-
1
-
-
77953229747
-
Missing pieces in the Parkinson's disease puzzle
-
Obeso, J. A., Rodriguez-Oroz, M. C., Goetz, C. G., Marin, C., Kordower, J. H., Rodriguez, M., Hirsch, E. C., Farrer, M., Schapira, A. H., and Halliday, G. (2010) Missing pieces in the Parkinson's disease puzzle. Nat. Med. 16, 653-661
-
(2010)
Nat. Med.
, vol.16
, pp. 653-661
-
-
Obeso, J.A.1
Rodriguez-Oroz, M.C.2
Goetz, C.G.3
Marin, C.4
Kordower, J.H.5
Rodriguez, M.6
Hirsch, E.C.7
Farrer, M.8
Schapira, A.H.9
Halliday, G.10
-
2
-
-
0035109738
-
Synucleinopathies: Clinical and pathological implications
-
Galvin, J. E., Lee, V. M., and Trojanowski, J. Q. (2001) Synucleinopathies: clinical and pathological implications. Arch. Neurol. 58, 186-190
-
(2001)
Arch. Neurol.
, vol.58
, pp. 186-190
-
-
Galvin, J.E.1
Lee, V.M.2
Trojanowski, J.Q.3
-
3
-
-
0029688041
-
Electron microscopy of Lewy bodies in the amygdala-parahippocampal region. Comparison with inclusion bodies in the MPTP-treated squirrel monkey
-
Forno, L. S., DeLanney, L. E., Irwin, I., and Langston, J. W. (1996) Electron microscopy of Lewy bodies in the amygdala-parahippocampal region. Comparison with inclusion bodies in the MPTP-treated squirrel monkey. Adv. Neurol. 69, 217-228
-
(1996)
Adv. Neurol.
, vol.69
, pp. 217-228
-
-
Forno, L.S.1
DeLanney, L.E.2
Irwin, I.3
Langston, J.W.4
-
4
-
-
0030882856
-
α-Synuclein in Lewy bodies
-
Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) α-Synuclein in Lewy bodies. Nature 388, 839-840
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
5
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
6
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schöls, L., and Riess, O. (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18, 106-108
-
(1998)
Nat. Genet.
, vol.18
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Müller, T.3
Woitalla, D.4
Graeber, M.5
Kösel, S.6
Przuntek, H.7
Epplen, J.T.8
Schöls, L.9
Riess, O.10
-
7
-
-
10744230149
-
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J. J., Alegre, J., Gómez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., Llorens, V., Gomez Tortosa, E., del Ser, T., Muñoz, D. G., and de Yebenes, J. G. (2004) The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55, 164-173
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gómez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atarés, B.10
Llorens, V.11
Gomez Tortosa, E.12
Del Ser, T.13
Muñoz, D.G.14
De Yebenes, J.G.15
-
8
-
-
0242300619
-
α-Synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Maraganore, D., Adler, C., Cookson, M. R., Muenter, M., Baptista, M., Miller, D., Blancato, J., Hardy, J., and Gwinn-Hardy, K. (2003) α-Synuclein locus triplication causes Parkinson's disease. Science 302, 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
9
-
-
77955366745
-
Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: Implications for Parkinson's disease pathogenesis and therapies
-
Oueslati, A., Fournier, M., and Lashuel, H. A. (2010) Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: implications for Parkinson's disease pathogenesis and therapies. Prog. Brain Res. 183, 115-145
-
(2010)
Prog. Brain Res.
, vol.183
, pp. 115-145
-
-
Oueslati, A.1
Fournier, M.2
Lashuel, H.A.3
-
10
-
-
0023931333
-
Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study
-
Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M., and Ihara, Y. (1988) Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathol. 75, 345-353
-
(1988)
Acta Neuropathol.
