메뉴 건너뛰기




Volumn 1, Issue 6, 2015, Pages 420-433

When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?

Author keywords

Aging; Cancer; Chemoprevention; Nutrient sensing signaling pathways

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ACETYLSALICYLIC ACID; ANTIMITOTIC AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOXORUBICIN; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); EVEROLIMUS; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LITHOCHOLIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METFORMIN; ORGANIC CATION TRANSPORTER 1; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; RESVERATROL; SIRTUIN 1; SOMATOMEDIN B; SOMATOMEDIN C; TEMSIROLIMUS; THEANINE;

EID: 84991305576     PISSN: None     EISSN: 2198641X     Source Type: Journal    
DOI: 10.1007/s40495-015-0039-5     Document Type: Review
Times cited : (13)

References (193)
  • 1
    • 84904420941 scopus 로고    scopus 로고
    • 2nd Edition accessed on December 3
    • American Cancer Society: http://www.cancer.org/research/cancerfactsfigures/globalcancerfactsfigures/global-facts-figures-2nd-ed; Global Cancer Facts & Figures 2nd Edition accessed on December 3, 2014
    • (2014) American Cancer Society: ; Global Cancer Facts & Figures
  • 4
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • COI: 1:CAS:528:DC%2BD2MXitVWntbk%3D, PID: 15734677
    • Kirkwood TB. Understanding the odd science of aging. Cell. 2005;120:437–47.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 5
    • 78349262359 scopus 로고    scopus 로고
    • Why women live longer. Stress alone does not explain the longevity gap
    • PID: 21033280
    • Kirkwood T. Why women live longer. Stress alone does not explain the longevity gap. Sci Am. 2010;303:34–5.
    • (2010) Sci Am , vol.303 , pp. 34-35
    • Kirkwood, T.1
  • 6
    • 84904249842 scopus 로고    scopus 로고
    • Circadian clock: linking epigenetics to aging
    • COI: 1:CAS:528:DC%2BC2cXht12nu7rN
    • Orozco-Solis R, Sassone-Corsi P. Circadian clock: linking epigenetics to aging. Curr Opin Genet Dev. 2014;26C:66–72.
    • (2014) Curr Opin Genet Dev , vol.26C , pp. 66-72
    • Orozco-Solis, R.1    Sassone-Corsi, P.2
  • 7
    • 84864847125 scopus 로고    scopus 로고
    • Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle
    • COI: 1:CAS:528:DC%2BC38XhsFKrsr%2FN, PID: 22674476
    • Draznin B, Wang C, Adochio R, Leitner JW, Cornier MA. Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle. Horm Metab Res. 2012;44:650–5.
    • (2012) Horm Metab Res , vol.44 , pp. 650-655
    • Draznin, B.1    Wang, C.2    Adochio, R.3    Leitner, J.W.4    Cornier, M.A.5
  • 8
    • 84890215172 scopus 로고    scopus 로고
    • What are the roles of calorie restriction and diet quality in promoting healthy longevity?
    • PID: 24291541
    • Rizza W, Veronese N, Fontana L. What are the roles of calorie restriction and diet quality in promoting healthy longevity? Ageing Res Rev. 2014;13:38–45.
    • (2014) Ageing Res Rev , vol.13 , pp. 38-45
    • Rizza, W.1    Veronese, N.2    Fontana, L.3
  • 9
    • 84864541430 scopus 로고    scopus 로고
    • Metformin in obesity, cancer and aging: addressing controversies
    • COI: 1:CAS:528:DC%2BC38XptV2jtr8%3D
    • Berstein LM. Metformin in obesity, cancer and aging: addressing controversies. Aging (Albany NY). 2012;4:320–9.
    • (2012) Aging (Albany NY) , vol.4 , pp. 320-329
    • Berstein, L.M.1
  • 10
    • 84875673610 scopus 로고    scopus 로고
    • Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
    • COI: 1:CAS:528:DC%2BC3sXlt1Cgtrs%3D, PID: 23485446
    • Wan QL, Zheng SQ, Wu GS, Luo HR. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol. 2013;48:499–506.
    • (2013) Exp Gerontol , vol.48 , pp. 499-506
    • Wan, Q.L.1    Zheng, S.Q.2    Wu, G.S.3    Luo, H.R.4
  • 11
    • 84880378679 scopus 로고    scopus 로고
    • Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span
    • COI: 1:CAS:528:DC%2BC3sXhsVKltbfO, PID: 23855467
    • Marchal J, Pifferi F, Aujard F. Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span. Ann N Y Acad Sci. 2013;1290:67–73.
    • (2013) Ann N Y Acad Sci , vol.1290 , pp. 67-73
    • Marchal, J.1    Pifferi, F.2    Aujard, F.3
  • 12
    • 84877995343 scopus 로고    scopus 로고
    • Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction
    • PID: 23704949
    • Schriner SE, Lee K, Truong S, Salvadora KT, Maler S, Nam A, et al. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PLoS One. 2013;8:e63886.
    • (2013) PLoS One , vol.8
    • Schriner, S.E.1    Lee, K.2    Truong, S.3    Salvadora, K.T.4    Maler, S.5    Nam, A.6
  • 13
    • 84895420566 scopus 로고    scopus 로고
    • Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance
    • PID: 24472572
    • Gospodaryov DV, Yurkevych IS, Jafari M, Lushchak VI, Lushchak OV. Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance. Longev Healthspan. 2013;2:5.
    • (2013) Longev Healthspan , vol.2 , pp. 5
    • Gospodaryov, D.V.1    Yurkevych, I.S.2    Jafari, M.3    Lushchak, V.I.4    Lushchak, O.V.5
  • 14
    • 84895433537 scopus 로고    scopus 로고
    • Concentration-dependent effects of rhodiola rosea on long-term survival and stress resistance of yeast Saccharomyces cerevisiae: the involvement of YAP 1 and MSN2/4 regulatory proteins
    • PID: 24659935
    • Bayliak MM, Burdyliuk NI, Izers’ka LI, Lushchak VI. Concentration-dependent effects of rhodiola rosea on long-term survival and stress resistance of yeast Saccharomyces cerevisiae: the involvement of YAP 1 and MSN2/4 regulatory proteins. Dose Response. 2013;12:93–109.
    • (2013) Dose Response , vol.12 , pp. 93-109
    • Bayliak, M.M.1    Burdyliuk, N.I.2    Izers’ka, L.I.3    Lushchak, V.I.4
  • 15
    • 84885460070 scopus 로고    scopus 로고
    • Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer
    • COI: 1:CAS:528:DC%2BC3sXhvVeiu7vP, PID: 24064057
    • Cha YI, Kim HS. Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. BMB Rep. 2013;46:429–38.
    • (2013) BMB Rep , vol.46 , pp. 429-438
    • Cha, Y.I.1    Kim, H.S.2
  • 16
    • 84857640868 scopus 로고    scopus 로고
    • The insulin and insulin-like growth factor receptor family in neoplasia: an update
    • COI: 1:CAS:528:DC%2BC38Xit12jsrs%3D, PID: 22337149
    • Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer. 2012;12:159–69.
    • (2012) Nat Rev Cancer , vol.12 , pp. 159-169
    • Pollak, M.1
  • 17
    • 84877851087 scopus 로고    scopus 로고
    • AMPK: a contextual oncogene or tumor suppressor?
    • COI: 1:CAS:528:DC%2BC3sXnsFejs70%3D, PID: 23644529
    • Liang J, Mills GB. AMPK: a contextual oncogene or tumor suppressor? Cancer Res. 2013;73:2929–35.
    • (2013) Cancer Res , vol.73 , pp. 2929-2935
    • Liang, J.1    Mills, G.B.2
  • 18
    • 84877927481 scopus 로고    scopus 로고
    • mTOR in aging, metabolism, and cancer
    • COI: 1:CAS:528:DC%2BC3sXosF2ntg%3D%3D, PID: 23317514
    • Cornu M, Albert V, Hall MN. mTOR in aging, metabolism, and cancer. Curr Opin Genet Dev. 2013;23:53–62.
    • (2013) Curr Opin Genet Dev , vol.23 , pp. 53-62
    • Cornu, M.1    Albert, V.2    Hall, M.N.3
  • 19
    • 84884376302 scopus 로고    scopus 로고
    • Health span extension through green chemoprevention
    • PID: 23566780
    • Fahey JW, Kensler TW. Health span extension through green chemoprevention. Virtual Mentor. 2013;15:311–8.
    • (2013) Virtual Mentor , vol.15 , pp. 311-318
    • Fahey, J.W.1    Kensler, T.W.2
  • 20
    • 50849110457 scopus 로고    scopus 로고
    • Prevention of cancer by inhibiting aging
    • COI: 1:CAS:528:DC%2BD1cXhsFWktLzN, PID: 18769112
    • Blagosklonny MV. Prevention of cancer by inhibiting aging. Cancer Biol Ther. 2008;7:1520–4.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1520-1524
    • Blagosklonny, M.V.1
  • 21
    • 84880300172 scopus 로고    scopus 로고
    • Cancer chemoprevention: a rapidly evolving field
    • COI: 1:CAS:528:DC%2BC3sXhtFSiurnL, PID: 23736035
    • Steward WP, Brown K. Cancer chemoprevention: a rapidly evolving field. Br J Cancer. 2013;109:1–7.
    • (2013) Br J Cancer , vol.109 , pp. 1-7
    • Steward, W.P.1    Brown, K.2
  • 23
    • 84905045240 scopus 로고    scopus 로고
    • Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
    • COI: 1:CAS:528:DC%2BC2cXht1aksrzP, PID: 24618355
    • Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, et al. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 2014;13:769–71.
    • (2014) Aging Cell , vol.13 , pp. 769-771
    • Milman, S.1    Atzmon, G.2    Huffman, D.M.3    Wan, J.4    Crandall, J.P.5    Cohen, P.6
  • 24
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span—from yeast to humans
    • COI: 1:CAS:528:DC%2BC3cXks1Snsro%3D, PID: 20395504
    • Fontana L, Partridge L, Longo VD. Extending healthy life span—from yeast to humans. Science. 2010;328:321–6.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 26
    • 84911457047 scopus 로고    scopus 로고
    • Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging
    • COI: 1:CAS:528:DC%2BC2cXitVamtbvE, PID: 25244225
    • Arum O, Boparai RK, Saleh JK, Wang F, Dirks AL, Turner JG, et al. Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging. Aging Cell. 2014;13:981–1000.
    • (2014) Aging Cell , vol.13 , pp. 981-1000
    • Arum, O.1    Boparai, R.K.2    Saleh, J.K.3    Wang, F.4    Dirks, A.L.5    Turner, J.G.6
  • 27
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • COI: 1:CAS:528:DC%2BD3sXhs1KhtA%3D%3D, PID: 12483226
    • Holzenberger M, Dupont J, Ducos B, Leneuve P, Géloën A, Even PC, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421:182–7.
