Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Freeman, David ^a   Cedillos, Rudy ^a   Choyke, Samantha ^a   Lukic, Zana ^a   McGuire, Kathleen ^a   Marvin, Shauna ^a   Burrage, Andrew M ^a   Sudholt, Stacey ^b   Rana, Ajay ^a   O'Connor, Christopher ^c   Wiethoff, Christopher M ^a   Campbell, Edward M ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b University of Missouri   (United States)

^c NORTH CENTRAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CATHEPSIN B; GALECTIN 3; INFLAMMASOME; REACTIVE OXYGEN METABOLITE; CATHEPSIN;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL COMPARTMENTALIZATION; CELL DAMAGE; CELL TRANSFER; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LEUKEMIA CELL; LYSOSOME; MICROGLIA; MONOCYTIC LEUKEMIA; NERVE CELL CULTURE; NONHUMAN; PARKINSON DISEASE; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; ANIMAL; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; TUMOR CELL LINE;

ALPHA-SYNUCLEIN; ANIMALS; CATHEPSINS; CELL LINE, TUMOR; ENDOCYTOSIS; HUMANS; INFLAMMASOMES; LYSOSOMES; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; RATS; REACTIVE OXYGEN SPECIES;

EID: 84876722731     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062143     Document Type: Article

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