-
1
-
-
84878864199
-
The hallmarks of aging
-
Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. and Kroemer, G. (2013) The hallmarks of aging. Cell 153, 1194-1217.
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
Lopez-Otin, C.1
Blasco, M.A.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
2
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan, D. and Weinberg, R. A. (2011) Hallmarks of cancer: the next generation. Cell 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. and Weinberg, R. A. (2000) The hallmarks of cancer. Cell 100, 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
4
-
-
84878552183
-
The role of DNA damage and repair in aging ugh the prism of Koch-like criteria
-
Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H. and Fraifeld, V. E. (2012) The role of DNA damage and repair in aging ugh the prism of Koch-like criteria. Ageing Res. Rev. 12, 661-684.
-
(2012)
Ageing Res. Rev.
, vol.12
, pp. 661-684
-
-
Moskalev, A.A.1
Shaposhnikov, M.V.2
Plyusnina, E.N.3
Zhavoronkov, A.4
Budovsky, A.5
Yanai, H.6
Fraifeld, V.E.7
-
5
-
-
70349859881
-
DNA damage, aging, and cancer
-
Hoeijmakers, J. H. (2009) DNA damage, aging, and cancer. N. Engl. J. Med. 361, 1475-1485.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.1
-
6
-
-
33749534161
-
Telomeres and telomerase: the path from maize Tetrahymena and yeast to human cancer and aging
-
Blackburn, E. H., Greider, C. W. and Szostak, J. W. (2006) Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat. Med. 12, 1133-1138.
-
(2006)
Nat. Med.
, vol.12
, pp. 1133-1138
-
-
Blackburn, E.H.1
Greider, C.W.2
Szostak, J.W.3
-
7
-
-
34447625911
-
Epigenetics and aging: the targets and the marks
-
Fraga, M. F. and Esteller, M. (2007) Epigenetics and aging: the targets and the marks. Trends Genet. 23, 413-418.
-
(2007)
Trends Genet
, vol.23
, pp. 413-418
-
-
Fraga, M.F.1
Esteller, M.2
-
8
-
-
67650410543
-
Biological and chemical approaches to diseases of proteostasis deficiency
-
Powers, E. T., Morimoto, R. I., Dillin, A., Kelly, J. W. and Balch, W. E. (2009) Biological and chemical approaches to diseases of proteostasis deficiency. Annu. Rev. Biochem. 78, 959-991.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 959-991
-
-
Powers, E.T.1
Morimoto, R.I.2
Dillin, A.3
Kelly, J.W.4
Balch, W.E.5
-
9
-
-
79959354999
-
Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
-
Green, D. R., Galluzzi, L. and Kroemer, G. (2011) Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 333, 1109-1112.
-
(2011)
Science
, vol.333
, pp. 1109-1112
-
-
Green, D.R.1
Galluzzi, L.2
Kroemer, G.3
-
10
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi, J. and d'Adda di Fagagna, F. (2007) Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729-740.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 729-740
-
-
Campisi, J.1
d'Adda di Fagagna, F.2
-
11
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J. and Weissman, I. L. (2007) Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447, 725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
12
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante, M. and Sabatini, D. M. (2012) mTOR signaling in growth control and disease. Cell. 149, 274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
13
-
-
84861885929
-
The critical role of metabolic pathways in aging
-
Barzilai, N., Huffman, D. M., Muzumdar, R. H. and Bartke, A. (2012) The critical role of metabolic pathways in aging. Diabetes 61, 1315-1322.
-
(2012)
Diabetes
, vol.61
, pp. 1315-1322
-
-
Barzilai, N.1
Huffman, D.M.2
Muzumdar, R.H.3
Bartke, A.4
-
14
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai, S., Armstrong, C. M., Kaeberlein, M. and Guarente, L. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
15
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye, R. A. (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273, 793-798.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
16
-
-
84861852370
-
Are sirtuins viable targets for im proving healthspan and lifespan?
-
Baur, J. A., Ungvari, Z., Minor, R. K., Le Couteur, D. G. and de Cabo, R. (2012) Are sirtuins viable targets for im proving healthspan and lifespan? Nat. Rev. Drug Discov. 11, 443-461.
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 443-461
-
-
Baur, J.A.1
Ungvari, Z.2
Minor, R.K.3
Le Couteur, D.G.4
de Cabo, R.5
-
17
-
-
77949887506
-
Mammalian sirtuins: biological insights and disease relevance
-
Haigis, M. C. and Sinclair, D. A. (2010) Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5, 253-295.
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
18
-
-
84880607654
-
Caloric restriction and its mimetics
-
Lee, S. H. and Min, K. J. (2013) Caloric restriction and its mimetics. BMB Rep. 46, 181-187.
-
(2013)
BMB Rep
, vol.46
, pp. 181-187
-
-
Lee, S.H.1
Min, K.J.2
-
19
-
-
81055122671
-
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
-
Du, J., Zhou, Y., Su, X., Yu, J. J., Khan, S., Jiang, H., Kim, J., Woo, J., Kim, J. H., Choi, B. H., He, B., Chen, W., Zhang, S., Cerione, R. A., Auwerx, J., Hao, Q. and Lin, H. (2011) Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334, 806-809.
-
(2011)
Science
, vol.334
, pp. 806-809
-
-
Du, J.1
Zhou, Y.2
Su, X.3
Yu, J.J.4
Khan, S.5
Jiang, H.6
Kim, J.7
Woo, J.8
Kim, J.H.9
Choi, B.H.10
He, B.11
Chen, W.12
Zhang, S.13
Cerione, R.A.14
Auwerx, J.15
Hao, Q.16
Lin, H.17
-
20
-
-
84875881601
-
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
-
Jiang, H., Khan, S., Wang, Y., Charron, G., He, B., Sebastian, C., Du, J., Kim, R., Ge, E., Mostoslavsky, R., Hang, H. C., Hao, Q. and Lin, H. (2013) SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-113.
