Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 15, 2014, Pages 5646-5651

  Kuniyoshi, Kanako ^a,b,c   Takeuchi, Osamu ^a,d   Pandey, Surya ^a,b,c   Satoh, Takashi ^a,b   Iwasaki, Hidenori ^a,e   Akira, Shizuo ^a,b   Kawai, Taro ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e JAPAN TOBACCO INC   (Japan)

Author keywords

Cytoplasmic puncta; Signal transduction

Indexed keywords

BETA INTERFERON; INTERFERON; LYSINE; MEX3C ENZYME; RETINOIC ACID INDUCIBLE PROTEIN I; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL INNATE IMMUNITY; ARTICLE; CELL GRANULE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITIC CELL; EMBRYO; EMBRYO CELL; FIBROBLAST; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RING FINGER MOTIF; RNA BINDING; RNA VIRUS; RNA VIRUS INFECTION; SEQUENCE HOMOLOGY; UBIQUITINATION; VIRUS IMMUNITY;

CYTOPLASMIC PUNCTA; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LUCIFERASES; MICE; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, RETINOIC ACID; RNA-BINDING PROTEINS; UBIQUITINATION; VIRUS DISEASES;

EID: 84898776236     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1401674111     Document Type: Article

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