    • (2003) Nature , vol.421 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3    Leneuve, P.4    Géloën, A.5    Even, P.C.6
  • 28
    • 77957981121 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
    • COI: 1:CAS:528:DC%2BC3cXhtF2gsL%2FM, PID: 20805469
    • Marino G, Ugalde AP, AF F n, Osorio FG, Fueyo A, Freije JM, et al. Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Proc Natl Acad Sci U S A. 2010;107:16268–73.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 16268-16273
    • Marino, G.1    Ugalde, A.P.2    Osorio, F.G.3    Fueyo, A.4    Freije, J.M.5
  • 29
    • 0041382468 scopus 로고    scopus 로고
    • Reduced longevity in untreated patients with isolated growth hormone deficiency
    • COI: 1:CAS:528:DC%2BD3sXmsFOkt74%3D, PID: 12915652
    • Besson A, Salemi S, Gallati S, Jenal A, Horn R, Mullis PS, et al. Reduced longevity in untreated patients with isolated growth hormone deficiency. J Clin Endocrinol Metab. 2003;88:3664–7.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3664-3667
    • Besson, A.1    Salemi, S.2    Gallati, S.3    Jenal, A.4    Horn, R.5    Mullis, P.S.6
  • 30
    • 23844551318 scopus 로고    scopus 로고
    • Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging
    • COI: 1:CAS:528:DC%2BD2MXpsVehu7s%3D, PID: 15919742
    • Bartke A. Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology. 2005;146:3718–23.
    • (2005) Endocrinology , vol.146 , pp. 3718-3723
    • Bartke, A.1
  • 31
    • 79951938474 scopus 로고    scopus 로고
    • Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
    • COI: 1:CAS:528:DC%2BC3MXit1yjsL4%3D
    • Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011;3:70.
    • (2011) Sci Transl Med , vol.3 , pp. 70
    • Guevara-Aguirre, J.1    Balasubramanian, P.2    Guevara-Aguirre, M.3    Wei, M.4    Madia, F.5    Cheng, C.W.6
  • 32
    • 84905045240 scopus 로고    scopus 로고
    • Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
    • COI: 1:CAS:528:DC%2BC2cXht1aksrzP, PID: 24618355, This study reported that low IGF-1 levels are associated with longer survival in females and individuals with a history of cancer, who are at age between the age of 90 and 99
    • Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, et al. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 2014;13:769–71. This study reported that low IGF-1 levels are associated with longer survival in females and individuals with a history of cancer, who are at age between the age of 90 and 99.
    • (2014) Aging Cell , vol.13 , pp. 769-771
    • Milman, S.1    Atzmon, G.2    Huffman, D.M.3    Wan, J.4    Crandall, J.P.5    Cohen, P.6
  • 33
    • 84881661464 scopus 로고    scopus 로고
    • The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer
    • PID: 23434537
    • Anisimov VN, Bartke A. The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol. 2013;87:201–23.
    • (2013) Crit Rev Oncol Hematol , vol.87 , pp. 201-223
    • Anisimov, V.N.1    Bartke, A.2
  • 34
    • 84883144613 scopus 로고    scopus 로고
    • A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors
    • PID: 23983688, COI: 1:CAS:528:DC%2BC3sXhtlerurbN
    • Westley RL, May FE. A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors. Int J Endocrinol. 2013;2013:632461.
    • (2013) Int J Endocrinol , vol.2013 , pp. 632461
    • Westley, R.L.1    May, F.E.2
  • 35
    • 0032559272 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    • COI: 1:CAS:528:DyaK1cXotVOqsg%3D%3D, PID: 9438850
    • Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science. 1998;279:563–6.
    • (1998) Science , vol.279 , pp. 563-566
    • Chan, J.M.1    Stampfer, M.J.2    Giovannucci, E.3    Gann, P.H.4    Ma, J.5    Wilkinson, P.6
  • 36
  • 37
    • 84896400782 scopus 로고    scopus 로고
    • Insulin-like growth factor I and risk of breast cancer by age and hormone receptor status-A prospective study within the EPIC cohort
    • COI: 1:CAS:528:DC%2BC3sXhslyrtrzN, PID: 24248481
    • Kaaks R, Johnson T, Tikk K, Sookthai D, Tjønneland A, Roswall N, et al. Insulin-like growth factor I and risk of breast cancer by age and hormone receptor status-A prospective study within the EPIC cohort. Int J Cancer. 2014;134:2683–90.
    • (2014) Int J Cancer , vol.134 , pp. 2683-2690
    • Kaaks, R.1    Johnson, T.2    Tikk, K.3    Sookthai, D.4    Tjønneland, A.5    Roswall, N.6
  • 38
    • 84861581140 scopus 로고    scopus 로고
    • Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps
    • COI: 1:CAS:528:DC%2BC38XntlSktbg%3D, PID: 21898383
    • Soubry A, Il’yasova D, Sedjo R, Wang F, Byers T, Rosen C, et al. Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps. Int J Cancer. 2012;131:512–7.
    • (2012) Int J Cancer , vol.131 , pp. 512-517
    • Soubry, A.1    Il’yasova, D.2    Sedjo, R.3    Wang, F.4    Byers, T.5    Rosen, C.6
  • 39
    • 0027366338 scopus 로고
    • Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor
    • COI: 1:CAS:528:DyaK2cXnsVCrsg%3D%3D, PID: 8248231
    • Sell C, Rubini M, Rubin R, Liu JP, Efstratiadis A, Baserga R. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci U S A. 1993;90:11217–21.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11217-11221
    • Sell, C.1    Rubini, M.2    Rubin, R.3    Liu, J.P.4    Efstratiadis, A.5    Baserga, R.6
  • 40
    • 68849121246 scopus 로고    scopus 로고
    • Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice
    • COI: 1:CAS:528:DC%2BD1MXpt1Wlsbw%3D, PID: 19415693
    • Hursting SD, Perkins SN, Lavigne JA, Beltran L, Haines DC, Hill HL, et al. Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice. Mol Carcinog. 2009;48:671–7.
    • (2009) Mol Carcinog , vol.48 , pp. 671-677
    • Hursting, S.D.1    Perkins, S.N.2    Lavigne, J.A.3    Beltran, L.4    Haines, D.C.5    Hill, H.L.6
  • 41
    • 1842866389 scopus 로고    scopus 로고
    • A prospective study of plasma C-peptide and colorectal cancer risk in men
    • COI: 1:CAS:528:DC%2BD2cXjtVShtbw%3D, PID: 15069117
    • Ma J, Giovannucci E, Pollak M, Leavitt A, Tao Y, Gaziano JM, et al. A prospective study of plasma C-peptide and colorectal cancer risk in men. J Natl Cancer Inst. 2004;96:546–53.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 546-553
    • Ma, J.1    Giovannucci, E.2    Pollak, M.3    Leavitt, A.4    Tao, Y.5    Gaziano, J.M.6
  • 42
    • 0029835895 scopus 로고    scopus 로고
    • Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3
    • COI: 1:CAS:528:DyaK28XnsVWntbk%3D, PID: 8958225
    • Harrela M, Koistinen H, Kaprio J, Lehtovirta M, Tuomilehto J, Eriksson J, et al. Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3. J Clin Invest. 1996;98:2612–5.
    • (1996) J Clin Invest , vol.98 , pp. 2612-2615
    • Harrela, M.1    Koistinen, H.2    Kaprio, J.3    Lehtovirta, M.4    Tuomilehto, J.5    Eriksson, J.6
  • 43
    • 78650848337 scopus 로고    scopus 로고
    • mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
    • COI: 1:CAS:528:DC%2BC3MXotlGrtw%3D%3D, PID: 21179166
    • Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature. 2010;468:1100–4.
    • (2010) Nature , vol.468 , pp. 1100-1104
    • Sengupta, S.1    Peterson, T.R.2    Laplante, M.3    Oh, S.4    Sabatini, D.M.5
  • 44
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • COI: 1:CAS:528:DC%2BD28XptlKjtA%3D%3D, PID: 16418483
    • Powers 3rd RW, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006;20:174–84.
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 46
    • 72649091698 scopus 로고    scopus 로고
    • Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
    • COI: 1:CAS:528:DC%2BC3cXlt1Klu7Y%3D, PID: 20074526
    • Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, et al. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 2010;11:35–46.
    • (2010) Cell Metab , vol.11 , pp. 35-46
    • Bjedov, I.1    Toivonen, J.M.2    Kerr, F.3    Slack, C.4    Jacobson, J.5    Foley, A.6
  • 47
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • COI: 1:CAS:528:DC%2BD1MXotlSgtLg%3D, PID: 19587680
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460:392–5.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 49
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • COI: 1:CAS:528:DC%2BC38XksVyqsbY%3D, PID: 22461615
    • Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012;335:1638–43.
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1    Ye, L.2    Katajisto, P.3    Goncalves, M.D.4    Saitoh, M.5    Stevens, D.M.6
  • 50
    • 84881247539 scopus 로고    scopus 로고
    • Rapamycin extends murine lifespan but has limited effects on aging
    • COI: 1:CAS:528:DC%2BC3sXht1OgtbvL, PID: 23863708
    • Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, et al. Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest. 2013;123:3272–91.
    • (2013) J Clin Invest , vol.123 , pp. 3272-3291
    • Neff, F.1    Flores-Dominguez, D.2    Ryan, D.P.3    Horsch, M.4    Schröder, S.5    Adler, T.6
  • 51
    • 84887645055 scopus 로고    scopus 로고
    • Biomedicine. A putative antiaging drug takes a step from mice to men
    • COI: 1:CAS:528:DC%2BC3sXhvVGgtLfP, PID: 24233701
    • Leslie M. Biomedicine. A putative antiaging drug takes a step from mice to men. Science. 2013;342:789.
    • (2013) Science , vol.342 , pp. 789
    • Leslie, M.1
  • 52
    • 84880566446 scopus 로고    scopus 로고
    • A growing role for mTOR in promoting anabolic metabolism
    • COI: 1:CAS:528:DC%2BC3sXhtF2msr3K, PID: 23863154
    • Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans. 2013;41:906–12.
    • (2013) Biochem Soc Trans , vol.41 , pp. 906-912
    • Howell, J.J.1    Ricoult, S.J.2    Ben-Sahra, I.3    Manning, B.D.4
  • 53
    • 84859489680 scopus 로고    scopus 로고
    • Molecular damage in cancer: an argument for mTOR-driven aging
    • COI: 1:CAS:528:DC%2BC38Xitlaru7c%3D, PID: 22246147
    • Blagosklonny MV. Molecular damage in cancer: an argument for mTOR-driven aging. Aging. 2011;3:1130–41.
