The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Immunity

Volumn 44, Issue 3, 2016, Pages 597-608

  Carroll, Elizabeth C ^a   Jin, Lei ^b   Mori, Andres ^a   Muñoz Wolf, Natalia ^a   Oleszycka, Ewa ^a   Moran, Hannah B T ^a   Mansouri, Samira ^b   McEntee, Craig P ^a   Lambe, Eimear ^a   Agger, Else Marie ^c   Andersen, Peter ^c   Cunningham, Colm ^a   Hertzog, Paul ^d   Fitzgerald, Katherine A ^e,f   Bowie, Andrew G ^a   Lavelle, Ed C ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ALBANY MEDICAL COLLEGE   (United States)

^c STATENS SERUM INSTITUT   (Denmark)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; CHITOSAN; DNA; EXTRACHROMOSOMAL DNA; IMMUNOGLOBULIN; INTERFERON; REACTIVE OXYGEN METABOLITE; VACCINE; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE;

ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVATION; CELL MATURATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; VACCINATION; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CELL MOTION; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; CHITOSAN; DENDRITIC CELLS; DNA; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOGLOBULIN G; INTERFERON TYPE I; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; NUCLEOTIDYLTRANSFERASES; REACTIVE OXYGEN SPECIES; TH1 CELLS; VACCINES;

EID: 84960415391     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.02.004     Document Type: Article

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