, vol.75
, pp. 345-353
-
-
Kuzuhara, S.1
Mori, H.2
Izumiyama, N.3
Yoshimura, M.4
Ihara, Y.5
-
11
-
-
2242472974
-
Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions
-
Hasegawa, M., Fujiwara, H., Nonaka, T., Wakabayashi, K., Takahashi, H., Lee, V. M., Trojanowski, J. Q., Mann, D., and Iwatsubo, T. (2002) Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions. J. Biol. Chem. 277, 49071-49076
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49071-49076
-
-
Hasegawa, M.1
Fujiwara, H.2
Nonaka, T.3
Wakabayashi, K.4
Takahashi, H.5
Lee, V.M.6
Trojanowski, J.Q.7
Mann, D.8
Iwatsubo, T.9
-
12
-
-
0242666359
-
Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
-
Tofaris, G. K., Razzaq, A., Ghetti, B., Lilley, K. S., and Spillantini, M. G. (2003) Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J. Biol. Chem. 278, 44405-44411
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 44405-44411
-
-
Tofaris, G.K.1
Razzaq, A.2
Ghetti, B.3
Lilley, K.S.4
Spillantini, M.G.5
-
13
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
-
Giasson, B. I., Duda, J. E., Murray, I. V., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., and Lee, V. M. (2000) Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions. Science 290, 985-989
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, B.I.1
Duda, J.E.2
Murray, I.V.3
Chen, Q.4
Souza, J.M.5
Hurtig, H.I.6
Ischiropoulos, H.7
Trojanowski, J.Q.8
Lee, V.M.9
-
14
-
-
9144229591
-
Functional consequences of α-synuclein tyrosine nitration: Diminished binding to lipid vesicles and increased fibril formation
-
Hodara, R., Norris, E. H., Giasson, B. I., Mishizen-Eberz, A. J., Lynch, D. R., Lee, V. M., and Ischiropoulos, H. (2004) Functional consequences of α-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. J. Biol. Chem. 279, 47746-47753
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47746-47753
-
-
Hodara, R.1
Norris, E.H.2
Giasson, B.I.3
Mishizen-Eberz, A.J.4
Lynch, D.R.5
Lee, V.M.6
Ischiropoulos, H.7
-
15
-
-
79960261026
-
Sumoylation inhibits α-synuclein aggregation and toxicity
-
Krumova, P., Meulmeester, E., Garrido, M., Tirard, M., Hsiao, H. H., Bossis, G., Urlaub, H., Zweckstetter, M., Kügler, S., Melchior, F., Bähr, M., and Weishaupt, J. H. (2011) Sumoylation inhibits α-synuclein aggregation and toxicity. J. Cell Biol. 194, 49-60
-
(2011)
J. Cell Biol.
, vol.194
, pp. 49-60
-
-
Krumova, P.1
Meulmeester, E.2
Garrido, M.3
Tirard, M.4
Hsiao, H.H.5
Bossis, G.6
Urlaub, H.7
Zweckstetter, M.8
Kügler, S.9
Melchior, F.10
Bähr, M.11
Weishaupt, J.H.12
-
16
-
-
84878579784
-
Sumoylation in neurodegenerative diseases
-
Krumova, P., and Weishaupt, J. H. (2013) Sumoylation in neurodegenerative diseases. Cell. Mol. Life Sci. 70, 2123-2138
-
(2013)
Cell. Mol. Life Sci.
, vol.70
, pp. 2123-2138
-
-
Krumova, P.1
Weishaupt, J.H.2
-
17
-
-
84888197170
-
SUMO and Parkinson's disease
-
Eckermann, K. (2013) SUMO and Parkinson's disease. Neuromol. Med. 15, 737-759
-
(2013)
Neuromol. Med.
, vol.15
, pp. 737-759
-
-
Eckermann, K.1
-
18
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease
-
Anderson, J. P., Walker, D. E., Goldstein, J. M., de Laat, R., Banducci, K., Caccavello, R. J., Barbour, R., Huang, J., Kling, K., Lee, M., Diep, L., Keim, P. S., Shen, X., Chataway, T., Schlossmacher, M. G., Seubert, P., Schenk, D., Sinha, S., Gai, W. P., and Chilcote, T. J. (2006) Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease. J. Biol. Chem. 281, 29739-29752
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 29739-29752
-
-
Anderson, J.P.1
Walker, D.E.2
Goldstein, J.M.3
De Laat, R.4
Banducci, K.5
Caccavello, R.J.6
Barbour, R.7
Huang, J.8
Kling, K.9
Lee, M.10
Diep, L.11
Keim, P.S.12
Shen, X.13
Chataway, T.14
Schlossmacher, M.G.15
Seubert, P.16
Schenk, D.17
Sinha, S.18
Gai, W.P.19
Chilcote, T.J.20
more..
-
19
-
-
0036174010
-
α-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and Iwatsubo, T. (2002) α-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 4, 160-164
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
20
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
-
Okochi, M., Walter, J., Koyama, A., Nakajo, S., Baba, M., Iwatsubo, T., Meijer, L., Kahle, P. J., and Haass, C. (2000) Constitutive phosphorylation of the Parkinson's disease associated α-synuclein. J. Biol. Chem. 275, 390-397
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
21
-
-
0034714204
-
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
-
Pronin, A. N., Morris, A. J., Surguchov, A., and Benovic, J. L. (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 275, 26515-26522
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26515-26522
-
-
Pronin, A.N.1
Morris, A.J.2
Surguchov, A.3
Benovic, J.L.4
-
22
-
-
43249108653
-
Specificity and regulation of casein kinase-mediated phosphorylation of α-synuclein
-
Waxman, E. A., and Giasson, B. I. (2008) Specificity and regulation of casein kinase-mediated phosphorylation of α-synuclein. J. Neuropathol. Exp. Neurol. 67, 402-416
-
(2008)
J. Neuropathol. Exp. Neurol.
, vol.67
, pp. 402-416
-
-
Waxman, E.A.1
Giasson, B.I.2
-
23
-
-
84885363886
-
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
-
Oueslati, A., Schneider, B. L., Aebischer, P., and Lashuel, H. A. (2013) Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo. Proc. Natl. Acad. Sci. U.S.A. 110, E3945-E3954
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. E3945-E3954
-
-
Oueslati, A.1
Schneider, B.L.2
Aebischer, P.3
Lashuel, H.A.4
-
24
-
-
84888000967
-
PLK2 Modulates α-synuclein aggregation in yeast and mammalian cells
-
Basso, E., Antas, P., Marijanovic, Z., Gonc¸alves, S., Tenreiro, S., and Outeiro, T. F. (2013) PLK2 Modulates α-synuclein aggregation in yeast and mammalian cells. Mol. Neurobiol. 48, 854-862
-
(2013)
Mol. Neurobiol.