    • (2011) Aging , vol.3 , pp. 1130-1141
    • Blagosklonny, M.V.1
  • 54
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • COI: 1:CAS:528:DC%2BD28XkvVyrsr8%3D, PID: 16724053
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441:424–30.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 55
    • 84870666200 scopus 로고    scopus 로고
    • Rapalogs in cancer prevention: anti-aging or anticancer?
    • COI: 1:CAS:528:DC%2BC3sXjsFentrc%3D, PID: 23151465
    • Blagosklonny MV. Rapalogs in cancer prevention: anti-aging or anticancer? Cancer Biol Ther. 2012;13:1349–54.
    • (2012) Cancer Biol Ther , vol.13 , pp. 1349-1354
    • Blagosklonny, M.V.1
  • 56
    • 84901008792 scopus 로고    scopus 로고
    • Targeting PI3K/Akt/mTOR signaling in cancer
    • PID: 24782981
    • Porta C, Paglino C, Mosca A. Targeting PI3K/Akt/mTOR signaling in cancer. Front Oncol. 2014;4:64.
    • (2014) Front Oncol , vol.4 , pp. 64
    • Porta, C.1    Paglino, C.2    Mosca, A.3
  • 57
    • 79957983577 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway—beyond rapalogs
    • PID: 21317449
    • Markman B, Dienstmann R, Tabernero J. Targeting the PI3K/Akt/mTOR pathway—beyond rapalogs. Oncotarget. 2010;1:530–43.
    • (2010) Oncotarget , vol.1 , pp. 530-543
    • Markman, B.1    Dienstmann, R.2    Tabernero, J.3
  • 58
    • 84880512771 scopus 로고    scopus 로고
    • Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseases
    • COI: 1:CAS:528:DC%2BC3sXhsVersbnF, PID: 23659703
    • Lebwohl D, Anak O, Sahmoud T, Klimovsky J, Elmroth I, Haas T, et al. Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseases. Ann N Y Acad Sci. 2013;1291:14–32.
    • (2013) Ann N Y Acad Sci , vol.1291 , pp. 14-32
    • Lebwohl, D.1    Anak, O.2    Sahmoud, T.3    Klimovsky, J.4    Elmroth, I.5    Haas, T.6
  • 59
    • 84874650275 scopus 로고    scopus 로고
    • Development of PI3K inhibitors: lessons learned from early clinical trials
    • COI: 1:CAS:528:DC%2BC3sXjsFGgs7w%3D, PID: 23400000
    • Rodon J, Dienstmann R, Serra V, Tabernero J. Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol. 2013;10:143–53.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 143-153
    • Rodon, J.1    Dienstmann, R.2    Serra, V.3    Tabernero, J.4
  • 60
    • 74949083809 scopus 로고    scopus 로고
    • The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis
    • COI: 1:CAS:528:DC%2BC3cXot1Wi, PID: 20028747
    • Memmott RM, Dennis PA. The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. Clin Cancer Res. 2010;16:4–10.
    • (2010) Clin Cancer Res , vol.16 , pp. 4-10
    • Memmott, R.M.1    Dennis, P.A.2
  • 61
    • 84875257898 scopus 로고    scopus 로고
    • A review of oral toxicity associated with mTOR inhibitor therapy in cancer patients
    • COI: 1:CAS:528:DC%2BC3sXnt1WgtQ%3D%3D, PID: 23312237
    • Martins F, de Oliveira MA, Wang Q, Sonis S, Gallottini M, George S, et al. A review of oral toxicity associated with mTOR inhibitor therapy in cancer patients. Oral Oncol. 2013;49:293–8.
    • (2013) Oral Oncol , vol.49 , pp. 293-298
    • Martins, F.1    de Oliveira, M.A.2    Wang, Q.3    Sonis, S.4    Gallottini, M.5    George, S.6
  • 62
    • 84881543064 scopus 로고    scopus 로고
    • Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: pharmacokinetic considerations and clinical implications
    • COI: 1:CAS:528:DC%2BC3sXhslCgs7o%3D, PID: 23375248
    • Danesi R, Boni JP, Ravaud A. Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: pharmacokinetic considerations and clinical implications. Cancer Treat Rev. 2013;39:784–92.
    • (2013) Cancer Treat Rev , vol.39 , pp. 784-792
    • Danesi, R.1    Boni, J.P.2    Ravaud, A.3
  • 63
    • 57349169258 scopus 로고    scopus 로고
    • Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
    • COI: 1:CAS:528:DC%2BD1MXhtVKrsL8%3D, PID: 19029811
    • Fulco M, Sartorelli V. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle. 2008;7:3669–79.
    • (2008) Cell Cycle , vol.7 , pp. 3669-3679
    • Fulco, M.1    Sartorelli, V.2
  • 64
    • 10644282295 scopus 로고    scopus 로고
    • The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
    • COI: 1:CAS:528:DC%2BD2MXhtFagtQ%3D%3D, PID: 15574588
    • Apfeld J, O’Connor G, McDonagh T, DiStefano PS, Curtis R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 2004;18:3004–9.
    • (2004) Genes Dev , vol.18 , pp. 3004-3009
    • Apfeld, J.1    O’Connor, G.2    McDonagh, T.3    DiStefano, P.S.4    Curtis, R.5
  • 65
    • 84872137308 scopus 로고    scopus 로고
    • Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies
    • COI: 1:CAS:528:DC%2BC3sXmvFSmtQ%3D%3D, PID: 23312286
    • Stenesen D, Suh JM, Seo J, Yu K, Lee KS, Kim JS, et al. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab. 2013;17:101–12.
    • (2013) Cell Metab , vol.17 , pp. 101-112
    • Stenesen, D.1    Suh, J.M.2    Seo, J.3    Yu, K.4    Lee, K.S.5    Kim, J.S.6
  • 66
    • 79951952916 scopus 로고    scopus 로고
    • A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila
    • COI: 1:CAS:528:DC%2BC3MXisFylsb8%3D, PID: 21281604
    • Funakoshi M, Tsuda M, Muramatsu K, Hatsuda H, Morishita S, Aigaki T. A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila. Biochem Biophys Res Commun. 2011;405:667–72.
    • (2011) Biochem Biophys Res Commun , vol.405 , pp. 667-672
    • Funakoshi, M.1    Tsuda, M.2    Muramatsu, K.3    Hatsuda, H.4    Morishita, S.5    Aigaki, T.6
  • 67
    • 79951787452 scopus 로고    scopus 로고
    • Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
    • COI: 1:CAS:528:DC%2BC3MXitVCksr0%3D, PID: 21331044
    • Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, et al. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 2011;470:404–8.
    • (2011) Nature , vol.470 , pp. 404-408
    • Mair, W.1    Morantte, I.2    Rodrigues, A.P.3    Manning, G.4    Montminy, M.5    Shaw, R.J.6
  • 68
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • COI: 1:CAS:528:DC%2BD1MXks1SrsLY%3D, PID: 19239417
    • Greer EL, Brunet A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell. 2009;8:113–27.
    • (2009) Aging Cell , vol.8 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 69
    • 84855182851 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
    • COI: 1:CAS:528:DC%2BC38Xjs1Cqtb0%3D, PID: 22186033
    • Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev. 2012;11:230–41.
    • (2012) Ageing Res Rev , vol.11 , pp. 230-241
    • Salminen, A.1    Kaarniranta, K.2
  • 70
    • 33744514139 scopus 로고    scopus 로고
    • Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
    • COI: 1:CAS:528:DC%2BD28Xmt1eku70%3D, PID: 16753576
    • Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 2006;3:403–16.
    • (2006) Cell Metab , vol.3 , pp. 403-416
    • Cool, B.1    Zinker, B.2    Chiou, W.3    Kifle, L.4    Cao, N.5    Perham, M.6
  • 71
    • 84861222690 scopus 로고    scopus 로고
    • The ancient drug salicylate directly activates AMP-activated protein kinase
    • COI: 1:CAS:528:DC%2BC38XmvFensLc%3D, PID: 22517326, This paper demonstrated that salicylate, the major metabolite of aspirin, binds to AMPKβ1 and causes its allosteric activation to low plasma fatty acids in vivo in mice
    • Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 2012;336:918–22. This paper demonstrated that salicylate, the major metabolite of aspirin, binds to AMPKβ1 and causes its allosteric activation to low plasma fatty acids in vivo in mice.
    • (2012) Science , vol.336 , pp. 918-922
    • Hawley, S.A.1    Fullerton, M.D.2    Ross, F.A.3    Schertzer, J.D.4    Chevtzoff, C.5    Walker, K.J.6
  • 72
    • 84888203586 scopus 로고    scopus 로고
    • Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice
    • COI: 1:CAS:528:DC%2BC3sXhslKqtrnO, PID: 24055643
    • Li YY, Yu LF, Zhang LN, Qiu BY, Su MB, Wu F, et al. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol Appl Pharmacol. 2013;273:325–34.
    • (2013) Toxicol Appl Pharmacol , vol.273 , pp. 325-334
    • Li, Y.Y.1    Yu, L.F.2    Zhang, L.N.3    Qiu, B.Y.4    Su, M.B.5    Wu, F.6
  • 73
    • 84872202268 scopus 로고    scopus 로고
    • Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BC3sXkvVCrsQ%3D%3D, PID: 22866967
    • Ayyadevara S, Bharill P, Dandapat A, Hu C, Khaidakov M, Mitra S, et al. Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Antioxid Redox Signal. 2013;18:481–90.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 481-490
    • Ayyadevara, S.1    Bharill, P.2    Dandapat, A.3    Hu, C.4    Khaidakov, M.5    Mitra, S.6
  • 74
    • 84884211823 scopus 로고    scopus 로고
    • Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
    • COI: 1:CAS:528:DC%2BC38XotVSqs70%3D, PID: 22665053
    • Pierotti MA, Berrino F, Gariboldi M, Melani C, Mogavero A, Negri T, et al. Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects. Oncogene. 2013;32:1475–87.
    • (2013) Oncogene , vol.32 , pp. 1475-1487
    • Pierotti, M.A.1    Berrino, F.2    Gariboldi, M.3    Melani, C.4    Mogavero, A.5    Negri, T.6
  • 75
    • 80052297991 scopus 로고    scopus 로고
    • Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BC3MXlsVGlur4%3D, PID: 21532627
    • Gill RK, Yang SH, Meerzaman D, Mechanic LE, Bowman ED, Jeon HS, et al. Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer. Oncogene. 2011;30:3784–91.
    • (2011) Oncogene , vol.30 , pp. 3784-3791
    • Gill, R.K.1    Yang, S.H.2    Meerzaman, D.3    Mechanic, L.E.4    Bowman, E.D.5    Jeon, H.S.6
  • 77
    • 67650480092 scopus 로고    scopus 로고
    • mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
    • COI: 1:CAS:528:DC%2BD1MXptVWgu78%3D, PID: 19541609
    • Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, et al. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A. 2009;106:11137–42.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 11137-11142
    • Shackelford, D.B.1    Vasquez, D.S.2    Corbeil, J.3    Wu, S.4    Leblanc, M.5    Wu, C.L.6
  • 78
    • 66449117931 scopus 로고    scopus 로고
    • AMP-activated protein kinase promotes human prostate cancer cell growth and survival
    • COI: 1:CAS:528:DC%2BD1MXks1amsb4%3D, PID: 19372545
    • Park HU, Suy S, Danner M, Dailey V, Zhang Y, Li H, et al. AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Mol Cancer Ther. 2009;8:733–41.
