-
1
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Epub 1997/07/24, 9237759
-
Medzhitov R, Preston-Hurlburt P, Janeway Jr.CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388(6640):394–397. Epub 1997/07/24. doi:10.1038/41131. PubMed PMID:9237759
-
(1997)
Nature
, vol.388
, Issue.6640
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway, C.A.3
-
2
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
-
Epub 1999/04/14. PubMed PMID: 10201887
-
Hoshino K, Takeuchi O, Kawai T, Sanjo H, et al. Cutting edge:Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide:evidence for TLR4 as the Lps gene product. J Immunol 1999;162(7):3749–3752. Epub 1999/04/14. PubMed PMID:10201887
-
(1999)
J Immunol
, vol.162
, Issue.7
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
-
3
-
-
84941755669
-
Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors
-
Epub 2014/10/11, 25301932, PubMed Central PMCID: PMCPMC4292165
-
Pandey S, Kawai T, Akira S. Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors. Cold Spring Harb Perspect Biol 2014;7(1):a016246. Epub 2014/10/11. doi:10.1101/cshperspect.a016246. PubMed PMID:25301932; PubMed Central PMCID:PMCPMC4292165
-
(2014)
Cold Spring Harb Perspect Biol
, vol.7
, Issue.1
, pp. a016246
-
-
Pandey, S.1
Kawai, T.2
Akira, S.3
-
4
-
-
1942521223
-
Does Toll-like receptor 3 play a biological role in virus infections?
-
Epub 2004/04/28, 15110521
-
Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, et al. Does Toll-like receptor 3 play a biological role in virus infections? Virology 2004;322(2):231–238. Epub 2004/04/28. doi:10.1016/j.virol.2004.01.033. PubMed PMID:15110521
-
(2004)
Virology
, vol.322
, Issue.2
, pp. 231-238
-
-
Edelmann, K.H.1
Richardson-Burns, S.2
Alexopoulou, L.3
Tyler, K.L.4
-
5
-
-
8444226670
-
Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus
-
Epub 2004/11/06. PubMed PMID: 15528327
-
Hornung V, Schlender J, Guenthner-Biller M, Rothenfusser S, et al. Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus. J Immunol 2004;173(10):5935–5943. Epub 2004/11/06. PubMed PMID:15528327
-
(2004)
J Immunol
, vol.173
, Issue.10
, pp. 5935-5943
-
-
Hornung, V.1
Schlender, J.2
Guenthner-Biller, M.3
Rothenfusser, S.4
-
6
-
-
9144238160
-
TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses
-
Epub 2004/11/24. PubMed PMID: 15557183
-
Lopez CB, Moltedo B, Alexopoulou L, Bonifaz L, Flavell RA, et al. TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses. J Immunol 2004;173(11):6882–6889. Epub 2004/11/24. PubMed PMID:15557183
-
(2004)
J Immunol
, vol.173
, Issue.11
, pp. 6882-6889
-
-
Lopez, C.B.1
Moltedo, B.2
Alexopoulou, L.3
Bonifaz, L.4
Flavell, R.A.5
-
7
-
-
3242813113
-
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
-
Epub 2004/06/23, 15208624
-
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol 2004;5(7):730–737. Epub 2004/06/23. doi:10.1038/ni1087. PubMed PMID:15208624
-
(2004)
Nature Immunol
, vol.5
, Issue.7
, pp. 730-737
-
-
Yoneyama, M.1
Kikuchi, M.2
Natsukawa, T.3
Shinobu, N.4
-
8
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
Epub 2009/01/23, 19158676, PubMed Central PMCID: PMCPMC2862225
-
Fernandes-Alnemri T, Yu JW, Datta P, Wu J, et al. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009;458(7237):509–513. Epub 2009/01/23. doi:10.1038/nature07710. PubMed PMID:19158676; PubMed Central PMCID:PMCPMC2862225
-
(2009)
Nature
, vol.458
, Issue.7237
, pp. 509-513
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Datta, P.3
Wu, J.4
-
9
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Epub 2009/01/23, 19158675, PubMed Central PMCID: PMCPMC2726264
-
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009;458(7237):514–518. Epub 2009/01/23. doi:10.1038/nature07725. PubMed PMID:19158675; PubMed Central PMCID:PMCPMC2726264
-
(2009)
Nature
, vol.458
, Issue.7237
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
Bauernfeind, F.4
-
10
-
-
60749136484
-
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
Epub 2009/01/23, 19158679
-
Burckstummer T, Baumann C, Bluml S, Dixit E, et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nature Immunol 2009;10(3):266–272. Epub 2009/01/23. doi:10.1038/ni.1702. PubMed PMID:19158679
-
(2009)
Nature Immunol
, vol.10
, Issue.3
, pp. 266-272
-
-
Burckstummer, T.1
Baumann, C.2
Bluml, S.3
Dixit, E.4
-
11
-
-
60749104535
-
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
-
Epub 2009/01/10, 19131592
-
Roberts TL, Idris A, Dunn JA, Kelly GM, et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science (New York) 2009;323(5917):1057–1060. Epub 2009/01/10. doi:10.1126/science.1169841. PubMed PMID:19131592
-
(2009)
Science (New York)
, vol.323
, Issue.5917
, pp. 1057-1060
-
-
Roberts, T.L.1
Idris, A.2
Dunn, J.A.3
Kelly, G.M.4
-
12
-
-
70349459734
-
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
-
Epub 2009/07/18, 19609254, PubMed Central PMCID: PMCPMC3878616
-
Ablasser A, Bauernfeind F, Hartmann G, Latz E, et al. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nature Immunol 2009;10(10):1065–1072. Epub 2009/07/18. doi:10.1038/ni.1779. PubMed PMID:19609254; PubMed Central PMCID:PMCPMC3878616
-
(2009)
Nature Immunol
, vol.10
, Issue.10
, pp. 1065-1072
-
-
Ablasser, A.1
Bauernfeind, F.2
Hartmann, G.3
Latz, E.4
-
13
-
-
68049092912
-
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
-
Epub 2009/07/28, 19631370, PubMed Central PMCID: PMCPMC2747301
-
Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009;138(3):576–591. Epub 2009/07/28. doi:10.1016/j.cell.2009.06.015. PubMed PMID:19631370; PubMed Central PMCID:PMCPMC2747301
-
(2009)
Cell
, vol.138
, Issue.3
, pp. 576-591
-
-
Chiu, Y.H.1
Macmillan, J.B.2
Chen, Z.J.3
-
14
-
-
77958140656
-
IFI16 is an innate immune sensor for intracellular DNA
-
Epub 2010/10/05, 20890285, PubMed Central PMCID: PMCPMC3142795
-
Unterholzner L, Keating SE, Baran M, Horan KA, et al. IFI16 is an innate immune sensor for intracellular DNA. Nature Immunol 2010;11(11):997–1004. Epub 2010/10/05. doi:10.1038/ni.1932. PubMed PMID:20890285; PubMed Central PMCID:PMCPMC3142795
-
(2010)
Nature Immunol
, vol.11
, Issue.11
, pp. 997-1004
-
-
Unterholzner, L.1
Keating, S.E.2
Baran, M.3
Horan, K.A.4
-
15
-
-
84862976171
-
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
-
Epub 2012/06/14, 22691496, PubMed Central PMCID: PMCPMC3387042
-
Li T, Diner BA, Chen J, Cristea IM. Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc Nat Acad Sci USA 2012;109(26):10558–10563. Epub 2012/06/14. doi:10.1073/pnas.1203447109. PubMed PMID:22691496; PubMed Central PMCID:PMCPMC3387042
-
(2012)
Proc Nat Acad Sci USA
, vol.109
, Issue.26
, pp. 10558-10563
-
-
Li, T.1
Diner, B.A.2
Chen, J.3
Cristea, I.M.4
-
16
-
-
79956061094
-
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
-
Epub 2011/05/18, 21575908, PubMed Central PMCID: PMCPMC3113467
-
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 2011;9(5):363–375. Epub 2011/05/18. doi:10.1016/j.chom.2011.04.008. PubMed PMID:21575908; PubMed Central PMCID:PMCPMC3113467
-
(2011)
Cell Host Microbe
, vol.9
, Issue.5
, pp. 363-375
-
-
Kerur, N.1
Veettil, M.V.2
Sharma-Walia, N.3
Bottero, V.4
-
17
-
-
84905375825
-
Listeria monocytogenes induces IFNbeta expression through an IFI16-, cGAS- and STING-dependent pathway
-
Epub 2014/06/28, 24970844, PubMed Central PMCID: PMCPMC4194099
-
Hansen K, Prabakaran T, Laustsen A, Jorgensen SE, et al. Listeria monocytogenes induces IFNbeta expression through an IFI16-, cGAS- and STING-dependent pathway. EMBO J 2014;33(15):1654–1666. Epub 2014/06/28. doi:10.15252/embj.201488029. PubMed PMID:24970844; PubMed Central PMCID:PMCPMC4194099
-
(2014)
EMBO J
, vol.33
, Issue.15
, pp. 1654-1666
-
-
Hansen, K.1
Prabakaran, T.2
Laustsen, A.3
Jorgensen, S.E.4
-
18
-
-
84888002403
-
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
-
Epub 2013/10/25, 24154727, PubMed Central PMCID: PMCPMC3845190
-
Jakobsen MR, Bak RO, Andersen A, Berg RK, et al. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proc Nat Acad Sci USA 2013;110(48):E4571–E4580. Epub 2013/10/25. doi:10.1073/pnas.1311669110. PubMed PMID:24154727; PubMed Central PMCID:PMCPMC3845190
-
(2013)
Proc Nat Acad Sci USA
, vol.110
, Issue.48
, pp. E4571-E4580
-
-
Jakobsen, M.R.1
Bak, R.O.2
Andersen, A.3
Berg, R.K.4
-
19
-
-
84868095535
-
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
-
Epub 2012/10/03, 23027953, PubMed Central PMCID: PMCPMC3497734
-
Orzalli MH, DeLuca NA, Knipe DM. Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc Nat Acad Sci USA 2012;109(44):E3008–E3017. Epub 2012/10/03. doi:10.1073/pnas.1211302109. PubMed PMID:23027953; PubMed Central PMCID:PMCPMC3497734
-
(2012)
Proc Nat Acad Sci USA
, vol.109
, Issue.44
, pp. E3008-E3017
-
-
Orzalli, M.H.1
DeLuca, N.A.2
Knipe, D.M.3
-
20
-
-
0037154176
-
Mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
-
Epub 2002/01/24, 11805321, PubMed Central PMCID: PMCPMC117358
-
Kang DC, Gopalkrishnan RV, Wu Q, Jankowsky E, et al. Mda-5:an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc Nat Acad Sci USA 2002;99(2):637–642. Epub 2002/01/24. doi:10.1073/pnas.022637199. PubMed PMID:11805321; PubMed Central PMCID:PMCPMC117358
-
(2002)
Proc Nat Acad Sci USA
, vol.99
, Issue.2
, pp. 637-642
-
-
Kang, D.C.1
Gopalkrishnan, R.V.2
Wu, Q.3
Jankowsky, E.4
-
21
-
-
79956314622
-
Immune signaling by RIG-I-like receptors
-
Epub 2011/05/28, 21616437, PubMed Central PMCID: PMCPMC3177755
-
Loo YM, Gale Jr.M. Immune signaling by RIG-I-like receptors. Immunity 2011;34(5):680–692. Epub 2011/05/28. doi:10.1016/j.immuni.2011.05.003. PubMed PMID:21616437; PubMed Central PMCID:PMCPMC3177755
-
(2011)
Immunity
, vol.34
, Issue.5
, pp. 680-692
-
-
Loo, Y.M.1
Gale, M.2
-
22
-
-
22544455673
-
Cell type-specific involvement of RIG-I in antiviral response
-
Epub 2005/07/26, 16039576
-