-
(2013)
Nature
, vol.496
, pp. 110-113
-
-
Jiang, H.1
Khan, S.2
Wang, Y.3
Charron, G.4
He, B.5
Sebastian, C.6
Du, J.7
Kim, R.8
Ge, E.9
Mostoslavsky, R.10
Hang, H.C.11
Hao, Q.12
Lin, H.13
-
22
-
-
84874108083
-
Seven sirtuins for seven deadly diseases of aging
-
Morris, B. J. (2013) Seven sirtuins for seven deadly diseases of aging. Free Radic. Biol. Med. 56, 133-171.
-
(2013)
Free Radic. Biol. Med.
, vol.56
, pp. 133-171
-
-
Morris, B.J.1
-
23
-
-
84865979906
-
Sirtuins, metabolism, and cancer
-
doi: 10.3389/fphar.2012.00022. Epub 2012 Feb 21. 2012;
-
Martinez-Pastor, B. and Mostoslavsky, R. (2012) Sirtuins, metabolism, and cancer. Front Pharmacol. 2012;3:22. doi: 10.3389/fphar.2012.00022. Epub 2012 Feb 21.
-
(2012)
Front Pharmacol
, vol.3
, pp. 22
-
-
Martinez-Pastor, B.1
Mostoslavsky, R.2
-
24
-
-
84874594425
-
The sirtuin family's role in aging and age-associated pathologies
-
Hall, J. A., Dominy, J. E., Lee, Y. and Puigserver, P. (2013) The sirtuin family's role in aging and age-associated pathologies. J. Clin Invest. 123, 973-979.
-
(2013)
J. Clin Invest.
, vol.123
, pp. 973-979
-
-
Hall, J.A.1
Dominy, J.E.2
Lee, Y.3
Puigserver, P.4
-
25
-
-
0037405043
-
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
-
Dryden, S. C., Nahhas, F. A., Nowak, J. E., Goustin, A. S. and Tainsky, M. A. (2003) Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol. Cell Biol. 23, 3173-3185.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 3173-3185
-
-
Dryden, S.C.1
Nahhas, F.A.2
Nowak, J.E.3
Goustin, A.S.4
Tainsky, M.A.5
-
26
-
-
84875309392
-
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation
-
Serrano, L., Martínez-Redondo, P., Marazuela-Duque, A., Vazquez, B. N., Dooley, S. J., Voigt, P., Beck, D. B., Kane-Goldsmith, N., Tong, Q., Rabanal, R. M., Fondevila, D., Muñoz, P., Krüger, M., Tischfield, J. A. and Vaquero, A. (2013) The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev. 27, 639-653.
-
(2013)
Genes Dev
, vol.27
, pp. 639-653
-
-
Serrano, L.1
Martínez-Redondo, P.2
Marazuela-Duque, A.3
Vazquez, B.N.4
Dooley, S.J.5
Voigt, P.6
Beck, D.B.7
Kane-Goldsmith, N.8
Tong, Q.9
Rabanal, R.M.10
Fondevila, D.11
Muñoz, P.12
Krüger, M.13
Tischfield, J.A.14
Vaquero, A.15
-
27
-
-
33751515840
-
Nuclear export modulates the cytoplasmic Sir2 homologue Hst2
-
Wilson, J. M., Le, V. Q., Zimmerman, C., Marmorstein, R. and Pillus, L. (2006) Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep. 7, 1247-1251.
-
(2006)
EMBO Rep
, vol.7
, pp. 1247-1251
-
-
Wilson, J.M.1
Le, V.Q.2
Zimmerman, C.3
Marmorstein, R.4
Pillus, L.5
-
28
-
-
0037291214
-
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
-
North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M. and Verdin, E. (2003) The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell. 11, 437-444.
-
(2003)
Mol. Cell.
, vol.11
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
29
-
-
34547397081
-
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
-
Jing, E., Gesta, S. and Kahn, C. R. (2007) SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 6, 105-114.
-
(2007)
Cell Metab
, vol.6
, pp. 105-114
-
-
Jing, E.1
Gesta, S.2
Kahn, C.R.3
-
30
-
-
34447626095
-
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
-
Wang, F., Nguyen, M., Qin, F. X. and Tong, Q. (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell. 6, 505-514.
-
(2007)
Aging Cell
, vol.6
, pp. 505-514
-
-
Wang, F.1
Nguyen, M.2
Qin, F.X.3
Tong, Q.4
-
31
-
-
39749143163
-
Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53
-
Jin, Y. H., Kim, Y. J., Kim, D. W., Baek, K. H., Kang, B. Y., Yeo, C. Y. and Lee, K. Y. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem. Biophys. Res. Commun. 368, 690-695.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.368
, pp. 690-695
-
-
Jin, Y.H.1
Kim, Y.J.2
Kim, D.W.3
Baek, K.H.4
Kang, B.Y.5
Yeo, C.Y.6
Lee, K.Y.7
-
32
-
-
80054769188
-
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
-
Kim, H. S., Vassilopoulos, A., Wang, R. H., Lahusen, T., Xiao, Z., Xu, X., Li, C., Veenstra, T. D., Li, B., Yu, H., Ji, J., Wang, X. W., Park, S. H., Cha, Y. I., Gius, D. and Deng, C. X. (2011) SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell. 20, 487-499.
