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Volumn 97, Issue 2, 2012, Pages 205-219

Can Parkinson's disease pathology be propagated from one neuron to another?

Author keywords

Synuclein; Cell to cell transfer; Neurodegenerative disease; Parkinson's disease; Prion like

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; HEAT SHOCK PROTEIN 70; HUNTINGTIN; LEUCINE RICH REPEAT KINASE 2; TAU PROTEIN;

EID: 84860686110     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2011.11.003     Document Type: Review
Times cited : (87)

References (210)
  • 2
    • 72149125838 scopus 로고    scopus 로고
    • The transcellular spread of cytosolic amyloids, prions, and prionoids
    • Aguzzi A., Rajendran L. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron 2009, 64:783-790.
    • (2009) Neuron , vol.64 , pp. 783-790
    • Aguzzi, A.1    Rajendran, L.2
  • 3
    • 33644954146 scopus 로고    scopus 로고
    • Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein
    • Ahn K.J., Paik S.R., Chung K.C., Kim J. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. J. Neurochem. 2006, 97:265-279.
    • (2006) J. Neurochem. , vol.97 , pp. 265-279
    • Ahn, K.J.1    Paik, S.R.2    Chung, K.C.3    Kim, J.4
  • 8
    • 84873074468 scopus 로고    scopus 로고
    • Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo, submitted.
    • Angot, E.A., Steiner, J.A., Lema Tomé, C.M., Mattsson, B., Björklund, A., Brundin, P., 2011. Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo, submitted.
    • (2011)
    • Angot, E.A.1    Steiner, J.A.2    Lema Tomé, C.M.3    Mattsson, B.4    Björklund, A.5    Brundin, P.6
  • 9
    • 71849117852 scopus 로고    scopus 로고
    • Dissecting the potential molecular mechanisms underlying α-synuclein cell-to-cell transfer in Parkinson's disease
    • Angot E., Brundin P. Dissecting the potential molecular mechanisms underlying α-synuclein cell-to-cell transfer in Parkinson's disease. Parkinsonism Relat. Disord. 2009, 15:S143-S147.
    • (2009) Parkinsonism Relat. Disord. , vol.15
    • Angot, E.1    Brundin, P.2
  • 10
    • 47749147444 scopus 로고    scopus 로고
    • The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease
    • Attems J., Jellinger K.A. The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease. Neuropathol. Appl. Neurobiol. 2008, 34:466-467.
    • (2008) Neuropathol. Appl. Neurobiol. , vol.34 , pp. 466-467
    • Attems, J.1    Jellinger, K.A.2
  • 11
    • 77958449984 scopus 로고    scopus 로고
    • α-Synuclein: membrane interactions and toxicity in Parkinson's disease
    • Auluck P.K., Caraveo G., Lindquist S. α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu. Rev. Cell Dev. Biol. 2010, 26:211-233.
    • (2010) Annu. Rev. Cell Dev. Biol. , vol.26 , pp. 211-233
    • Auluck, P.K.1    Caraveo, G.2    Lindquist, S.3
  • 12
    • 80052398365 scopus 로고    scopus 로고
    • α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
    • Bartels T., Choi J.G., Selkoe D.J. α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 2011, 477(7362):107-110.
    • (2011) Nature , vol.477 , Issue.7362 , pp. 107-110
    • Bartels, T.1    Choi, J.G.2    Selkoe, D.J.3
  • 14
    • 77949423619 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    • Blennow K., Hampel H., Weiner M., Zetterberg H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat. Rev. Neurol. 2010, 6:131-144.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 131-144
    • Blennow, K.1    Hampel, H.2    Weiner, M.3    Zetterberg, H.4
  • 16
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • Braak H., de Vos R.A.I., Bohl J., Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci. Lett. 2006, 396:67-72.
    • (2006) Neurosci. Lett. , vol.396 , pp. 67-72
    • Braak, H.1    de Vos, R.A.I.2    Bohl, J.3    Del Tredici, K.4
  • 18
    • 43649106356 scopus 로고    scopus 로고
    • Invited Article: nervous system pathology in sporadic Parkinson disease
    • Braak H., Del Tredici K. Invited Article: nervous system pathology in sporadic Parkinson disease. Neurology 2008, 70:1916-1925.
    • (2008) Neurology , vol.70 , pp. 1916-1925
    • Braak, H.1    Del Tredici, K.2
  • 20
    • 0036392590 scopus 로고    scopus 로고
    • Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)
    • III/1-5
    • Braak H., Del Tredici K., Bratzke H., Hamm-Clement J., Sandmann-Keil D., Rüb U. Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). J. Neurol. 2002, 249(Suppl 3). III/1-5.
    • (2002) J. Neurol. , vol.249 , Issue.SUPPL. 3
    • Braak, H.1    Del Tredici, K.2    Bratzke, H.3    Hamm-Clement, J.4    Sandmann-Keil, D.5    Rüb, U.6
  • 21
    • 0027490614 scopus 로고
    • Staging of Alzheimer-related cortical destruction
    • Braak H., Braak E., Bohl J. Staging of Alzheimer-related cortical destruction. Eur. Neurol. 1993, 33:403-408.
    • (1993) Eur. Neurol. , vol.33 , pp. 403-408
    • Braak, H.1    Braak, E.2    Bohl, J.3
  • 23
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • Bruijn L.I., Miller T.M., Cleveland D.W. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu. Rev. Neurosci. 2004, 27:723-749.
    • (2004) Annu. Rev. Neurosci. , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 25
    • 79959965774 scopus 로고    scopus 로고
    • Can α-synuclein be targeted in novel therapies for Parkinson's disease?
