescence lifetime imaging
    • DOI 10.1096/fj.05-5422com
    • Klucken J., Outeiro T. F., Nguyen P., McLean P. J. Hyman B. T. (2006) Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. FASEB J. 20, 2050 2057. (Pubitemid 44953904)
    • (2006) FASEB Journal , vol.20 , Issue.12 , pp. 2050-2057
    • Klucken, J.1    Outeiro, T.F.2    Nguyen, P.3    McLean, P.J.4    Hyman, B.T.5
  • 22
    • 61349201380 scopus 로고    scopus 로고
    • Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
    • Lauren J., Gimbel D. A., Nygaard H. B., Gilbert J. W. Strittmatter S. M. (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457, 1128 1132.
    • (2009) Nature , vol.457 , pp. 1128-1132
    • Lauren, J.1    Gimbel, D.A.2    Nygaard, H.B.3    Gilbert, J.W.4    Strittmatter, S.M.5
  • 23
    • 1442275729 scopus 로고    scopus 로고
    • Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway
    • DOI 10.1523/JNEUROSCI.3809-03.2004
    • Lee H.-J., Khoshaghideh F., Patel S. Lee S.-J. (2004) Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J. Neurosci. 24, 1888 1896. (Pubitemid 38292800)
    • (2004) Journal of Neuroscience , vol.24 , Issue.8 , pp. 1888-1896
    • Lee, H.-J.1    Khoshaghideh, F.2    Patel, S.3    Lee, S.-J.4
  • 24
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of α-synuclein and its aggregates
    • DOI 10.1523/JNEUROSCI.0692-05.2005
    • Lee H.-J., Patel S. Lee S.-J. (2005) Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J. Neurosci. 25, 6016 6024. (Pubitemid 40911433)
    • (2005) Journal of Neuroscience , vol.25 , Issue.25 , pp. 6016-6024
    • Lee, H.-J.1    Patel, S.2    Lee, S.-J.3
  • 25
    • 0037085288 scopus 로고    scopus 로고
    • Formation and removal of α-synuclein aggregates in cells exposed to mitochondrial inhibitors
    • DOI 10.1074/jbc.M105326200
    • Lee H.-J., Shin S. Y., Choi C., Lee Y. H. Lee S.-J. (2002) Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J. Biol. Chem. 277, 5411 5417. (Pubitemid 34968588)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.7 , pp. 5411-5417
    • Lee, H.-J.1    Shin, S.Y.2    Choi, C.3    Lee, Y.H.4    Lee, S.-J.5
  • 27
    • 44749090147 scopus 로고    scopus 로고
    • Clearance and deposition of extracellular alpha-synuclein aggregates in microglia
    • Lee H.-J., Suk J. E., Bae E. J. Lee S.-J. (2008b) Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. Biochem. Biophys. Res. Commun. 372, 423 428.
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 423-428
    • Lee, H.-J.1    Suk, J.E.2    Bae, E.J.3    Lee, S.-J.4
  • 28
    • 77950571596 scopus 로고    scopus 로고
    • Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
    • Lee H. J., Suk J. E., Patrick C., Bae E. J., Cho J. H., Rho S., Hwang D., Masliah E. Lee S. J. (2010) Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem. 285, 9262 9272.
    • (2010) J Biol Chem. , vol.285 , pp. 9262-9272
    • Lee, H.J.1    Suk, J.E.2    Patrick, C.3    Bae, E.J.4    Cho, J.H.5    Rho, S.6    Hwang, D.7    Masliah, E.8    Lee, S.J.9
  • 29
    • 40749094842 scopus 로고    scopus 로고
    • Origins and effects of extracellular alpha-synuclein: Implications in Parkinson's disease
    • Lee S.-J. (2008) Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease. J. Mol. Neurosci. 34, 17 22.