-
(2011)
Cancer Cell
, vol.20
, pp. 487-499
-
-
Kim, H.S.1
Vassilopoulos, A.2
Wang, R.H.3
Lahusen, T.4
Xiao, Z.5
Xu, X.6
Li, C.7
Veenstra, T.D.8
Li, B.9
Yu, H.10
Ji, J.11
Wang, X.W.12
Park, S.H.13
Cha, Y.I.14
Gius, D.15
Deng, C.X.16
-
33
-
-
79959906869
-
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
-
Jiang, W., Wang, S., Xiao, M., Lin, Y., Zhou, L., Lei, Q., Xiong, Y., Guan, K. L. and Zhao, S. (2011) Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol. Cell. 43, 33-44.
-
(2011)
Mol. Cell.
, vol.43
, pp. 33-44
-
-
Jiang, W.1
Wang, S.2
Xiao, M.3
Lin, Y.4
Zhou, L.5
Lei, Q.6
Xiong, Y.7
Guan, K.L.8
Zhao, S.9
-
34
-
-
65549113750
-
-
Das, C., Lucia, M. S., Hansen, K. C. and Tyler, J. K. (2009) CBP/p300-mediated acetylation of histone H3 on lysine Nature 459, 113-117.
-
(2009)
CBP/p300-mediated acetylation of histone H3 on lysine Nature
, vol.459
, pp. 113-117
-
-
Das, C.1
Lucia, M.S.2
Hansen, K.C.3
Tyler, J.K.4
-
35
-
-
34547098165
-
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
-
North, B. J. and Verdin, E. (2007) Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J. Biol. Chem. 282, 19546-19555.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 19546-19555
-
-
North, B.J.1
Verdin, E.2
-
36
-
-
40849113090
-
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
-
Pandithage, R., Lilischkis, R., Harting, K., Wolf, A., Jedamzik, B., Lüscher-Firzlaff, J., Vervoorts, J., Lasonder, E., Kremmer, E., Knöll, B. and Lüscher, B. (2008) The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J. Cell Biol. 180, 915-929.
-
(2008)
J. Cell Biol.
, vol.180
, pp. 915-929
-
-
Pandithage, R.1
Lilischkis, R.2
Harting, K.3
Wolf, A.4
Jedamzik, B.5
Lüscher-Firzlaff, J.6
Vervoorts, J.7
Lasonder, E.8
Kremmer, E.9
Knöll, B.10
Lüscher, B.11
-
37
-
-
84874709843
-
SIRT1 and SIRT2: emerging targets in neurodegeneration
-
Donmez, G. and Outeiro, T. F. (2013) SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol. Med. 5, 344-352.
-
(2013)
EMBO Mol. Med.
, vol.5
, pp. 344-352
-
-
Donmez, G.1
Outeiro, T.F.2
-
38
-
-
34547599329
-
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
-
Outeiro, T. F., Kontopoulos, E., Altmann, S. M., Kufareva, I., Strathearn, K. E., Amore, A. M., Volk, C. B., Maxwell, M. M., Rochet, J. C., McLean, P. J., Young, A. B., Abagyan, R., Feany, M. B., Hyman, B. T. and Kazantsev, A. G. (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317, 516-519.
-
(2007)
Science
, vol.317
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
Amore, A.M.6
Volk, C.B.7
Maxwell, M.M.8
Rochet, J.C.9
McLean, P.J.10
Young, A.B.11
Abagyan, R.12
Feany, M.B.13
Hyman, B.T.14
Kazantsev, A.G.15
-
39
-
-
84870999850
-
The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
-
Narayan, N., Lee, I. H., Borenstein, R., Sun, J., Wong, R., Tong, G., Fergusson, M. M., Liu, J., Rovira, I. I., Cheng, H. L., Wang, G., Gucek, M., Lombard, D., Alt, F., Sack, M. N., Murphy, E., Cao, L. and Finkel, T. (2013) The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature 492, 199-204.
-
(2013)
Nature
, vol.492
, pp. 199-204
-
-
Narayan, N.1
Lee, I.H.2
Borenstein, R.3
Sun, J.4
Wong, R.5
Tong, G.6
Fergusson, M.M.7
Liu, J.8
Rovira, I.I.9
Cheng, H.L.10
Wang, G.11
Gucek, M.12
Lombard, D.13
Alt, F.14
Sack, M.N.15
Murphy, E.16
Cao, L.17
Finkel, T.18
-
40
-
-
0041829415
-
Proteomicsbased identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene
-
Hiratsuka, M., Inoue, T., Toda, T., Kimura, N., Shirayoshi, Y., Kamitani, H., Watanabe, T., Ohama, E., Tahimic, C. G., Kurimasa, A. and Oshimura, M. (2003) Proteomicsbased identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. BBRC 309, 558-566.
-
(2003)
BBRC
, vol.309
, pp. 558-566
-
-
Hiratsuka, M.1
Inoue, T.2
Toda, T.3
Kimura, N.4
Shirayoshi, Y.5
Kamitani, H.6
Watanabe, T.7
Ohama, E.8
Tahimic, C.G.9
Kurimasa, A.10
Oshimura, M.11
-
41
-
-
33847053144
-
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress
-
Inoue, T., Hiratsuka, M., Osaki, M., Yamada, H., Kishimoto, I., Yamaguchi, S., Nakano, S., Katoh, M., Ito, H. and Oshimura, M. (2007) SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene. 26, 945-957.
-
(2007)
Oncogene
, vol.26
, pp. 945-957
-
-
Inoue, T.1
Hiratsuka, M.2
Osaki, M.3
Yamada, H.4
Kishimoto, I.5
Yamaguchi, S.6
Nakano, S.7
Katoh, M.8
Ito, H.9
Oshimura, M.10
-
42
-
-
34248151365
-
The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation
-
Inoue, T., Hiratsuka, M., Osaki, M. and Oshimura, M. (2007) The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 6, 1011-1018.
