Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

Science

Volumn 324, Issue 5925, 2009, Pages 387-389

  Nejentsev, Sergey ^a   Walker, Neil ^a   Riches, David ^b   Egholm, Michael ^b   Todd, John A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b 454 Life Sciences ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; VIRUS RNA;

DIABETES; DISEASE CONTROL; GENE EXPRESSION; GENOME; RARITY;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EXON; GENE; GENE EXPRESSION; GENE STRUCTURE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTERFERON INDUCED WITH HELICASE C DOMAIN 1 GENE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

BASE SEQUENCE; CASE-CONTROL STUDIES; CODON, NONSENSE; DEAD-BOX RNA HELICASES; DIABETES MELLITUS, TYPE 1; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK; RISK FACTORS; RNA SPLICE SITES; SEQUENCE ANALYSIS, DNA;

EID: 65249131713     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1167728     Document Type: Article

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27. We thank the patients, control participants, and family members for participating in the study. S.N. held the Diabetes Research and Wellness Foundation Non-Clinical Fellowship at the early stages of the project and now holds the Royal Society University Research Fellowship. The Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory is funded by the Juvenile Diabetes Research Foundation, the Wellcome Trust, and the National Institute for Health Research Biomedical Research Centre. The Cambridge Institute for Medical Research is in receipt of a Wellcome Trust Strategic Award (079895). Full acknowledgements are in the supporting online material. Previously unseen SNPs were submitted to dbSNP database (www.ncbi.nlm.nih.gov/SNP/); their submission numbers are in table S3.