Kato H, Sato S, Yoneyama M, Yamamoto M, et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005;23(1):19–28. Epub 2005/07/26. doi:10.1016/j.immuni.2005.04.010. PubMed PMID:16039576
-
(2005)
Immunity
, vol.23
, Issue.1
, pp. 19-28
-
-
Kato, H.1
Sato, S.2
Yoneyama, M.3
Yamamoto, M.4
-
23
-
-
84921047960
-
Viral RNA detection by RIG-I-like receptors
-
Epub 2015/01/17, 25594890
-
Yoneyama M, Onomoto K, Jogi M, Akaboshi T, et al. Viral RNA detection by RIG-I-like receptors. Curr Opin Immunol 2015;32:48–53. Epub 2015/01/17. doi:10.1016/j.coi.2014.12.012. PubMed PMID:25594890
-
(2015)
Curr Opin Immunol
, vol.32
, pp. 48-53
-
-
Yoneyama, M.1
Onomoto, K.2
Jogi, M.3
Akaboshi, T.4
-
24
-
-
33846307026
-
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
-
Epub 2006/12/28, 17190814, PubMed Central PMCID: PMCPMC1766428
-
Saito T, Hirai R, Loo YM, Owen D, et al. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Nat Acad Sci USA 2007;104(2):582–587. Epub 2006/12/28. doi:10.1073/pnas.0606699104. PubMed PMID:17190814; PubMed Central PMCID:PMCPMC1766428
-
(2007)
Proc Nat Acad Sci USA
, vol.104
, Issue.2
, pp. 582-587
-
-
Saito, T.1
Hirai, R.2
Loo, Y.M.3
Owen, D.4
-
25
-
-
23844438864
-
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
-
Epub 2005/08/24. PubMed PMID: 16116171
-
Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 2005;175(5):2851–2858. Epub 2005/08/24. PubMed PMID:16116171
-
(2005)
J Immunol
, vol.175
, Issue.5
, pp. 2851-2858
-
-
Yoneyama, M.1
Kikuchi, M.2
Matsumoto, K.3
Imaizumi, T.4
-
26
-
-
48949094095
-
Structural mechanism of RNA recognition by the RIG-I-like receptors
-
Epub 2008/08/15, 18701081
-
Yoneyama M, Fujita T. Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity 2008;29(2):178–181. Epub 2008/08/15. doi:10.1016/j.immuni.2008.07.009. PubMed PMID:18701081
-
(2008)
Immunity
, vol.29
, Issue.2
, pp. 178-181
-
-
Yoneyama, M.1
Fujita, T.2
-
27
-
-
76549109497
-
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses
-
Epub 2010/01/19, 20080593, PubMed Central PMCID: PMCPMC2824407
-
Satoh T, Kato H, Kumagai Y, Yoneyama M, et al. LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Nat Acad Sci USA 2010;107(4):1512–1517. Epub 2010/01/19. doi:10.1073/pnas.0912986107. PubMed PMID:20080593; PubMed Central PMCID:PMCPMC2824407
-
(2010)
Proc Nat Acad Sci USA
, vol.107
, Issue.4
, pp. 1512-1517
-
-
Satoh, T.1
Kato, H.2
Kumagai, Y.3
Yoneyama, M.4
-
28
-
-
0035816675
-
Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop
-
Epub 2001/05/05, 11337501
-
Zhang F, Romano PR, Nagamura-Inoue T, Tian B, et al. Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem 2001;276(27):24946–24958. Epub 2001/05/05. doi:10.1074/jbc.M102108200. PubMed PMID:11337501
-
(2001)
J Biol Chem
, vol.276
, Issue.27
, pp. 24946-24958
-
-
Zhang, F.1
Romano, P.R.2
Nagamura-Inoue, T.3
Tian, B.4
-
29
-
-
84905123345
-
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
-
Epub 2014/07/19, 25033909
-
Hornung V, Hartmann R, Ablasser A, Hopfner KP. OAS proteins and cGAS:unifying concepts in sensing and responding to cytosolic nucleic acids. Nat Rev Immunol 2014;14(8):521–528. Epub 2014/07/19. doi:10.1038/nri3719. PubMed PMID:25033909
-
(2014)
Nat Rev Immunol
, vol.14
, Issue.8
, pp. 521-528
-
-
Hornung, V.1
Hartmann, R.2
Ablasser, A.3
Hopfner, K.P.4
-
30
-
-
23944516870
-
The host type I interferon response to viral and bacterial infections
-
Epub 2005/07/01, 15987599
-
Perry AK, Chen G, Zheng D, Tang H, et al. The host type I interferon response to viral and bacterial infections. Cell Res 2005;15(6):407–422. Epub 2005/07/01. doi:10.1038/sj.cr.7290309. PubMed PMID:15987599
-
(2005)
Cell Res
, vol.15
, Issue.6
, pp. 407-422
-
-
Perry, A.K.1
Chen, G.2
Zheng, D.3
Tang, H.4
-
31
-
-
79961133270
-
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
-
Epub 2011/07/26, 21782231, PubMed Central PMCID: PMCPMC3179916
-
Hou F, Sun L, Zheng H, Skaug B, et al. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell 2011;146(3):448–461. Epub 2011/07/26. doi:10.1016/j.cell.2011.06.041. PubMed PMID:21782231; PubMed Central PMCID:PMCPMC3179916
-
(2011)
Cell
, vol.146
, Issue.3
, pp. 448-461
-
-
Hou, F.1
Sun, L.2
Zheng, H.3
Skaug, B.4
-
32
-
-
77952503750
-
Peroxisomes are signaling platforms for antiviral innate immunity
-
Epub 2010/05/11, 20451243, PubMed Central PMCID: PMCPMC3670185
-
Dixit E, Boulant S, Zhang Y, Lee AS, et al. Peroxisomes are signaling platforms for antiviral innate immunity. Cell 2010;141(4):668–881. Epub 2010/05/11. doi:10.1016/j.cell.2010.04.018. PubMed PMID:20451243; PubMed Central PMCID:PMCPMC3670185
-
(2010)
Cell
, vol.141
, Issue.4
, pp. 668-881
-
-
Dixit, E.1
Boulant, S.2
Zhang, Y.3
Lee, A.S.4
-
33
-
-
77952885088
-
The role of mitochondria in the mammalian antiviral defense system
-
Epub 2010/03/09, 20206303, PubMed Central PMCID: PMCPMC2874622
-
Scott I. The role of mitochondria in the mammalian antiviral defense system. Mitochondrion 2010;10(4):316–320. Epub 2010/03/09. doi:10.1016/j.mito.2010.02.005. PubMed PMID:20206303; PubMed Central PMCID:PMCPMC2874622
-
(2010)
Mitochondrion
, vol.10
, Issue.4
, pp. 316-320
-
-
Scott, I.1
-
34
-
-
31344461659
-
Innate immune recognition of viral infection
-
Epub 2006/01/21, 16424890
-
Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol 2006;7(2):131–137. Epub 2006/01/21. doi:10.1038/ni1303. PubMed PMID:16424890
-
(2006)
Nat Immunol
, vol.7
, Issue.2
, pp. 131-137
-
-
Kawai, T.1
Akira, S.2
-
35
-
-
30544447047
-
Critical role of TRAF3 in the Toll-like receptor-dependent and independent antiviral response
-
Epub 2005/11/25, 16306936
-
Oganesyan G, Saha SK, Guo B, He JQ, et al. Critical role of TRAF3 in the Toll-like receptor-dependent and independent antiviral response. Nature 2006;439(7073):208–211. Epub 2005/11/25. doi:10.1038/nature04374. PubMed PMID:16306936
-
(2006)
Nature
, vol.439
, Issue.7073
, pp. 208-211
-
-
Oganesyan, G.1
Saha, S.K.2
Guo, B.3
He, J.Q.4
-
36
-
-
33746479050
-
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
-
Epub 2006/07/22, 16858409, PubMed Central PMCID: PMCPMC1523175
-
Saha SK, Pietras EM, He JQ, Kang JR, et al. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J 2006;25(14):3257–3263. Epub 2006/07/22. doi:10.1038/sj.emboj.7601220. PubMed PMID:16858409; PubMed Central PMCID:PMCPMC1523175
-
(2006)
EMBO J
, vol.25
, Issue.14
, pp. 3257-3263
-
-
Saha, S.K.1
Pietras, E.M.2
He, J.Q.3
Kang, J.R.4
-
37
-
-
24944538819
-
VISA is an adapter protein required for virus-triggered IFN-beta signaling
-
Epub 2005/09/13, 16153868
-
Xu LG, Wang YY, Han KJ, Li LY, et al. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Molecular Cell 2005;19(6):727–740. Epub 2005/09/13. doi:10.1016/j.molcel.2005.08.014. PubMed PMID:16153868
-
(2005)
Molecular Cell
, vol.19
, Issue.6
, pp. 727-740
-
-
Xu, L.G.1
Wang, Y.Y.2
Han, K.J.3
Li, L.Y.4
-
38
-
-
9244236078
-
A FADD-dependent innate immune mechanism in mammalian cells
-
Epub 2004/11/19, 15549108
-
Balachandran S, Thomas E, Barber GN. A FADD-dependent innate immune mechanism in mammalian cells. Nature 2004;432(7015):401–405. Epub 2004/11/19. doi:10.1038/nature03124. PubMed PMID:15549108
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 401-405
-
-
Balachandran, S.1
Thomas, E.2
Barber, G.N.3
-
39
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
-
Epub 2005/08/30, 16127453
-
Kawai T, Takahashi K, Sato S, Coban C, et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005;6(10):981–988. Epub 2005/08/30. doi:10.1038/ni1243. PubMed PMID:16127453
-
(2005)
Nat Immunol
, vol.6
, Issue.10
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
-
40
-
-
43049174990
-
TRADD protein is an essential component of the RIG-like helicase antiviral pathway
-
Epub 2008/04/29, 18439848
-
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, et al. TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 2008;28(5):651–661. Epub 2008/04/29. doi:10.1016/j.immuni.2008.03.013. PubMed PMID:18439848
-
(2008)
Immunity
, vol.28
, Issue.5
, pp. 651-661
-
-
Michallet, M.C.1
Meylan, E.2
Ermolaeva, M.A.3
Vazquez, J.4
-
41
-
-
53349178089
-
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Epub 2008/08/30, 18724357, PubMed Central PMCID: PMCPMC2804933
-
Ishikawa H, Barber GN. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008;455(7213):674–678. Epub 2008/08/30. doi:10.1038/nature07317. PubMed PMID:18724357; PubMed Central PMCID:PMCPMC2804933
-
(2008)
Nature
, vol.455
, Issue.7213
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
42
-
-
57749122048
-
Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates
-
Epub 2008/09/27, 18818195, PubMed Central PMCID: PMCPMC2586265
-
Porubsky PR, Meneely KM, Scott EE. Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J Biol Chem 2008;283(48):33698–33707. Epub 2008/09/27. doi:10.1074/jbc.M805999200. PubMed PMID:18818195; PubMed Central PMCID:PMCPMC2586265
-
(2008)
J Biol Chem
, vol.283
, Issue.48
, pp. 33698-33707
-
-
Porubsky, P.R.1
Meneely, K.M.2
Scott, E.E.3
-
43
-
-
33750984771
-
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates
-
Epub 2006/10/14, 17038589
-
Pichlmair A, Schulz O, Tan CP, Naslund TI, et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science (New York) 2006;314(5801):997–1001. Epub 2006/10/14. doi:10.1126/science.1132998. PubMed PMID:17038589
-
(2006)
Science (New York)
, vol.314
, Issue.5801
, pp. 997-1001
-
-
Pichlmair, A.1
Schulz, O.2
Tan, C.P.3
Naslund, T.I.4
-
44
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Epub 2010/03/23, 20303872
-
Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010;140(6):805–820. Epub 2010/03/23. doi:10.1016/j.cell.2010.01.022. PubMed PMID:20303872
-
(2010)
Cell
, vol.140
, Issue.6
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
45
-
-
79959634861
-