-
(2007)
Cell Cycle
, vol.6
, pp. 1011-1018
-
-
Inoue, T.1
Hiratsuka, M.2
Osaki, M.3
Oshimura, M.4
-
43
-
-
84878721346
-
Altered expression of SIRT gene family in head and neck squamous cell carcinoma
-
Lai, C. C., Lin, P. M., Lin, S. F., Hsu, C. H., Lin, H. C., Hu, M. L., Hsu, C. M. and Yang, M. Y. (2013) Altered expression of SIRT gene family in head and neck squamous cell carcinoma. Tumour Biol. 34, 1847-1854.
-
(2013)
Tumour Biol
, vol.34
, pp. 1847-1854
-
-
Lai, C.C.1
Lin, P.M.2
Lin, S.F.3
Hsu, C.H.4
Lin, H.C.5
Hu, M.L.6
Hsu, C.M.7
Yang, M.Y.8
-
44
-
-
84876523738
-
Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prog nosis for patients with esophageal adenocarcinoma
-
Ong, C. A., Shapiro, J., Nason, K. S., Davison, J. M., Liu, X., Ross-Innes, C., O'Donovan, M., Dinjens, W. N., Biermann, K., Shannon, N., Worster, S., Schulz, L. K., Luketich, J. D., Wijnhoven, B. P., Hardwick, R. H. and Fitzgerald, R. C. (2013) Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prog nosis for patients with esophageal adenocarcinoma. J. Clin. Oncol. 31, 1576-1582.
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 1576-1582
-
-
Ong, C.A.1
Shapiro, J.2
Nason, K.S.3
Davison, J.M.4
Liu, X.5
Ross-Innes, C.6
O'Donovan, M.7
Dinjens, W.N.8
Biermann, K.9
Shannon, N.10
Worster, S.11
Schulz, L.K.12
Luketich, J.D.13
Wijnhoven, B.P.14
Hardwick, R.H.15
Fitzgerald, R.C.16
-
45
-
-
84859447698
-
The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells
-
Dan, L., Klimenkova, O., Klimiankou, M., Klusman, J. H., van den Heuvel-Eibrink, M. M., Reinhardt, D., Welte, K. and Skokowa, J. (2012) The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica. 97, 551-559.
-
(2012)
Haematologica
, vol.97
, pp. 551-559
-
-
Dan, L.1
Klimenkova, O.2
Klimiankou, M.3
Klusman, J.H.4
van den Heuvel-Eibrink, M.M.5
Reinhardt, D.6
Welte, K.7
Skokowa, J.8
-
46
-
-
84873736861
-
The histone deacetylase SIRT2 stabilizes Myc oncoproteins
-
Liu, P. Y., Xu, N., Malyukova, A., Scarlett, C. J., Sun, Y. T., Zhang, X. D., Ling, D., Su, S. P., Nelson, C., Chang, D. K., Koach, J., Tee, A. E., Haber, M., Norris, M. D., Toon, C., Rooman, I., Xue, C., Cheung, B. B., Kumar, S., Marshall, G. M., Biankin, A. V. and Liu, T. (2013) The histone deacetylase SIRT2 stabilizes Myc oncoproteins. Cell Death Differ. 20, 503-514.
-
(2013)
Cell Death Differ
, vol.20
, pp. 503-514
-
-
Liu, P.Y.1
Xu, N.2
Malyukova, A.3
Scarlett, C.J.4
Sun, Y.T.5
Zhang, X.D.6
Ling, D.7
Su, S.P.8
Nelson, C.9
Chang, D.K.10
Koach, J.11
Tee, A.E.12
Haber, M.13
Norris, M.D.14
Toon, C.15
Rooman, I.16
Xue, C.17
Cheung, B.B.18
Kumar, S.19
Marshall, G.M.20
Biankin, A.V.21
Liu, T.22
more..
-
47
-
-
84879081348
-
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling
-
Chen, J., Chan, A. W., To, K. F., Chen, W., Zhang, Z., Ren, J., Song, C., Cheung, Y. S., Lai, P. B., Cheng, S. H., Ng, M. H., Huang, A. and Ko, B. C. (2013) SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling. Hepatology 57, 2287-2298.
-
(2013)
Hepatology
, vol.57
, pp. 2287-2298
-
-
Chen, J.1
Chan, A.W.2
To, K.F.3
Chen, W.4
Zhang, Z.5
Ren, J.6
Song, C.7
Cheung, Y.S.8
Lai, P.B.9
Cheng, S.H.10
Ng, M.H.11
Huang, A.12
Ko, B.C.13
-
48
-
-
84883555139
-
HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS
-
Cancer Res. [Epub ahead of print]
-
Yang, M. H., Laurent, G., Bause, A. S., Spang, R., German, N., Haigis, M. C. and Haigis, K. M. (2013) HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol. Cancer Res. [Epub ahead of print].
-
(2013)
Mol
-
-
Yang, M.H.1
Laurent, G.2
Bause, A.S.3
Spang, R.4
German, N.5
Haigis, M.C.6
Haigis, K.M.7
-
49
-
-
77953287165
-
Mitochondrial sirtuins
-
Huang, J. Y., Hirschey, M. D., Shimazu, T., Ho, L. and Verdin, E. (2010) Mitochondrial sirtuins. Biochim. Biophys. Acta. 1804, 1645-1651.
-
(2010)
Biochim. Biophys. Acta.
, vol.1804
, pp. 1645-1651
-
-
Huang, J.Y.1
Hirschey, M.D.2
Shimazu, T.3
Ho, L.4
Verdin, E.5
-
50
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim, S. C., Sprung, R., Chen, Y., Xu, Y., Ball, H., Pei, J., Cheng, T., Kho, Y., Xiao, H., Xiao, L., Grishin, N. V., White, M., Yang, X. J. and Zhao, Y. (2006) Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell. 23, 607-618.
