-
1
-
-
22244442489
-
The biochemistry of Parkinson's disease
-
Cookson MR. The biochemistry of Parkinson's disease. Annu Rev Biochem 2005; 74: 29-52.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 29-52
-
-
Cookson, M.R.1
-
2
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997; 276: 2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
-
3
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease [letter]
-
Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease [letter]. Nat Genet 1998; 18: 106-108.
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
-
4
-
-
0242300619
-
Alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J et al. alpha-Synuclein locus triplication causes Parkinson's disease. Science 2003; 302: 841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
-
5
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S et al. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004; 364: 1167-1169.
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
-
6
-
-
4644236043
-
Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
-
Ibanez P, Bonnet AM, Debarges B, Lohmann E, Tison F, Pollak P et al. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 2004; 364: 1169-1171.
-
(2004)
Lancet
, vol.364
, pp. 1169-1171
-
-
Ibanez, P.1
Bonnet, A.M.2
Debarges, B.3
Lohmann, E.4
Tison, F.5
Pollak, P.6
-
7
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, Ampuero I et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 2004; 55: 164-173.
-
(2004)
Ann Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
-
8
-
-
34548620297
-
Neuropathology, biochemistry, and biophysics of alphasynuclein aggregation
-
Uversky VN. Neuropathology, biochemistry, and biophysics of alphasynuclein aggregation. J Neurochem 2007; 103: 17-37.
-
(2007)
J Neurochem
, vol.103
, pp. 17-37
-
-
Uversky, V.N.1
-
9
-
-
80052398365
-
Alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
-
Bartels T, Choi JG, Selkoe DJ. alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 2011; 477: 107-110.
-
(2011)
Nature
, vol.477
, pp. 107-110
-
-
Bartels, T.1
Choi, J.G.2
Selkoe, D.J.3
-
10
-
-
54749104651
-
Controlling the mass action of alpha-synuclein in Parkinson's disease
-
Kim C, Lee S-J. Controlling the mass action of alpha-synuclein in Parkinson's disease. J Neurochem 2008; 107: 303-316.
-
(2008)
J Neurochem
, vol.107
, pp. 303-316
-
-
Kim, C.1
Lee, S.-J.2
-
11
-
-
5444255434
-
Stages in the development of Parkinson's disease-related pathology
-
Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res 2004; 318: 121-134.
-
(2004)
Cell Tissue Res
, vol.318
, pp. 121-134
-
-
Braak, H.1
Ghebremedhin, E.2
Rub, U.3
Bratzke, H.4
Del Tredici, K.5
-
12
-
-
1442275729
-
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway
-
Lee H-J, Khoshaghideh F, Patel S, Lee S-J. Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci 2004; 24: 1888-1896.
-
(2004)
J Neurosci
, vol.24
, pp. 1888-1896
-
-
Lee, H.-J.1
Khoshaghideh, F.2
Patel, S.3
Lee, S.-J.4
-
13
-
-
84934444265
-
Clearance of mutant aggregate-prone proteins by autophagy
-
Ravikumar B, Sarkar S, Rubinsztein DC. Clearance of mutant aggregate-prone proteins by autophagy. Methods Mol Biol 2008; 445: 195-211.
-
(2008)
Methods Mol Biol
, vol.445
, pp. 195-211
-
-
Ravikumar, B.1
Sarkar, S.2
Rubinsztein, D.C.3
-
14
-
-
84864842887
-
The role of autophagy in Parkinson's disease
-
Lynch-Day MA, Mao K, Wang K, Zhao M, Klionsky DJ. The role of autophagy in Parkinson's disease. Cold Spring Harb Perspect Med 2012; 2: a009357.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Lynch-Day, M.A.1
Mao, K.2
Wang, K.3
Zhao, M.4
Klionsky, D.J.5
-
15
-
-
4344659685
-
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
-
Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004; 305: 1292-1295.
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
16
-
-
53049098471
-
Wild type α-synuclein is degraded by chaperone mediated autophagy and macroautophagy in neuronal cells
-
Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L. Wild type α-synuclein is degraded by chaperone mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 2008; 283: 23542-23556.
-
(2008)
J Biol Chem
, vol.283
, pp. 23542-23556
-
-
Vogiatzi, T.1
Xilouri, M.2
Vekrellis, K.3
Stefanis, L.4
-
17
-
-
0041589248
-
Alpha-Synuclein is degraded by both autophagy and the proteasome
-
Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 2003; 278: 25009-25013.