    • Brundin P., Olsson R. Can α-synuclein be targeted in novel therapies for Parkinson's disease?. Exp. Rev. Neurother. 2011, 11:917-919.
    • (2011) Exp. Rev. Neurother. , vol.11 , pp. 917-919
    • Brundin, P.1    Olsson, R.2
  • 26
    • 77949848854 scopus 로고    scopus 로고
    • Prion-like transmission of protein aggregates in neurodegenerative diseases
    • Brundin P., Melki R., Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat. Rev. Mol. Cell Biol. 2010, 11:301-307.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 301-307
    • Brundin, P.1    Melki, R.2    Kopito, R.3
  • 27
    • 52449117926 scopus 로고    scopus 로고
    • Research in motion: the enigma of Parkinson's disease pathology spread
    • Brundin P., Li J.-Y., Holton J.L., Lindvall O., Revesz T. Research in motion: the enigma of Parkinson's disease pathology spread. Nat. Med. 2008, 9:741-745.
    • (2008) Nat. Med. , vol.9 , pp. 741-745
    • Brundin, P.1    Li, J.-Y.2    Holton, J.L.3    Lindvall, O.4    Revesz, T.5
  • 31
    • 66749133370 scopus 로고    scopus 로고
    • Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS
    • Chattopadhyay M., Valentine J.S. Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS. Antioxid. Redox Signal. 2009, 11:1603-1614.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 1603-1614
    • Chattopadhyay, M.1    Valentine, J.S.2
  • 33
    • 33746377894 scopus 로고    scopus 로고
    • Protein misfolding, functional amyloid, and human disease
    • Chiti F., Dobson C.M. Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 2006, 75:333-366.
    • (2006) Annu. Rev. Biochem. , vol.75 , pp. 333-366
    • Chiti, F.1    Dobson, C.M.2
  • 34
    • 79954609544 scopus 로고    scopus 로고
    • Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death
    • Choi D.-H., Kim Y.-J., Kim Y.-G., Joh T.H., Beal M.F., Kim Y.-S. Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death. J. Biol. Chem. 2011, 286:14168-14177.
    • (2011) J. Biol. Chem. , vol.286 , pp. 14168-14177
    • Choi, D.-H.1    Kim, Y.-J.2    Kim, Y.-G.3    Joh, T.H.4    Beal, M.F.5    Kim, Y.-S.6
  • 35
    • 77949906891 scopus 로고    scopus 로고
    • Lewy body pathology in fetal grafts
    • Chu Y., Kordower J.H. Lewy body pathology in fetal grafts. Ann. N. Y. Acad. Sci. 2010, 1184:55-67.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1184 , pp. 55-67
    • Chu, Y.1    Kordower, J.H.2
  • 36
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    • Chu Y., Kordower J.H. Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?. Neurobiol. Dis. 2007, 25:134-149.
    • (2007) Neurobiol. Dis. , vol.25 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 39
    • 79957467314 scopus 로고    scopus 로고
    • Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates
    • Collier T.J., Kanaan N.M., Kordower J.H. Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nat. Med. 2011, 12:359-366.
    • (2011) Nat. Med. , vol.12 , pp. 359-366
    • Collier, T.J.1    Kanaan, N.M.2    Kordower, J.H.3
  • 40
    • 77953890085 scopus 로고    scopus 로고
    • Parkinson's disease: insights from pathways
    • Cookson M.R., Bandmann O. Parkinson's disease: insights from pathways. Hum. Mol. Gen. 2010, 19:R21-R27.
    • (2010) Hum. Mol. Gen. , vol.19
    • Cookson, M.R.1    Bandmann, O.2
  • 41
    • 79551655290 scopus 로고    scopus 로고
    • Huntington's disease: can mice lead the way to treatment?
    • Crook Z.R., Housman D. Huntington's disease: can mice lead the way to treatment?. Neuron 2011, 69:423-435.
    • (2011) Neuron , vol.69 , pp. 423-435
    • Crook, Z.R.1    Housman, D.2
  • 43
    • 0026635322 scopus 로고
    • Preliminary diagnosis of Parkinson's disease by olfactory bulb pathology
    • Daniel S.E., Hawkes C.H. Preliminary diagnosis of Parkinson's disease by olfactory bulb pathology. Lancet 1992, 340:186.
    • (1992) Lancet , vol.340 , pp. 186
    • Daniel, S.E.1    Hawkes, C.H.2
  • 44
    • 79251565507 scopus 로고    scopus 로고
    • Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity
    • Danzer K.M., Ruf W.P., Putcha P., Joyner D., Hashimoto T., Glabe C., Hyman B.T., McLean P.J. Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J. 2011, 25:326-336.
    • (2011) FASEB J. , vol.25 , pp. 326-336
    • Danzer, K.M.1    Ruf, W.P.2    Putcha, P.3    Joyner, D.4    Hashimoto, T.5    Glabe, C.6    Hyman, B.T.7    McLean, P.J.8
  • 45
    • 70349223775 scopus 로고    scopus 로고
    • Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology
    • Danzer K.M., Krebs S.K., Wolff M., Birk G., Hengerer B. Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology. J. Neurochem. 2009, 111:192-203.
    • (2009) J. Neurochem. , vol.111 , pp. 192-203
    • Danzer, K.M.1    Krebs, S.K.2    Wolff, M.3    Birk, G.4    Hengerer, B.5
  • 48
    • 79958748545 scopus 로고    scopus 로고
    • Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage
    • De Maio A. Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. Cell Stress Chaperones 2011, 16:235-249.