-
(2006)
Mol. Cell.
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
Cheng, T.7
Kho, Y.8
Xiao, H.9
Xiao, L.10
Grishin, N.V.11
White, M.12
Yang, X.J.13
Zhao, Y.14
-
51
-
-
55749084738
-
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
-
Ahn, B. H., Kim, H. S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C. X. and Finkel, T. (2008) A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl. Acad. Sci. U. S. A. 105, 14447-14452.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
Kim, H.S.2
Song, S.3
Lee, I.H.4
Liu, J.5
Vassilopoulos, A.6
Deng, C.X.7
Finkel, T.8
-
52
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
-
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., Stevens, R. D., Li, Y., Saha, A. K., Ruderman, N. B., Bain, J. R., Newgard, C. B., Farese, R. V. Jr., Alt, F. W., Kahn, C. R. and Verdin, E. (2010) SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464, 121-125.
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
Jing, E.4
Schwer, B.5
Lombard, D.B.6
Grueter, C.A.7
Harris, C.8
Biddinger, S.9
Ilkayeva, O.R.10
Stevens, R.D.11
Li, Y.12
Saha, A.K.13
Ruderman, N.B.14
Bain, J.R.15
Newgard, C.B.16
Farese, R.V.17
Alt Jr., F.W.18
Kahn, C.R.19
Verdin, E.20
more..
-
53
-
-
77955347446
-
Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis
-
Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F. and Chang, Y. (2010) Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One 5, e11707.
-
(2010)
PLoS One
, vol.5
-
-
Kong, X.1
Wang, R.2
Xue, Y.3
Liu, X.4
Zhang, H.5
Chen, Y.6
Fang, F.7
Chang, Y.8
-
54
-
-
74049094817
-
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
-
Kim, H. S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., Vassilopoulos, A., Ozden, O., Park, S. H., Singh, K. K., Abdulkadir, S. A., Spitz, D. R., Deng, C. X. and Gius, D. (2010) SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 17, 41-52.
-
(2010)
Cancer Cell
, vol.17
, pp. 41-52
-
-
Kim, H.S.1
Patel, K.2
Muldoon-Jacobs, K.3
Bisht, K.S.4
Aykin-Burns, N.5
Pennington, J.D.6
van der Meer, R.7
Nguyen, P.8
Savage, J.9
Owens, K.M.10
Vassilopoulos, A.11
Ozden, O.12
Park, S.H.13
Singh, K.K.14
Abdulkadir, S.A.15
Spitz, D.R.16
Deng, C.X.17
Gius, D.18
-
55
-
-
84867594869
-
Mitochondrial protein acetylation regulates metabolism
-
Anderson, K. A. and Hirschey, M. D. (2012) Mitochondrial protein acetylation regulates metabolism. Essays Biochem. 52, 23-35.
-
(2012)
Essays Biochem
, vol.52
, pp. 23-35
-
-
Anderson, K.A.1
Hirschey, M.D.2
-
56
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya, S., Yu, W., Hallows, W. C., Xu, J., Vann, J. M., Leeuwenburgh, C., Tanokura, M., Denu, J. M. and Prolla, T. A. (2010) Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143, 802-812.
-
(2010)
Cell
, vol.143
, pp. 802-812
-
-
Someya, S.1
Yu, W.2
Hallows, W.C.3
Xu, J.4
Vann, J.M.5
Leeuwenburgh, C.6
Tanokura, M.7
Denu, J.M.8
Prolla, T.A.9
-
57
-
-
84872276165
-
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
-
Hebert, A. S., Dittenhafer-Reed, K. E., Yu, W., Bailey, D. J., Selen, E. S., Boersma, M. D., Carson, J. J., Tonelli, M., Balloon, A. J., Higbee, A. J., Westphall, M. S., Pagliarini, D. J., Prolla, T. A., Assadi-Porter, F., Roy, S., Denu, J. M. and Coon, J. J. (2013) Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol. Cell 49, 186-199.
-
(2013)
Mol. Cell
, vol.49
, pp. 186-199
-
-
Hebert, A.S.1
Dittenhafer-Reed, K.E.2
Yu, W.3
Bailey, D.J.4
Selen, E.S.5
Boersma, M.D.6
Carson, J.J.7
Tonelli, M.8
Balloon, A.J.9
Higbee, A.J.10
Westphall, M.S.11
Pagliarini, D.J.12
Prolla, T.A.13
Assadi-Porter, F.14
Roy, S.15
Denu, J.M.16
Coon, J.J.17
-
58
-
-
78650248160
-
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
-
Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S. H., Jiang, H., Kim, H. S., Flynn, C. R., Hill, S., Hayes McDonald, W., Olivier, A. K., Spitz, D. R. and Gius, D. (2010) Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol. Cell 40, 893-904.
-
(2010)
Mol. Cell
, vol.40
, pp. 893-904
-
-
Tao, R.1
Coleman, M.C.2
Pennington, J.D.3
Ozden, O.4
Park, S.H.5
Jiang, H.6
Kim, H.S.7
Flynn, C.R.8
Hill, S.9
Hayes McDonald, W.10
Olivier, A.K.11
Spitz, D.R.12
Gius, D.13
-
59
-
-
79957979314
-
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS
-
Chen, Y., Zhang, J., Lin, Y., Lei, Q., Guan, K. L., Zhao, S. and Xiong, Y. (2011) Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep. 12, 534-541.
-
(2011)
EMBO Rep
, vol.12
, pp. 534-541
-
-
Chen, Y.1
Zhang, J.2
Lin, Y.3
Lei, Q.4
Guan, K.L.5
Zhao, S.6
Xiong, Y.7
-
60
-
-
79952501323
-
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization
-
Finley, L. W., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., Pandolfi, P. P. and Haigis, M. C. (2011) SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell 19, 416-428.