    • (2008) J. Mol. Neurosci. , vol.34 , pp. 17-22
    • Lee, S.-J.1
  • 30
    • 34548180606 scopus 로고    scopus 로고
    • Investigation of tyrosine nitration and nitrosylation of angiotensin II and bovine serum albumin with electrospray ionization mass spectrometry
    • Lee S. J., Lee J. R., Kim Y. H., Park Y. S., Park S. I., Park H. S. Kim K. P. (2007) Investigation of tyrosine nitration and nitrosylation of angiotensin II and bovine serum albumin with electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 21, 2797 2804.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 2797-2804
    • Lee, S.J.1    Lee, J.R.2    Kim, Y.H.3    Park, Y.S.4    Park, S.I.5    Park, H.S.6    Kim, K.P.7
  • 31
    • 63149090431 scopus 로고    scopus 로고
    • Parkinson's disease: From monogenic forms to genetic susceptibility factors
    • Lesage S. Brice A. (2009) Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum. Mol. Genet. 18, R48 59.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 48-59
    • Lesage, S.1    Brice, A.2
  • 32
    • 0038701886 scopus 로고    scopus 로고
    • The mystery of nonclassical protein secretion: A current view on cargo proteins and potential export routes
    • DOI 10.1046/j.1432-1033.2003.03577.x
    • Nickel W. (2003) The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. Eur. J. Biochem. 270, 2109 2119. (Pubitemid 36608925)
    • (2003) European Journal of Biochemistry , vol.270 , Issue.10 , pp. 2109-2119
    • Nickel, W.1
  • 34
    • 36249026458 scopus 로고    scopus 로고
    • Dysautonomia and cognitive dysfunction in Parkinson's disease
    • DOI 10.1002/mds.21681
    • Poewe W. (2007) Dysautonomia and cognitive dysfunction in Parkinson's disease. Mov. Disord. 22 (Suppl. 17 S374 S378. (Pubitemid 350134191)
    • (2007) Movement Disorders , vol.22 , Issue.SUPPL. 17
    • Poewe, W.1
  • 35
    • 34247130917 scopus 로고    scopus 로고
    • Effect of 4-hydroxy-2-nonenal modification on α-synuclein aggregation
    • DOI 10.1074/jbc.M608126200
    • Qin Z., Hu D., Han S., Reaney S. H., Di Monte D. A. Fink A. L. (2007) Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation. J. Biol. Chem. 282, 5862 5870. (Pubitemid 47093740)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.8 , pp. 5862-5870
    • Qin, Z.1    Hu, D.2    Han, S.3    Reaney, S.H.4    Di Monte, D.A.5    Fink, A.L.6
  • 38
    • 70349323417 scopus 로고    scopus 로고
    • CD14 and toll-like receptors 2 and 4 are required for fibrillar Abeta-stimulated microglial activation
    • Reed-Geaghan E. G., Savage J. C., Hise A. G. Landreth G. E. (2009) CD14 and toll-like receptors 2 and 4 are required for fibrillar Abeta-stimulated microglial activation. J. Neurosci. 29, 11982 11992.
    • (2009) J. Neurosci. , vol.29 , pp. 11982-11992
    • Reed-Geaghan, E.G.1    Savage, J.C.2    Hise, A.G.3    Landreth, G.E.4
  • 40
    • 0025255629 scopus 로고
    • A novel secretory pathway for interleukin-1β, a protein lacking a signal sequence
    • Rubartelli A., Cozzolino F., Talio M. Sitia R. (1990) A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J. 9, 1503 1510. (Pubitemid 20137006)
    • (1990) EMBO Journal , vol.9 , Issue.5 , pp. 1503-1510
    • Rubartelli, A.1    Cozzolino, F.2    Talio, M.3    Sitia, R.4
  • 45
    • 0036798783 scopus 로고    scopus 로고
    • Improperly folded green fluorescent protein is secreted via a non-classical pathway
    • DOI 10.1242/jcs.00047
    • Tanudji M., Hevi S. Chuck S. L. (2002) Improperly folded green fluorescent protein is secreted via a non-classical pathway. J. Cell. Sci. 115, 3849 3857. (Pubitemid 35203611)
    • (2002) Journal of Cell Science , vol.115 , Issue.19 , pp. 3849-3857
    • Tanudji, M.1    Hevi, S.2    Chuck, S.L.3
  • 46
    • 29444443348 scopus 로고    scopus 로고
    • Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
    • DOI 10.1038/nn1603
    • Urushitani M., Sik A., Sakurai T., Nukina N., Takahashi R. Julien J. P. (2006) Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat. Neurosci. 9, 108 118. (Pubitemid 43011916)
    • (2006) Nature Neuroscience , vol.9 , Issue.1 , pp. 108-118
    • Urushitani, M.1    Sik, A.2    Sakurai, T.3    Nukina, N.4    Takahashi, R.5    Julien, J.-P.6
  • 47
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
    • DOI 10.1021/bi961799n
    • Weinreb P. H., Zhen W., Poon A. W., Conway K. A. Lansbury P. T., Jr. (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35, 13709 13715. (Pubitemid 26363912)
    • (1996) Biochemistry , vol.35 , Issue.43 , pp. 13709-13715
    • Weinreb, P.H.1    Zhen, W.2    Poon, A.W.3    Conway, K.A.4    Lansbury Jr., P.T.5


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