Pattern recognition receptors and the innate immune response to viral infection
-
Epub 2011/10/14, 21994762, PubMed Central PMCID: PMCPMC3186011
-
Thompson MR, Kaminski JJ, Kurt-Jones EA, Fitzgerald KA. Pattern recognition receptors and the innate immune response to viral infection. Viruses 2011;3(6):920–940. Epub 2011/10/14. doi:10.3390/v3060920. PubMed PMID:21994762; PubMed Central PMCID:PMCPMC3186011
-
(2011)
Viruses
, vol.3
, Issue.6
, pp. 920-940
-
-
Thompson, M.R.1
Kaminski, J.J.2
Kurt-Jones, E.A.3
Fitzgerald, K.A.4
-
46
-
-
39649092731
-
Non-self-RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses
-
Epub 2008/02/05, 18242112
-
Takahasi K, Yoneyama M, Nishihori T, Hirai R, et al. Non-self-RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol Cell 2008;29(4):428–440. Epub 2008/02/05. doi:10.1016/j.molcel.2007.11.028. PubMed PMID:18242112
-
(2008)
Mol Cell
, vol.29
, Issue.4
, pp. 428-440
-
-
Takahasi, K.1
Yoneyama, M.2
Nishihori, T.3
Hirai, R.4
-
47
-
-
38649089789
-
The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I
-
Epub 2008/02/05, 18243112
-
Cui S, Eisenacher K, Kirchhofer A, Brzozka K, et al. The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I. Mol Cell 2008;29(2):169–179. Epub 2008/02/05. doi:10.1016/j.molcel.2007.10.032. PubMed PMID:18243112
-
(2008)
Mol Cell
, vol.29
, Issue.2
, pp. 169-179
-
-
Cui, S.1
Eisenacher, K.2
Kirchhofer, A.3
Brzozka, K.4
-
48
-
-
80054703126
-
Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA
-
Epub 2011/10/18, 22000019
-
Kowalinski E, Lunardi T, McCarthy AA, Louber J, et al. Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA. Cell 2011;147(2):423–435. Epub 2011/10/18. doi:10.1016/j.cell.2011.09.039. PubMed PMID:22000019
-
(2011)
Cell
, vol.147
, Issue.2
, pp. 423-435
-
-
Kowalinski, E.1
Lunardi, T.2
McCarthy, A.A.3
Louber, J.4
-
49
-
-
80054685883
-
Structural insights into RNA recognition by RIG-I
-
Epub 2011/10/18, 22000018, PubMed Central PMCID: PMCPMC3222294
-
Luo D, Ding SC, Vela A, Kohlway A, et al. Structural insights into RNA recognition by RIG-I. Cell 2011;147(2):409–422. Epub 2011/10/18. doi:10.1016/j.cell.2011.09.023. PubMed PMID:22000018; PubMed Central PMCID:PMCPMC3222294
-
(2011)
Cell
, vol.147
, Issue.2
, pp. 409-422
-
-
Luo, D.1
Ding, S.C.2
Vela, A.3
Kohlway, A.4
-
50
-
-
81555204380
-
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
-
Epub 2011/09/29, 21947008, PubMed Central PMCID: PMCPMC3430514
-
Jiang F, Ramanathan A, Miller MT, Tang GQ, et al. Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature 2011;479(7373):423–427. Epub 2011/09/29. doi:10.1038/nature10537. PubMed PMID:21947008; PubMed Central PMCID:PMCPMC3430514
-
(2011)
Nature
, vol.479
, Issue.7373
, pp. 423-427
-
-
Jiang, F.1
Ramanathan, A.2
Miller, M.T.3
Tang, G.Q.4
-
51
-
-
77955481642
-
The structural basis of 5′ triphosphate double-stranded RNA recognition by RIG-I C-terminal domain
-
Epub 2010/07/20, 20637642, PubMed Central PMCID: PMCPMC2919622
-
Lu C, Xu H, Ranjith-Kumar CT, Brooks MT, et al. The structural basis of 5′ triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure (London) 2010;18(8):1032–1043. Epub 2010/07/20. doi:10.1016/j.str.2010.05.007. PubMed PMID:20637642; PubMed Central PMCID:PMCPMC2919622
-
(2010)
Structure (London)
, vol.18
, Issue.8
, pp. 1032-1043
-
-
Lu, C.1
Xu, H.2
Ranjith-Kumar, C.T.3
Brooks, M.T.4
-
52
-
-
77954386541
-
Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I
-
Epub 2010/06/29, 20581823, PubMed Central PMCID: PMCPMC3744876
-
Wang Y, Ludwig J, Schuberth C, Goldeck M, et al. Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol 2010;17(7):781–787. Epub 2010/06/29. doi:10.1038/nsmb.1863. PubMed PMID:20581823; PubMed Central PMCID:PMCPMC3744876
-
(2010)
Nat Struct Mol Biol
, vol.17
, Issue.7
, pp. 781-787
-
-
Wang, Y.1
Ludwig, J.2
Schuberth, C.3
Goldeck, M.4
-
53
-
-
84908192059
-
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
-
Epub 2014/08/15, 25119032, PubMed Central PMCID: PMCPMC4201573
-
Goubau D, Schlee M, Deddouche S, Pruijssers AJ, et al. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates. Nature 2014;514(7522):372–375. Epub 2014/08/15. doi:10.1038/nature13590. PubMed PMID:25119032; PubMed Central PMCID:PMCPMC4201573
-
(2014)
Nature
, vol.514
, Issue.7522
, pp. 372-375
-
-
Goubau, D.1
Schlee, M.2
Deddouche, S.3
Pruijssers, A.J.4
-
54
-
-
46949097299
-
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
-
Epub 2008/07/02, 18591409, PubMed Central PMCID: PMCPMC2442638
-
Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med. 2008;205(7):1601–1610. Epub 2008/07/02. doi:10.1084/jem.20080091. PubMed PMID:18591409; PubMed Central PMCID:PMCPMC2442638
-
(2008)
J Exp Med.
, vol.205
, Issue.7
, pp. 1601-1610
-
-
Kato, H.1
Takeuchi, O.2
Mikamo-Satoh, E.3
Hirai, R.4
-
55
-
-
84872604349
-
Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5
-
Epub 2013/01/01, 23273991
-
Wu B, Peisley A, Richards C, Yao H, et al. Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell 2013;152(1–2):276–289. Epub 2013/01/01. doi:10.1016/j.cell.2012.11.048. PubMed PMID:23273991
-
(2013)
Cell
, vol.152
, Issue.1-2
, pp. 276-289
-
-
Wu, B.1
Peisley, A.2
Richards, C.3
Yao, H.4
-
56
-
-
70349728538
-
Activation of MDA5 requires higher-order RNA structures generated during virus infection
-
Epub 2009/08/07., 19656871, PubMed Central PMCID: PMCPMC2753146
-
Pichlmair A, Schulz O, Tan CP, Rehwinkel J, et al. Activation of MDA5 requires higher-order RNA structures generated during virus infection. J Virol 2009;83(20):10761–10769. Epub 2009/08/07. doi:10.1128/jvi.00770-09. PubMed PMID:19656871; PubMed Central PMCID:PMCPMC2753146
-
(2009)
J Virol
, vol.83
, Issue.20
, pp. 10761-10769
-
-
Pichlmair, A.1
Schulz, O.2
Tan, C.P.3
Rehwinkel, J.4
-
57
-
-
67651232539
-
Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5
-
Epub 2009/06/18, 19531363
-
Li X, Lu C, Stewart M, Xu H, et al. Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5. Arch Biochem Biophys 2009;488(1):23–33. Epub 2009/06/18. doi:10.1016/j.abb.2009.06.008. PubMed PMID:19531363
-
(2009)
Arch Biochem Biophys
, vol.488
, Issue.1
, pp. 23-33
-
-
Li, X.1
Lu, C.2
Stewart, M.3
Xu, H.4
-
58
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
Epub 2006/04/21, 16625202
-
Kato H, Takeuchi O, Sato S, Yoneyama M, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006;441(7089):101–105. Epub 2006/04/21. doi:10.1038/nature04734. PubMed PMID:16625202
-
(2006)
Nature
, vol.441
, Issue.7089
, pp. 101-105
-
-
Kato, H.1
Takeuchi, O.2
Sato, S.3
Yoneyama, M.4
-
59
-
-
67650510680
-
Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors
-
Epub 2009/04/22, 19380577, PubMed Central PMCID: PMCPMC2719387
-
Takahasi K, Kumeta H, Tsuduki N, Narita R, et al. Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains:identification of the RNA recognition loop in RIG-I-like receptors. J Biol Chem 2009;284(26):17465–17474. Epub 2009/04/22. doi:10.1074/jbc.M109.007179. PubMed PMID:19380577; PubMed Central PMCID:PMCPMC2719387
-
(2009)
J Biol Chem
, vol.284
, Issue.26
, pp. 17465-17474
-
-
Takahasi, K.1
Kumeta, H.2
Tsuduki, N.3
Narita, R.4
-
60
-
-
0017840406
-
Encephalomyocarditis virus RNA. III. Presence of a genome-associated protein
-
Epub 1978/01/01. PubMed PMID: 202751; PubMed Central PMCID: PMCPMC353939
-
Hruby DE, Roberts WK. Encephalomyocarditis virus RNA. III. Presence of a genome-associated protein. J Virol 1978;25(1):413–415. Epub 1978/01/01. PubMed PMID:202751; PubMed Central PMCID:PMCPMC353939
-
(1978)
J Virol
, vol.25
, Issue.1
, pp. 413-415
-
-
Hruby, D.E.1
Roberts, W.K.2
-
61
-
-
0002988050
-
A protein covalently linked to poliovirus genome RNA
-
Epub 1977/01/01. PubMed PMID: 189316; PubMed Central PMCID: PMCPMC393196
-
Lee YF, Nomoto A, Detjen BM, Wimmer E. A protein covalently linked to poliovirus genome RNA. Proc Nat Acad Sci USA 1977;74(1):59–63. Epub 1977/01/01. PubMed PMID:189316; PubMed Central PMCID:PMCPMC393196
-
(1977)
Proc Nat Acad Sci USA
, vol.74
, Issue.1
, pp. 59-63
-
-
Lee, Y.F.1
Nomoto, A.2
Detjen, B.M.3
Wimmer, E.4
-
62
-
-
33745768604
-
Protein-primed and de novo initiation of RNA synthesis by norovirus 3Dpol
-
Epub 2006/07/01, 16809311, PubMed Central PMCID: PMCPMC1489054
-
Rohayem J, Robel I, Jager K, Scheffler U, et al. Protein-primed and de novo initiation of RNA synthesis by norovirus 3Dpol. J. Virol 2006;80(14):7060–7069. Epub 2006/07/01. doi:10.1128/jvi.02195-05. PubMed PMID:16809311; PubMed Central PMCID:PMCPMC1489054
-
(2006)
J. Virol
, vol.80
, Issue.14
, pp. 7060-7069
-
-
Rohayem, J.1
Robel, I.2
Jager, K.3
Scheffler, U.4
-
63
-
-
84926421887
-
MDA5 plays a critical role in interferon response during hepatitis C virus infection
-
Epub 2014/12/03, 25463548
-
Cao X, Ding Q, Lu J, Tao W, et al. MDA5 plays a critical role in interferon response during hepatitis C virus infection. J Hepatol 2015;62(4):771–778. Epub 2014/12/03. doi:10.1016/j.jhep.2014.11.007. PubMed PMID:25463548
-
(2015)
J Hepatol
, vol.62
, Issue.4
, pp. 771-778
-
-
Cao, X.1
Ding, Q.2
Lu, J.3
Tao, W.4
-
64
-
-
84886878320
-
The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
-
Epub 2013/08/24, 23966395, PubMed Central PMCID: PMCPMC3807316
-
Errett JS, Suthar MS, McMillan A, Diamond MS, et al. The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection. J. Virol 2013;87(21):11416–11425. Epub 2013/08/24. doi:10.1128/jvi.01488-13. PubMed PMID:23966395; PubMed Central PMCID:PMCPMC3807316
-
(2013)
J. Virol
, vol.87
, Issue.21
, pp. 11416-11425
-
-
Errett, J.S.1
Suthar, M.S.2
McMillan, A.3
Diamond, M.S.4
-
65
-
-
37349052379
-
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity
-
Epub 2007/10/19, 17942531, PubMed Central PMCID: PMCPMC2224404
-
Loo YM, Fornek J, Crochet N, Bajwa G, et al. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol 2008;82(1):335–345. Epub 2007/10/19. doi:10.1128/jvi.01080-07. PubMed PMID:17942531; PubMed Central PMCID:PMCPMC2224404