-
(2011)
Cancer Cell
, vol.19
, pp. 416-428
-
-
Finley, L.W.1
Carracedo, A.2
Lee, J.3
Souza, A.4
Egia, A.5
Zhang, J.6
Teruya-Feldstein, J.7
Moreira, P.I.8
Cardoso, S.M.9
Clish, C.B.10
Pandolfi, P.P.11
Haigis, M.C.12
-
61
-
-
84863618431
-
Acetylation-dependent regulation of Skp2 function
-
Inuzuka, H., Gao, D., Finley, L. W., Yang, W., Wan, L., Fukushima, H., Chin, Y. R., Zhai, B., Shaik, S., Lau, A. W., Wang, Z., Gygi, S. P., Nakayama, K., Teruya-Feldstein, J., Toker, A., Haigis, M. C., Pandolfi, P. P. and Wei, W. (2012) Acetylation-dependent regulation of Skp2 function. Cell 50, 179-193.
-
(2012)
Cell
, vol.50
, pp. 179-193
-
-
Inuzuka, H.1
Gao, D.2
Finley, L.W.3
Yang, W.4
Wan, L.5
Fukushima, H.6
Chin, Y.R.7
Zhai, B.8
Shaik, S.9
Lau, A.W.10
Wang, Z.11
Gygi, S.P.12
Nakayama, K.13
Teruya-Feldstein, J.14
Toker, A.15
Haigis, M.C.16
Pandolfi, P.P.17
Wei, W.18
-
62
-
-
84865576222
-
Metabolic regulation by SIRT3: implications for tumorigenesis
-
Finley, L. W. and Haigis, M. C. (2012) Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol. Med. 18, 516-523.
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 516-523
-
-
Finley, L.W.1
Haigis, M.C.2
-
63
-
-
33748316536
-
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
-
Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., Wolberger, C., Prolla, T. A., Weindruch, R., Alt, F. W. and Guarente, L. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126, 941-954.
-
(2006)
Cell
, vol.126
, pp. 941-954
-
-
Haigis, M.C.1
Mostoslavsky, R.2
Haigis, K.M.3
Fahie, K.4
Christodoulou, D.C.5
Murphy, A.J.6
Valenzuela, D.M.7
Yancopoulos, G.D.8
Karow, M.9
Blander, G.10
Wolberger, C.11
Prolla, T.A.12
Weindruch, R.13
Alt, F.W.14
Guarente, L.15
-
64
-
-
84878891625
-
SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase
-
Laurent, G., German, N. J., Saha, A. K., de Boer, V. C., Davies, M., Koves, T. R., Dephoure, N., Fischer, F., Boanca, G., Vaitheesvaran, B., Lovitch, S. B., Sharpe, A. H., Kurland, I. J., Steegborn, C., Gygi, S. P., Muoio, D. M., Ruderman, N. B. and Haigis, M. C. (2013) SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase. Mol. Cell 50, 686-698.
-
(2013)
Mol. Cell
, vol.50
, pp. 686-698
-
-
Laurent, G.1
German, N.J.2
Saha, A.K.3
de Boer, V.C.4
Davies, M.5
Koves, T.R.6
Dephoure, N.7
Fischer, F.8
Boanca, G.9
Vaitheesvaran, B.10
Lovitch, S.B.11
Sharpe, A.H.12
Kurland, I.J.13
Steegborn, C.14
Gygi, S.P.15
Muoio, D.M.16
Ruderman, N.B.17
Haigis, M.C.18
-
65
-
-
77957762687
-
SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells
-
Nasrin, N., Wu, X., Fortier, E., Feng, Y., Bare', O. C., Chen, S., Ren, X., Wu, Z., Streeper, R. S. and Bordone, L. (2010) SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. J. Biol. Chem. 285, 31995-32002.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 31995-32002
-
-
Nasrin, N.1
Wu, X.2
Fortier, E.3
Feng, Y.4
Bare', O.C.5
Chen, S.6
Ren, X.7
Wu, Z.8
Streeper, R.S.9
Bordone, L.10
-
66
-
-
34548627517
-
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
-
Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., de Cabo, R., Sauve, A. A. and Sinclair, D. A. (2007) Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130, 1095-1107.
-
(2007)
Cell
, vol.130
, pp. 1095-1107
-
-
Yang, H.1
Yang, T.2
Baur, J.A.3
Perez, E.4
Matsui, T.5
Carmona, J.J.6
Lamming, D.W.7
Souza-Pinto, N.C.8
Bohr, V.A.9
Rosenzweig, A.10
de Cabo, R.11
Sauve, A.A.12
Sinclair, D.A.13
-
67
-
-
84876359638
-
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
-
Jeong, S. M., Xiao, C., Finley, L. W., Lahusen, T., Souza, A. L., Pierce, K., Li, Y. H., Wang, X., Laurent, G., German, N. J., Xu, X., Li, C., Wang, R. H., Lee, J., Csibi, A., Cerione, R., Blenis, J., Clish, C. B., Kimmelman, A., Deng, C. X. and Haigis, M. C. (2013) SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell 23, 450-463.
-
(2013)
Cancer Cell
, vol.23
, pp. 450-463
-
-
Jeong, S.M.1
Xiao, C.2
Finley, L.W.3
Lahusen, T.4
Souza, A.L.5
Pierce, K.6
Li, Y.H.7
Wang, X.8
Laurent, G.9
German, N.J.10
Xu, X.11
Li, C.12
Wang, R.H.13
Lee, J.14
Csibi, A.15
Cerione, R.16
Blenis, J.17
Clish, C.B.18
Kimmelman, A.19
Deng, C.X.20
Haigis, M.C.21
more..
