Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

Immunity

Volumn 43, Issue 5, 2015, Pages 933-944

  Pestal, Kathleen ^a   Funk, Cory C ^b   Snyder, Jessica M ^a   Price, Nathan D ^b   Treuting, Piper M ^a   Stetson, Daniel B ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAR1 PROTEIN; MDA5 PROTEIN; MEMBRANE PROTEIN; NUCLEIC ACID; P150 PROTEIN; PROTEIN P110; REGULATOR PROTEIN; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; ADAR1 PROTEIN, MOUSE; ADENOSINE DEAMINASE; DEAD BOX PROTEIN; IFIH1 PROTEIN, MOUSE; INTERFERON; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; IPS-1 PROTEIN, MOUSE; ISOPROTEIN; RNA; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; EMBRYO; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; HOMEOSTASIS; IN VIVO STUDY; MOUSE; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RNA EDITING; SIGNAL TRANSDUCTION; ANIMAL; HEK293 CELL LINE; HUMAN; METABOLISM; NERVOUS SYSTEM MALFORMATION; NEUROLOGIC DISEASE; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE DEAMINASE; ANIMALS; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; AUTOIMMUNITY; DEAD-BOX RNA HELICASES; HEK293 CELLS; HUMANS; INTERFERON TYPE I; INTERFERON-INDUCED HELICASE, IFIH1; MICE; NERVOUS SYSTEM MALFORMATIONS; PROTEIN ISOFORMS; RNA; RNA EDITING; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84947434056     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.11.001     Document Type: Article

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