Assembly-dependent endocytosis and clearance of extracellular α-synuclein

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 9, 2008, Pages 1835-1849

  Lee, He Jin ^a,c   Suk, Ji Eun ^a   Bae, Eun Jin ^b   Lee, Jung Ho ^d   Paik, Seung R ^d   Lee, Seung Jae ^a,b  

^a Konkuk University   (South Korea)

^b Konkuk University   (South Korea)

^c Konkuk University School of Medicine   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Synuclein; Endocytosis; Lysosome; Parkinson's disease; Protein aggregation

Indexed keywords

ALANINE; ALPHA SYNUCLEIN; DYNAMIN I; LYSINE; MONOMER; OLIGOMER;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE; COLD; CONTROLLED STUDY; CULTURE MEDIUM; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; PARKINSON DISEASE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SECRETION; PROTEIN TRANSPORT;

ALPHA-SYNUCLEIN; CELL LINE; CELL MEMBRANE; DIFFUSION; ENDOCYTOSIS; ENDOSOMES; EXTRACELLULAR SPACE; HUMANS; LYSOSOMES; NEURONS; PROTEIN BINDING;

EID: 44749083979     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.01.017     Document Type: Article

References (31)

1. Ahn K.J., Paik S.R., Chung K.C., and Kim J. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. Journal of Neurochemistry 97 (2006) 265-279
2. Albani D., Peverelli E., Rametta R., Batelli S., Veschini L., Negro A., et al. Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70. FASEB Journal 18 (2004) 1713-1715
3. Bodles A.M., Guthrie D.J., Harriott P., Campbell P., and Irvine G.B. Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils. European Journal of Biochemistry 267 (2000) 2186-2194
4. Borghi R., Marchese R., Negro A., Marinelli L., Forloni G., Zaccheo D., et al. Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects. Neuroscience Letters 287 (2000) 65-67
5. Cookson M.R. The biochemistry of Parkinson's disease. Annual Review of Biochemistry 74 (2005) 29-52
6. Du H.N., Tang L., Luo X.Y., Li H.T., Hu J., Zhou J.W., et al. A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein. Biochemistry 42 (2003) 8870-8878
7. El-Agnaf O.M., Jakes R., Curran M.D., Middleton D., Ingenito R., Bianchi E., et al. Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Letters 440 (1998) 71-75
8. El-Agnaf O.M., Salem S.A., Paleologou K.E., Curran M.D., Gibson M.J., Court J.A., et al. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB Journal 20 (2006) 419-425
9. Farrer M.J. Genetics of Parkinson disease: paradigm shifts and future prospects. Nature Review Genetics 7 (2006) 306-318
10. Forloni G., Bertani I., Calella A.M., Thaler F., and Invernizzi R. Alpha-synuclein and Parkinson's disease: Selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Annals of Neurology 47 (2000) 632-640
11. Iwata A., Christianson J.C., Bucci M., Ellerby L.M., Nukina N., Forno L.S., et al. Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proceedings of National Academy of Science USA 102 (2005) 13135-13140
12. Jellinger K.A. Neuropathological spectrum of synucleinopathies. Movement Disorder 18 Supplement 6 (2003) S2-S12
13. Kim Y.S., Lee D., Lee E.K., Sung J.Y., Chung K.C., Kim J., et al. Multiple ligand interaction of alpha-synuclein produced various forms of protein aggregates in the presence of Abeta25-35, copper, and eosin. Brain Research 908 (2001) 93-98
14. Klegeris A., Giasson B.I., Zhang H., Maguire J., Pelech S., and McGeer P.L. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. FASEB Journal 20 (2006) 2000-2008
15. Lee H.-J., Shin S.Y., Choi C., Lee Y.H., and Lee S.-J. Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. Journal of Biological Chemistry 277 (2002) 5411-5417
16. Lee E.N., Cho H.J., Lee C.H., Lee D., Chung K.C., and Paik S.R. Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein. Biochemistry 43 (2004) 3704-3715
17. Lee H.-J., Khoshaghideh F., Patel S., and Lee S.-J. Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. The Journal of Neuroscience 24 (2004) 1888-1896
18. Lee H.-J., Patel S., and Lee S.-J. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. The Journal of Neuroscience 25 (2005) 6016-6024
19. Lee P.H., Lee G., Park H.J., Bang O.Y., Joo I.S., and Huh K. The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy. Journal Neural Transmission (2006)
20. Maries E., Dass B., Collier T.J., Kordower J.H., and Steece-Collier K. The role of alpha-synuclein in Parkinson's disease: insights from animal models. Nature Review Neuroscience 4 (2003) 727-738
21. Masliah E., Rockenstein E., Adame A., Alford M., Crews L., Hashimoto M., et al. Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron 46 (2005) 857-868
22. Perrin R.J., Payton J.E., Barnett D.H., Wraight C.L., Woods W.S., Ye L., et al. Epitope mapping and specificity of the anti-alpha-synuclein monoclonal antibody Syn-1 in mouse brain and cultured cell lines. Neuroscience Letters 349 (2003) 133-135
23. Seo J.H., Rah J.C., Choi S.H., Shin J.K., Min K., Kim H.S., et al. Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB Journal 16 (2002) 1826-1828
24. Sever S. Dynamin and endocytosis. Current Opinions in Cell Biology 14 (2002) 463-467
25. Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., and Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proceedings of National Academy of Science USA 95 (1998) 6469-6473
26. Sung J.Y., Kim J., Paik S.R., Park J.H., Ahn Y.S., and Chung K.C. Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. Journal of Biological Chemistry 276 (2001) 27441-27448
27. Sung J.Y., Park S.M., Lee C.H., Um J.W., Lee H.J., Kim J., et al. Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. Journal of Biological Chemistry 280 (2005) 25216-25224
28. Tokuda T., Salem S.A., Allsop D., Mizuno T., Nakagawa M., Qureshi M.M., et al. Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. Biochemical Biophysical Research Communications 349 (2006) 162-166
29. Zhang J., Ferguson S.S., Barak L.S., Menard L., and Caron M.G. Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. Journal of Biological Chemistry 271 (1996) 18302-18305
30. Zhang W., Wang T., Pei Z., Miller D.S., Wu X., Block M.L., et al. Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson's disease. FASEB Journal 19 (2005) 533-542
31. Zhou Y., Gu G., Goodlett D.R., Zhang T., Pan C., Montine T.J., et al. Analysis of alpha-synuclein-associated proteins by quantitative proteomics. Journal of Biological Chemistry 279 (2004) 39155-39164