    • (2011) Cell Stress Chaperones , vol.16 , pp. 235-249
    • De Maio, A.1
  • 51
    • 0021326210 scopus 로고
    • Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function
    • Doty R.L., Shaman P., Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol. Behav. 1984, 32:489-502.
    • (1984) Physiol. Behav. , vol.32 , pp. 489-502
    • Doty, R.L.1    Shaman, P.2    Dann, M.3
  • 57
    • 77951976610 scopus 로고    scopus 로고
    • Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
    • Emmanouilidou E., Stefanis L., Vekrellis K. Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome. Neurobiol. Aging 2010, 31:953-968.
    • (2010) Neurobiol. Aging , vol.31 , pp. 953-968
    • Emmanouilidou, E.1    Stefanis, L.2    Vekrellis, K.3
  • 60
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: substantia nigra regional selectivity
    • Fearnley J.M., Lees A.J. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991, 114(Pt 5):2283-2301.
    • (1991) Brain , vol.114 , Issue.PART 5 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 62
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno L.S. Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 1996, 55:259-272.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 63
    • 67649273927 scopus 로고    scopus 로고
    • Propagation of tau misfolding from the outside to the inside of a cell
    • Frost B., Jacks R.L., Diamond M.I. Propagation of tau misfolding from the outside to the inside of a cell. J. Biol. Chem. 2009, 284:12845-12852.
    • (2009) J. Biol. Chem. , vol.284 , pp. 12845-12852
    • Frost, B.1    Jacks, R.L.2    Diamond, M.I.3
  • 65
    • 33646025535 scopus 로고    scopus 로고
    • Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases
    • Gagnon J.F., Postuma R.B., Mazza S., Doyon J., Montplaisir J. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol. 2006, 5:424-432.
    • (2006) Lancet Neurol. , vol.5 , pp. 424-432
    • Gagnon, J.F.1    Postuma, R.B.2    Mazza, S.3    Doyon, J.4    Montplaisir, J.5
  • 67
    • 47149114386 scopus 로고    scopus 로고
    • Intercellular transfer mediated by tunneling nanotubes
    • Gerdes H.-H., Carvalho R.N. Intercellular transfer mediated by tunneling nanotubes. Curr. Opin. Cell Biol. 2008, 20:470-475.
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 470-475
    • Gerdes, H.-H.1    Carvalho, R.N.2
  • 68
    • 34248178294 scopus 로고    scopus 로고
    • Tunneling nanotubes: a new route for the exchange of components between animal cells
    • Gerdes H.-H., Bukoreshtliev N.V., Barroso J.F.V. Tunneling nanotubes: a new route for the exchange of components between animal cells. FEBS Lett. 2007, 581:2194-2201.
    • (2007) FEBS Lett. , vol.581 , pp. 2194-2201
    • Gerdes, H.-H.1    Bukoreshtliev, N.V.2    Barroso, J.F.V.3
  • 70
    • 77949897463 scopus 로고    scopus 로고
    • The progression of pathology in Parkinson's disease
    • Halliday G.M., McCann H. The progression of pathology in Parkinson's disease. Ann. N. Y. Acad. Sci. 2010, 1184:188-195.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1184 , pp. 188-195
    • Halliday, G.M.1    McCann, H.2
  • 73
  • 75
    • 0035997016 scopus 로고    scopus 로고
    • Protein aggregation in Huntington's disease
    • Hoffner G., Djian P. Protein aggregation in Huntington's disease. Biochimie 2002, 84:273-278.
    • (2002) Biochimie , vol.84 , pp. 273-278
    • Hoffner, G.1    Djian, P.2
  • 76
    • 0030933980 scopus 로고    scopus 로고
    • Sniffin 'sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold
    • Hummel T., Sekinger B., Wolf S.R., Pauli E., Kobal G. Sniffin 'sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem. Senses 1997, 22:39-52.
    • (1997) Chem. Senses , vol.22 , pp. 39-52
    • Hummel, T.1    Sekinger, B.2    Wolf, S.R.3    Pauli, E.4    Kobal, G.5
  • 77
    • 79951811351 scopus 로고    scopus 로고
    • International Parkinson Disease Genomics Consortium Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
    • International Parkinson Disease Genomics Consortium Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 2011, 377:641-649.
    • (2011) Lancet , vol.377 , pp. 641-649
  • 79
    • 77951885732 scopus 로고    scopus 로고
    • Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions
    • Jang A., Lee H.-J., Suk J.-E., Jung J.-W., Kim K.-P., Lee S.-J. Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J. Neurochem. 2010, 113:1263-1274.
    • (2010) J. Neurochem. , vol.113 , pp. 1263-1274
    • Jang, A.1    Lee, H.-J.2    Suk, J.-E.3    Jung, J.-W.4    Kim, K.-P.5    Lee, S.-J.6
  • 80
    • 69549120391 scopus 로고    scopus 로고
    • Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration
    • Jang H., Boltz D., Sturm-Ramirez K., Shepherd K.R., Jiao Y., Webster R., Smeyne R.J. Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:14063-14068.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 14063-14068
    • Jang, H.1    Boltz, D.2    Sturm-Ramirez, K.3    Shepherd, K.R.4    Jiao, Y.5    Webster, R.6    Smeyne, R.J.7
  • 82
    • 34547152267 scopus 로고    scopus 로고
    • Membrane interaction of islet amyloid polypeptide
    • Jayasinghe S.A., Langen R. Membrane interaction of islet amyloid polypeptide. Biochim. Biophys. Acta 2007, 1768:2002-2009.