    • (2009) Mol Cancer Ther , vol.8 , pp. 733-741
    • Park, H.U.1    Suy, S.2    Danner, M.3    Dailey, V.4    Zhang, Y.5    Li, H.6
  • 79
    • 84861142867 scopus 로고    scopus 로고
    • AMPKalpha modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer
    • COI: 1:CAS:528:DC%2BC38XmvF2ntLg%3D, PID: 22434430
    • Kim YH, Liang H, Liu X, Lee JS, Cho JY, Cheong JH, et al. AMPKalpha modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer. Cancer Res. 2012;72:2512–21.
    • (2012) Cancer Res , vol.72 , pp. 2512-2521
    • Kim, Y.H.1    Liang, H.2    Liu, X.3    Lee, J.S.4    Cho, J.Y.5    Cheong, J.H.6
  • 80
    • 84864942652 scopus 로고    scopus 로고
    • Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications
    • COI: 1:CAS:528:DC%2BC3sXitVWlug%3D%3D, PID: 22897928
    • Li C, Liu VW, Chiu PM, Chan DW, Ngan HY. Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications. BMC Cancer. 2012;12:357.
    • (2012) BMC Cancer , vol.12 , pp. 357
    • Li, C.1    Liu, V.W.2    Chiu, P.M.3    Chan, D.W.4    Ngan, H.Y.5
  • 81
    • 84884177957 scopus 로고    scopus 로고
    • Introduction: sirtuins in aging and diseases
    • COI: 1:CAS:528:DC%2BC2MXktVOit7o%3D, PID: 24014396
    • Guarente L. Introduction: sirtuins in aging and diseases. Methods Mol Biol. 2013;1077:3–10.
    • (2013) Methods Mol Biol , vol.1077 , pp. 3-10
    • Guarente, L.1
  • 82
    • 34249669270 scopus 로고    scopus 로고
    • Sirt1 regulates aging and resistance to oxidative stress in the heart
    • COI: 1:CAS:528:DC%2BD2sXltl2nsbY%3D, PID: 17446436
    • Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res. 2007;100:1512–21.
    • (2007) Circ Res , vol.100 , pp. 1512-1521
    • Alcendor, R.R.1    Gao, S.2    Zhai, P.3    Zablocki, D.4    Holle, E.5    Yu, X.6
  • 83
    • 84880809991 scopus 로고    scopus 로고
    • SIRT1 promotes RGC survival and delays loss of function following optic nerve crush
    • PID: 23821198, COI: 1:CAS:528:DC%2BC3sXhsVagtrrI
    • Zuo L, Khan RS, Lee V, Dine K, Wu W, Shindler KS. SIRT1 promotes RGC survival and delays loss of function following optic nerve crush. Invest Ophthalmol Vis Sci. 2013;54:5097–102.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 5097-5102
    • Zuo, L.1    Khan, R.S.2    Lee, V.3    Dine, K.4    Wu, W.5    Shindler, K.S.6
  • 84
    • 84874238886 scopus 로고    scopus 로고
    • SIRT3 reverses aging-associated degeneration
    • COI: 1:CAS:528:DC%2BC3sXhvFWjurk%3D, PID: 23375372
    • Brown K, Xie S, Qiu X, Mohrin M, Shin J, Liu Y, et al. SIRT3 reverses aging-associated degeneration. Cell Rep. 2013;3:319–27.
    • (2013) Cell Rep , vol.3 , pp. 319-327
    • Brown, K.1    Xie, S.2    Qiu, X.3    Mohrin, M.4    Shin, J.5    Liu, Y.6
  • 85
    • 84891039686 scopus 로고    scopus 로고
    • SIRT3: as simple as it seems?
    • COI: 1:CAS:528:DC%2BC3sXitVSqtLjF, PID: 24192814
    • Lombard DB, Zwaans BM. SIRT3: as simple as it seems? Gerontology. 2014;60:56–64.
    • (2014) Gerontology , vol.60 , pp. 56-64
    • Lombard, D.B.1    Zwaans, B.M.2
  • 86
    • 84858000209 scopus 로고    scopus 로고
    • The sirtuin SIRT6 regulates lifespan in male mice
    • COI: 1:CAS:528:DC%2BC38XislyntbY%3D, PID: 22367546, This publication shows that the overexpression of Sirt6 decreases plasma IGF-1 levels and significantly extends the lifespan of male mice but not female mice
    • Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature. 2012;483:218–21. This publication shows that the overexpression of Sirt6 decreases plasma IGF-1 levels and significantly extends the lifespan of male mice but not female mice.
    • (2012) Nature , vol.483 , pp. 218-221
    • Kanfi, Y.1    Naiman, S.2    Amir, G.3    Peshti, V.4    Zinman, G.5    Nahum, L.6
  • 87
    • 31044445366 scopus 로고    scopus 로고
    • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    • COI: 1:CAS:528:DC%2BD28Xht1KktLc%3D, PID: 16439206
    • Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006;124:315–29.
    • (2006) Cell , vol.124 , pp. 315-329
    • Mostoslavsky, R.1    Chua, K.F.2    Lombard, D.B.3    Pang, W.W.4    Fischer, M.R.5    Gellon, L.6
  • 88
    • 84869201195 scopus 로고    scopus 로고
    • The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
    • COI: 1:CAS:528:DC%2BC38XhsFeqs7zL, PID: 23086477
    • Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, et al. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med. 2012;18:1643–50.
    • (2012) Nat Med , vol.18 , pp. 1643-1650
    • Sundaresan, N.R.1    Vasudevan, P.2    Zhong, L.3    Kim, G.4    Samant, S.5    Parekh, V.6
  • 89
    • 84861852370 scopus 로고    scopus 로고
    • Are sirtuins viable targets for improving healthspan and lifespan?
    • COI: 1:CAS:528:DC%2BC38XnslKrsLo%3D, PID: 22653216
    • Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R. Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov. 2012;11:443–61.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 443-461
    • Baur, J.A.1    Ungvari, Z.2    Minor, R.K.3    Le Couteur, D.G.4    de Cabo, R.5
  • 90
    • 84889598061 scopus 로고    scopus 로고
    • Sirtuins and cancer: new insights and cell signaling
    • PID: 24299209, COI: 1:CAS:528:DC%2BC3sXhvVyqt7%2FI
    • de Oliveira MV, Andrade JM, Paraíso AF, Santos SH. Sirtuins and cancer: new insights and cell signaling. Cancer Invest. 2013;31:645–53.
    • (2013) Cancer Invest , vol.31 , pp. 645-653
    • de Oliveira, M.V.1    Andrade, J.M.2    Paraíso, A.F.3    Santos, S.H.4
  • 91
    • 0041829415 scopus 로고    scopus 로고
    • Proteomics based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene
    • COI: 1:CAS:528:DC%2BD3sXntVGmsbc%3D, PID: 12963026
    • Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H, et al. Proteomics based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem Biophys Res Commun. 2003;309:558–66.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 558-566
    • Hiratsuka, M.1    Inoue, T.2    Toda, T.3    Kimura, N.4    Shirayoshi, Y.5    Kamitani, H.6
  • 92
    • 84878721346 scopus 로고    scopus 로고
    • Altered expression of SIRT gene family in head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC3sXos1ylur8%3D, PID: 23475622
    • Lai CC, Lin PM, Lin SF, Hsu CH, Lin HC, Hu ML, et al. Altered expression of SIRT gene family in head and neck squamous cell carcinoma. Tumour Biol. 2013;34:1847–54.
    • (2013) Tumour Biol , vol.34 , pp. 1847-1854
    • Lai, C.C.1    Lin, P.M.2    Lin, S.F.3    Hsu, C.H.4    Lin, H.C.5    Hu, M.L.6
  • 93
    • 84876523738 scopus 로고    scopus 로고
    • Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal adenocarcinoma
    • PID: 23509313
    • Ong CA, Shapiro J, Nason KS, Davison JM, Liu X, Ross-Innes C, et al. Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal adenocarcinoma. J Clin Oncol. 2013;31:1576–82.
    • (2013) J Clin Oncol , vol.31 , pp. 1576-1582
    • Ong, C.A.1    Shapiro, J.2    Nason, K.S.3    Davison, J.M.4    Liu, X.5    Ross-Innes, C.6
  • 94
    • 84891828748 scopus 로고    scopus 로고
    • SIRT2: tumour suppressor or tumour promoter in operable breast cancer?
    • COI: 1:CAS:528:DC%2BC3sXhslSlt77O, PID: 24183459
    • McGlynn LM, Zino S, MacDonald AI, Curle J, Reilly JE, Mohammed ZM, et al. SIRT2: tumour suppressor or tumour promoter in operable breast cancer? Eur J Cancer. 2014;50:290–301.
    • (2014) Eur J Cancer , vol.50 , pp. 290-301
    • McGlynn, L.M.1    Zino, S.2    MacDonald, A.I.3    Curle, J.4    Reilly, J.E.5    Mohammed, Z.M.6
  • 95
    • 80054769188 scopus 로고    scopus 로고
    • SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
    • COI: 1:CAS:528:DC%2BC3MXhtlKrtrbL, PID: 22014574
    • Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, et al. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell. 2011;20:487–99.
    • (2011) Cancer Cell , vol.20 , pp. 487-499
    • Kim, H.S.1    Vassilopoulos, A.2    Wang, R.H.3    Lahusen, T.4    Xiao, Z.5    Xu, X.6
  • 96
    • 84865576222 scopus 로고    scopus 로고
    • Metabolic regulation by SIRT3: implications for tumorigenesis
    • COI: 1:CAS:528:DC%2BC38XhtlaisLbI, PID: 22749020
    • Finley LW, Haigis MC. Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med. 2012;18:516–23.
    • (2012) Trends Mol Med , vol.18 , pp. 516-523
    • Finley, L.W.1    Haigis, M.C.2
  • 97
    • 74049094817 scopus 로고    scopus 로고
    • SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
    • COI: 1:CAS:528:DC%2BC3cXkvFKgs7s%3D, PID: 20129246
    • Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 2010;17:41–52.
    • (2010) Cancer Cell , vol.17 , pp. 41-52
    • Kim, H.S.1    Patel, K.2    Muldoon-Jacobs, K.3    Bisht, K.S.4    Aykin-Burns, N.5    Pennington, J.D.6
  • 98
    • 84876359638 scopus 로고    scopus 로고
    • SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
    • COI: 1:CAS:528:DC%2BC3sXlsFegu7c%3D, PID: 23562301
    • Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013;23:450–63.