-
(2003)
J Biol Chem
, vol.278
, pp. 25009-25013
-
-
Webb, J.L.1
Ravikumar, B.2
Atkins, J.3
Skepper, J.N.4
Rubinsztein, D.C.5
-
18
-
-
21344456506
-
Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
-
Lee H-J, Patel S, Lee S-J. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci 2005; 25: 6016-6024.
-
(2005)
J Neurosci
, vol.25
, pp. 6016-6024
-
-
Lee, H.-J.1
Patel, S.2
Lee, S.-J.3
-
19
-
-
77951885732
-
Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions
-
Jang A, Lee H-J, Suk JE, Jung JW, Kim KP, Lee S-J. Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J Neurochem 2010; 113: 1263-1274.
-
(2010)
J Neurochem
, vol.113
, pp. 1263-1274
-
-
Jang, A.1
Lee, H.-J.2
Suk, J.E.3
Jung, J.W.4
Kim, K.P.5
Lee, S.-J.6
-
20
-
-
79955660630
-
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
-
Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ. Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. Exp Mol Med 2011.
-
(2011)
Exp Mol Med
-
-
Lee, H.J.1
Baek, S.M.2
Ho, D.H.3
Suk, J.E.4
Cho, E.D.5
Lee, S.J.6
-
21
-
-
33748447845
-
Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease
-
Kim YS, TH Joh. Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp Mol Med 2006; 38: 333-347.
-
(2006)
Exp Mol Med
, vol.38
, pp. 333-347
-
-
Kim, Y.S.1
Joh, T.H.2
-
22
-
-
44749090147
-
Clearance and deposition of extracellular alpha-synuclein aggregates in microglia
-
Lee H-J, Suk JE, Bae EJ, Lee S-J. Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. Biochem Biophys Res Commun 2008; 372: 423-428.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 423-428
-
-
Lee, H.-J.1
Suk, J.E.2
Bae, E.J.3
Lee, S.-J.4
-
23
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
-
Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci USA 2009; 106: 13010-13015.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.J.2
Bae, E.J.3
Patrick, C.4
Rockenstein, E.5
Crews, L.6
-
24
-
-
77950571596
-
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
-
Lee H-J, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S et al. Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem 2010; 285: 9262-9272.
-
(2010)
J Biol Chem
, vol.285
, pp. 9262-9272
-
-
Lee, H.-J.1
Suk, J.E.2
Patrick, C.3
Bae, E.J.4
Cho, J.H.5
Rho, S.6
-
25
-
-
80053613574
-
Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
-
Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A et al. Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 2011; 72: 57-71.
-
(2011)
Neuron
, vol.72
, pp. 57-71
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Patel, T.P.3
Tanik, S.A.4
Riddle, D.M.5
Stieber, A.6
-
26
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008; 14: 504-506.
-
(2008)
Nat Med
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
27
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-tograft disease propagation
-
Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-tograft disease propagation. Nat Med 2008; 14: 501-503.
-
(2008)
Nat Med
, vol.14
, pp. 501-503
-
-
Li, J.Y.1
Englund, E.2
Holton, J.L.3
Soulet, D.4
Hagell, P.5
Lees, A.J.6
-
28
-
-
79960259164
-
Enzyme-linked immunosorbent assays for alpha-synuclein with species and multimeric state specificities
-
Lee HJ, Bae EJ, Jang A, Ho DH, Cho ED, Suk JE et al. Enzyme-linked immunosorbent assays for alpha-synuclein with species and multimeric state specificities. J Neurosci Methods 2011; 199: 249-257.
-
(2011)
J Neurosci Methods
, vol.199
, pp. 249-257
-
-
Lee, H.J.1
Bae, E.J.2
Jang, A.3
Ho, D.H.4
Cho, E.D.5
Suk, J.E.6
-
29
-
-
0037085288
-
Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors
-
Lee H-J, Shin SY, Choi C, Lee YH, Lee S-J. Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem 2002; 277: 5411-5417.
