α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

Journal of Clinical Investigation

Volumn 121, Issue 2, 2011, Pages 715-725

  Hansen, Christian ^a   Angot, Elodie ^a   Bergström, Ann Louise ^b   Steiner, Jennifer A ^a   Pieri, Laura ^c   Paul, Gesine ^a   Outeiro, Tiago F ^d,e   Melki, Ronald ^c   Kallunki, Pekka ^b   Fog, Karina ^b   Li, Jia Yi ^a   Brundin, Patrik ^a  

^a LUND UNIVERSITY   (Sweden)

^b H LUNDBECK A S   (Denmark)

^c LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^d INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^e UNIVERSITY OF LISBON   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; GREEN FLUORESCENT PROTEIN; RED FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CELL INTERACTION; CELL LABELING; CELL LINE; CELL TRANSFER; CELLULAR DISTRIBUTION; COCULTURE; CONTROLLED STUDY; CYTOPLASM; DOPAMINERGIC NERVE CELL; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; HOST CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; MICROSCOPY; MOUSE; NEUROBLASTOMA CELL; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

ALPHA-SYNUCLEIN; ANIMALS; BRAIN; CELL TRANSPLANTATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DOPAMINE; HEK293 CELLS; HUMANS; LEWY BODIES; MICE; NEURONS; PARKINSON DISEASE; RATS; RECOMBINANT FUSION PROTEINS;

EID: 79551519276     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI43366     Document Type: Article

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