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 2002-2009
    • Jayasinghe, S.A.1    Langen, R.2
  • 83
    • 68749116710 scopus 로고    scopus 로고
    • A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders
    • Jellinger K.A. A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders. Biochim. Biophys. Acta 2009, 1792:730-740.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 730-740
    • Jellinger, K.A.1
  • 84
    • 68349109646 scopus 로고    scopus 로고
    • Absence of α-synuclein pathology in postencephalitic parkinsonism
    • Jellinger K.A. Absence of α-synuclein pathology in postencephalitic parkinsonism. Acta Neuropathol. 2009, 118:371-379.
    • (2009) Acta Neuropathol. , vol.118 , pp. 371-379
    • Jellinger, K.A.1
  • 85
    • 69549116777 scopus 로고    scopus 로고
    • Formation and development of Lewy pathology: a critical update
    • Jellinger K.A. Formation and development of Lewy pathology: a critical update. J. Neurol. 2009, 256(Suppl. 3):270-279.
    • (2009) J. Neurol. , vol.256 , Issue.SUPPL. 3 , pp. 270-279
    • Jellinger, K.A.1
  • 86
    • 45749155306 scopus 로고    scopus 로고
    • A critical reappraisal of current staging of Lewy-related pathology in human brain
    • Jellinger K.A. A critical reappraisal of current staging of Lewy-related pathology in human brain. Acta Neuropathol. 2008, 116:1-16.
    • (2008) Acta Neuropathol. , vol.116 , pp. 1-16
    • Jellinger, K.A.1
  • 88
    • 42549125030 scopus 로고    scopus 로고
    • The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging
    • Kalaitzakis M.E., Graeber M.B., Gentleman S.M., Pearce R.K.B. The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging. Neuropathol. Appl. Neurobiol. 2008, 34:284-295.
    • (2008) Neuropathol. Appl. Neurobiol. , vol.34 , pp. 284-295
    • Kalaitzakis, M.E.1    Graeber, M.B.2    Gentleman, S.M.3    Pearce, R.K.B.4
  • 90
    • 33750121865 scopus 로고    scopus 로고
    • Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells
    • Klegeris A., Giasson B.I., Zhang H., Maguire J., Pelech S., McGeer P.L. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. FASEB J. 2006, 20:2000-2008.
    • (2006) FASEB J. , vol.20 , pp. 2000-2008
    • Klegeris, A.1    Giasson, B.I.2    Zhang, H.3    Maguire, J.4    Pelech, S.5    McGeer, P.L.6
  • 91
    • 79960334171 scopus 로고    scopus 로고
    • α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells
    • Kondo K., Obitsu S., Teshima R. α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells. Biol. Pharm. Bull. 2011, 34:1078-1083.
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 1078-1083
    • Kondo, K.1    Obitsu, S.2    Teshima, R.3
  • 93
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower J.H., Chu Y., Hauser R.A., Freeman T.B., Olanow C.W. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat. Med. 2008, 14:504-506.
    • (2008) Nat. Med. , vol.14 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 94
    • 61449216234 scopus 로고    scopus 로고
    • Transplanted dopaminergic neurons develop PD pathologic changes: a second case report
    • Kordower J.H., Chu Y., Hauser R.A., Olanow C.W., Freeman T.B. Transplanted dopaminergic neurons develop PD pathologic changes: a second case report. Mov. Disord. 2008, 23:2303-2306.
    • (2008) Mov. Disord. , vol.23 , pp. 2303-2306
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Olanow, C.W.4    Freeman, T.B.5
  • 95
    • 74249089262 scopus 로고    scopus 로고
    • Prion-like propagation of cytosolic protein aggregates: insights from cell culture models
    • Krammer C., Schätzl H.M., Vorberg I. Prion-like propagation of cytosolic protein aggregates: insights from cell culture models. Prion 2009, 3:206-212.
    • (2009) Prion , vol.3 , pp. 206-212
    • Krammer, C.1    Schätzl, H.M.2    Vorberg, I.3
  • 96
    • 0025296453 scopus 로고
    • Evidence that the blockade of mitochondrial respiration by the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) involves binding at the same site as the respiratory inhibitor, rotenone
    • Krueger M.J., Singer T.P., Casida J.E., Ramsay R.R. Evidence that the blockade of mitochondrial respiration by the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) involves binding at the same site as the respiratory inhibitor, rotenone. Biochem. Biophys. Res. Commun. 1990, 169:123-128.
    • (1990) Biochem. Biophys. Res. Commun. , vol.169 , pp. 123-128
    • Krueger, M.J.1    Singer, T.P.2    Casida, J.E.3    Ramsay, R.R.4
  • 98
    • 79958227103 scopus 로고    scopus 로고
    • Signs of Degeneration in 12-22-Year Old Grafts of Mesencephalic Dopamine Neurons in Patients with Parkinson's Disease
    • Kurowska Z., Englund E., Widnerd H., Lindvalle O., Lia J.-Y., Brundin P. Signs of Degeneration in 12-22-Year Old Grafts of Mesencephalic Dopamine Neurons in Patients with Parkinson's Disease. J. Park. Dis. 2011, 83-92.
    • (2011) J. Park. Dis. , pp. 83-92
    • Kurowska, Z.1    Englund, E.2    Widnerd, H.3    Lindvalle, O.4    Lia, J.-Y.5    Brundin, P.6
  • 99
    • 20744436655 scopus 로고    scopus 로고
    • Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins
    • Lancaster G.I., Febbraio M.A. Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J. Biol. Chem. 2005, 280:23349-23355.