    • (2013) Cancer Cell , vol.23 , pp. 450-463
    • Jeong, S.M.1    Xiao, C.2    Finley, L.W.3    Lahusen, T.4    Souza, A.L.5    Pierce, K.6
  • 99
    • 84870874690 scopus 로고    scopus 로고
    • The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
    • PID: 23217706, COI: 1:CAS:528:DC%2BC38XhvVaisr3J
    • Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012;151:1185–99.
    • (2012) Cell , vol.151 , pp. 1185-1199
    • Sebastián, C.1    Zwaans, B.M.2    Silberman, D.M.3    Gymrek, M.4    Goren, A.5    Zhong, L.6
  • 100
    • 84883223984 scopus 로고    scopus 로고
    • Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients
    • COI: 1:CAS:528:DC%2BC3sXhtlOkt7rO, PID: 23526469
    • Marquardt JU, Fischer K, Baus K, Kashyap A, Ma S, Krupp M, et al. Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology. 2013;58:1054–64.
    • (2013) Hepatology , vol.58 , pp. 1054-1064
    • Marquardt, J.U.1    Fischer, K.2    Baus, K.3    Kashyap, A.4    Ma, S.5    Krupp, M.6
  • 101
    • 84870363221 scopus 로고    scopus 로고
    • +-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses
    • COI: 1:CAS:528:DC%2BC38XhslGjs7nN, PID: 23086953
    • +-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J Biol Chem. 2012;287:40924–37.
    • (2012) J Biol Chem , vol.287 , pp. 40924-40937
    • Bauer, I.1    Grozio, A.2    Lasigliè, D.3    Basile, G.4    Sturla, L.5    Magnone, M.6
  • 102
    • 84873736861 scopus 로고    scopus 로고
    • The histone deacetylase SIRT2 stabilizes Myc oncoproteins
    • COI: 1:CAS:528:DC%2BC3sXis1Cjurg%3D, PID: 23175188
    • Liu PY, Xu N, Malyukova A, Scarlett CJ, Sun YT, Zhang XD, et al. The histone deacetylase SIRT2 stabilizes Myc oncoproteins. Cell Death Differ. 2013;20:503–14.
    • (2013) Cell Death Differ , vol.20 , pp. 503-514
    • Liu, P.Y.1    Xu, N.2    Malyukova, A.3    Scarlett, C.J.4    Sun, Y.T.5    Zhang, X.D.6
  • 103
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: biological insights and disease relevance
    • COI: 1:CAS:528:DC%2BC3cXivFekt7c%3D, PID: 20078221
    • Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010;5:253–95.
    • (2010) Annu Rev Pathol , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 104
    • 84894174433 scopus 로고    scopus 로고
    • Rotifers as models for the biology of aging
    • COI: 1:CAS:528:DC%2BC2cXks1Sit74%3D, PID: 24791148
    • Snell TW. Rotifers as models for the biology of aging. Int Rev Hydrobiol. 2014;99:84–95.
    • (2014) Int Rev Hydrobiol , vol.99 , pp. 84-95
    • Snell, T.W.1
  • 105
    • 84885355365 scopus 로고    scopus 로고
    • Calorie restriction and sirtuins revisited
    • COI: 1:CAS:528:DC%2BC3sXhs1Ohs7bE, PID: 24115767
    • Guarente L. Calorie restriction and sirtuins revisited. Genes Dev. 2013;27:2072–85.
    • (2013) Genes Dev , vol.27 , pp. 2072-2085
    • Guarente, L.1
  • 106
    • 84897524640 scopus 로고    scopus 로고
    • Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
    • PID: 24691430, COI: 1:CAS:528:DC%2BC2cXns1amtLk%3D
    • Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 2014;5:3557.
    • (2014) Nat Commun , vol.5 , pp. 3557
    • Colman, R.J.1    Beasley, T.M.2    Kemnitz, J.W.3    Johnson, S.C.4    Weindruch, R.5    Anderson, R.M.6
  • 107
    • 2342647592 scopus 로고    scopus 로고
    • Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    • COI: 1:CAS:528:DC%2BD2cXjvVyiu7c%3D, PID: 15096581
    • Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci U S A. 2004;101:6659–63.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6659-6663
    • Fontana, L.1    Meyer, T.E.2    Klein, S.3    Holloszy, J.O.4
  • 108
    • 33645526333 scopus 로고    scopus 로고
    • Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BD28Xjt12itr0%3D, PID: 16595757
    • Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA. 2006;295:1539–48.
    • (2006) JAMA , vol.295 , pp. 1539-1548
    • Heilbronn, L.K.1    de Jonge, L.2    Frisard, M.I.3    DeLany, J.P.4    Larson-Meyer, D.E.5    Rood, J.6
  • 109
    • 33748805784 scopus 로고    scopus 로고
    • One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. Washington School of Medicine CALERIE Team
    • PID: 16960025
    • Racette SB, Weiss EP, Villareal DT, Arif H, Steger-May K, Schechtman KB, et al. One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. Washington School of Medicine CALERIE Team. J Gerontol A Biol Sci Med Sci. 2006;61:943–50.
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 943-950
    • Racette, S.B.1    Weiss, E.P.2    Villareal, D.T.3    Arif, H.4    Steger-May, K.5    Schechtman, K.B.6
  • 110
    • 33845945453 scopus 로고    scopus 로고
    • Hepatic gene expression profile of lipid metabolism in rats: impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression
    • PID: 17167150
    • Higami Y, Tsuchiya T, Chiba T, Yamaza H, Muraoka I, Hirose M, et al. Hepatic gene expression profile of lipid metabolism in rats: impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression. J Gerontol A Biol Sci Med Sci. 2006;61:1099–110.
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 1099-1110
    • Higami, Y.1    Tsuchiya, T.2    Chiba, T.3    Yamaza, H.4    Muraoka, I.5    Hirose, M.6
  • 111
    • 84907352763 scopus 로고    scopus 로고
    • Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice
    • COI: 1:CAS:528:DC%2BC2cXhsVyhsLnE, PID: 25152388
    • Gesing A, Al-Regaiey KA, Bartke A, Masternak MM. Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice. Exp Gerontol. 2014;58:219–29.
    • (2014) Exp Gerontol , vol.58 , pp. 219-229
    • Gesing, A.1    Al-Regaiey, K.A.2    Bartke, A.3    Masternak, M.M.4
  • 112
    • 77953149043 scopus 로고    scopus 로고
    • Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans)
    • COI: 1:CAS:528:DC%2BC3cXpt1Cju7o%3D, PID: 20139716
    • Blagosklonny MV. Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans). Cell Cycle. 2010;9:683–8.
    • (2010) Cell Cycle , vol.9 , pp. 683-688
    • Blagosklonny, M.V.1
  • 113
    • 84911447491 scopus 로고    scopus 로고
    • Dietary restriction involves NAD(+) -dependent mechanisms and a shift toward oxidative metabolism
    • COI: 1:CAS:528:DC%2BC2cXitVamtbjI, PID: 25257342
    • Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD(+) -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 2014;13:1075–85.
    • (2014) Aging Cell , vol.13 , pp. 1075-1085
    • Moroz, N.1    Carmona, J.J.2    Anderson, E.3    Hart, A.C.4    Sinclair, D.A.5    Blackwell, T.K.6
  • 114
    • 84883448345 scopus 로고    scopus 로고
    • Benefits of short-term dietary restriction in mammals
    • COI: 1:CAS:528:DC%2BC3sXksFCisr0%3D, PID: 23376627
    • Robertson LT, Mitchell JR. Benefits of short-term dietary restriction in mammals. Exp Gerontol. 2013;48:1043–8.
    • (2013) Exp Gerontol , vol.48 , pp. 1043-1048
    • Robertson, L.T.1    Mitchell, J.R.2
  • 115
    • 74049092809 scopus 로고    scopus 로고
    • Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research
    • COI: 1:CAS:528:DC%2BC3cXktlCgtQ%3D%3D, PID: 19969554
    • Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN. Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis. 2010;31:83–9.
    • (2010) Carcinogenesis , vol.31 , pp. 83-89
    • Hursting, S.D.1    Smith, S.M.2    Lashinger, L.M.3    Harvey, A.E.4    Perkins, S.N.5
  • 117
    • 0030727705 scopus 로고    scopus 로고
    • Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice
    • COI: 1:CAS:528:DyaK2sXnt12gtb8%3D, PID: 9354418
    • Dunn SE, Kari FW, French J, Leininger JR, Travlos G, Wilson R, et al. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res. 1997;57:4667–72.
    • (1997) Cancer Res , vol.57 , pp. 4667-4672
    • Dunn, S.E.1    Kari, F.W.2    French, J.3    Leininger, J.R.4    Travlos, G.5    Wilson, R.6
  • 118
    • 84902603273 scopus 로고    scopus 로고
    • Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
    • PID: 24889636, COI: 1:CAS:528:DC%2BC2cXptlKrtL0%3D
    • De Haes W, Frooninckx L, Van Assche R, Smolders A, Depuydt G, Billen J, et al. Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci U S A. 2014;111:E2501–9.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E2501-E2509
    • De Haes, W.1    Frooninckx, L.2    Van Assche, R.3    Smolders, A.4    Depuydt, G.5    Billen, J.6
  • 119
    • 84875738351 scopus 로고    scopus 로고
    • Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
    • COI: 1:CAS:528:DC%2BC3sXltVeru7o%3D, PID: 23540700
    • Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell. 2013;153:228–39.
    • (2013) Cell , vol.153 , pp. 228-239
    • Cabreiro, F.1    Au, C.2    Leung, K.Y.3    Vergara-Irigaray, N.4    Cochemé, H.M.5    Noori, T.6
  • 121
    • 34548095002 scopus 로고    scopus 로고
    • Metformin therapy in a transgenic mouse model of Huntington’s disease
    • COI: 1:CAS:528:DC%2BD28Xht1KgurrE, PID: 17110029
    • Ma TC, Buescher JL, Oatis B, Funk JA, Nash AJ, Carrier RL, et al. Metformin therapy in a transgenic mouse model of Huntington’s disease. Neurosci Lett. 2007;411:98–103.
    • (2007) Neurosci Lett , vol.411 , pp. 98-103
    • Ma, T.C.1    Buescher, J.L.2    Oatis, B.3    Funk, J.A.4    Nash, A.J.5    Carrier, R.L.6
  • 122
    • 33644809525 scopus 로고    scopus 로고
    • Use of microarray biomarkers to identify longevity therapeutics
    • COI: 1:CAS:528:DC%2BD28XislKnsro%3D, PID: 16441842
    • Spindler SR. Use of microarray biomarkers to identify longevity therapeutics. Aging Cell. 2006;5:39–50.
