DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type i interferon by regulating STING trafficking

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 8, 2013, Pages 2969-2974

  Kondo, Takeshi ^a,b   Kobayashi, Junya ^c   Saitoh, Tatsuya ^a,b   Maruyama, Kenta ^a,b   Ishii, Ken J ^a,d   Barber, Glen N ^e   Komatsu, Kenshi ^c   Akira, Shizuo ^a,b   Kawai, Taro ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^e UNIVERSITY OF MIAMI   (United States)

Author keywords

Innate immunity; Pattern recognition receptor; Signal transduction

Indexed keywords

DOUBLE STRANDED DNA; INTERFERON; INTERFERON REGULATORY FACTOR 3; MRE11 PROTEIN; NIBRIN; RAD50 PROTEIN;

ANIMAL CELL; ARTICLE; ATAXIA TELANGIECTASIA; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; GENE ACTIVATION; GENE MUTATION; HOST CELL; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTRACELLULAR TRANSPORT; MOLECULAR SENSOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; CYTOSOL; DNA; DNA DAMAGE; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; INTERFERON TYPE I; MEMBRANE PROTEINS; MICE; MUTATION; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84874278336     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222694110     Document Type: Article

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