, vol.48
, pp. 854-862
-
-
Basso, E.1
Antas, P.2
Marijanovic, Z.3
Gonc¸alves, S.4
Tenreiro, S.5
Outeiro, T.F.6
-
25
-
-
33748483511
-
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease
-
Arawaka, S., Wada, M., Goto, S., Karube, H., Sakamoto, M., Ren, C. H., Koyama, S., Nagasawa, H., Kimura, H., Kawanami, T., Kurita, K., Tajima, K., Daimon, M., Baba, M., Kido, T., Saino, S., Goto, K., Asao, H., Kitanaka, C., Takashita, E., Hongo, S., Nakamura, T., Kayama, T., Suzuki, Y., Kobayashi, K., Katagiri, T., Kurokawa, K., Kurimura, M., Toyoshima, I., Niizato, K., Tsuchiya, K., Iwatsubo, T., Muramatsu, M., Matsumine, H., and Kato, T. (2006) The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease. J. Neurosci. 26, 9227-9238
-
(2006)
J. Neurosci.
, vol.26
, pp. 9227-9238
-
-
Arawaka, S.1
Wada, M.2
Goto, S.3
Karube, H.4
Sakamoto, M.5
Ren, C.H.6
Koyama, S.7
Nagasawa, H.8
Kimura, H.9
Kawanami, T.10
Kurita, K.11
Tajima, K.12
Daimon, M.13
Baba, M.14
Kido, T.15
Saino, S.16
Goto, K.17
Asao, H.18
Kitanaka, C.19
Takashita, E.20
Hongo, S.21
Nakamura, T.22
Kayama, T.23
Suzuki, Y.24
Kobayashi, K.25
Katagiri, T.26
Kurokawa, K.27
Kurimura, M.28
Toyoshima, I.29
Niizato, K.30
Tsuchiya, K.31
Iwatsubo, T.32
Muramatsu, M.33
Matsumine, H.34
Kato, T.35
more..
-
26
-
-
84856507495
-
Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants
-
Salvi, M., Trashi, E., Marin, O., Negro, A., Sarno, S., and Pinna, L. A. (2012) Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants. Biochem. Biophys. Res. Commun. 418, 156-160
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.418
, pp. 156-160
-
-
Salvi, M.1
Trashi, E.2
Marin, O.3
Negro, A.4
Sarno, S.5
Pinna, L.A.6
-
27
-
-
77449113371
-
Phosphorylation of synucleins by members of the Polo-like kinase family
-
Mbefo, M. K., Paleologou, K. E., Boucharaba, A., Oueslati, A., Schell, H., Fournier, M., Olschewski, D., Yin, G., Zweckstetter, M., Masliah, E., Kahle, P. J., Hirling, H., and Lashuel, H. A. (2010) Phosphorylation of synucleins by members of the Polo-like kinase family. J. Biol. Chem. 285, 2807-2822
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2807-2822
-
-
Mbefo, M.K.1
Paleologou, K.E.2
Boucharaba, A.3
Oueslati, A.4
Schell, H.5
Fournier, M.6
Olschewski, D.7
Yin, G.8
Zweckstetter, M.9
Masliah, E.10
Kahle, P.J.11
Hirling, H.12
Lashuel, H.A.13
-
28
-
-
59149090357
-
Polo-like kinase 2 (PLK2) phosphorylates α-synuclein at serine 129 in central nervous system
-
Inglis, K. J., Chereau, D., Brigham, E. F., Chiou, S. S., Schöbel, S., Frigon, N. L., Yu, M., Caccavello, R. J., Nelson, S., Motter, R., Wright, S., Chian, D., Santiago, P., Soriano, F., Ramos, C., Powell, K., Goldstein, J. M., Babcock, M., Yednock, T., Bard, F., Basi, G. S., Sham, H., Chilcote, T. J., McConlogue, L., Griswold-Prenner, I., and Anderson, J. P. (2009) Polo-like kinase 2 (PLK2) phosphorylates α-synuclein at serine 129 in central nervous system. J. Biol. Chem. 284, 2598-2602
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 2598-2602
-
-
Inglis, K.J.1
Chereau, D.2
Brigham, E.F.3
Chiou, S.S.4
Schöbel, S.5
Frigon, N.L.6
Yu, M.7
Caccavello, R.J.8
Nelson, S.9
Motter, R.10
Wright, S.11
Chian, D.12
Santiago, P.13
Soriano, F.14
Ramos, C.15
Powell, K.16
Goldstein, J.M.17
Babcock, M.18
Yednock, T.19
Bard, F.20
Basi, G.S.21
Sham, H.22
Chilcote, T.J.23
McConlogue, L.24
Griswold-Prenner, I.25
Anderson, J.P.26
more..