-
(2008)
J Virol
, vol.82
, Issue.1
, pp. 335-345
-
-
Loo, Y.M.1
Fornek, J.2
Crochet, N.3
Bajwa, G.4
-
66
-
-
84870476784
-
MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells
-
Epub 2012/11/13, 23142662
-
Feng Q, Hato SV, Langereis MA, Zoll J, et al. MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells. Cell Rep 2012;2(5):1187–1196. Epub 2012/11/13. doi:10.1016/j.celrep.2012.10.005. PubMed PMID:23142662
-
(2012)
Cell Rep
, vol.2
, Issue.5
, pp. 1187-1196
-
-
Feng, Q.1
Hato, S.V.2
Langereis, M.A.3
Zoll, J.4
-
67
-
-
37849045856
-
Establishment and maintenance of the innate antiviral response to West Nile virus involves both RIG-I and MDA5 signaling through IPS-1
-
Epub 2007/11/06, 17977974, PubMed Central PMCID: PMCPMC2224571
-
Fredericksen BL, Keller BC, Fornek J, Katze MG, et al. Establishment and maintenance of the innate antiviral response to West Nile virus involves both RIG-I and MDA5 signaling through IPS-1. J Virol 2008;82(2):609–616. Epub 2007/11/06. doi:10.1128/jvi.01305-07. PubMed PMID:17977974; PubMed Central PMCID:PMCPMC2224571
-
(2008)
J Virol
, vol.82
, Issue.2
, pp. 609-616
-
-
Fredericksen, B.L.1
Keller, B.C.2
Fornek, J.3
Katze, M.G.4
-
68
-
-
0024589265
-
Distribution of 5′-triphosphate termini on the mRNA of Escherichia coli
-
Epub 1989/01/01. PubMed PMID: 2464575; PubMed Central PMCID: PMCPMC209566
-
Bieger CD, Nierlich DP. Distribution of 5′-triphosphate termini on the mRNA of Escherichia coli. J Bacteriol 1989;171(1):141–147. Epub 1989/01/01. PubMed PMID:2464575; PubMed Central PMCID:PMCPMC209566
-
(1989)
J Bacteriol
, vol.171
, Issue.1
, pp. 141-147
-
-
Bieger, C.D.1
Nierlich, D.P.2
-
69
-
-
84868569570
-
RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids
-
Epub 2012/10/16, 23064150, PubMed Central PMCID: PMCPMC3492734
-
Abdullah Z, Schlee M, Roth S, Mraheil MA, et al. RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J 2012;31(21):4153–4164. Epub 2012/10/16. doi:10.1038/emboj.2012.274. PubMed PMID:23064150; PubMed Central PMCID:PMCPMC3492734
-
(2012)
EMBO J
, vol.31
, Issue.21
, pp. 4153-4164
-
-
Abdullah, Z.1
Schlee, M.2
Roth, S.3
Mraheil, M.A.4
-
70
-
-
84877004303
-
RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells
-
Epub 2013/05/09, 23653683, PubMed Central PMCID: PMCPMC3639904
-
Hagmann CA, Herzner AM, Abdullah Z, Zillinger T, et al. RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells. PloS One 2013;8(4):e62872. Epub 2013/05/09. doi:10.1371/journal.pone.0062872. PubMed PMID:23653683; PubMed Central PMCID:PMCPMC3639904
-
(2013)
PloS One
, vol.8
, Issue.4
, pp. e62872
-
-
Hagmann, C.A.1
Herzner, A.M.2
Abdullah, Z.3
Zillinger, T.4
-
71
-
-
73549090166
-
Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila
-
Epub 2009/11/26, 19936053, PubMed Central PMCID: PMCPMC2773930
-
Monroe KM, McWhirter SM, Vance RE. Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila. PLoS Pathogens 2009;5(11):e1000665. Epub 2009/11/26. doi:10.1371/journal.ppat.1000665. PubMed PMID:19936053; PubMed Central PMCID:PMCPMC2773930
-
(2009)
PLoS Pathogens
, vol.5
, Issue.11
, pp. e1000665
-
-
Monroe, K.M.1
McWhirter, S.M.2
Vance, R.E.3
-
72
-
-
84891874162
-
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
-
Epub 2013/12/24, 24362933, PubMed Central PMCID: PMCPMC4096771
-
Liehl P, Zuzarte-Luis V, Chan J, Zillinger T, et al. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 2014;20(1):47–53. Epub 2013/12/24. doi:10.1038/nm.3424. PubMed PMID:24362933; PubMed Central PMCID:PMCPMC4096771
-
(2014)
Nat Med
, vol.20
, Issue.1
, pp. 47-53
-
-
Liehl, P.1
Zuzarte-Luis, V.2
Chan, J.3
Zillinger, T.4
-
73
-
-
66149110970
-
Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori
-
Epub 2009/03/11, 19272387
-
Rad R, Ballhorn W, Voland P, Eisenacher K, et al. Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 2009;136(7):2247–2257. Epub 2009/03/11. doi:10.1053/j.gastro.2009.02.066. PubMed PMID:19272387
-
(2009)
Gastroenterology
, vol.136
, Issue.7
, pp. 2247-2257
-
-
Rad, R.1
Ballhorn, W.2
Voland, P.3
Eisenacher, K.4
-
74
-
-
33846014297
-
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
-
Epub 2006/09/30, 17008311
-
Kanneganti TD, Body-Malapel M, Amer A, Park JH, et al. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 2006;281(48):36560–36568. Epub 2006/09/30. doi:10.1074/jbc.M607594200. PubMed PMID:17008311
-
(2006)
J Biol Chem
, vol.281
, Issue.48
, pp. 36560-36568
-
-
Kanneganti, T.D.1
Body-Malapel, M.2
Amer, A.3
Park, J.H.4
-
75
-
-
78249269470
-
Activation of the NLRP3 inflammasome by intracellular poly I:C
-
Epub 2010/10/26, 20971108, PubMed Central PMCID: PMCPMC3005299
-
Rajan JV, Warren SE, Miao EA, Aderem A. Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett 2010;584(22):4627–4632. Epub 2010/10/26. doi:10.1016/j.febslet.2010.10.036. PubMed PMID:20971108; PubMed Central PMCID:PMCPMC3005299
-
(2010)
FEBS Lett
, vol.584
, Issue.22
, pp. 4627-4632
-
-
Rajan, J.V.1
Warren, S.E.2
Miao, E.A.3
Aderem, A.4
-
76
-
-
84880745984
-
The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome
-
Epub 2013/07/23, 23871209, PubMed Central PMCID: PMCPMC3756931
-
Mitoma H, Hanabuchi S, Kim T, Bao M, et al. The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. Immunity 2013;39(1):123–135. Epub 2013/07/23. doi:10.1016/j.immuni.2013.07.001. PubMed PMID:23871209; PubMed Central PMCID:PMCPMC3756931
-
(2013)
Immunity
, vol.39
, Issue.1
, pp. 123-135
-
-
Mitoma, H.1
Hanabuchi, S.2
Kim, T.3
Bao, M.4
-
77
-
-
34247341367
-
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
-
Epub 2007/03/30, 17392790
-
Gack MU, Shin YC, Joo CH, Urano T, et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 2007;446(7138):916–920. Epub 2007/03/30. doi:10.1038/nature05732. PubMed PMID:17392790
-
(2007)
Nature
, vol.446
, Issue.7138
, pp. 916-920
-
-
Gack, M.U.1
Shin, Y.C.2
Joo, C.H.3
Urano, T.4
-
78
-
-
84898776236
-
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity
-
Epub 2014/04/08, 24706898, PubMed Central PMCID: PMCPMC3992669
-
Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, et al. Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity. Proc Nat Acad Sci USA 2014;111(15):5646–5651. Epub 2014/04/08. doi:10.1073/pnas.1401674111. PubMed PMID:24706898; PubMed Central PMCID:PMCPMC3992669
-
(2014)
Proc Nat Acad Sci USA
, vol.111
, Issue.15
, pp. 5646-5651
-
-
Kuniyoshi, K.1
Takeuchi, O.2
Pandey, S.3
Satoh, T.4
-
79
-
-
34250632829
-
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
-
Epub 2007/04/27, 17460044, PubMed Central PMCID: PMCPMC1863485
-
Arimoto K, Takahashi H, Hishiki T, Konishi H, et al. Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Nat Acad Sci USA 2007;104(18):7500–7505. Epub 2007/04/27. doi:10.1073/pnas.0611551104. PubMed PMID:17460044; PubMed Central PMCID:PMCPMC1863485
-
(2007)
Proc Nat Acad Sci USA
, vol.104
, Issue.18
, pp. 7500-7505
-
-
Arimoto, K.1
Takahashi, H.2
Hishiki, T.3
Konishi, H.4
-
80
-
-
51049106824
-
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
-
Epub 2008/07/19, 18636086, PubMed Central PMCID: PMCPMC2529351
-
Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, et al. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep 2008;9(9):930–936. Epub 2008/07/19. doi:10.1038/embor.2008.136. PubMed PMID:18636086; PubMed Central PMCID:PMCPMC2529351
-
(2008)
EMBO Rep
, vol.9
, Issue.9
, pp. 930-936
-
-
Friedman, C.S.1
O'Donnell, M.A.2
Legarda-Addison, D.3
Ng, A.4
-
81
-
-
84875789033
-
USP4 positively regulates RIG-I-mediated antiviral response through deubiquitination and stabilization of RIG-I
-
Epub 2013/02/08, 23388719, PubMed Central PMCID: PMCPMC3624380
-
Wang L, Zhao W, Zhang M, Wang P, et al. USP4 positively regulates RIG-I-mediated antiviral response through deubiquitination and stabilization of RIG-I. J Virol 2013;87(8):4507–4515. Epub 2013/02/08. doi:10.1128/jvi.00031-13. PubMed PMID:23388719; PubMed Central PMCID:PMCPMC3624380
-
(2013)
J Virol
, vol.87
, Issue.8
, pp. 4507-4515
-
-
Wang, L.1
Zhao, W.2
Zhang, M.3
Wang, P.4
-
82
-
-
84875542059
-
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling
-
Epub 2013/03/19, 23499489, PubMed Central PMCID: PMCPMC3616631
-
Wies E, Wang MK, Maharaj NP, Chen K, et al. Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling. Immunity 2013;38(3):437–449. Epub 2013/03/19. doi:10.1016/j.immuni.2012.11.018. PubMed PMID:23499489; PubMed Central PMCID:PMCPMC3616631
-
(2013)
Immunity
, vol.38
, Issue.3
, pp. 437-449
-
-
Wies, E.1
Wang, M.K.2
Maharaj, N.P.3
Chen, K.4
-
83
-
-
84919389203
-
Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients
-
Epub 2014/10/08, 25288302
-
Varzari A, Bruch K, Deyneko IV, Chan A, et al. Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients. J Neuroimmunol 2014;277(1–2):140–144. Epub 2014/10/08. doi:10.1016/j.jneuroim.2014.09.015. PubMed PMID:25288302
-
(2014)
J Neuroimmunol
, vol.277
, Issue.1-2
, pp. 140-144
-
-
Varzari, A.1
Bruch, K.2
Deyneko, I.V.3
Chan, A.4
-
84
-
-
84907024547
-
Association of innate immune IFIH1 gene polymorphisms with dilated cardiomyopathy in a Chinese population
-
Epub 2014/06/25, 24960033
-
Dou Q, Peng Y, Zhou B, Lin J, et al. Association of innate immune IFIH1 gene polymorphisms with dilated cardiomyopathy in a Chinese population. Immunol Investigat 2014;43(7):627–637. Epub 2014/06/25. doi:10.3109/08820139.2014.909455. PubMed PMID:24960033
-
(2014)
Immunol Investigat
, vol.43
, Issue.7
, pp. 627-637
-
-
Dou, Q.1
Peng, Y.2
Zhou, B.3
Lin, J.4
-
85
-
-
65249131713
-
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
-
Epub 2009/03/07, 19264985, PubMed Central PMCID: PMCPMC2707798
-
Nejentsev S, Walker N, Riches D, Egholm M, et al. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (New York) 2009;324(5925):387–389. Epub 2009/03/07. doi:10.1126/science.1167728. PubMed PMID:19264985; PubMed Central PMCID:PMCPMC2707798