    • (2006) Aging Cell , vol.5 , pp. 39-50
    • Spindler, S.R.1
  • 123
    • 84914165449 scopus 로고    scopus 로고
    • Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
    • COI: 1:CAS:528:DC%2BC2cXhslemtrbF, PID: 25041462
    • Bannister CA, Holden SE, Jenkins-Jones S, Morgan CL, Halcox JP, Schernthaner G, et al. Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls. Diabetes Obes Metab. 2014;16:1165–73.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1165-1173
    • Bannister, C.A.1    Holden, S.E.2    Jenkins-Jones, S.3    Morgan, C.L.4    Halcox, J.P.5    Schernthaner, G.6
  • 126
    • 34547127614 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of breast cancer: a meta-analysis
    • COI: 1:CAS:528:DC%2BD2sXotlequ7w%3D, PID: 17397032
    • Larsson SC, Mantzoros CS, Wolk A. Diabetes mellitus and risk of breast cancer: a meta-analysis. Int J Cancer. 2007;121:856–62.
    • (2007) Int J Cancer , vol.121 , pp. 856-862
    • Larsson, S.C.1    Mantzoros, C.S.2    Wolk, A.3
  • 127
    • 77955511122 scopus 로고    scopus 로고
    • Cancer and diabetes: are we ready for prime time?
    • COI: 1:STN:280:DC%2BC3crovFKisg%3D%3D, PID: 20549181
    • Smith U, Gale EM. Cancer and diabetes: are we ready for prime time? Diabetologia. 2010;53:1541–4.
    • (2010) Diabetologia , vol.53 , pp. 1541-1544
    • Smith, U.1    Gale, E.M.2
  • 128
    • 3142729250 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of prostate cancer: a meta-analysis
    • COI: 1:STN:280:DC%2BD2czhvVCksg%3D%3D, PID: 15164171
    • Bonovas S, Filioussi K, Tsantes A. Diabetes mellitus and risk of prostate cancer: a meta-analysis. Diabetologia. 2004;47:1071–8.
    • (2004) Diabetologia , vol.47 , pp. 1071-1078
    • Bonovas, S.1    Filioussi, K.2    Tsantes, A.3
  • 129
    • 84859076050 scopus 로고    scopus 로고
    • Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population‐based follow‐up study
    • COI: 1:CAS:528:DC%2BC38XitFWis7g%3D, PID: 22100960, This large pharmaco-epidemiological study analyzed drug dispensing records from community pharmacies of 2.5 million individuals in the Netherlands. It shows that metformin use is associated with a lower risk of cancer in general (hazard ratio 0.90 [95% CI 0.88-0.91]) compared with use of sulfonylurea derivatives
    • Ruiter R, Visser LE, van Herk‐Sukel MP, Coebergh JW, Haak HR, Geelhoed‐Duijvestijn PH, et al. Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population‐based follow‐up study. Diabetes Care. 2012;35:119–24. This large pharmaco-epidemiological study analyzed drug dispensing records from community pharmacies of 2.5 million individuals in the Netherlands. It shows that metformin use is associated with a lower risk of cancer in general (hazard ratio 0.90 [95% CI 0.88-0.91]) compared with use of sulfonylurea derivatives.
    • (2012) Diabetes Care , vol.35 , pp. 119-124
    • Ruiter, R.1    Visser, L.E.2    van Herk‐Sukel, M.P.3    Coebergh, J.W.4    Haak, H.R.5    Geelhoed‐Duijvestijn, P.H.6
  • 130
    • 84861576077 scopus 로고    scopus 로고
    • The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus
    • COI: 1:CAS:528:DC%2BC38XnsFOqt7o%3D, PID: 21913184
    • Lee JH, Kim TI, Jeon SM, Hong SP, Cheon JH, Kim WH. The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus. Int J Cancer. 2012;131:752–9.
    • (2012) Int J Cancer , vol.131 , pp. 752-759
    • Lee, J.H.1    Kim, T.I.2    Jeon, S.M.3    Hong, S.P.4    Cheon, J.H.5    Kim, W.H.6
  • 131
    • 84255169908 scopus 로고    scopus 로고
    • Relationship of Type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity
    • PID: 22183212
    • Romero IL, McCormick A, McEwen KA, Park S, Karrison T, Yamada SD, et al. Relationship of Type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity. Obstet Gynecol. 2012;119:61–7.
    • (2012) Obstet Gynecol , vol.119 , pp. 61-67
    • Romero, I.L.1    McCormick, A.2    McEwen, K.A.3    Park, S.4    Karrison, T.5    Yamada, S.D.6
  • 132
    • 84857372409 scopus 로고    scopus 로고
    • Effect of metformin on survival outcomes in diabetic patients with triple receptor negative breast cancer
    • COI: 1:CAS:528:DC%2BC38XisVyhsrg%3D, PID: 21800293
    • Bayraktar S, Hernadez‐Aya LF, Lei X, Meric‐Bernstam F, Litton JK, Hsu L, et al. Effect of metformin on survival outcomes in diabetic patients with triple receptor negative breast cancer. Cancer. 2012;118:1202–11.
    • (2012) Cancer , vol.118 , pp. 1202-1211
    • Bayraktar, S.1    Hernadez‐Aya, L.F.2    Lei, X.3    Meric‐Bernstam, F.4    Litton, J.K.5    Hsu, L.6
  • 133
    • 78149357382 scopus 로고    scopus 로고
    • Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin
    • PID: 20627287
    • Patel T, Kirby W, Hruby G, Benson MC, McKiernan JM, Badani K. Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin. Urology. 2010;76:1240–4.
    • (2010) Urology , vol.76 , pp. 1240-1244
    • Patel, T.1    Kirby, W.2    Hruby, G.3    Benson, M.C.4    McKiernan, J.M.5    Badani, K.6
  • 134
    • 85017634767 scopus 로고    scopus 로고
    • Accessed on December 7, 2014
    • www.ClinicalTrials.gov Accessed on December 7, 2014.
  • 135
    • 84861155928 scopus 로고    scopus 로고
    • Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study
    • COI: 1:CAS:528:DC%2BC38XntlWmtbc%3D, PID: 22607767
    • Campagnoli C, Pasanisi P, Abbà C, Ambroggio S, Biglia N, Brucato T, et al. Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study. Clin Breast Cancer. 2012;12:175–82.
    • (2012) Clin Breast Cancer , vol.12 , pp. 175-182
    • Campagnoli, C.1    Pasanisi, P.2    Abbà, C.3    Ambroggio, S.4    Biglia, N.5    Brucato, T.6
  • 136
    • 77956411030 scopus 로고    scopus 로고
    • Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial
    • COI: 1:CAS:528:DC%2BC3cXht1Gju77K
    • Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, et al. Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila). 2010;3:1077–83.
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 1077-1083
    • Hosono, K.1    Endo, H.2    Takahashi, H.3    Sugiyama, M.4    Sakai, E.5    Uchiyama, T.6
  • 137
    • 53849118108 scopus 로고    scopus 로고
    • Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth
    • COI: 1:CAS:528:DC%2BD1cXhtlWitL7M
    • Algire C, Zakikhani M, Blouin MJ, Shuai JH, Pollak M. Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth. Endocrinol Relat Cancer. 2008;15:833–9.
    • (2008) Endocrinol Relat Cancer , vol.15 , pp. 833-839
    • Algire, C.1    Zakikhani, M.2    Blouin, M.J.3    Shuai, J.H.4    Pollak, M.5
  • 138
    • 84893854522 scopus 로고    scopus 로고
    • Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models
    • COI: 1:CAS:528:DC%2BC2cXisVCgu7k%3D
    • Zhu P, Davis M, Blackwelder AJ, Bachman N, Liu B, Edgerton S, et al. Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models. Cancer Prev Res (Phila). 2014;7:199–210.
    • (2014) Cancer Prev Res (Phila) , vol.7 , pp. 199-210
    • Zhu, P.1    Davis, M.2    Blackwelder, A.J.3    Bachman, N.4    Liu, B.5    Edgerton, S.6
  • 140
    • 84907370814 scopus 로고    scopus 로고
    • Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
    • COI: 1:CAS:528:DC%2BC2cXhsVeksb7M, PID: 25017630
    • Bridges HR, Jones AJ, Pollak MN, Hirst J. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J. 2014;462:475–87.
    • (2014) Biochem J , vol.462 , pp. 475-487
    • Bridges, H.R.1    Jones, A.J.2    Pollak, M.N.3    Hirst, J.4
  • 141
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • COI: 1:CAS:528:DC%2BD1MXht1Skt7rN, PID: 19752085
    • Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009;69:7507–11.
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 142
    • 84930537115 scopus 로고    scopus 로고
    • Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation
    • Yan L, Zhou J, Gao Y, Ghazal S, Lu L, Bellone S, et al. Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation. Oncogene. 2014.
    • (2014) Oncogene
    • Yan, L.1    Zhou, J.2    Gao, Y.3    Ghazal, S.4    Lu, L.5    Bellone, S.6
  • 143
    • 84858729494 scopus 로고    scopus 로고
    • Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205
    • PID: 22356767, COI: 1:CAS:528:DC%2BC38XmslWntbY%3D
    • Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, Quirantes R, Segura-Carretero A, Micol V, et al. Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205. Cell Cycle. 2012;11:1235–46.
    • (2012) Cell Cycle , vol.11 , pp. 1235-1246
    • Cufí, S.1    Vazquez-Martin, A.2    Oliveras-Ferraros, C.3    Quirantes, R.4    Segura-Carretero, A.5    Micol, V.6
  • 144
    • 79955642725 scopus 로고    scopus 로고
    • Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response
    • COI: 1:CAS:528:DC%2BC3MXhs1ChtbnN, PID: 21566461
    • Vazquez-Martin A, Oliveras-Ferraros C, Cufí S, Martin-Castillo B, Menendez JA. Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response. Cell Cycle. 2011;10:1499–501.
    • (2011) Cell Cycle , vol.10 , pp. 1499-1501
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Cufí, S.3    Martin-Castillo, B.4    Menendez, J.A.5
  • 146
    • 84903977464 scopus 로고    scopus 로고
    • OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
    • COI: 1:CAS:528:DC%2BC2cXhtVamu7nI, PID: 24961373
    • Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, et al. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014;111:9983–8.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 9983-9988
    • Chen, L.1    Shu, Y.2    Liang, X.3    Chen, E.C.4    Yee, S.W.5    Zur, A.A.6
  • 147
    • 0026651085 scopus 로고
    • Wine, alcohol, platelets, and the French paradox for coronary heart disease
    • COI: 1:STN:280:DyaK383pt1ygtA%3D%3D, PID: 1351198
    • Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992;339:1523–6.