-
29
-
-
33744544785
-
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and α-synuclein
-
Dorval, V., and Fraser, P. E. (2006) Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and α-synuclein. J. Biol. Chem. 281, 9919-9924
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 9919-9924
-
-
Dorval, V.1
Fraser, P.E.2
-
30
-
-
3943099375
-
Protein modification by SUMO
-
Johnson, E. S. (2004) Protein modification by SUMO. Annu. Rev. Biochem. 73, 355-382
-
(2004)
Annu. Rev. Biochem.
, vol.73
, pp. 355-382
-
-
Johnson, E.S.1
-
31
-
-
0033607801
-
Degradation of α-synuclein by proteasome
-
Bennett, M. C., Bishop, J. F., Leng, Y., Chock, P. B., Chase, T. N., and Mouradian, M. M. (1999) Degradation of α-synuclein by proteasome. J. Biol. Chem. 274, 33855-33858
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33855-33858
-
-
Bennett, M.C.1
Bishop, J.F.2
Leng, Y.3
Chock, P.B.4
Chase, T.N.5
Mouradian, M.M.6
-
32
-
-
0035976835
-
α-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
-
Tofaris, G. K., Layfield, R., and Spillantini, M. G. (2001) α-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Lett. 509, 22-26
-
(2001)
FEBS Lett.
, vol.509
, pp. 22-26
-
-
Tofaris, G.K.1
Layfield, R.2
Spillantini, M.G.3
-
33
-
-
0041589248
-
α-Synuclein is degraded by both autophagy and the proteasome
-
Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N., and Rubinsztein, D. C. (2003) α-Synuclein is degraded by both autophagy and the proteasome. J. Biol. Chem. 278, 25009-25013
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25009-25013
-
-
Webb, J.L.1
Ravikumar, B.2
Atkins, J.3
Skepper, J.N.4
Rubinsztein, D.C.5
-
34
-
-
80054026084
-
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagylysosomal pathway in the degradation of α-synuclein
-
Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B. T., McLean, P. J., and Unni, V. K. (2011) Distinct roles in vivo for the ubiquitin-proteasome system and the autophagylysosomal pathway in the degradation of α-synuclein. J. Neurosci. 31, 14508-14520
-
(2011)
J. Neurosci.
, vol.31
, pp. 14508-14520
-
-
Ebrahimi-Fakhari, D.1
Cantuti-Castelvetri, I.2
Fan, Z.3
Rockenstein, E.4
Masliah, E.5
Hyman, B.T.6
McLean, P.J.7
Unni, V.K.8
-
35
-
-
53049098471
-
Wild type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
-
Vogiatzi, T., Xilouri, M., Vekrellis, K., and Stefanis, L. (2008) Wild type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem. 283, 23542-23556
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 23542-23556
-
-
Vogiatzi, T.1
Xilouri, M.2
Vekrellis, K.3
Stefanis, L.4
-
36
-
-
21244499845
-
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates α-synuclein degradation decisions between proteasomal and lysosomal pathways
-
Shin, Y., Klucken, J., Patterson, C., Hyman, B. T., and McLean, P. J. (2005) The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates α-synuclein degradation decisions between proteasomal and lysosomal pathways. J. Biol. Chem. 280, 23727-23734
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23727-23734
-
-
Shin, Y.1
Klucken, J.2
Patterson, C.3
Hyman, B.T.4
McLean, P.J.5
-
37
-
-
0345189364
-
Yeast cells provide insight into α-synuclein biology and pathobiology
-
Outeiro, T. F., and Lindquist, S. (2003) Yeast cells provide insight into α-synuclein biology and pathobiology. Science 302, 1772-1775
-
(2003)
Science
, vol.302
, pp. 1772-1775
-
-
Outeiro, T.F.1
Lindquist, S.2
-
38
-
-
84864979359
-
Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome
-
Petroi, D., Popova, B., Taheri-Talesh, N., Irniger, S., Shahpasandzadeh, H., Zweckstetter, M., Outeiro, T. F., and Braus, G. H. (2012) Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome. J. Biol. Chem. 287, 27567-27579
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 27567-27579
-
-
Petroi, D.1
Popova, B.2
Taheri-Talesh, N.3
Irniger, S.4
Shahpasandzadeh, H.5
Zweckstetter, M.6
Outeiro, T.F.7
Braus, G.H.8
-
39
-
-
15944378475
-
Characterization of α-synuclein aggregation and synergistic toxicity with protein tau in yeast
-
Zabrocki, P., Pellens, K., Vanhelmont, T., Vandebroek, T., Griffioen, G., Wera, S., Van Leuven, F., and Winderickx, J. (2005) Characterization of α-synuclein aggregation and synergistic toxicity with protein tau in yeast. FEBS J. 272, 1386-1400
-
(2005)
FEBS J.