    • (2005) J. Biol. Chem. , vol.280 , pp. 23349-23355
    • Lancaster, G.I.1    Febbraio, M.A.2
  • 100
    • 33645755812 scopus 로고    scopus 로고
    • The Parkinson's complex: Parkinsonism is just the tip of the iceberg
    • Langston J.W. The Parkinson's complex: Parkinsonism is just the tip of the iceberg. Ann. Neurol. 2006, 59:591-596.
    • (2006) Ann. Neurol. , vol.59 , pp. 591-596
    • Langston, J.W.1
  • 101
    • 0005444118 scopus 로고
    • Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Langston J.W., Ballard P.A. Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N. Engl. J. Med. 1983, 309:310.
    • (1983) N. Engl. J. Med. , vol.309 , pp. 310
    • Langston, J.W.1    Ballard, P.A.2
  • 106
    • 77956194977 scopus 로고    scopus 로고
    • Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1
    • Lee E.-J., Woo M.-S., Moon P.-G., Baek M.-C., Choi I.-Y., Kim W.-K., Junn E., Kim H.-S. Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1. J. Immunol. 2010, 185:615-623.
    • (2010) J. Immunol. , vol.185 , pp. 615-623
    • Lee, E.-J.1    Woo, M.-S.2    Moon, P.-G.3    Baek, M.-C.4    Choi, I.-Y.5    Kim, W.-K.6    Junn, E.7    Kim, H.-S.8
  • 108
    • 40749094842 scopus 로고    scopus 로고
    • Origins and Effects of Extracellular α-synuclein: implications in Parkinson's Disease
    • Lee S.-J. Origins and Effects of Extracellular α-synuclein: implications in Parkinson's Disease. J. Mol. Neurosci. 2007, 34(1):17-22.
    • (2007) J. Mol. Neurosci. , vol.34 , Issue.1 , pp. 17-22
    • Lee, S.-J.1
  • 109
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
    • Lee H.-J., Patel S., Lee S.-J. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J. Neurosci. 2005, 25:6016-6024.
    • (2005) J. Neurosci. , vol.25 , pp. 6016-6024
    • Lee, H.-J.1    Patel, S.2    Lee, S.-J.3
  • 111
    • 79959923467 scopus 로고    scopus 로고
    • Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives
    • Lee S.-J., Lim H.-S., Masliah E., Lee H.-J. Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives. Neurosci. Res. 2011.
    • (2011) Neurosci. Res.
    • Lee, S.-J.1    Lim, H.-S.2    Masliah, E.3    Lee, H.-J.4
  • 113
    • 77949820437 scopus 로고    scopus 로고
    • Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
    • Li J.-Y., Englund E., Widner H., Rehncrona S., Björklund A., Lindvall O., Brundin P. Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease. Mov. Disord. 2010, 25:1091-1096.
    • (2010) Mov. Disord. , vol.25 , pp. 1091-1096
    • Li, J.-Y.1    Englund, E.2    Widner, H.3    Rehncrona, S.4    Björklund, A.5    Lindvall, O.6    Brundin, P.7
  • 115
    • 7244243876 scopus 로고    scopus 로고
    • Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation
    • Li W., Lesuisse C., Xu Y., Troncoso J.C., Price D.L., Lee M.K. Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. J. Neurosci. 2004, 24:7400-7409.
    • (2004) J. Neurosci. , vol.24 , pp. 7400-7409
    • Li, W.1    Lesuisse, C.2    Xu, Y.3    Troncoso, J.C.4    Price, D.L.5    Lee, M.K.6
  • 117
    • 0036797552 scopus 로고    scopus 로고
    • Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
    • Lotharius J., Brundin P. Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. Hum. Mol. Gen. 2002, 11:2395-2407.
    • (2002) Hum. Mol. Gen. , vol.11 , pp. 2395-2407
    • Lotharius, J.1    Brundin, P.2
  • 118
    • 0034624017 scopus 로고    scopus 로고
    • The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity
    • Lotharius J., O'Malley K.L. The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity. J. Biol. Chem. 2000, 275:38581-38588.
    • (2000) J. Biol. Chem. , vol.275 , pp. 38581-38588
    • Lotharius, J.1    O'Malley, K.L.2
  • 122
    • 65449120034 scopus 로고    scopus 로고
    • Virus entry by macropinocytosis
    • Mercer J., Helenius A. Virus entry by macropinocytosis. Nat. Cell Biol. 2009, 11:510-520.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 510-520
    • Mercer, J.1    Helenius, A.2
  • 125
    • 77953231865 scopus 로고    scopus 로고
    • The relationship between dopaminergic axons and glutamatergic synapses in the striatum: structural considerations
    • Oxford University Press, Oxford, UK, L.L. Iversen, S.D. Iversen, S.B. Dunnett, A. Björklund (Eds.)
    • Moss J., Bolam J.P. The relationship between dopaminergic axons and glutamatergic synapses in the striatum: structural considerations. Dopamine Handbook 2010, 49-59. Oxford University Press, Oxford, UK. L.L. Iversen, S.D. Iversen, S.B. Dunnett, A. Björklund (Eds.).
    • (2010) Dopamine Handbook , pp. 49-59
    • Moss, J.1    Bolam, J.P.2
  • 128
    • 0036327321 scopus 로고    scopus 로고
    • Olfactory function in idiopathic Parkinson's disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients
    • Müller A., Reichmann H., Livermore A., Hummel T. Olfactory function in idiopathic Parkinson's disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients. J. Neural. Transm. 2002, 109:805-811.
