α-Synuclein promotes SNARE-complex assembly in vivo and in vitro

Science

Volumn 329, Issue 5999, 2010, Pages 1663-1667

  Burré, Jacqueline ^a   Sharma, Manu ^a   Tsetsenis, Theodoros ^a   Buchman, Vladimir ^b   Etherton, Mark R ^a   Südhof, Thomas C ^a  

^a STANFORD UNIVERSITY   (United States)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CHAPERONE; SNARE PROTEIN; SYNAPTOBREVIN 2; CYSTEINE STRING PROTEIN; HEAT SHOCK PROTEIN 40; HYBRID PROTEIN; MEMBRANE PROTEIN; PROTEIN BINDING; SNCA PROTEIN, HUMAN; SNCA PROTEIN, MOUSE; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2, MOUSE;

AGING; MORTALITY; NEUROLOGY; ORGANIC NITROGEN COMPOUND; PATHOGEN; PROTEIN; RODENT;

ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FUNCTION; AGING; ANIMAL; CELL CULTURE; CELL LINE; CHEMISTRY; GENETICS; HUMAN; KNOCKOUT MOUSE; MEMBRANE FUSION; METABOLISM; NERVE CELL; NERVE DEGENERATION; RAT; SYNAPTOSOME; TRANSGENIC MOUSE;

AGING; ALPHA-SYNUCLEIN; ANIMALS; CELL LINE; CELLS, CULTURED; HSP40 HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE FUSION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE DEGENERATION; NEURONS; PRESYNAPTIC TERMINALS; PROTEIN BINDING; RATS; RECOMBINANT FUSION PROTEINS; SNARE PROTEINS; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

MUS;

EID: 77957347060     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1195227     Document Type: Article

References (28)

1. S. Martens, H. T. McMahon, Nat. Rev. Mol. Cell Biol. 9, 543 (2008).
2. W. Wickner, R. Schekman, Nat. Struct. Mol. Biol. 15, 658 (2008).
3. T. C. Südhof, J. E. Rothman, Science 23, 474 (2009).
4. M. L. Kramer, W. J. Schulz-Schaeffer, J. Neurosci. 27, 1405 (2007).
5. S. W. Scheff, D. A. Price, F. A. Schmitt, S. T. DeKosky, E. J. Mufson, Neurology 68, 1501 (2007).
6. B. C. Gray, Z. Siskova, V. H. Perry, V. O'Connor, Neurobiol. Dis. 35, 63 (2009).
7. R. Fernández-Chacón et al., Neuron 42, 237 (2004).
8. D. F. Clayton, J. M. George, Trends Neurosci. 21, 249 (1998).
9. M. H. Polymeropoulos et al., Science 276, 2045 (1997).
10. M. G. Spillantini et al., Nature 388, 839 (1997).
11. A. Gupta, V. L. Dawson, T. M. Dawson, Ann. Neurol. 64 (suppl. 2), S3 (2008).
12. M. Ahmad, S. Attoub, M. N. Singh, F. L. Martin, O. M. El-Agnaf, FASEB J. 21, 3419 (2007).
13. S. Liu et al., EMBO J. 23, 4506 (2004).
14. V. M. Nemani et al., Neuron 65, 66 (2010).
15. S. Chandra, G. Gallardo, R. Fernández-Chacón, O. M. Schlüter, T. C. Südhof, Cell 123, 383 (2005).
16. Materials and methods are available as supporting material on Science Online.
17. S. Chandra, X. Chen, J. Rizo, R. Jahn, T. C. Südhof, J. Biol. Chem. 278, 15313 (2003).
18. P. García-Junco-Clemente et al., J. Neurosci. 30, 7377 (2010).
19. T. Hayashi et al., EMBO J. 13, 5051 (1994).
20. A. Abeliovich et al., Neuron 25, 239 (2000).
21. S. Chandra et al., Proc. Natl. Acad. Sci. U.S.A. 101, 14966 (2004).
22. N. Ninkina et al., Mol. Cell. Biol. 23, 8233 (2003).
23. M. G. Spillantini et al., Nature 388, 839 (1997).
24. A. Takeda et al., Am. J. Pathol. 152, 367 (1998).
25. P. J. Kahle et al., Am. J. Pathol. 159, 2215 (2001).
26. C. W. Liu et al., J. Biol. Chem. 280, 22670 (2005).
27. P. K. Auluck, H. Y. Chan, J. Q. Trojanowski, V. M. Lee, N. M. Bonini, Science 295, 865 (2002).
28. We thank S. Chandra for advice. This work was supported by postdoctoral fellowships from the Human Frontiers Program (LT00527/2006-L to M.S. and LT000135/2009-L to T.T.) and the Deutsche Akademie der Naturforscher Leopoldina (BMBF-LPD 9901/8-161 to J.B.).