, vol.272
, pp. 1386-1400
-
-
Zabrocki, P.1
Pellens, K.2
Vanhelmont, T.3
Vandebroek, T.4
Griffioen, G.5
Wera, S.6
Van Leuven, F.7
Winderickx, J.8
-
40
-
-
77950854717
-
Yeast unfolds the road map toward α-synuclein-induced cell death
-
Franssens, V., Boelen, E., Anandhakumar, J., Vanhelmont, T., Büttner, S., and Winderickx, J. (2010) Yeast unfolds the road map toward α-synuclein-induced cell death. Cell Death Differ. 17, 746-753
-
(2010)
Cell Death Differ.
, vol.17
, pp. 746-753
-
-
Franssens, V.1
Boelen, E.2
Anandhakumar, J.3
Vanhelmont, T.4
Büttner, S.5
Winderickx, J.6
-
41
-
-
0024669291
-
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
-
Sikorski, R. S., and Hieter, P. (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27
-
(1989)
Genetics
, vol.122
, pp. 19-27
-
-
Sikorski, R.S.1
Hieter, P.2
-
42
-
-
0026562884
-
Improved method for high efficiency transformation of intact yeast cells
-
Gietz, D., St Jean, A., Woods, R. A., and Schiestl, R. H. (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20, 1425
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 1425
-
-
Gietz, D.1
St Jean, A.2
Woods, R.A.3
Schiestl, R.H.4
-
43
-
-
0025994140
-
Guide to yeast genetics and molecular biology
-
Guthrie, C., and Fink, G. (1991) Guide to yeast genetics and molecular biology. Methods Enzymol. 194, 1-863
-
(1991)
Methods Enzymol.
, vol.194
, pp. 1-863
-
-
Guthrie, C.1
Fink, G.2
-
44
-
-
33744981623
-
Image processing with ImageJ
-
Abramoff, M. D., Magelhaes, P. J., and Ram, S. J. (2004) Image processing with ImageJ. Biophotonics Int. 11, 36-42
-
(2004)
Biophotonics Int.
, vol.11
, pp. 36-42
-
-
Abramoff, M.D.1
Magelhaes, P.J.2
Ram, S.J.3
-
45
-
-
0000870917
-
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae
-
Lee, D. H., and Goldberg, A. L. (1996) Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae. J. Biol. Chem. 271, 27280-27284
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27280-27284
-
-
Lee, D.H.1
Goldberg, A.L.2
-
46
-
-
34247574716
-
Proteasome inhibition in wild-type yeast Saccharomyces cerevisiae cells
-
Liu, C., Apodaca, J., Davis, L. E., and Rao, H. (2007) Proteasome inhibition in wild-type yeast Saccharomyces cerevisiae cells. BioTechniques 42, 158-162
-
(2007)
BioTechniques
, vol.42
, pp. 158-162
-
-
Liu, C.1
Apodaca, J.2
Davis, L.E.3
Rao, H.4
-
47
-
-
2942534856
-
A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability
-
Soustelle, C., Vernis, L., Fréon, K., Reynaud-Angelin, A., Chanet, R., Fabre, F., and Heude, M. (2004) A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability. Mol. Cell. Biol. 24, 5130-5143
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5130-5143
-
-
Soustelle, C.1
Vernis, L.2
Fréon, K.3
Reynaud-Angelin, A.4
Chanet, R.5
Fabre, F.6
Heude, M.7
-
48
-
-
1542407105
-
Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast
-
Dieckhoff, P., Bolte, M., Sancak, Y., Braus, G. H., and Irniger, S. (2004) Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast. Mol. Microbiol. 51, 1375-1387
-
(2004)
Mol. Microbiol.
, vol.51
, pp. 1375-1387
-
-
Dieckhoff, P.1
Bolte, M.2
Sancak, Y.3
Braus, G.H.4
Irniger, S.5
-
49
-
-
0034754698
-
Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae
-
Biggins, S., Bhalla, N., Chang, A., Smith, D. L., and Murray, A. W. (2001) Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics 159, 453-470
-
(2001)
Genetics
, vol.159
, pp. 453-470
-
-
Biggins, S.1
Bhalla, N.2
Chang, A.3
Smith, D.L.4
Murray, A.W.5
-
50
-
-
77955286868
-
Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase
-
Mullen, J. R., Chen, C. F., and Brill, S. J. (2010) Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase. Mol. Cell. Biol. 30, 3737-3748
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 3737-3748
-
-
Mullen, J.R.1
Chen, C.F.2
Brill, S.J.3
-
51
-
-
17844406856
-
α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
Chen, L., and Feany, M. B. (2005) α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat. Neurosci. 8, 657-663
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
-
52
-
-
34447570901
-
Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice
-
Freichel, C., Neumann, M., Ballard, T., Müller, V., Woolley, M., Ozmen, L., Borroni, E., Kretzschmar, H. A., Haass, C., Spooren, W., and Kahle, P. J. (2007) Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice. Neurobiol. Aging 28, 1421-1435
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1421-1435
-
-
Freichel, C.1
Neumann, M.2
Ballard, T.3
Müller, V.4
Woolley, M.5
Ozmen, L.6
Borroni, E.7
Kretzschmar, H.A.8
Haass, C.9
Spooren, W.10
Kahle, P.J.11
-
53
-
-
38649084032
-
The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease
-
Gorbatyuk, O. S., Li, S., Sullivan, L. F., Chen, W., Kondrikova, G., Manfredsson, F. P., Mandel, R. J., and Muzyczka, N. (2008) The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. U.S.A. 105, 763-768