    • (2002) J. Neural. Transm. , vol.109 , pp. 805-811
    • Müller, A.1    Reichmann, H.2    Livermore, A.3    Hummel, T.4
  • 129
    • 79952743365 scopus 로고    scopus 로고
    • Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
    • Münch C., O'Brien J., Bertolotti A. Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:3548-3553.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 3548-3553
    • Münch, C.1    O'Brien, J.2    Bertolotti, A.3
  • 130
    • 0036855635 scopus 로고    scopus 로고
    • Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
    • Neumann M., Kahle P.J., Giasson B.I., Ozmen L., Borroni E., Spooren W., Müller V., Odoy S., Fujiwara H., Hasegawa M., et al. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. J. Clin. Invest. 2002, 110:1429-1439.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1429-1439
    • Neumann, M.1    Kahle, P.J.2    Giasson, B.I.3    Ozmen, L.4    Borroni, E.5    Spooren, W.6    Müller, V.7    Odoy, S.8    Fujiwara, H.9    Hasegawa, M.10
  • 131
    • 78049376559 scopus 로고    scopus 로고
    • Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases
    • Nonaka T., Watanabe S.T., Iwatsubo T., Hasegawa M. Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases. J. Biol. Chem. 2010, 285:34885-34898.
    • (2010) J. Biol. Chem. , vol.285 , pp. 34885-34898
    • Nonaka, T.1    Watanabe, S.T.2    Iwatsubo, T.3    Hasegawa, M.4
  • 134
    • 77953538310 scopus 로고    scopus 로고
    • LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation
    • Okabayashi S., Kimura N. LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation. Neuro Report 2010, 21:606-610.
    • (2010) Neuro Report , vol.21 , pp. 606-610
    • Okabayashi, S.1    Kimura, N.2
  • 138
    • 77955366745 scopus 로고    scopus 로고
    • Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies
    • Oueslati A., Fournier M., Lashuel H.A. Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies. Prog. Brain Res. 2010, 183:115-145.
    • (2010) Prog. Brain Res. , vol.183 , pp. 115-145
    • Oueslati, A.1    Fournier, M.2    Lashuel, H.A.3
  • 141
    • 41149141259 scopus 로고    scopus 로고
    • Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance
    • Parkkinen L., Pirttilä T., Alafuzoff I. Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol. 2008, 115:399-407.
    • (2008) Acta Neuropathol. , vol.115 , pp. 399-407
    • Parkkinen, L.1    Pirttilä, T.2    Alafuzoff, I.3
  • 142
    • 0029031709 scopus 로고
    • The anterior olfactory nucleus in Parkinson's disease
    • Pearce R.K., Hawkes C.H., Daniel S.E. The anterior olfactory nucleus in Parkinson's disease. Mov. Disord. 1995, 10:283-287.
    • (1995) Mov. Disord. , vol.10 , pp. 283-287
    • Pearce, R.K.1    Hawkes, C.H.2    Daniel, S.E.3
  • 145
    • 33751529589 scopus 로고    scopus 로고
    • The natural history of Parkinson's disease
    • VII2-6
    • Poewe W. The natural history of Parkinson's disease. J. Neurol. 2006, 253(Suppl. 7). VII2-6.
    • (2006) J. Neurol. , vol.253 , Issue.SUPPL. 7
    • Poewe, W.1
  • 148
    • 68749083546 scopus 로고    scopus 로고
    • Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease
    • Prudencio M., Hart P.J., Borchelt D.R., Andersen P.M. Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease. Hum. Mol. Genet. 2009, 18:3217-3226.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 3217-3226
    • Prudencio, M.1    Hart, P.J.2    Borchelt, D.R.3    Andersen, P.M.4
  • 149
    • 0003661592 scopus 로고    scopus 로고
    • Cold Spring Harbor Lab Press, Cold Spring Harbor, NY
    • Prusiner S. Prion Biology and Diseases 2004, Cold Spring Harbor Lab Press, Cold Spring Harbor, NY. 2nd ed.
    • (2004) Prion Biology and Diseases
    • Prusiner, S.1
  • 150
    • 0020321767 scopus 로고
    • Novel proteinaceous infectious particles cause scrapie
    • Prusiner S.B. Novel proteinaceous infectious particles cause scrapie. Science 1982, 216:136-144.
    • (1982) Science , vol.216 , pp. 136-144
    • Prusiner, S.B.1
  • 152
    • 79957603259 scopus 로고    scopus 로고
    • Milestones in Parkinson's disease therapeutics
    • Rascol O., Lozano A., Stern M., Poewe W. Milestones in Parkinson's disease therapeutics. Mov. Disord. 2011, 26:1072-1082.
    • (2011) Mov. Disord. , vol.26 , pp. 1072-1082
    • Rascol, O.1    Lozano, A.2    Stern, M.3    Poewe, W.4
  • 153
    • 79955481749 scopus 로고    scopus 로고
    • Exosomes as intercellular signalosomes and pharmacological effectors
    • Record M., Subra C., Silvente-Poirot S., Poirot M. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem. Pharmacol. 2011, 81:1171-1182.
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 1171-1182
    • Record, M.1    Subra, C.2    Silvente-Poirot, S.3    Poirot, M.4
  • 154
    • 77954258078 scopus 로고    scopus 로고
    • Clinical criteria for the diagnosis of Parkinson's disease
    • Reichmann H. Clinical criteria for the diagnosis of Parkinson's disease. Neurodegen. Dis. 2010, 7:284-290.