-
(2002)
J Biol Chem
, vol.277
, pp. 5411-5417
-
-
Lee, H.-J.1
Shin, S.Y.2
Choi, C.3
Lee, Y.H.4
Lee, S.-J.5
-
30
-
-
44749083979
-
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein
-
Lee H-J, Suk JE, Bae EJ, Lee JH, Paik SR, Lee S-J. Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol 2008; 40: 1835-1849.
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 1835-1849
-
-
Lee, H.-J.1
Suk, J.E.2
Bae, E.J.3
Lee, J.H.4
Paik, S.R.5
Lee, S.-J.6
-
31
-
-
77951217000
-
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class i and III phosphoinositide 3-kinase
-
Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 2010; 285: 10850-10861.
-
(2010)
J Biol Chem
, vol.285
, pp. 10850-10861
-
-
Wu, Y.T.1
Tan, H.L.2
Shui, G.3
Bauvy, C.4
Huang, Q.5
Wenk, M.R.6
-
32
-
-
34548077575
-
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
-
Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3: 452-460.
-
(2007)
Autophagy
, vol.3
, pp. 452-460
-
-
Kimura, S.1
Noda, T.2
Yoshimori, T.3
-
33
-
-
57549094368
-
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice
-
Sou YS, Waguri S, Iwata J, Ueno T, Fujimura T, Hara T et al. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell 2008; 19: 4762-4775.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 4762-4775
-
-
Sou, Y.S.1
Waguri, S.2
Iwata, J.3
Ueno, T.4
Fujimura, T.5
Hara, T.6
-
34
-
-
78149471570
-
Autophagy in neurodegenerative disorders: Pathogenic roles and therapeutic implications
-
Banerjee R, Beal MF, Thomas B. Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications. Trends Neurosci 2010; 33: 541-549.
-
(2010)
Trends Neurosci
, vol.33
, pp. 541-549
-
-
Banerjee, R.1
Beal, M.F.2
Thomas, B.3
-
35
-
-
77149155386
-
Unconventional secretion of Acb1 is mediated by autophagosomes
-
Duran JM, Anjard C, Stefan C, Loomis WF, Malhotra V. Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol 2010; 188: 527-536.
-
(2010)
J Cell Biol
, vol.188
, pp. 527-536
-
-
Duran, J.M.1
Anjard, C.2
Stefan, C.3
Loomis, W.F.4
Malhotra, V.5
-
36
-
-
77149152566
-
Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation
-
Manjithaya R, Anjard C, Loomis WF, Subramani S. Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation. J Cell Biol 2010; 188: 537-546.
-
(2010)
J Cell Biol
, vol.188
, pp. 537-546
-
-
Manjithaya, R.1
Anjard, C.2
Loomis, W.F.3
Subramani, S.4
-
37
-
-
77952648551
-
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
-
Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH et al. Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci 2010; 30: 6838-6851.
-
(2010)
J Neurosci
, vol.30
, pp. 6838-6851
-
-
Emmanouilidou, E.1
Melachroinou, K.2
Roumeliotis, T.3
Garbis, S.D.4
Ntzouni, M.5
Margaritis, L.H.6
-
38
-
-
79954631518
-
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
-
Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, Sargent IL, Wood MJ et al. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis 2011; 42: 360-367.
-
(2011)
Neurobiol Dis
, vol.42
, pp. 360-367
-
-
Alvarez-Erviti, L.1
Seow, Y.2
Schapira, A.H.3
Gardiner, C.4
Sargent, I.L.5
Wood, M.J.6
-
39
-
-
84055207529
-
The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of alpha-synuclein
-
Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M et al. The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of alpha-synuclein. PLoS One 2011; 6: e29460.
-
(2011)
PLoS One
, vol.6
-
-
Hasegawa, T.1
Konno, M.2
Baba, T.3
Sugeno, N.4
Kikuchi, A.5
Kobayashi, M.6
-
40
-
-
77957189194
-
Alpha-Synuclein impairs macroautophagy: Implications for Parkinson's disease
-
Winslow AR, Chen CW, Corrochano S, Acevedo-Arozena A, Gordon DE, Peden AA et al. alpha-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol 2010; 190: 1023-1037.
-
(2010)
J Cell Biol
, vol.190
, pp. 1023-1037
-
-
Winslow, A.R.1
Chen, C.W.2
Corrochano, S.3
Acevedo-Arozena, A.4
Gordon, D.E.5
Peden, A.A.6
|