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 763-768
-
-
Gorbatyuk, O.S.1
Li, S.2
Sullivan, L.F.3
Chen, W.4
Kondrikova, G.5
Manfredsson, F.P.6
Mandel, R.J.7
Muzyczka, N.8
-
54
-
-
60549109895
-
Phosphorylation does not prompt, nor prevent, the formation of α-synuclein toxic species in a rat model of Parkinson's disease
-
Azeredo da Silveira, S., Schneider, B. L., Cifuentes-Diaz, C., Sage, D., Abbas-Terki, T., Iwatsubo, T., Unser, M., and Aebischer, P. (2009) Phosphorylation does not prompt, nor prevent, the formation of α-synuclein toxic species in a rat model of Parkinson's disease. Hum. Mol. Genet. 18, 872-887
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 872-887
-
-
Azeredo Da Silveira, S.1
Schneider, B.L.2
Cifuentes-Diaz, C.3
Sage, D.4
Abbas-Terki, T.5
Iwatsubo, T.6
Unser, M.7
Aebischer, P.8
-
55
-
-
84867045179
-
α-Synuclein disrupts stress signaling by inhibiting pololike kinase Cdc5/Plk2
-
Wang, S., Xu, B., Liou, L. C., Ren, Q., Huang, S., Luo, Y., Zhang, Z., and Witt, S. N. (2012) α-Synuclein disrupts stress signaling by inhibiting pololike kinase Cdc5/Plk2. Proc. Natl. Acad. Sci. U.S.A. 109, 16119-16124
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 16119-16124
-
-
Wang, S.1
Xu, B.2
Liou, L.C.3
Ren, Q.4
Huang, S.5
Luo, Y.6
Zhang, Z.7
Witt, S.N.8
-
56
-
-
0035830913
-
α-Synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases
-
Ellis, C. E., Schwartzberg, P. L., Grider, T. L., Fink, D. W., and Nussbaum, R. L. (2001) α-Synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases. J. Biol. Chem. 276, 3879-3884
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3879-3884
-
-
Ellis, C.E.1
Schwartzberg, P.L.2
Grider, T.L.3
Fink, D.W.4
Nussbaum, R.L.5
-
57
-
-
78650203006
-
Characterization of kinases involved in the phosphorylation of aggregated α-synuclein
-
Waxman, E. A., and Giasson, B. I. (2011) Characterization of kinases involved in the phosphorylation of aggregated α-synuclein. J. Neurosci. Res. 89, 231-247
-
(2011)
J. Neurosci. Res.
, vol.89
, pp. 231-247
-
-
Waxman, E.A.1
Giasson, B.I.2
-
58
-
-
65649116247
-
Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of α-synuclein in HEK293 cells
-
Sakamoto, M., Arawaka, S., Hara, S., Sato, H., Cui, C., Machiya, Y., Koyama, S., Wada, M., Kawanami, T., Kurita, K., and Kato, T. (2009) Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of α-synuclein in HEK293 cells. Biochem. Biophys. Res. Commun. 384, 378-382
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.384
, pp. 378-382
-
-
Sakamoto, M.1
Arawaka, S.2
Hara, S.3
Sato, H.4
Cui, C.5
Machiya, Y.6
Koyama, S.7
Wada, M.8
Kawanami, T.9
Kurita, K.10
Kato, T.11
-
59
-
-
84887510168
-
In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain
-
Bergeron, M., Motter, R., Tanaka, P., Fauss, D., Babcock, M., Chiou, S. S., Nelson, S., San Pablo, F., and Anderson, J. P. (2014) In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain. Neuroscience 256, 72-82
-
(2014)
Neuroscience
, vol.256
, pp. 72-82
-
-
Bergeron, M.1
Motter, R.2
Tanaka, P.3
Fauss, D.4
Babcock, M.5
Chiou, S.S.6
Nelson, S.7
San Pablo, F.8
Anderson, J.P.9
-
60
-
-
47749107973
-
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein
-
Paleologou, K. E., Schmid, A. W., Rospigliosi, C. C., Kim, H. Y., Lamberto, G. R., Fredenburg, R. A., Lansbury, P. T., Jr., Fernandez, C. O., Eliezer, D., Zweckstetter, M., and Lashuel, H. A. (2008) Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein. J. Biol. Chem. 283, 16895-16905
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16895-16905
-
-
Paleologou, K.E.1
Schmid, A.W.2
Rospigliosi, C.C.3
Kim, H.Y.4
Lamberto, G.R.5
Fredenburg, R.A.6
Lansbury, P.T.7
Fernandez, C.O.8
Eliezer, D.9
Zweckstetter, M.10
Lashuel, H.A.11
-
61
-
-
0030983504
-
Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
-
Matsuura, A., Tsukada, M., Wada, Y., and Ohsumi, Y. (1997) Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 192, 245-250
-
(1997)
Gene
, vol.192
, pp. 245-250
-
-
Matsuura, A.1
Tsukada, M.2
Wada, Y.3
Ohsumi, Y.4
-
62
-
-
0032898636
-
Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy
-
Tanida, I., Mizushima, N., Kiyooka, M., Ohsumi, M., Ueno, T., Ohsumi, Y., and Kominami, E. (1999) Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol. Biol. Cell 10, 1367-1379
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 1367-1379
-
-
Tanida, I.1
Mizushima, N.2
Kiyooka, M.3
Ohsumi, M.4
Ueno, T.5
Ohsumi, Y.6
Kominami, E.7
-
63
-
-
0036270964
-
Vacuolar proteases and proteolytic artifacts in Saccharomyces cerevisiae
-
Jones, E. W. (2002) Vacuolar proteases and proteolytic artifacts in Saccharomyces cerevisiae. Methods Enzymol. 351, 127-150
-
(2002)
Methods Enzymol.
