Binding of Double-stranded RNA to Protein Kinase PKR is Required for Dimerization and Promotes Critical Autophosphorylation Events in the Activation Loop

Journal of Biological Chemistry

Volumn 276, Issue 27, 2001, Pages 24946-24958

  Zhang, Fan ^a   Romano, Patrick R ^b   Nagamura Inoue, Tokiko ^a,d   Tian, Bin ^c   Dever, Thomas E ^a   Mathews, Michael B ^c   Ozato, Keiko ^a   Hinnebusch, Alan G ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ASSAYS; CELLS; DIMERIZATION; ENZYME INHIBITION; PROTEINS; RNA; YEAST;

AUTOPHOSPHORYLATION SITES;

BIOCHEMISTRY;

ALANINE; DOUBLE STRANDED RNA; GLUTAMINE; INITIATION FACTOR 2; INITIATION FACTOR 2 ALPHA KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE; PROTEIN KINASE R; THREONINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; POLYINOSINIC POLYCYTIDYLIC ACID;

AMINO ACID SUBSTITUTION; ANTIBODY SPECIFICITY; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DIMERIZATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SYNTHESIS; RNA BINDING; VIRUS INFECTION; YEAST; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS;

MAMMALIA;

AMINO ACID SEQUENCE; DIMERIZATION; EIF-2 KINASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PLASMIDS; POLY I-C; RNA, DOUBLE-STRANDED; THREONINE; YEASTS;

EID: 0035816675     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102108200     Document Type: Article

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