    • (2010) Neurodegen. Dis. , vol.7 , pp. 284-290
    • Reichmann, H.1
  • 155
    • 59649095699 scopus 로고    scopus 로고
    • Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
    • Ren P.-H., Lauckner J.E., Kachirskaia I., Heuser J.E., Melki R., Kopito R.R. Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat. Cell Biol. 2009, 11:219-225.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 219-225
    • Ren, P.-H.1    Lauckner, J.E.2    Kachirskaia, I.3    Heuser, J.E.4    Melki, R.5    Kopito, R.R.6
  • 156
    • 33747878233 scopus 로고    scopus 로고
    • Very long term studies of the seeding of β-amyloidosis in primates
    • Ridley R.M., Baker H.F., Windle C.P., Cummings R.M. Very long term studies of the seeding of β-amyloidosis in primates. J. Neural Transm. 2005, 113:1243-1251.
    • (2005) J. Neural Transm. , vol.113 , pp. 1243-1251
    • Ridley, R.M.1    Baker, H.F.2    Windle, C.P.3    Cummings, R.M.4
  • 158
  • 159
    • 0021111491 scopus 로고
    • The origin of " Awakenings"
    • Sacks O. The origin of " Awakenings" . Br. Med. J. (Clin. Res. Ed.) 1983, 287:1968-1969.
    • (1983) Br. Med. J. (Clin. Res. Ed.) , vol.287 , pp. 1968-1969
    • Sacks, O.1
  • 160
    • 84856476872 scopus 로고    scopus 로고
    • Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid (CSF) in early Alzheimer's Disease
    • Saman S., Kim W., Raya M., Visnick Y., Miro S., Saman S., Jackson B., McKee A.C., Lee N.C., Hall G.F. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid (CSF) in early Alzheimer's Disease. J. Biol. Chem. 2011.
    • (2011) J. Biol. Chem.
    • Saman, S.1    Kim, W.2    Raya, M.3    Visnick, Y.4    Miro, S.5    Saman, S.6    Jackson, B.7    McKee, A.C.8    Lee, N.C.9    Hall, G.F.10
  • 164
    • 58149131277 scopus 로고    scopus 로고
    • Neurobiology and treatment of Parkinson's disease
    • Schapira A.H.V. Neurobiology and treatment of Parkinson's disease. Trends Pharmacol. Sci. 2009, 30:41-47.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 41-47
    • Schapira, A.H.V.1
  • 166
    • 33644824423 scopus 로고    scopus 로고
    • Timing of treatment initiation in Parkinson's disease: a need for reappraisal?
    • Schapira A.H.V., Obeso J. Timing of treatment initiation in Parkinson's disease: a need for reappraisal?. Ann. Neurol. 2006, 59:559-562.
    • (2006) Ann. Neurol. , vol.59 , pp. 559-562
    • Schapira, A.H.V.1    Obeso, J.2
  • 167
    • 0029878953 scopus 로고    scopus 로고
    • Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder
    • Schenck C.H., Bundlie S.R., Mahowald M.W. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 1996, 46:388-393.
    • (1996) Neurology , vol.46 , pp. 388-393
    • Schenck, C.H.1    Bundlie, S.R.2    Mahowald, M.W.3
  • 168
    • 79960343359 scopus 로고    scopus 로고
    • Amyloid: little proteins, big clues
    • Schnabel J. Amyloid: little proteins, big clues. Nature 2011, 475:S12-S14.
    • (2011) Nature , vol.475
    • Schnabel, J.1
  • 169
    • 43149120419 scopus 로고    scopus 로고
    • Exosome function: from tumor immunology to pathogen biology
    • Schorey J.S., Bhatnagar S. Exosome function: from tumor immunology to pathogen biology. Traffic 2008, 9:871-881.
    • (2008) Traffic , vol.9 , pp. 871-881
    • Schorey, J.S.1    Bhatnagar, S.2
  • 170
    • 0028170411 scopus 로고
    • Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure
    • Schweers O., Schönbrunn-Hanebeck E., Marx A., Mandelkow E. Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure. J. Biol. Chem. 1994, 269:24290-24297.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24290-24297
    • Schweers, O.1    Schönbrunn-Hanebeck, E.2    Marx, A.3    Mandelkow, E.4
  • 173
    • 43249087541 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
    • Sharples R.A., Vella L.J., Nisbet R.M., Naylor R., Perez K., Barnham K.J., Masters C.L., Hill A.F. Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. FASEB J. 2008, 22:1469-1478.
    • (2008) FASEB J. , vol.22 , pp. 1469-1478
    • Sharples, R.A.1    Vella, L.J.2    Nisbet, R.M.3    Naylor, R.4    Perez, K.5    Barnham, K.J.6    Masters, C.L.7    Hill, A.F.8
  • 174
    • 0035353726 scopus 로고    scopus 로고
    • Comorbidity of the nonmotor symptoms of Parkinson's disease
    • Shulman L.M., Taback R.L., Bean J., Weiner W.J. Comorbidity of the nonmotor symptoms of Parkinson's disease. Mov. Disord. 2001, 16:507-510.
    • (2001) Mov. Disord. , vol.16 , pp. 507-510
    • Shulman, L.M.1    Taback, R.L.2    Bean, J.3    Weiner, W.J.4
  • 175
    • 67949097489 scopus 로고    scopus 로고
    • Exosomes-vesicular carriers for intercellular communication
    • Simons M., Raposo G. Exosomes-vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 2009, 21:575-581.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 575-581
    • Simons, M.1    Raposo, G.2
  • 181
  • 182
    • 11244260421 scopus 로고    scopus 로고
    • Combination of " idiopathic" REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT
    • Stiasny-Kolster K., Doerr Y., Möller J.C., Höffken H., Behr T.M., Oertel W.H., Mayer G. Combination of " idiopathic" REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain 2005, 128:126-137.