, vol.351
, pp. 127-150
-
-
Jones, E.W.1
-
64
-
-
0026486168
-
Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family
-
Dubiel, W., Ferrell, K., Pratt, G., and Rechsteiner, M. (1992) Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family. J. Biol. Chem. 267, 22699-22702
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 22699-22702
-
-
Dubiel, W.1
Ferrell, K.2
Pratt, G.3
Rechsteiner, M.4
-
65
-
-
0026668042
-
Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction
-
Takeshige, K., Baba, M., Tsuboi, S., Noda, T., and Ohsumi, Y. (1992) Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J. Cell Biol. 119, 301-311
-
(1992)
J. Cell Biol.
, vol.119
, pp. 301-311
-
-
Takeshige, K.1
Baba, M.2
Tsuboi, S.3
Noda, T.4
Ohsumi, Y.5
-
66
-
-
0030608395
-
Structural and functional analyses of APG5, a gene involved in autophagy in yeast
-
Kametaka, S., Matsuura, A., Wada, Y., and Ohsumi, Y. (1996) Structural and functional analyses of APG5, a gene involved in autophagy in yeast. Gene 178, 139-143
-
(1996)
Gene
, vol.178
, pp. 139-143
-
-
Kametaka, S.1
Matsuura, A.2
Wada, Y.3
Ohsumi, Y.4
-
67
-
-
0032189348
-
Proteasome inhibitors: Valuable new tools for cell biologists
-
Lee, D. H., and Goldberg, A. L. (1998) Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol. 8, 397-403
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 397-403
-
-
Lee, D.H.1
Goldberg, A.L.2
-
68
-
-
11844306551
-
Ubiquitination of α-synuclein
-
Nonaka, T., Iwatsubo, T., and Hasegawa, M. (2005) Ubiquitination of α-synuclein. Biochemistry 44, 361-368
-
(2005)
Biochemistry
, vol.44
, pp. 361-368
-
-
Nonaka, T.1
Iwatsubo, T.2
Hasegawa, M.3
-
69
-
-
41249090880
-
Monoubiquitylation of α-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells
-
Rott, R., Szargel, R., Haskin, J., Shani, V., Shainskaya, A., Manov, I., Liani, E., Avraham, E., and Engelender, S. (2008) Monoubiquitylation of α-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells. J. Biol. Chem. 283, 3316-3328
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3316-3328
-
-
Rott, R.1
Szargel, R.2
Haskin, J.3
Shani, V.4
Shainskaya, A.5
Manov, I.6
Liani, E.7
Avraham, E.8
Engelender, S.9
-
70
-
-
81755185877
-
α-Synuclein fate is determined by USP9X-regulated monoubiquitination
-
Rott, R., Szargel, R., Haskin, J., Bandopadhyay, R., Lees, A. J., Shani, V., and Engelender, S. (2011) α-Synuclein fate is determined by USP9X-regulated monoubiquitination. Proc. Natl. Acad. Sci. U.S.A. 108, 18666-18671
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 18666-18671
-
-
Rott, R.1
Szargel, R.2
Haskin, J.3
Bandopadhyay, R.4
Lees, A.J.5
Shani, V.6
Engelender, S.7
-
71
-
-
69249090927
-
Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation
-
Mukherjee, S., Thomas, M., Dadgar, N., Lieberman, A. P., and Iñiguez-Lluhí, J. A. (2009) Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation. J. Biol. Chem. 284, 21296-21306
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21296-21306
-
-
Mukherjee, S.1
Thomas, M.2
Dadgar, N.3
Lieberman, A.P.4
Iñiguez-Lluhí, J.A.5
-
72
-
-
77649186048
-
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7
-
Janer, A., Werner, A., Takahashi-Fujigasaki, J., Daret, A., Fujigasaki, H., Takada, K., Duyckaerts, C., Brice, A., Dejean, A., and Sittler, A. (2010) SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7. Hum. Mol. Genet. 19, 181-195
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 181-195
-
-
Janer, A.1
Werner, A.2
Takahashi-Fujigasaki, J.3
Daret, A.4
Fujigasaki, H.5
Takada, K.6
Duyckaerts, C.7
Brice, A.8
Dejean, A.9
Sittler, A.10
-
73
-
-
79956299086
-
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO)
-
Droescher, M., Begitt, A., Marg, A., Zacharias, M., and Vinkemeier, U. (2011) Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). J. Biol. Chem. 286, 18731-18746