-
(2009)
Science (New York)
, vol.324
, Issue.5925
, pp. 387-389
-
-
Nejentsev, S.1
Walker, N.2
Riches, D.3
Egholm, M.4
-
86
-
-
77956646451
-
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
-
Epub 2010/08/10, 20694011
-
Ferreira RC, Pan-Hammarstrom Q, Graham RR, Gateva V, et al. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nat Genet 2010;42(9):777–780. Epub 2010/08/10. doi:10.1038/ng.644. PubMed PMID:20694011
-
(2010)
Nat Genet
, vol.42
, Issue.9
, pp. 777-780
-
-
Ferreira, R.C.1
Pan-Hammarstrom, Q.2
Graham, R.R.3
Gateva, V.4
-
87
-
-
84903188015
-
A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes
-
Epub 2014/02/25, 24561305, PubMed Central PMCID: PMCPMC4066333
-
Ferreira RC, Guo H, Coulson RM, Smyth DJ, et al. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes 2014;63(7):2538–2550. Epub 2014/02/25. doi:10.2337/db13-1777. PubMed PMID:24561305; PubMed Central PMCID:PMCPMC4066333
-
(2014)
Diabetes
, vol.63
, Issue.7
, pp. 2538-2550
-
-
Ferreira, R.C.1
Guo, H.2
Coulson, R.M.3
Smyth, D.J.4
-
88
-
-
84891802663
-
Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus
-
Epub 2013/10/15, 24117221
-
Zouk H, Marchand L, Li Q, Polychronakos C. Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus. Autoimmunity 2014;47(1):40–45. Epub 2013/10/15. doi:10.3109/08916934.2013.832758. PubMed PMID:24117221
-
(2014)
Autoimmunity
, vol.47
, Issue.1
, pp. 40-45
-
-
Zouk, H.1
Marchand, L.2
Li, Q.3
Polychronakos, C.4
-
89
-
-
77950534717
-
The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody
-
Epub 2009/12/18, 20015976
-
Nakashima R, Imura Y, Kobayashi S, Yukawa N, et al. The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. Rheumatology (Oxford) 2010;49(3):433–440. Epub 2009/12/18. doi:10.1093/rheumatology/kep375. PubMed PMID:20015976
-
(2010)
Rheumatology (Oxford)
, vol.49
, Issue.3
, pp. 433-440
-
-
Nakashima, R.1
Imura, Y.2
Kobayashi, S.3
Yukawa, N.4
-
90
-
-
67650084778
-
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: association with rapidly progressive interstitial lung disease
-
Epub 2009/07/01, 19565506
-
Sato S, Hoshino K, Satoh T, Fujita T, et al. RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis:association with rapidly progressive interstitial lung disease. Arthritis Rheum 2009;60(7):2193–2200. Epub 2009/07/01. doi:10.1002/art.24621. PubMed PMID:19565506
-
(2009)
Arthritis Rheum
, vol.60
, Issue.7
, pp. 2193-2200
-
-
Sato, S.1
Hoshino, K.2
Satoh, T.3
Fujita, T.4
-
91
-
-
84894028950
-
Autoimmune disorders associated with gain of function of the intracellular sensor MDA5
-
Epub 2014/02/18, 24530055
-
Funabiki M, Kato H, Miyachi Y, Toki H, et al. Autoimmune disorders associated with gain of function of the intracellular sensor MDA5. Immunity 2014;40(2):199–212. Epub 2014/02/18. doi:10.1016/j.immuni.2013.12.014. PubMed PMID:24530055
-
(2014)
Immunity
, vol.40
, Issue.2
, pp. 199-212
-
-
Funabiki, M.1
Kato, H.2
Miyachi, Y.3
Toki, H.4
-
92
-
-
84904004005
-
Aicardi–Goutieres syndrome is caused by IFIH1 mutations
-
Epub 2014/07/06, 24995871, PubMed Central PMCID: PMCPMC4085581
-
Oda H, Nakagawa K, Abe J, Awaya T, et al. Aicardi–Goutieres syndrome is caused by IFIH1 mutations. Am J Hum Genet 2014;95(1):121–125. Epub 2014/07/06. doi:10.1016/j.ajhg.2014.06.007. PubMed PMID:24995871; PubMed Central PMCID:PMCPMC4085581
-
(2014)
Am J Hum Genet
, vol.95
, Issue.1
, pp. 121-125
-
-
Oda, H.1
Nakagawa, K.2
Abe, J.3
Awaya, T.4
-
93
-
-
84899495767
-
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling
-
Epub 2014/04/02, 24686847, PubMed Central PMCID: PMCPMC4004585
-
Rice GI, del Toro Duany Y, Jenkinson EM, Forte GM, et al. Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling. Nat Genet 2014;46(5):503–509. Epub 2014/04/02. doi:10.1038/ng.2933. PubMed PMID:24686847; PubMed Central PMCID:PMCPMC4004585
-
(2014)
Nat Genet
, vol.46
, Issue.5
, pp. 503-509
-
-
Rice, G.I.1
del Toro Duany, Y.2
Jenkinson, E.M.3
Forte, G.M.4
-
94
-
-
84929920092
-
Brief report: IFIH1 mutation causes systemic lupus erythematosus with selective iga deficiency
-
Epub 2015/03/18, 25777993
-
Van Eyck L, De Somer L, Pombal D, Bornschein S, et al. Brief report:IFIH1 mutation causes systemic lupus erythematosus with selective iga deficiency. Arthritis Rheum (Hoboken, NJ). 2015;67(6):1592–1597. Epub 2015/03/18. doi:10.1002/art.39110. PubMed PMID:25777993
-
(2015)
Arthritis Rheum (Hoboken, NJ).
, vol.67
, Issue.6
, pp. 1592-1597
-
-
Van Eyck, L.1
De Somer, L.2
Pombal, D.3
Bornschein, S.4
-
95
-
-
84924164221
-
A specific IFIH1 gain-of-function mutation causes Singleton–Merten syndrome
-
Epub 2015/01/27, 25620204, PubMed Central PMCID: PMCPMC4320263
-
Rutsch F, MacDougall M, Lu C, Buers I, et al. A specific IFIH1 gain-of-function mutation causes Singleton–Merten syndrome. Am J Hum Genet 2015;96(2):275–282. Epub 2015/01/27. doi:10.1016/j.ajhg.2014.12.014. PubMed PMID:25620204; PubMed Central PMCID:PMCPMC4320263
-
(2015)
Am J Hum Genet
, vol.96
, Issue.2
, pp. 275-282
-
-
Rutsch, F.1
MacDougall, M.2
Lu, C.3
Buers, I.4
-
96
-
-
84925137606
-
Mutations in DDX58, which encodes RIG-I, cause atypical Singleton–Merten syndrome
-
Epub 2015/01/27, 25620203, PubMed Central PMCID: PMCPMC4320253
-
Jang MA, Kim EK, Now H, Nguyen NT, et al. Mutations in DDX58, which encodes RIG-I, cause atypical Singleton–Merten syndrome. Am J Hum Genet 2015;96(2):266–274. Epub 2015/01/27. doi:10.1016/j.ajhg.2014.11.019. PubMed PMID:25620203; PubMed Central PMCID:PMCPMC4320253
-
(2015)
Am J Hum Genet
, vol.96
, Issue.2
, pp. 266-274
-
-
Jang, M.A.1
Kim, E.K.2
Now, H.3
Nguyen, N.T.4
-
97
-
-
84941100160
-
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as non-self
-
Epub 2015/08/15, 26275108
-
Liddicoat BJ, Piskol R, Chalk AM, Ramaswami G, et al. RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as non-self. Science (New York) 2015;349(6252):1115–1120. Epub 2015/08/15. doi:10.1126/science.aac7049. PubMed PMID:26275108
-
(2015)
Science (New York)
, vol.349
, Issue.6252
, pp. 1115-1120
-
-
Liddicoat, B.J.1
Piskol, R.2
Chalk, A.M.3
Ramaswami, G.4
-
98
-
-
84947434056
-
Isoforms of RNA-editing enzyme ADAR1 independently control nucleic acid sensor MDA5-driven autoimmunity and multi-organ development
-
Epub 2015/11/21, 26588779, PubMed Central PMCID: PMCPMC4654992
-
Pestal K, Funk CC, Snyder JM, Price ND, et al. Isoforms of RNA-editing enzyme ADAR1 independently control nucleic acid sensor MDA5-driven autoimmunity and multi-organ development. Immunity 2015;43(5):933–944. Epub 2015/11/21. doi:10.1016/j.immuni.2015.11.001. PubMed PMID:26588779; PubMed Central PMCID:PMCPMC4654992
-
(2015)
Immunity
, vol.43
, Issue.5
, pp. 933-944
-
-
Pestal, K.1
Funk, C.C.2
Snyder, J.M.3
Price, N.D.4
-
99
-
-
84901038448
-
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production
-
Epub 2014/04/30, 24777530, PubMed Central PMCID: PMCPMC4309842
-
Roth S, Rottach A, Lotz-Havla AS, Laux V, et al. Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production. Nat Immunol 2014;15(6):538–545. Epub 2014/04/30. doi:10.1038/ni.2888. PubMed PMID:24777530; PubMed Central PMCID:PMCPMC4309842
-
(2014)
Nat Immunol
, vol.15
, Issue.6
, pp. 538-545
-
-
Roth, S.1
Rottach, A.2
Lotz-Havla, A.S.3
Laux, V.4
-
100
-
-
74049126045
-
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
-
Epub 2009/11/17, 19915568
-
Poeck H, Bscheider M, Gross O, Finger K, et al. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol 2010;11(1):63–69. Epub 2009/11/17. doi:10.1038/ni.1824. PubMed PMID:19915568
-
(2010)
Nat Immunol
, vol.11
, Issue.1
, pp. 63-69
-
-
Poeck, H.1
Bscheider, M.2
Gross, O.3
Finger, K.4
-
101
-
-
29244471275
-
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
-
Epub 2005/11/16, 16286919
-
Ishii KJ, Coban C, Kato H, Takahashi K, et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2006;7(1):40–48. Epub 2005/11/16. doi:10.1038/ni1282. PubMed PMID:16286919
-
(2006)
Nat Immunol
, vol.7
, Issue.1
, pp. 40-48
-
-
Ishii, K.J.1
Coban, C.2
Kato, H.3
Takahashi, K.4
-
102
-
-
84873724533
-
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
-
Epub 2012/12/22, 23258412, PubMed Central PMCID: PMCPMC3855410
-
Wu J, Sun L, Chen X, Du F, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science (New York) 2013;339(6121):826–830. Epub 2012/12/22. doi:10.1126/science.1229963. PubMed PMID:23258412; PubMed Central PMCID:PMCPMC3855410
-
(2013)
Science (New York)
, vol.339
, Issue.6121
, pp. 826-830
-
-
Wu, J.1
Sun, L.2
Chen, X.3
Du, F.4
-
103
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
-
Epub 2012/12/22, 23258413, PubMed Central PMCID: PMCPMC3863629
-
Sun L, Wu J, Du F, Chen X, et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (New York) 2013;339(6121):786–791. Epub 2012/12/22. doi:10.1126/science.1232458. PubMed PMID:23258413; PubMed Central PMCID:PMCPMC3863629
-
(2013)
Science (New York)
, vol.339
, Issue.6121
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
-
104
-
-
84884675857
-
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects
-
Epub 2013/08/31, 23989956, PubMed Central PMCID: PMCPMC3863637
-
Li XD, Wu J, Gao D, Wang H, et al. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science (New York) 2013;341(6152):1390–1394. Epub 2013/08/31. doi:10.1126/science.1244040. PubMed PMID:23989956; PubMed Central PMCID:PMCPMC3863637
-
(2013)
Science (New York)
, vol.341
, Issue.6152
, pp. 1390-1394
-
-
Li, X.D.1
Wu, J.2
Gao, D.3
Wang, H.4
-
105
-
-
84991214605
-
Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system
-
Epub 2016/10/19, 27751656
-
Luecke S, Paludan SR. Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system. Cytokine 2016. Epub 2016/10/19. doi:10.1016/j.cyto.2016.10.003. PubMed PMID:27751656.