    • (1992) Lancet , vol.339 , pp. 1523-1526
    • Renaud, S.1    de Lorgeril, M.2
  • 148
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • COI: 1:CAS:528:DC%2BD3sXntFCitr4%3D, PID: 12939617
    • Howitz KT, Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425:191–6.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Howitz, K.T.2    Bitterman, K.J.3    Cohen, H.Y.4    Lamming, D.W.5    Lavu, S.6
  • 149
    • 78851470225 scopus 로고    scopus 로고
    • Resveratrol and life extension
    • COI: 1:CAS:528:DC%2BC3MXjsFOlsbs%3D, PID: 21261652
    • Agarwal B, Baur JA. Resveratrol and life extension. Ann N Y Acad Sci. 2011;1215:138–43.
    • (2011) Ann N Y Acad Sci , vol.1215 , pp. 138-143
    • Agarwal, B.1    Baur, J.A.2
  • 150
    • 48349110303 scopus 로고    scopus 로고
    • A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
    • PID: 18523577, COI: 1:CAS:528:DC%2BD1cXnsVOmsb8%3D
    • Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One. 2008;3:e2264.
    • (2008) PLoS One , vol.3
    • Barger, J.L.1    Kayo, T.2    Vann, J.M.3    Arias, E.B.4    Wang, J.5    Hacker, T.A.6
  • 151
    • 31944450272 scopus 로고    scopus 로고
    • Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate
    • COI: 1:CAS:528:DC%2BD28XhtlKltL4%3D, PID: 16461283
    • Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006;16:296–300.
    • (2006) Curr Biol , vol.16 , pp. 296-300
    • Valenzano, D.R.1    Terzibasi, E.2    Genade, T.3    Cattaneo, A.4    Domenici, L.5    Cellerino, A.6
  • 153
    • 84872594486 scopus 로고    scopus 로고
    • The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster
    • COI: 1:CAS:528:DC%2BC3sXptlWltA%3D%3D, PID: 22083438
    • Wang C, Wheeler CT, Alberico T, Sun X, Seeberger J, Laslo M, et al. The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age. 2013;35:69–81.
    • (2013) Age , vol.35 , pp. 69-81
    • Wang, C.1    Wheeler, C.T.2    Alberico, T.3    Sun, X.4    Seeberger, J.5    Laslo, M.6
  • 154
    • 48349144852 scopus 로고    scopus 로고
    • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    • COI: 1:CAS:528:DC%2BD1cXpvVKrs74%3D, PID: 18599363
    • Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008;8:157–68.
    • (2008) Cell Metab , vol.8 , pp. 157-168
    • Pearson, K.J.1    Baur, J.A.2    Lewis, K.N.3    Peshkin, L.4    Price, N.L.5    Labinskyy, N.6
  • 155
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • COI: 1:CAS:528:DC%2BD2sXhs1egsQ%3D%3D, PID: 17112576
    • Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127:1109–22.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3    Meziane, H.4    Lerin, C.5    Daussin, F.6
  • 156
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • COI: 1:CAS:528:DC%2BC38XhvFakurc%3D, PID: 22304913, This article provides a novel mechanism of resveratrol’s action, which resveratrol competitively inhibits cAMP-degrading phosphodiesterases, leading to activate the CamKKβ-AMPK pathway and Sirt1
    • Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012;148:421–33. This article provides a novel mechanism of resveratrol’s action, which resveratrol competitively inhibits cAMP-degrading phosphodiesterases, leading to activate the CamKKβ-AMPK pathway and Sirt1.
    • (2012) Cell , vol.148 , pp. 421-433
    • Park, S.J.1    Ahmad, F.2    Philp, A.3    Baar, K.4    Williams, T.5    Luo, H.6
  • 157
    • 80052910300 scopus 로고    scopus 로고
    • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    • PID: 21385509, COI: 1:CAS:528:DC%2BC3MXps1aktbk%3D
    • Brasnyó P, Molnár GA, Mohás M, Markó L, Laczy B, Cseh J, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011;106:383–9.
    • (2011) Br J Nutr , vol.106 , pp. 383-389
    • Brasnyó, P.1    Molnár, G.A.2    Mohás, M.3    Markó, L.4    Laczy, B.5    Cseh, J.6
  • 158
    • 84865181393 scopus 로고    scopus 로고
    • Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC38XhtFahtL7E, PID: 22901562
    • Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res. 2012;32:537–41.
    • (2012) Nutr Res , vol.32 , pp. 537-541
    • Bhatt, J.K.1    Thomas, S.2    Nanjan, M.J.3
  • 160
    • 34547882115 scopus 로고    scopus 로고
    • Resveratrol: a review of preclinical studies for human cancer prevention
    • COI: 1:CAS:528:DC%2BD2sXhtF2mtL7K, PID: 17306316
    • Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, et al. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol. 2007;224:274–83.
    • (2007) Toxicol Appl Pharmacol , vol.224 , pp. 274-283
    • Athar, M.1    Back, J.H.2    Tang, X.3    Kim, K.H.4    Kopelovich, L.5    Bickers, D.R.6
  • 161
    • 79958099432 scopus 로고    scopus 로고
    • Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer
    • COI: 1:CAS:528:DC%2BD1MXhsVGqurfJ, PID: 21188121
    • Nguyen AV, Martinez M, Stamos MJ, Moyer MP, Planutis K, Hope C, et al. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009;1:25–37.
    • (2009) Cancer Manag Res , vol.1 , pp. 25-37
    • Nguyen, A.V.1    Martinez, M.2    Stamos, M.J.3    Moyer, M.P.4    Planutis, K.5    Hope, C.6
  • 162
    • 9444296057 scopus 로고    scopus 로고
    • High absorption but very low bioavailability of oral resveratrol in humans
    • COI: 1:CAS:528:DC%2BD2cXhtFGitrfE, PID: 15333514
    • Walle T, Hsieh F, DeLegge MH, Oatis Jr JE, Walle UK. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004;32:1377–82.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1377-1382
    • Walle, T.1    Hsieh, F.2    DeLegge, M.H.3    Oatis, J.E.4    Walle, U.K.5
  • 163
    • 2542445157 scopus 로고    scopus 로고
    • Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: mechanistic approach to the design of COX-1 selective agents
    • COI: 1:CAS:528:DC%2BD2cXjvF2rurk%3D, PID: 15020596
    • Szewczuk LM, Forti L, Stivala LA, Penning TM. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004;279:22727–37.
    • (2004) J Biol Chem , vol.279 , pp. 22727-22737
    • Szewczuk, L.M.1    Forti, L.2    Stivala, L.A.3    Penning, T.M.4
  • 164
    • 52649086870 scopus 로고    scopus 로고
    • Resveratrol directly targets COX-2 to inhibit carcinogenesis
    • COI: 1:CAS:528:DC%2BD1cXht1agurjN, PID: 18381589
    • Zykova TA, Zhu F, Zhai X, Ma WY, Ermakova SP, Lee KW, et al. Resveratrol directly targets COX-2 to inhibit carcinogenesis. Mol Carcinog. 2008;47:797–805.
    • (2008) Mol Carcinog , vol.47 , pp. 797-805
    • Zykova, T.A.1    Zhu, F.2    Zhai, X.3    Ma, W.Y.4    Ermakova, S.P.5    Lee, K.W.6
  • 165
    • 84861222690 scopus 로고    scopus 로고
    • The ancient drug salicylate directly activates AMP-activated protein kinase
    • COI: 1:CAS:528:DC%2BC38XmvFensLc%3D, PID: 22517326
    • Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 2012;336:918–22.
    • (2012) Science , vol.336 , pp. 918-922
    • Hawley, S.A.1    Fullerton, M.D.2    Ross, F.A.3    Schertzer, J.D.4    Chevtzoff, C.5    Walker, K.J.6
  • 166
    • 75149133927 scopus 로고    scopus 로고
    • Aspirin is associated with reduced cardiovascular and all-cause mortality in type 2 diabetes in a primary prevention setting: The Fremantle Diabetes study
    • COI: 1:CAS:528:DC%2BC3cXitlaltr8%3D, PID: 19918016
    • Ong G, Davis TM, Davis WA. Aspirin is associated with reduced cardiovascular and all-cause mortality in type 2 diabetes in a primary prevention setting: The Fremantle Diabetes study. Diabetes Care. 2010;33:317–21.
    • (2010) Diabetes Care , vol.33 , pp. 317-321
    • Ong, G.1    Davis, T.M.2    Davis, W.A.3
  • 167
    • 84904193620 scopus 로고    scopus 로고
    • Prevention and treatment of cancer with aspirin: where do we stand?
    • COI: 1:CAS:528:DC%2BC2cXhtFCqt7vJ, PID: 25023355
    • Pasche B, Wang M, Pennison M, Jimenez H. Prevention and treatment of cancer with aspirin: where do we stand? Semin Oncol. 2014;41:397–401.
    • (2014) Semin Oncol , vol.41 , pp. 397-401
    • Pasche, B.1    Wang, M.2    Pennison, M.3    Jimenez, H.4
  • 168
    • 84890038901 scopus 로고    scopus 로고
    • Role of aspirin in cancer prevention
    • COI: 1:CAS:528:DC%2BC3sXhvVWlsrzF, PID: 24114189
    • Thorat MA, Cuzick J. Role of aspirin in cancer prevention. Curr Oncol Rep. 2013;15:533–40.
    • (2013) Curr Oncol Rep , vol.15 , pp. 533-540
    • Thorat, M.A.1    Cuzick, J.2
  • 169
    • 84887370094 scopus 로고    scopus 로고
    • Study design of Aspirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial
    • ASPREE Investigator Group. Study design of Aspirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemp Clin Trials. 2013;36:555–64.
    • (2013) Contemp Clin Trials , vol.36 , pp. 555-564
    • ASPREE Investigator Group1
  • 170
    • 0034961614 scopus 로고    scopus 로고
    • Rhodiola rosea: a possible plant adaptogen
    • COI: 1:STN:280:DC%2BD3MzkslSktA%3D%3D, PID: 11410073
    • Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001;6:293–302.
    • (2001) Altern Med Rev , vol.6 , pp. 293-302
    • Kelly, G.S.1
  • 171
    • 70349305420 scopus 로고    scopus 로고
    • Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea
    • COI: 1:CAS:528:DC%2BD1MXpvFKhtbs%3D, PID: 19634056
    • Schriner SE, Abrahamyan A, Avanessian A, Bussel I, Maler S, Gazarian M, et al. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res. 2009;43:836–43.
    • (2009) Free Radic Res , vol.43 , pp. 836-843
    • Schriner, S.E.1    Abrahamyan, A.2    Avanessian, A.3    Bussel, I.4    Maler, S.5    Gazarian, M.6
  • 173
    • 84855856487 scopus 로고    scopus 로고
    • Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy
    • COI: 1:CAS:528:DC%2BC38XlvVKisQ%3D%3D, PID: 21520297, This study describes that Rhodila rosea, a novel plant adaptogen, has both anti-aging and anti-cancer properties via inhibition of the mTOR pathway
    • Liu Z, Li X, Simoneau AR, Jafari M, Zi X. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. 2012;51:257–67. This study describes that Rhodila rosea, a novel plant adaptogen, has both anti-aging and anti-cancer properties via inhibition of the mTOR pathway.