-
68
-
-
81055122671
-
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
-
Du, J., Zhou, Y., Su, X., Yu, J. J., Khan, S., Jiang, H., Kim, J., Woo, J., Kim, J. H., Choi, B. H., He, B., Chen, W., Zhang, S., Cerione, R. A., Auwerx, J., Hao, Q. and Lin, H. (2011) Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334, 806-809.
-
(2011)
Science
, vol.334
, pp. 806-809
-
-
Du, J.1
Zhou, Y.2
Su, X.3
Yu, J.J.4
Khan, S.5
Jiang, H.6
Kim, J.7
Woo, J.8
Kim, J.H.9
Choi, B.H.10
He, B.11
Chen, W.12
Zhang, S.13
Cerione, R.A.14
Auwerx, J.15
Hao, Q.16
Lin, H.17
-
69
-
-
65249087389
-
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
Nakagawa, T., Lomb, D. J., Haigis, M. C. and Guarente, L. (2009) SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137, 560-570.
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
70
-
-
84880791239
-
SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways
-
Park, J., Chen, Y., Tishkoff, D. X., Peng, C., Tan, M., Dai, L., Xie, Z., Zhang, Y., Zwaans, B. M., Skinner, M. E., Lombard, D. B. and Zhao, Y. (2013) SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Mol. Cell 50, 919-930.
-
(2013)
Mol. Cell
, vol.50
, pp. 919-930
-
-
Park, J.1
Chen, Y.2
Tishkoff, D.X.3
Peng, C.4
Tan, M.5
Dai, L.6
Xie, Z.7
Zhang, Y.8
Zwaans, B.M.9
Skinner, M.E.10
Lombard, D.B.11
Zhao, Y.12
-
71
-
-
84863981612
-
Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging
-
Jia, G., Su, L., Singhal, S. and Liu, X. (2012) Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging. Mol. Cell Biochem. 364, 345-350.
-
(2012)
Mol. Cell Biochem.
, vol.364
, pp. 345-350
-
-
Jia, G.1
Su, L.2
Singhal, S.3
Liu, X.4
-
72
-
-
84875881601
-
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
-
Jiang, H., Khan, S., Wang, Y., Charron, G., He, B., Sebastian, C., Du, J., Kim, R., Ge, E., Mostoslavsky, R., Hang, H. C., Hao, Q. and Lin, H. (2013) SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-113.
-
(2013)
Nature
, vol.496
, pp. 110-113
-
-
Jiang, H.1
Khan, S.2
Wang, Y.3
Charron, G.4
He, B.5
Sebastian, C.6
Du, J.7
Kim, R.8
Ge, E.9
Mostoslavsky, R.10
Hang, H.C.11
Hao, Q.12
Lin, H.13
-
73
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., Mills, K. D., Patel, P., Hsu, J. T., Hong, A. L., Ford, E., Cheng, H. L., Kennedy, C., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hottiger, M. O., Hursting, S., Barrett, J. C., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G. D. and Alt, F. W. (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329.
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
Liu, P.7
Mostoslavsky, G.8
Franco, S.9
Murphy, M.M.10
Mills, K.D.11
Patel, P.12
Hsu, J.T.13
Hong, A.L.14
Ford, E.15
Cheng, H.L.16
Kennedy, C.17
Nunez, N.18
Bronson, R.19
Frendewey, D.20
Auerbach, W.21
Valenzuela, D.22
Karow, M.23
Hottiger, M.O.24
Hursting, S.25
Barrett, J.C.26
Guarente, L.27
Mulligan, R.28
Demple, B.29
Yancopoulos, G.D.30
Alt, F.W.31
more..
-
74
-
-
41349090663
-
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L., Barrett, J. C., Chang, H. Y., Bohr, V. A., Ried, T., Gozani, O. and Chua, K. F. (2008) SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492-496.
-
(2008)
Nature
, vol.452
, pp. 492-496
-
-
Michishita, E.1
McCord, R.A.2
Berber, E.3
Kioi, M.4
Padilla-Nash, H.5
Damian, M.6
Cheung, P.7
Kusumoto, R.8
Kawahara, T.L.9
Barrett, J.C.10
Chang, H.Y.11
Bohr, V.A.12
Ried, T.13
Gozani, O.14
Chua, K.F.15
-
75
-
-
69249229772
-
The sirtuin SIRT6 deacetylates H3K56Ac in vivo to promote genomic stability
-
Yang, B., Zwaans, B. M., Eckersdorff, M. and Lombard, D. B. (2009) The sirtuin SIRT6 deacetylates H3K56Ac in vivo to promote genomic stability. Cell Cycle. 8, 2662-2663.
-
(2009)
Cell Cycle
, vol.8
, pp. 2662-2663
-
-
Yang, B.1
Zwaans, B.M.2
Eckersdorff, M.3
Lombard, D.B.4
-
76
-
-
77956550868
-
Human SIRT6 promotes DNA end resection through CtIP deacetylation
-
Kaidi, A., Weinert, B. T., Choudhary, C. and Jackson, S. P. (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329, 1348-1353.
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
Weinert, B.T.2
Choudhary, C.3
Jackson, S.P.4
-
77
-
-
79959363092
-
SIRT6 promotes DNA repair under stress by activating PARP1
-
Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A. and Gorbunova, V. (2011) SIRT6 promotes DNA repair under stress by activating PARP1. Science 332, 1443-1446.