-
(2016)
Cytokine
-
-
Luecke, S.1
Paludan, S.R.2
-
106
-
-
84878309796
-
Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
-
Epub 2013/05/08, 23647843, PubMed Central PMCID: PMCPMC4382009
-
Gao P, Ascano M, Wu Y, Barchet W, et al. Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 2013;153(5):1094–1107. Epub 2013/05/08. doi:10.1016/j.cell.2013.04.046. PubMed PMID:23647843; PubMed Central PMCID:PMCPMC4382009
-
(2013)
Cell
, vol.153
, Issue.5
, pp. 1094-1107
-
-
Gao, P.1
Ascano, M.2
Wu, Y.3
Barchet, W.4
-
107
-
-
84879408976
-
Structural mechanism of cytosolic DNA sensing by cGAS
-
Epub 2013/06/01, 23722159, PubMed Central PMCID: PMCPMC3768140
-
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 2013;498(7454):332–337. Epub 2013/06/01. doi:10.1038/nature12305. PubMed PMID:23722159; PubMed Central PMCID:PMCPMC3768140
-
(2013)
Nature
, vol.498
, Issue.7454
, pp. 332-337
-
-
Civril, F.1
Deimling, T.2
de Oliveira Mann, C.C.3
Ablasser, A.4
-
108
-
-
84890235012
-
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization
-
Epub 2013/12/18, 24332030, PubMed Central PMCID: PMCPMC3886715
-
Li X, Shu C, Yi G, Chaton CT, et al. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity 2013;39(6):1019–1031. Epub 2013/12/18. doi:10.1016/j.immuni.2013.10.019. PubMed PMID:24332030; PubMed Central PMCID:PMCPMC3886715
-
(2013)
Immunity
, vol.39
, Issue.6
, pp. 1019-1031
-
-
Li, X.1
Shu, C.2
Yi, G.3
Chaton, C.T.4
-
109
-
-
84893863593
-
The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop
-
Epub 2014/01/28, 24462292, PubMed Central PMCID: PMCPMC3969844
-
Zhang X, Wu J, Du F, Xu H, et al. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep 2014;6(3):421–430. Epub 2014/01/28. doi:10.1016/j.celrep.2014.01.003. PubMed PMID:24462292; PubMed Central PMCID:PMCPMC3969844
-
(2014)
Cell Rep
, vol.6
, Issue.3
, pp. 421-430
-
-
Zhang, X.1
Wu, J.2
Du, F.3
Xu, H.4
-
110
-
-
84878592773
-
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity
-
Epub 2013/05/28, 23707061, PubMed Central PMCID: PMCPMC3800681
-
Kranzusch PJ, Lee AS, Berger JM, Doudna JA. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep 2013;3(5):1362–1368. Epub 2013/05/28. doi:10.1016/j.celrep.2013.05.008. PubMed PMID:23707061; PubMed Central PMCID:PMCPMC3800681
-
(2013)
Cell Rep
, vol.3
, Issue.5
, pp. 1362-1368
-
-
Kranzusch, P.J.1
Lee, A.S.2
Berger, J.M.3
Doudna, J.A.4
-
111
-
-
84941954118
-
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
-
Epub 2015/09/08, 26343537, PubMed Central PMCID: PMCPMC4669199
-
Herzner AM, Hagmann CA, Goldeck M, Wolter S, et al. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunol 2015;16(10):1025–1033. Epub 2015/09/08. doi:10.1038/ni.3267. PubMed PMID:26343537; PubMed Central PMCID:PMCPMC4669199
-
(2015)
Nat Immunol
, vol.16
, Issue.10
, pp. 1025-1033
-
-
Herzner, A.M.1
Hagmann, C.A.2
Goldeck, M.3
Wolter, S.4
-
112
-
-
84918823623
-
Cytosolic RNA:DNA hybrids activate the cGAS–STING axis
-
Epub 2014/11/27, 25425575, PubMed Central PMCID: PMCPMC4282641
-
Mankan AK, Schmidt T, Chauhan D, Goldeck M, et al. Cytosolic RNA:DNA hybrids activate the cGAS–STING axis. EMBO J 2014;33(24):2937–2946. Epub 2014/11/27. doi:10.15252/embj.201488726. PubMed PMID:25425575; PubMed Central PMCID:PMCPMC4282641
-
(2014)
EMBO J
, vol.33
, Issue.24
, pp. 2937-2946
-
-
Mankan, A.K.1
Schmidt, T.2
Chauhan, D.3
Goldeck, M.4
-
113
-
-
84895904323
-
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
-
Epub 2013/11/29, 24284630, PubMed Central PMCID: PMCPMC4077721
-
Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 2014;505(7485):691–695. Epub 2013/11/29. doi:10.1038/nature12862. PubMed PMID:24284630; PubMed Central PMCID:PMCPMC4077721
-
(2014)
Nature
, vol.505
, Issue.7485
, pp. 691-695
-
-
Schoggins, J.W.1
MacDuff, D.A.2
Imanaka, N.3
Gainey, M.D.4
-
114
-
-
84975229736
-
Diminished Innate antiviral response to adenovirus vectors in cgas/sting-deficient mice minimally impacts adaptive immunity
-
Epub 2016/04/15, 27076643, PubMed Central PMCID: PMCPMC4907218
-
Anghelina D, Lam E, Falck-Pedersen E. Diminished Innate antiviral response to adenovirus vectors in cgas/sting-deficient mice minimally impacts adaptive immunity. J Virol 2016;90(13):5915–5927. Epub 2016/04/15. doi:10.1128/jvi.00500-16. PubMed PMID:27076643; PubMed Central PMCID:PMCPMC4907218
-
(2016)
J Virol
, vol.90
, Issue.13
, pp. 5915-5927
-
-
Anghelina, D.1
Lam, E.2
Falck-Pedersen, E.3
-
115
-
-
84984848329
-
The Mechanism for Type I interferon induction by mycobacterium tuberculosis is bacterial strain-dependent
-
Epub 2016/08/09, 27500737, PubMed Central PMCID: PMCPMC4976988
-
Wiens KE, Ernst JD. The Mechanism for Type I interferon induction by mycobacterium tuberculosis is bacterial strain-dependent. PLoS Pathogens 2016;12(8):e1005809. Epub 2016/08/09. doi:10.1371/journal.ppat.1005809. PubMed PMID:27500737; PubMed Central PMCID:PMCPMC4976988
-
(2016)
PLoS Pathogens
, vol.12
, Issue.8
, pp. e1005809
-
-
Wiens, K.E.1
Ernst, J.D.2
-
116
-
-
84974728178
-
Type I interferon induction by Neisseria gonorrhoeae: dual requirement of cyclic GMP-AMP synthase and Toll-like receptor 4
-
Epub 2016/06/07, 27264171
-
Andrade WA, Agarwal S, Mo S, Shaffer SA, et al. Type I interferon induction by Neisseria gonorrhoeae:dual requirement of cyclic GMP-AMP synthase and Toll-like receptor 4. Cell Rep 2016;15(11):2438–2448. Epub 2016/06/07. doi:10.1016/j.celrep.2016.05.030. PubMed PMID:27264171
-
(2016)
Cell Rep
, vol.15
, Issue.11
, pp. 2438-2448
-
-
Andrade, W.A.1
Agarwal, S.2
Mo, S.3
Shaffer, S.A.4
-
117
-
-
84960335466
-
Chitosan: an adjuvant with an unanticipated STING
-
Epub 2016/03/18, 26982361
-
Riteau N, Sher A. Chitosan:an adjuvant with an unanticipated STING. Immunity 2016;44(3):522–524. Epub 2016/03/18. doi:10.1016/j.immuni.2016.03.002. PubMed PMID:26982361
-
(2016)
Immunity
, vol.44
, Issue.3
, pp. 522-524
-
-
Riteau, N.1
Sher, A.2
-
118
-
-
84960415391
-
The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of Type I interferons
-
Epub 2016/03/06, 26944200, PubMed Central PMCID: PMCPMC4852885
-
Carroll EC, Jin L, Mori A, Munoz-Wolf N, et al. The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of Type I interferons. Immunity 2016;44(3):597–608. Epub 2016/03/06. doi:10.1016/j.immuni.2016.02.004. PubMed PMID:26944200; PubMed Central PMCID:PMCPMC4852885
-
(2016)
Immunity
, vol.44
, Issue.3
, pp. 597-608
-
-
Carroll, E.C.1
Jin, L.2
Mori, A.3
Munoz-Wolf, N.4
-
119
-
-
84947245185
-
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
-
Epub 2015/09/16, 26371324, PubMed Central PMCID: PMCPMC4620884
-
Gao D, Li T, Li XD, Chen X, et al. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc Nat Acad Sci USA 2015;112(42):E5699–E5705. Epub 2015/09/16. doi:10.1073/pnas.1516465112. PubMed PMID:26371324; PubMed Central PMCID:PMCPMC4620884
-
(2015)
Proc Nat Acad Sci USA
, vol.112
, Issue.42
, pp. E5699-E5705
-
-
Gao, D.1
Li, T.2
Li, X.D.3
Chen, X.4
-
120
-
-
84964342391
-
Recognition of endogenous nucleic acids by the innate immune system
-
Epub 2016/04/21, 27096317
-
Roers A, Hiller B, Hornung V. Recognition of endogenous nucleic acids by the innate immune system. Immunity 2016;44(4):739–754. Epub 2016/04/21. doi:10.1016/j.immuni.2016.04.002. PubMed PMID:27096317
-
(2016)
Immunity
, vol.44
, Issue.4
, pp. 739-754
-
-
Roers, A.1
Hiller, B.2
Hornung, V.3
-
121
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
-
Epub 2009/09/25, 19776740, PubMed Central PMCID: PMCPMC4664154
-
Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009;461(7265):788–792. Epub 2009/09/25. doi:10.1038/nature08476. PubMed PMID:19776740; PubMed Central PMCID:PMCPMC4664154
-
(2009)
Nature
, vol.461
, Issue.7265
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
122
-
-
84856301080
-
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
-
Epub 2012/01/31, 22284419, PubMed Central PMCID: PMCPMC3269499
-
Gall A, Treuting P, Elkon KB, Loo YM, et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 2012;36(1):120–131. Epub 2012/01/31. doi:10.1016/j.immuni.2011.11.018. PubMed PMID:22284419; PubMed Central PMCID:PMCPMC3269499
-
(2012)
Immunity
, vol.36
, Issue.1
, pp. 120-131
-
-
Gall, A.1
Treuting, P.2
Elkon, K.B.3
Loo, Y.M.4
-
123
-
-
84871218439
-
STING and the innate immune response to nucleic acids in the cytosol
-
Epub 2012/12/15, 23238760
-
Burdette DL, Vance RE. STING and the innate immune response to nucleic acids in the cytosol. Nat Immunol 2013;14(1):19–26. Epub 2012/12/15. doi:10.1038/ni.2491. PubMed PMID:23238760
-
(2013)
Nat Immunol
, vol.14
, Issue.1
, pp. 19-26
-
-
Burdette, D.L.1
Vance, R.E.2
-
124
-
-
73949083594
-
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
-
Epub 2009/11/21, 19926846, PubMed Central PMCID: PMCPMC2791563
-
Saitoh T, Fujita N, Hayashi T, Takahara K, et al. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Nat Acad Sci USA 2009;106(49):20842–20846. Epub 2009/11/21. doi:10.1073/pnas.0911267106. PubMed PMID:19926846; PubMed Central PMCID:PMCPMC2791563
-
(2009)
Proc Nat Acad Sci USA
, vol.106
, Issue.49
, pp. 20842-20846
-
-
Saitoh, T.1
Fujita, N.2
Hayashi, T.3
Takahara, K.4
-
125
-
-
84886789626
-
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling
-
Epub 2013/10/15, 24119841, PubMed Central PMCID: PMCPMC3881181
-
Konno H, Konno K, Barber GN. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 2013;155(3):688–698. Epub 2013/10/15. doi:10.1016/j.cell.2013.09.049. PubMed PMID:24119841; PubMed Central PMCID:PMCPMC3881181
-
(2013)
Cell
, vol.155
, Issue.3
, pp. 688-698
-
-
Konno, H.1
Konno, K.2
Barber, G.N.3
-
126
-
-
84865270570
-
TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination
-
Epub 2012/06/30, 22745133, PubMed Central PMCID: PMCPMC3436586