    • (2005) Brain , vol.128 , pp. 126-137
    • Stiasny-Kolster, K.1    Doerr, Y.2    Möller, J.C.3    Höffken, H.4    Behr, T.M.5    Oertel, W.H.6    Mayer, G.7
  • 187
    • 0035920226 scopus 로고    scopus 로고
    • Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein
    • Sung J.Y., Kim J., Paik S.R., Park J.H., Ahn Y.S., Chung K.C. Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. J. Biol. Chem. 2001, 276:27441-27448.
    • (2001) J. Biol. Chem. , vol.276 , pp. 27441-27448
    • Sung, J.Y.1    Kim, J.2    Paik, S.R.3    Park, J.H.4    Ahn, Y.S.5    Chung, K.C.6
  • 190
    • 78249280020 scopus 로고    scopus 로고
    • Single molecule characterization of α-synuclein in aggregation-prone states
    • Trexler A.J., Rhoades E. Single molecule characterization of α-synuclein in aggregation-prone states. Biophys. J. 2010, 99:3048-3055.
    • (2010) Biophys. J. , vol.99 , pp. 3048-3055
    • Trexler, A.J.1    Rhoades, E.2
  • 191
    • 0141677840 scopus 로고    scopus 로고
    • A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders
    • Uversky V.N. A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders. J. Biomol. Struct. Dyn. 2003, 21:211-234.
    • (2003) J. Biomol. Struct. Dyn. , vol.21 , pp. 211-234
    • Uversky, V.N.1
  • 193
    • 33947709328 scopus 로고    scopus 로고
    • Packaging of prions into exosomes is associated with a novel pathway of PrP processing
    • Vella L.J., Sharples R.A., Lawson V.A., Masters C.L., Cappai R., Hill A.F. Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J. Pathol. 2007, 211:582-590.
    • (2007) J. Pathol. , vol.211 , pp. 582-590
    • Vella, L.J.1    Sharples, R.A.2    Lawson, V.A.3    Masters, C.L.4    Cappai, R.5    Hill, A.F.6
  • 196
    • 0038386274 scopus 로고    scopus 로고
    • Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease
    • Volles M.J., Lansbury P.T. Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease. Biochemistry 2003, 42:7871-7878.
    • (2003) Biochemistry , vol.42 , pp. 7871-7878
    • Volles, M.J.1    Lansbury, P.T.2
  • 197
    • 0035800097 scopus 로고    scopus 로고
    • Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease
    • Volles M.J., Lee S.J., Rochet J.C., Shtilerman M.D., Ding T.T., Kessler J.C., Lansbury P.T. Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry 2001, 40:7812-7819.
    • (2001) Biochemistry , vol.40 , pp. 7812-7819
    • Volles, M.J.1    Lee, S.J.2    Rochet, J.C.3    Shtilerman, M.D.4    Ding, T.T.5    Kessler, J.C.6    Lansbury, P.T.7
  • 200
    • 77949706598 scopus 로고    scopus 로고
    • A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation
    • Waxman E.A., Giasson B.I. A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation. J. Neurochem. 2010, 113:374-388.
    • (2010) J. Neurochem. , vol.113 , pp. 374-388
    • Waxman, E.A.1    Giasson, B.I.2
  • 201
    • 33846904292 scopus 로고    scopus 로고
    • Dementia with Lewy bodies
    • Weisman D., McKeith I. Dementia with Lewy bodies. Semin. Neurol. 2007, 27:42-47.
    • (2007) Semin. Neurol. , vol.27 , pp. 42-47
    • Weisman, D.1    McKeith, I.2
  • 204
    • 65249116483 scopus 로고    scopus 로고
    • Tau mutations in neurodegenerative diseases
    • Wolfe M.S. Tau mutations in neurodegenerative diseases. J. Biol. Chem. 2009, 284:6021-6025.
    • (2009) J. Biol. Chem. , vol.284 , pp. 6021-6025
    • Wolfe, M.S.1
  • 205
    • 79956124664 scopus 로고    scopus 로고
    • Autophagic pathways in Parkinson disease and related disorders
    • Xilouri M., Stefanis L. Autophagic pathways in Parkinson disease and related disorders. Expert Rev. Mol. Med. 2011, 13:e8.
    • (2011) Expert Rev. Mol. Med. , vol.13
    • Xilouri, M.1    Stefanis, L.2
  • 206
    • 0036850529 scopus 로고    scopus 로고
    • Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells
    • Yang W., Dunlap J.R., Andrews R.B., Wetzel R. Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells. Hum. Mol. Gen. 2002, 11:2905-2917.
    • (2002) Hum. Mol. Gen. , vol.11 , pp. 2905-2917
    • Yang, W.1    Dunlap, J.R.2    Andrews, R.B.3    Wetzel, R.4
  • 208
    • 20144389524 scopus 로고    scopus 로고
    • Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    • Zhang W., Wang T., Pei Z., Miller D.S., Wu X., Block M.L., Wilson B., Zhang W., Zhou Y., Hong J.-S., et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005, 19:533-542.
    • (2005) FASEB J. , vol.19 , pp. 533-542
    • Zhang, W.1    Wang, T.2    Pei, Z.3    Miller, D.S.4    Wu, X.5    Block, M.L.6    Wilson, B.7    Zhang, W.8    Zhou, Y.9    Hong, J.-S.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.