    • (2012) Mol Carcinog , vol.51 , pp. 257-267
    • Liu, Z.1    Li, X.2    Simoneau, A.R.3    Jafari, M.4    Zi, X.5
  • 174
    • 85017592335 scopus 로고    scopus 로고
    • Rhodiola rosea L. extract, SHR-5, and metformin exhibit potent activity against bladder carcinogenesis in the UPII-mutant Ha-ras transgenic model
    • Liu Z, Li X, Liu S, Xu X, Tian X, Simoneau AR, et al. Rhodiola rosea L. extract, SHR-5, and metformin exhibit potent activity against bladder carcinogenesis in the UPII-mutant Ha-ras transgenic model. Cancer Res. 2012;72(8 Supplement):618.
    • (2012) Cancer Res , vol.72 , pp. 618
    • Liu, Z.1    Li, X.2    Liu, S.3    Xu, X.4    Tian, X.5    Simoneau, A.R.6
  • 176
    • 84897074999 scopus 로고    scopus 로고
    • Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress
    • COI: 1:CAS:528:DC%2BC2cXkvVGju7c%3D, PID: 24294904
    • Li X, Erden O, Li L, Ye Q, Wilson A, Du W. Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress. Antioxid Redox Signal. 2014;20:1853–65.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 1853-1865
    • Li, X.1    Erden, O.2    Li, L.3    Ye, Q.4    Wilson, A.5    Du, W.6
  • 177
    • 84857054909 scopus 로고    scopus 로고
    • Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells
    • COI: 1:CAS:528:DC%2BC38XitlGisb4%3D, PID: 21978886
    • Sun C, Wang Z, Zheng Q, Zhang H. Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells. Phytomedicine. 2012;19:355–63.
    • (2012) Phytomedicine , vol.19 , pp. 355-363
    • Sun, C.1    Wang, Z.2    Zheng, Q.3    Zhang, H.4
  • 178
    • 84899693464 scopus 로고    scopus 로고
    • Effects of salidroside on glioma formation and growth inhibition together with improvement of tumor microenvironment
    • COI: 1:CAS:528:DC%2BC2cXntVWmsL8%3D, PID: 24255575
    • Zhang Y, Yao Y, Wang H, Guo Y, Zhang H, Chen L. Effects of salidroside on glioma formation and growth inhibition together with improvement of tumor microenvironment. Chin J Cancer Res. 2013;25:520–6.
    • (2013) Chin J Cancer Res , vol.25 , pp. 520-526
    • Zhang, Y.1    Yao, Y.2    Wang, H.3    Guo, Y.4    Zhang, H.5    Chen, L.6
  • 179
    • 77950631233 scopus 로고    scopus 로고
    • Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients
    • COI: 1:CAS:528:DC%2BC3cXksValtL4%3D, PID: 20374035
    • Loo WT, Jin LJ, Chow LW, Cheung MN, Wang M. Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients. Expert Opin Investig Drugs. 2010;19 Suppl 1:S91–100.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. S91-S100
    • Loo, W.T.1    Jin, L.J.2    Chow, L.W.3    Cheung, M.N.4    Wang, M.5
  • 180
    • 78650799280 scopus 로고    scopus 로고
    • Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes
    • COI: 1:CAS:528:DC%2BC3cXpvVCrsLY%3D, PID: 20622262
    • Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, et al. Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging. 2010;2:393–414.
    • (2010) Aging , vol.2 , pp. 393-414
    • Goldberg, A.A.1    Richard, V.R.2    Kyryakov, P.3    Bourque, S.D.4    Beach, A.5    Burstein, M.T.6
  • 181
    • 84893666025 scopus 로고    scopus 로고
    • A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology
    • COI: 1:CAS:528:DC%2BC2cXht1Kqt7fF, PID: 24563847, This article revealed a novel mechanism for delaying aging in yeast by lithocholic bile acid. It shows that lithocholic bile acid interacts with mitochondrial membranes to remodel mitochondrial phospholipid dynamics and change redox process
    • Burstein MT, Titorenko VI. A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology. Redox Biol. 2014;2:305–7. This article revealed a novel mechanism for delaying aging in yeast by lithocholic bile acid. It shows that lithocholic bile acid interacts with mitochondrial membranes to remodel mitochondrial phospholipid dynamics and change redox process.
    • (2014) Redox Biol , vol.2 , pp. 305-307
    • Burstein, M.T.1    Titorenko, V.I.2
  • 182
    • 37849022070 scopus 로고    scopus 로고
    • Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids
    • COI: 1:CAS:528:DC%2BD2sXht1arsLfI, PID: 17963371
    • Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, et al. Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. J Med Chem. 2007;50:6048–58.
    • (2007) J Med Chem , vol.50 , pp. 6048-6058
    • Katona, B.W.1    Cummins, C.L.2    Ferguson, A.D.3    Li, T.4    Schmidt, D.R.5    Mangelsdorf, D.J.6
  • 183
    • 84885117753 scopus 로고    scopus 로고
    • Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells
    • PID: 23940835, COI: 1:CAS:528:DC%2BC2cXlsVemt78%3D
    • Goldberg AA, Titorenko VI, Beach A, Sanderson JT. Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells. Peer J. 2013;1:e122.
    • (2013) Peer J , vol.1
    • Goldberg, A.A.1    Titorenko, V.I.2    Beach, A.3    Sanderson, J.T.4
  • 184
    • 33947098035 scopus 로고    scopus 로고
    • Antiangiogenic and apoptotic properties of a novel amphiphilic folate-heparin-lithocholate derivative having cellular internality for cancer therapy
    • COI: 1:CAS:528:DC%2BD2sXivVSgsL4%3D, PID: 17318418
    • Yu MK, Lee DY, Kim YS, Park K, Park SA, Son DH, et al. Antiangiogenic and apoptotic properties of a novel amphiphilic folate-heparin-lithocholate derivative having cellular internality for cancer therapy. Pharm Res. 2007;24:705–14.
    • (2007) Pharm Res , vol.24 , pp. 705-714
    • Yu, M.K.1    Lee, D.Y.2    Kim, Y.S.3    Park, K.4    Park, S.A.5    Son, D.H.6
  • 185
    • 0034062728 scopus 로고    scopus 로고
    • The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a colon carcinogen
    • COI: 1:CAS:528:DC%2BD3cXjsFyhtL8%3D, PID: 10783324
    • Kozoni V, Tsioulias G, Shiff S, Rigas B. The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a colon carcinogen. Carcinogenesis. 2000;21:999–1005.
    • (2000) Carcinogenesis , vol.21 , pp. 999-1005
    • Kozoni, V.1    Tsioulias, G.2    Shiff, S.3    Rigas, B.4
  • 186
    • 21344466302 scopus 로고    scopus 로고
    • [No authors listed] L-theanine. Monograph. Altern Med Rev. 2005; 10: 136–8.
    • (2005) Monograph. Altern Med Rev , vol.10 , pp. 136-138
  • 187
    • 84865265863 scopus 로고    scopus 로고
    • Theanine extends lifespan of adult Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BC38Xht1amu77F, PID: 22422488
    • Zarse K, Jabin S, Ristow ML. Theanine extends lifespan of adult Caenorhabditis elegans. Eur J Nutr. 2012;51:765–8.
    • (2012) Eur J Nutr , vol.51 , pp. 765-768
    • Zarse, K.1    Jabin, S.2    Ristow, M.L.3
  • 188
    • 84907983217 scopus 로고    scopus 로고
    • Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives
    • PID: 25138052
    • Zhang G, Ye X, Ji D, Zhang H, Sun F, Shang C, et al. Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives. Oncotarget. 2014;5:8528–43.
    • (2014) Oncotarget , vol.5 , pp. 8528-8543
    • Zhang, G.1    Ye, X.2    Ji, D.3    Zhang, H.4    Sun, F.5    Shang, C.6
  • 189
    • 84926640833 scopus 로고    scopus 로고
    • Suppression of proliferation and migration in highly-metastatic lung cancer cells as well as tumor growth by a new synthesized compound TBrC and its molecular mechanisms of action
    • COI: 1:CAS:528:DC%2BC2cXhvFSnu7fJ, PID: 24132498
    • Ji D, Wang Y, Zhang H, Chen L, Liu X, Sun F, et al. Suppression of proliferation and migration in highly-metastatic lung cancer cells as well as tumor growth by a new synthesized compound TBrC and its molecular mechanisms of action. Cytotechnology. 2014;66:899–911.
    • (2014) Cytotechnology , vol.66 , pp. 899-911
    • Ji, D.1    Wang, Y.2    Zhang, H.3    Chen, L.4    Liu, X.5    Sun, F.6
  • 190
    • 0344823727 scopus 로고    scopus 로고
    • Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents
    • COI: 1:CAS:528:DC%2BD3sXpt1ers7c%3D, PID: 14643924
    • Sugiyama T, Sadzuka Y. Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents. Biochim Biophys Acta. 2003;1653:47–59.
    • (2003) Biochim Biophys Acta , vol.1653 , pp. 47-59
    • Sugiyama, T.1    Sadzuka, Y.2
  • 191
    • 3242888593 scopus 로고    scopus 로고
    • Theanine, a specific glutamate derivative in green tea, reduces traverse reactions of doxorubicin by changing the glutathione level
    • COI: 1:CAS:528:DC%2BD2cXlvFyqtLc%3D, PID: 15279898
    • Sugiyama T, Sadzuka Y. Theanine, a specific glutamate derivative in green tea, reduces traverse reactions of doxorubicin by changing the glutathione level. Cancer Lett. 2004;212:177–84.
    • (2004) Cancer Lett , vol.212 , pp. 177-184
    • Sugiyama, T.1    Sadzuka, Y.2
  • 192
    • 84904544431 scopus 로고    scopus 로고
    • Comparative genetics of longevity and cancer: insights from long-lived rodents
    • COI: 1:CAS:528:DC%2BC2cXhtVOisbzN, PID: 24981598
    • Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J. Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet. 2014;15:531–40.
    • (2014) Nat Rev Genet , vol.15 , pp. 531-540
    • Gorbunova, V.1    Seluanov, A.2    Zhang, Z.3    Gladyshev, V.N.4    Vijg, J.5
  • 193
    • 14944354861 scopus 로고    scopus 로고
    • Aging, longevity, inflammation, and cancer
    • COI: 1:CAS:528:DC%2BD2MXivFWgtbs%3D, PID: 15915584
    • Caruso C, Lio D, Cavallone L, Franceschi C. Aging, longevity, inflammation, and cancer. Ann N Y Acad Sci. 2004;1028:1–13.
    • (2004) Ann N Y Acad Sci , vol.1028 , pp. 1-13
    • Caruso, C.1    Lio, D.2    Cavallone, L.3    Franceschi, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.