-
Zhang J, Hu MM, Wang YY, Shu HB. TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem 2012;287(34):28646–286455. Epub 2012/06/30. doi:10.1074/jbc.M112.362608. PubMed PMID:22745133; PubMed Central PMCID:PMCPMC3436586
-
(2012)
J Biol Chem
, vol.287
, Issue.34
, pp. 28646-286455
-
-
Zhang, J.1
Hu, M.M.2
Wang, Y.Y.3
Shu, H.B.4
-
127
-
-
78650214109
-
The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
-
Epub 2010/11/16, 21074459
-
Tsuchida T, Zou J, Saitoh T, Kumar H, et al. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 2010;33(5):765–776. Epub 2010/11/16. doi:10.1016/j.immuni.2010.10.013. PubMed PMID:21074459
-
(2010)
Immunity
, vol.33
, Issue.5
, pp. 765-776
-
-
Tsuchida, T.1
Zou, J.2
Saitoh, T.3
Kumar, H.4
-
128
-
-
62049084519
-
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA
-
Epub 2009/03/17, 19285439
-
Zhong B, Zhang L, Lei C, Li Y, et al. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 2009;30(3):397–407. Epub 2009/03/17. doi:10.1016/j.immuni.2009.01.008. PubMed PMID:19285439
-
(2009)
Immunity
, vol.30
, Issue.3
, pp. 397-407
-
-
Zhong, B.1
Zhang, L.2
Lei, C.3
Li, Y.4
-
129
-
-
84936757319
-
TRIM30alpha is a negative-feedback regulator of the intracellular DNA and DNA virus-triggered response by targeting STING
-
Epub 2015/06/27, 26114947, PubMed Central PMCID: PMCPMC4482643
-
Wang Y, Lian Q, Yang B, Yan S, et al. TRIM30alpha is a negative-feedback regulator of the intracellular DNA and DNA virus-triggered response by targeting STING. PLoS Pathogens 2015;11(6):e1005012. Epub 2015/06/27. doi:10.1371/journal.ppat.1005012. PubMed PMID:26114947; PubMed Central PMCID:PMCPMC4482643
-
(2015)
PLoS Pathogens
, vol.11
, Issue.6
, pp. e1005012
-
-
Wang, Y.1
Lian, Q.2
Yang, B.3
Yan, S.4
-
130
-
-
84988566040
-
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
-
Epub 2016/09/21, 27648547
-
Chen Q, Sun L, Chen ZJ. Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nat Immunol 2016;17(10):1142–1149. Epub 2016/09/21. doi:10.1038/ni.3558. PubMed PMID:27648547
-
(2016)
Nat Immunol
, vol.17
, Issue.10
, pp. 1142-1149
-
-
Chen, Q.1
Sun, L.2
Chen, Z.J.3
-
131
-
-
84944067911
-
Akt kinase-mediated checkpoint of cGAS DNA sensing pathway
-
Epub 2015/10/07, 26440888, PubMed Central PMCID: PMCPMC4607670
-
Seo GJ, Yang A, Tan B, Kim S, et al. Akt kinase-mediated checkpoint of cGAS DNA sensing pathway. Cell Rep 2015;13(2):440–449. Epub 2015/10/07. doi:10.1016/j.celrep.2015.09.007. PubMed PMID:26440888; PubMed Central PMCID:PMCPMC4607670
-
(2015)
Cell Rep
, vol.13
, Issue.2
, pp. 440-449
-
-
Seo, G.J.1
Yang, A.2
Tan, B.3
Kim, S.4
-
132
-
-
84961938118
-
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
-
Epub 2016/02/02, 26829768
-
Xia P, Ye B, Wang S, Zhu X, et al. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol 2016;17(4):369–378. Epub 2016/02/02. doi:10.1038/ni.3356. PubMed PMID:26829768
-
(2016)
Nat Immunol
, vol.17
, Issue.4
, pp. 369-378
-
-
Xia, P.1
Ye, B.2
Wang, S.3
Zhu, X.4
-
133
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Epub 2007/07/10, 17618271
-
Takaoka A, Wang Z, Choi MK, Yanai H, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007;448(7152):501–505. Epub 2007/07/10. doi:10.1038/nature06013. PubMed PMID:17618271
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
Yanai, H.4
-
134
-
-
38949093002
-
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
-
Epub 2008/02/08, 18256672
-
Ishii KJ, Kawagoe T, Koyama S, Matsui K, et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 2008;451(7179):725–729. Epub 2008/02/08. doi:10.1038/nature06537. PubMed PMID:18256672
-
(2008)
Nature
, vol.451
, Issue.7179
, pp. 725-729
-
-
Ishii, K.J.1
Kawagoe, T.2
Koyama, S.3
Matsui, K.4
-
135
-
-
77957009390
-
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
-
Epub 2010/08/11, 20696886, PubMed Central PMCID: PMCPMC2930588
-
Kim T, Pazhoor S, Bao M, Zhang Z, et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Nat Acad Sci USA 2010;107(34):15181–1516. Epub 2010/08/11. doi:10.1073/pnas.1006539107. PubMed PMID:20696886; PubMed Central PMCID:PMCPMC2930588
-
(2010)
Proc Nat Acad Sci USA
, vol.107
, Issue.34
, pp. 11516-15181
-
-
Kim, T.1
Pazhoor, S.2
Bao, M.3
Zhang, Z.4
-
136
-
-
84874278336
-
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
-
Epub 2013/02/08, 23388631, PubMed Central PMCID: PMCPMC3581880
-
Kondo T, Kobayashi J, Saitoh T, Maruyama K, et al. DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Nat Acad Sci USA 2013;110(8):2969–2974. Epub 2013/02/08. doi:10.1073/pnas.1222694110. PubMed PMID:23388631; PubMed Central PMCID:PMCPMC3581880
-
(2013)
Proc Nat Acad Sci USA
, vol.110
, Issue.8
, pp. 2969-2974
-
-
Kondo, T.1
Kobayashi, J.2
Saitoh, T.3
Maruyama, K.4
-
137
-
-
84896332642
-
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
-
Epub 2014/03/19, 24630722, PubMed Central PMCID: PMCPMC4000066
-
Lu A, Magupalli VG, Ruan J, Yin Q, et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 2014;156(6):1193–206. Epub 2014/03/19. doi:10.1016/j.cell.2014.02.008. PubMed PMID:24630722; PubMed Central PMCID:PMCPMC4000066
-
(2014)
Cell
, vol.156
, Issue.6
, pp. 1193-1206
-
-
Lu, A.1
Magupalli, V.G.2
Ruan, J.3
Yin, Q.4
-
138
-
-
84937902109
-
Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC
-
Epub 2015/07/23, 26197926, PubMed Central PMCID: PMCPMC4525163
-
Morrone SR, Matyszewski M, Yu X, Delannoy M, et al. Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC. Nat. Commun 2015;6:7827. Epub 2015/07/23. doi:10.1038/ncomms8827. PubMed PMID:26197926; PubMed Central PMCID:PMCPMC4525163
-
(2015)
Nat. Commun
, vol.6
, pp. 7827
-
-
Morrone, S.R.1
Matyszewski, M.2
Yu, X.3
Delannoy, M.4
-
139
-
-
84859986329
-
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
-
Epub 2012/04/10, 22483801, PubMed Central PMCID: PMCPMC3334467
-
Jin T, Perry A, Jiang J, Smith P, et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 2012;36(4):561–571. Epub 2012/04/10. doi:10.1016/j.immuni.2012.02.014. PubMed PMID:22483801; PubMed Central PMCID:PMCPMC3334467
-
(2012)
Immunity
, vol.36
, Issue.4
, pp. 561-571
-
-
Jin, T.1
Perry, A.2
Jiang, J.3
Smith, P.4
-
140
-
-
84891933102
-
Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
-
Epub 2013/12/25, 24367117, PubMed Central PMCID: PMCPMC3890864
-
Morrone SR, Wang T, Constantoulakis LM, Hooy RM, et al. Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy. Proc Nat Acad Sci USA 2014;111(1):E62–E71. Epub 2013/12/25. doi:10.1073/pnas.1313577111. PubMed PMID:24367117; PubMed Central PMCID:PMCPMC3890864
-
(2014)
Proc Nat Acad Sci USA
, vol.111
, Issue.1
, pp. E62-E71
-
-
Morrone, S.R.1
Wang, T.2
Constantoulakis, L.M.3
Hooy, R.M.4
-
141
-
-
84874246480
-
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
-
Epub 2013/01/25, 23345332, PubMed Central PMCID: PMCPMC3578088
-
Horan KA, Hansen K, Jakobsen MR, Holm CK, et al. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol 2013;190(5):2311–2319. Epub 2013/01/25. doi:10.4049/jimmunol.1202749. PubMed PMID:23345332; PubMed Central PMCID:PMCPMC3578088
-
(2013)
J Immunol
, vol.190
, Issue.5
, pp. 2311-2319
-
-
Horan, K.A.1
Hansen, K.2
Jakobsen, M.R.3
Holm, C.K.4
-
142
-
-
77951269392
-
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
-
Epub 2010/03/31, 20351692, PubMed Central PMCID: PMCPMC2887480
-
Rathinam VA, Jiang Z, Waggoner SN, Sharma S, et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 2010;11(5):395–402. Epub 2010/03/31. doi:10.1038/ni.1864. PubMed PMID:20351692; PubMed Central PMCID:PMCPMC2887480
-
(2010)
Nat Immunol
, vol.11
, Issue.5
, pp. 395-402
-
-
Rathinam, V.A.1
Jiang, Z.2
Waggoner, S.N.3
Sharma, S.4
-
143
-
-
77951263260
-
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
-
Epub 2010/03/31, 20351693, PubMed Central PMCID: PMCPMC3111085
-
Fernandes-Alnemri T, Yu JW, Juliana C, Solorzano L, et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol 2010;11(5):385–393. Epub 2010/03/31. doi:10.1038/ni.1859. PubMed PMID:20351693; PubMed Central PMCID:PMCPMC3111085
-
(2010)
Nat Immunol
, vol.11
, Issue.5
, pp. 385-393
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Juliana, C.3
Solorzano, L.4
-
144
-
-
84867136602
-
Critical role of AIM2 in mycobacterium tuberculosis infection
-
Epub 2012/06/15, 22695634
-
Saiga H, Kitada S, Shimada Y, Kamiyama N, et al. Critical role of AIM2 in mycobacterium tuberculosis infection. Int Immunol 2012;24(10):637–644. Epub 2012/06/15. doi:10.1093/intimm/dxs062. PubMed PMID:22695634
-
(2012)
Int Immunol
, vol.24
, Issue.10
, pp. 637-644
-
-
Saiga, H.1
Kitada, S.2
Shimada, Y.3
Kamiyama, N.4
-
145
-
-
84875431649
-
Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection
-
Epub 2013/03/06, 23460746
-
Gomes MT, Campos PC, Oliveira FS, Corsetti PP, et al. Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection. J Immunol 2013;190(7):3629–3638. Epub 2013/03/06. doi:10.4049/jimmunol.1202817. PubMed PMID:23460746
-
(2013)
J Immunol
, vol.190
, Issue.7
, pp. 3629-3638
-
-
Gomes, M.T.1
Campos, P.C.2
Oliveira, F.S.3
Corsetti, P.P.4
-
146
-
-
84899474093
-
Critical role for the AIM2 inflammasome during acute CNS bacterial infection
-
Epub 2014/02/04, 24484406, PubMed Central PMCID: PMCPMC3999210
-
Hanamsagar R, Aldrich A, Kielian T. Critical role for the AIM2 inflammasome during acute CNS bacterial infection. J Neurochem 2014;129(4):704–711. Epub 2014/02/04. doi:10.1111/jnc.12669. PubMed PMID:24484406; PubMed Central PMCID:PMCPMC3999210
-
(2014)
J Neurochem
, vol.129
, Issue.4
, pp. 704-711
-
-
Hanamsagar, R.1
Aldrich, A.2
Kielian, T.3
-
147
-
-
84925841637
-
cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection
-
Epub 2015/02/25, 25710914, PubMed Central PMCID: PMCPMC4367159
-
