Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

Nature Immunology

Volumn 17, Issue 4, 2016, Pages 369-378

  Xia, Pengyan ^a   Ye, Buqing ^a   Wang, Shuo ^a   Zhu, Xiaoxiao ^a   Du, Ying ^a   Xiong, Zhen ^a,b   Tian, Yong ^a   Fan, Zusen ^a,b  

^a INSTITUTE OF BIOPHYSICS   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE; CYCLIC GMP; CYCLIC GMP AMP SYNTHASE; DNA; INTERFERON; SYNTHETASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IRF3; UNCLASSIFIED DRUG; CCP5 PROTEIN, MOUSE; CCP6 PROTEIN, MOUSE; CYCLIC GUANOSINE MONOPHOSPHATE-ADENOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE; DNA VIRUS; INTERFERON REGULATORY FACTOR 3; IRF3 PROTEIN, MOUSE; MB21D1 PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE; PEPTIDE SYNTHASE; TTLL6 PROTEIN, MOUSE; VIRUS DNA;

ANIMAL CELL; ANTIVIRAL IMMUNITY; ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA VIRUS; ENZYME ACTIVITY; IMMUNE RESPONSE; IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSOR; ANIMAL; BIOSYNTHESIS; CYTOSOL; DNA VIRUS INFECTION; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HERPES SIMPLEX; IMMUNOLOGY; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMPLEXVIRUS; VACCINIA; VACCINIA VIRUS;

ANIMALS; CARBOXYPEPTIDASES; CYTOSOL; DNA VIRUS INFECTIONS; DNA VIRUSES; DNA, VIRAL; FLUORESCENT ANTIBODY TECHNIQUE; HERPES SIMPLEX; IMMUNOPRECIPITATION; INTERFERON REGULATORY FACTOR-3; INTERFERONS; MICE; MICE, KNOCKOUT; NUCLEOTIDES, CYCLIC; NUCLEOTIDYLTRANSFERASES; PEPTIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIMPLEXVIRUS; VACCINIA; VACCINIA VIRUS;

EID: 84961938118     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3356     Document Type: Article

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