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 18731-18746
-
-
Droescher, M.1
Begitt, A.2
Marg, A.3
Zacharias, M.4
Vinkemeier, U.5
-
74
-
-
30444440554
-
PDSM, a motif for phosphorylation-dependent SUMO modification
-
Hietakangas, V., Anckar, J., Blomster, H. A., Fujimoto, M., Palvimo, J. J., Nakai, A., and Sistonen, L. (2006) PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl. Acad. Sci. U.S.A. 103, 45-50
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 45-50
-
-
Hietakangas, V.1
Anckar, J.2
Blomster, H.A.3
Fujimoto, M.4
Palvimo, J.J.5
Nakai, A.6
Sistonen, L.7
-
75
-
-
79961009220
-
SUMOylation-regulated protein phosphorylation, evidence from quantitative phosphoproteomics analyses
-
Yao, Q., Li, H., Liu, B. Q., Huang, X. Y., and Guo, L. (2011) SUMOylation-regulated protein phosphorylation, evidence from quantitative phosphoproteomics analyses. J. Biol. Chem. 286, 27342-27349
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 27342-27349
-
-
Yao, Q.1
Li, H.2
Liu, B.Q.3
Huang, X.Y.4
Guo, L.5
-
76
-
-
33845914340
-
Regulation of protein tyrosine phosphatase 1B by sumoylation
-
Dadke, S., Cotteret, S., Yip, S. C., Jaffer, Z. M., Haj, F., Ivanov, A., Rauscher, F., 3rd, Shuai, K., Ng, T., Neel, B. G., and Chernoff, J. (2007) Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat. Cell Biol. 9, 80-85
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 80-85
-
-
Dadke, S.1
Cotteret, S.2
Yip, S.C.3
Jaffer, Z.M.4
Haj, F.5
Ivanov, A.6
Rauscher, F.7
Shuai, K.8
Ng, T.9
Neel, B.G.10
Chernoff, J.11
-
77
-
-
34250854596
-
Nitration in neurodegeneration: Deciphering the "Hows" "nYs"
-
Reynolds, M. R., Berry, R. W., and Binder, L. I. (2007) Nitration in neurodegeneration: deciphering the "Hows" "nYs". Biochemistry 46, 7325-7336
-
(2007)
Biochemistry
, vol.46
, pp. 7325-7336
-
-
Reynolds, M.R.1
Berry, R.W.2
Binder, L.I.3
-
78
-
-
20444416315
-
α-Synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells
-
Smith, W. W., Margolis, R. L., Li, X., Troncoso, J. C., Lee, M. K., Dawson, V. L., Dawson, T. M., Iwatsubo, T., and Ross, C. A. (2005) α-Synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells. J. Neurosci. 25, 5544-5552
-
(2005)
J. Neurosci.
, vol.25
, pp. 5544-5552
-
-
Smith, W.W.1
Margolis, R.L.2
Li, X.3
Troncoso, J.C.4
Lee, M.K.5
Dawson, V.L.6
Dawson, T.M.7
Iwatsubo, T.8
Ross, C.A.9
-
79
-
-
70149118325
-
α-Synuclein Ser-129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease
-
McFarland, N. R., Fan, Z., Xu, K., Schwarzschild, M. A., Feany, M. B., Hyman, B. T., and McLean, P. J. (2009) α-Synuclein Ser-129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. J. Neuropathol. Exp. Neurol. 68, 515-524
-
(2009)
J. Neuropathol. Exp. Neurol.
, vol.68
, pp. 515-524
-
-
McFarland, N.R.1
Fan, Z.2
Xu, K.3
Schwarzschild, M.A.4
Feany, M.B.5
Hyman, B.T.6
McLean, P.J.7
-
80
-
-
84861144992
-
Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at Ser-129 in yeast depends on genetic context
-
Sancenon, V., Lee, S. A., Patrick, C., Griffith, J., Paulino, A., Outeiro, T. F., Reggiori, F., Masliah, E., and Muchowski, P. J. (2012) Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at Ser-129 in yeast depends on genetic context. Hum. Mol. Genet. 21, 2432-2449
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 2432-2449
-
-
Sancenon, V.1
Lee, S.A.2
Patrick, C.3
Griffith, J.4
Paulino, A.5
Outeiro, T.F.6
Reggiori, F.7
Masliah, E.8
Muchowski, P.J.9
-
82
-
-
0037068455
-
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
-
Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G., and Jentsch, S. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-141
-
(2002)
Nature
, vol.419
, pp. 135-141
-
-
Hoege, C.1
Pfander, B.2
Moldovan, G.L.3
Pyrowolakis, G.4
Jentsch, S.5
|