Storek KM, Gertsvolf NA, Ohlson MB, Monack DM. cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. J Immunol 2015;194(7):3236–3245. Epub 2015/02/25. doi:10.4049/jimmunol.1402764. PubMed PMID:25710914; PubMed Central PMCID:PMCPMC4367159
-
(2015)
J Immunol
, vol.194
, Issue.7
, pp. 3236-3245
-
-
Storek, K.M.1
Gertsvolf, N.A.2
Ohlson, M.B.3
Monack, D.M.4
-
148
-
-
84926164932
-
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection
-
Epub 2015/02/24, 25704009, PubMed Central PMCID: PMCPMC4359672
-
Karki R, Man SM, Malireddi RK, Gurung P, et al. Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection. Cell Host Microbe 2015;17(3):357–368. Epub 2015/02/24. doi:10.1016/j.chom.2015.01.006. PubMed PMID:25704009; PubMed Central PMCID:PMCPMC4359672
-
(2015)
Cell Host Microbe
, vol.17
, Issue.3
, pp. 357-368
-
-
Karki, R.1
Man, S.M.2
Malireddi, R.K.3
Gurung, P.4
-
149
-
-
84892552656
-
Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria
-
Epub 2014/01/07, 24388751, PubMed Central PMCID: PMCPMC4105362
-
Kalantari P, DeOliveira RB, Chan J, Corbett Y, et al. Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria. Cell Rep 2014;6(1):196–210. Epub 2014/01/07. doi:10.1016/j.celrep.2013.12.014. PubMed PMID:24388751; PubMed Central PMCID:PMCPMC4105362
-
(2014)
Cell Rep
, vol.6
, Issue.1
, pp. 196-210
-
-
Kalantari, P.1
DeOliveira, R.B.2
Chan, J.3
Corbett, Y.4
-
150
-
-
80054966913
-
STING is a direct innate immune sensor of cyclic di-GMP
-
Epub 2011/09/29., 21947006, PubMed Central PMCID: PMCPMC3203314
-
Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011;478(7370):515–518. Epub 2011/09/29. doi:10.1038/nature10429. PubMed PMID:21947006; PubMed Central PMCID:PMCPMC3203314
-
(2011)
Nature
, vol.478
, Issue.7370
, pp. 515-518
-
-
Burdette, D.L.1
Monroe, K.M.2
Sotelo-Troha, K.3
Iwig, J.S.4
-
151
-
-
84928537166
-
Mitochondrial DNA stress primes the antiviral innate immune response
-
Epub 2015/02/03, 25642965, PubMed Central PMCID: PMCPMC4409480
-
West AP, Khoury-Hanold W, Staron M, Tal MC, et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature 2015;520(7548):553–557. Epub 2015/02/03. doi:10.1038/nature14156. PubMed PMID:25642965; PubMed Central PMCID:PMCPMC4409480
-
(2015)
Nature
, vol.520
, Issue.7548
, pp. 553-557
-
-
West, A.P.1
Khoury-Hanold, W.2
Staron, M.3
Tal, M.C.4
-
152
-
-
84908680759
-
Type I interferonopathies: mendelian type I interferon up-regulation
-
Epub 2014/12/03, 25463593
-
Crow YJ. Type I interferonopathies:mendelian type I interferon up-regulation. Curr Opin Immunol 2015;32:7–12. Epub 2014/12/03. doi:10.1016/j.coi.2014.10.005. PubMed PMID:25463593
-
(2015)
Curr Opin Immunol
, vol.32
, pp. 7-12
-
-
Crow, Y.J.1
-
153
-
-
84940121945
-
Cutting edge: cGAS is required for lethal autoimmune disease in the trex1-deficient mouse model of aicardi-goutieres syndrome
-
Epub 2015/08/01, 26223655, PubMed Central PMCID: PMCPMC4546858
-
Gray EE, Treuting PM, Woodward JJ, Stetson DB. Cutting edge:cGAS is required for lethal autoimmune disease in the trex1-deficient mouse model of aicardi-goutieres syndrome. J Immunol 2015;195(5):1939–1943. Epub 2015/08/01. doi:10.4049/jimmunol.1500969. PubMed PMID:26223655; PubMed Central PMCID:PMCPMC4546858
-
(2015)
J Immunol
, vol.195
, Issue.5
, pp. 1939-1943
-
-
Gray, E.E.1
Treuting, P.M.2
Woodward, J.J.3
Stetson, D.B.4
-
154
-
-
84961214693
-
RNase H2 catalytic core Aicardi–Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice
-
Epub 2016/02/18, 26880576, PubMed Central PMCID: PMCPMC4813680
-
Pokatayev V, Hasin N, Chon H, Cerritelli SM, et al. RNase H2 catalytic core Aicardi–Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. J Exp Med 2016;213(3):329–336. Epub 2016/02/18. doi:10.1084/jem.20151464. PubMed PMID:26880576; PubMed Central PMCID:PMCPMC4813680
-
(2016)
J Exp Med
, vol.213
, Issue.3
, pp. 329-336
-
-
Pokatayev, V.1
Hasin, N.2
Chon, H.3
Cerritelli, S.M.4
-
155
-
-
84959450304
-
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response
-
Epub 2016/02/24, 26903602, PubMed Central PMCID: PMCPMC4855687
-
Mackenzie KJ, Carroll P, Lettice L, Tarnauskaite Z, et al. Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response. EMBO J 2016;35(8):831–844. Epub 2016/02/24. doi:10.15252/embj.201593339. PubMed PMID:26903602; PubMed Central PMCID:PMCPMC4855687
-
(2016)
EMBO J
, vol.35
, Issue.8
, pp. 831-844
-
-
Mackenzie, K.J.1
Carroll, P.2
Lettice, L.3
Tarnauskaite, Z.4
-
156
-
-
36248988008
-
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
-
Epub 2007/11/30, 18045533
-
Yang YG, Lindahl T, Barnes DE. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 2007;131(5):873–886. Epub 2007/11/30. doi:10.1016/j.cell.2007.10.017. PubMed PMID:18045533
-
(2007)
Cell
, vol.131
, Issue.5
, pp. 873-886
-
-
Yang, Y.G.1
Lindahl, T.2
Barnes, D.E.3
-
157
-
-
77950400643
-
Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity
-
Epub 2009/10/08, 19808788, PubMed Central PMCID: PMCPMC2758706
-
Crow YJ, Rehwinkel J. Aicardi-Goutieres syndrome and related phenotypes:linking nucleic acid metabolism with autoimmunity. Hum Mol Genet 2009;18(R2):R130–6. Epub 2009/10/08. doi:10.1093/hmg/ddp293. PubMed PMID:19808788; PubMed Central PMCID:PMCPMC2758706
-
(2009)
Hum Mol Genet
, vol.18
, Issue.R2
, pp. R130-R136
-
-
Crow, Y.J.1
Rehwinkel, J.2
-
158
-
-
84983094431
-
Unusual cutaneous features associated with a heterozygous gain-of-function mutation in IFIH1: overlap between Aicardi–Goutieres and Singleton–Merten syndromes
-
Epub 2015/08/19, 26284909, PubMed Central PMCID: PMCPMC4745891
-
Bursztejn AC, Briggs TA, del Toro Duany Y, Anderson BH, et al. Unusual cutaneous features associated with a heterozygous gain-of-function mutation in IFIH1:overlap between Aicardi–Goutieres and Singleton–Merten syndromes. Br J Dermatol 2015;173(6):1505–1513. Epub 2015/08/19. doi:10.1111/bjd.14073. PubMed PMID:26284909; PubMed Central PMCID:PMCPMC4745891
-
(2015)
Br J Dermatol
, vol.173
, Issue.6
, pp. 1505-1513
-
-
Bursztejn, A.C.1
Briggs, T.A.2
del Toro Duany, Y.3
Anderson, B.H.4
-
159
-
-
4444299085
-
Congenital glaucoma and brain stem atrophy as features of Aicardi-Goutieres syndrome
-
Epub 2004/08/25, 15326633
-
Crow YJ, Massey RF, Innes JR, Pairaudeau PW, et al. Congenital glaucoma and brain stem atrophy as features of Aicardi-Goutieres syndrome. Am J Med Genet A 2004;129a(3):303–307. Epub 2004/08/25. doi:10.1002/ajmg.a.30250. PubMed PMID:15326633
-
(2004)
Am J Med Genet A
, vol.129a
, Issue.3
, pp. 303-307
-
-
Crow, Y.J.1
Massey, R.F.2
Innes, J.R.3
Pairaudeau, P.W.4
-
160
-
-
0033915684
-
Familial systemic lupus erythematosus and congenital infection-like syndrome
-
Epub 2000/08/30, 10963105
-
Dale RC, Tang SP, Heckmatt JZ, Tatnall FM. Familial systemic lupus erythematosus and congenital infection-like syndrome. Neuropediatrics 2000;31(3):155–158. Epub 2000/08/30. doi:10.1055/s-2000-7492. PubMed PMID:10963105
-
(2000)
Neuropediatrics
, vol.31
, Issue.3
, pp. 155-158
-
-
Dale, R.C.1
Tang, S.P.2
Heckmatt, J.Z.3
Tatnall, F.M.4
-
161
-
-
84905825645
-
Activated STING in a vascular and pulmonary syndrome
-
Epub 2014/07/17, 25029335, PubMed Central PMCID: PMCPMC4174543
-
Liu Y, Jesus AA, Marrero B, Yang D, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med 2014;371(6):507–518. Epub 2014/07/17. doi:10.1056/NEJMoa1312625. PubMed PMID:25029335; PubMed Central PMCID:PMCPMC4174543
-
(2014)
N Engl J Med
, vol.371
, Issue.6
, pp. 507-518
-
-
Liu, Y.1
Jesus, A.A.2
Marrero, B.3
Yang, D.4
-
162
-
-
3242889151
-
Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis
-
Epub 2004/07/29, 15279810
-
Taylor AM, Groom A, Byrd PJ. Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. DNA Repair 2004;3(8–9):1219–1225. Epub 2004/07/29. doi:10.1016/j.dnarep.2004.04.009. PubMed PMID:15279810
-
(2004)
DNA Repair
, vol.3
, Issue.8-9
, pp. 1219-1225
-
-
Taylor, A.M.1
Groom, A.2
Byrd, P.J.3
-
163
-
-
84912120595
-
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
-
Epub 2014/12/18, 25517615, PubMed Central PMCID: PMCPMC4384884
-
Woo SR, Fuertes MB, Corrales L, Spranger S, et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 2014;41(5):830–842. Epub 2014/12/18. doi:10.1016/j.immuni.2014.10.017. PubMed PMID:25517615; PubMed Central PMCID:PMCPMC4384884
-
(2014)
Immunity
, vol.41
, Issue.5
, pp. 830-842
-
-
Woo, S.R.1
Fuertes, M.B.2
Corrales, L.3
Spranger, S.4
-
164
-
-
84912128872
-
STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
-
Epub 2014/12/18, 25517616, PubMed Central PMCID: PMCPMC5155593
-
Deng L, Liang H, Xu M, Yang X, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 2014;41(5):843–852. Epub 2014/12/18. doi:10.1016/j.immuni.2014.10.019. PubMed PMID:25517616; PubMed Central PMCID:PMCPMC5155593
-
(2014)
Immunity
, vol.41
, Issue.5
, pp. 843-852
-
-
Deng, L.1
Liang, H.2
Xu, M.3
Yang, X.4
-
165
-
-
84950141423
-
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
-
Epub 2015/11/27, 26607445, PubMed Central PMCID: PMCPMC4687570
-
Demaria O, De Gassart A, Coso S, Gestermann N, et al. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc Nat Acad Sci USA 2015;112(50):15408–15413. Epub 2015/11/27. doi:10.1073/pnas.1512832112. PubMed PMID:26607445; PubMed Central PMCID:PMCPMC4687570
-
(2015)
Proc Nat Acad Sci USA
, vol.112
, Issue.50
, pp. 15408-15413
-
-
Demaria, O.1
De Gassart, A.2
Coso, S.3
Gestermann, N.4
-
166
-
-
85014610090
-
DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity
-
Epub 2017/01/11, 28069806
-
Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, et al. DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity. J Immunol 2017. Epub 2017/01/11. doi:10.4049/jimmunol.1601694. PubMed PMID:28069806
-
(2017)
J Immunol
-
-
Kitai, Y.1
Kawasaki, T.2
Sueyoshi, T.3
Kobiyama, K.4
|