-
(2011)
Science
, vol.332
, pp. 1443-1446
-
-
Mao, Z.1
Hine, C.2
Tian, X.3
Van Meter, M.4
Au, M.5
Vaidya, A.6
Seluanov, A.7
Gorbunova, V.8
-
78
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
-
Zhong, L., D'Urso, A., Toiber, D., Sebastian, C., Henry, R. E., Vadysirisack, D. D., Guimaraes, A., Marinelli, B., Wikstrom, J. D., Nir, T., Clish, C. B., Vaitheesvaran, B., Iliopoulos, O., Kurland, I., Dor, Y., Weissleder, R., Shirihai, O. S., Ellisen, L. W., Espinosa, J. M. and Mostoslavsky, R. (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140, 280-293
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
D'Urso, A.2
Toiber, D.3
Sebastian, C.4
Henry, R.E.5
Vadysirisack, D.D.6
Guimaraes, A.7
Marinelli, B.8
Wikstrom, J.D.9
Nir, T.10
Clish, C.B.11
Vaitheesvaran, B.12
Iliopoulos, O.13
Kurland, I.14
Dor, Y.15
Weissleder, R.16
Shirihai, O.S.17
Ellisen, L.W.18
Espinosa, J.M.19
Mostoslavsky, R.20
more..
-
79
-
-
84870874690
-
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
-
Sebastián, C., Zwaans, B. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L., Ram, O., Truelove, J., Guimaraes, A. R., Toiber, D., Cosentino, C., Greenson, J. K., MacDonald, A. I., McGlynn, L., Maxwell, F., Edwards, J., Giacosa, S., Guccione, E., Weissleder, R., Bernstein, B. E., Regev, A., Shiels, P. G., Lombard, D. B. and Mostoslavsky, R. (2012) The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 151, 1185-1199.
-
(2012)
Cell
, vol.151
, pp. 1185-1199
-
-
Sebastián, C.1
Zwaans, B.M.2
Silberman, D.M.3
Gymrek, M.4
Goren, A.5
Zhong, L.6
Ram, O.7
Truelove, J.8
Guimaraes, A.R.9
Toiber, D.10
Cosentino, C.11
Greenson, J.K.12
MacDonald, A.I.13
McGlynn, L.14
Maxwell, F.15
Edwards, J.16
Giacosa, S.17
Guccione, E.18
Weissleder, R.19
Bernstein, B.E.20
Regev, A.21
Shiels, P.G.22
Lombard, D.B.23
Mostoslavsky, R.24
more..
-
80
-
-
84869082071
-
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
-
Min, L., Ji, Y., Bakiri, L., Qiu, Z., Cen, J., Chen, X., Chen, L., Scheuch, H., Zheng, H., Qin, L., Zatloukal, K., Hui, L. and Wagner, E. F. (2012) Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat. Cell Biol. 14, 1203-1211.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1203-1211
-
-
Min, L.1
Ji, Y.2
Bakiri, L.3
Qiu, Z.4
Cen, J.5
Chen, X.6
Chen, L.7
Scheuch, H.8
Zheng, H.9
Qin, L.10
Zatloukal, K.11
Hui, L.12
Wagner, E.F.13
-
81
-
-
84871336282
-
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice
-
Xiao, C., Wang, R. H., Lahusen, T. J., Park, O., Bertola, A., Maruyama, T., Reynolds, D., Chen, Q., Xu, X., Young, H. A., Chen, W. J., Gao, B. and Deng, C. X. (2012) Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J. Biol. Chem. 287, 41903-41913.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 41903-41913
-
-
Xiao, C.1
Wang, R.H.2
Lahusen, T.J.3
Park, O.4
Bertola, A.5
Maruyama, T.6
Reynolds, D.7
Chen, Q.8
Xu, X.9
Young, H.A.10
Chen, W.J.11
Gao, B.12
Deng, C.X.13
-
82
-
-
84883223984
-
-
Hepatology doi: 10.1002/hep.26413.[Epub ahead of print]
-
Marquardt, J. U., Fischer, K., Baus, K., Kashyap, A., Ma, S., Krupp, M., Linke, M., Teufel, A., Zechner, U., Strand, D., Thorgeirsson, S. S., Galle, P. R. and Strand, S. (2013) SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients. Hepatology doi: 10.1002/hep.26413. [Epub ahead of print].
-
(2013)
SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients
-
-
Marquardt, J.U.1
Fischer, K.2
Baus, K.3
Kashyap, A.4
Ma, S.5
Krupp, M.6
Linke, M.7
Teufel, A.8
Zechner, U.9
Strand, D.10
Thorgeirsson, S.S.11
Galle, P.R.12
Strand, S.13
-
83
-
-
84870363221
-
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses
-
Bauer, I., Grozio, A., Lasigliè, D., Basile, G., Sturla, L., Magnone, M., Sociali, G., Soncini, D., Caffa, I., Poggi, A., Zoppoli, G., Cea, M., Feldmann, G., Mostoslavsky, R., Ballestrero, A., Patrone, F., Bruzzone, S. and Nencioni, A. (2012) The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J. Biol. Chem. 287, 40924-40937.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 40924-40937
-
-
Bauer, I.1
Grozio, A.2
Lasigliè, D.3
Basile, G.4
Sturla, L.5
Magnone, M.6
Sociali, G.7
Soncini, D.8
Caffa, I.9
Poggi, A.10
Zoppoli, G.11
Cea, M.12
Feldmann, G.13
Mostoslavsky, R.14
Ballestrero, A.15
Patrone, F.16
Bruzzone, S.17
Nencioni, A.18
-
84
-
-
84878550317
-
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
-
Khongkow, M., Olmos, Y., Gong, C., Gomes, A. R., Monteiro, L. J., Yagüe, E., Cavaco, T. B., Khongkow, P., Man, E. P., Laohasinnarong, S., Koo, C. Y., Harada-Shoji, N., Tsang, J. W., Coombes, R. C., Schwer, B., Khoo, U. S. and Lam, E. W. (2013) SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer. Carcinogenesis. 34, 1476-1486.
-
(2013)
Carcinogenesis
, vol.34
, pp. 1476-1486
-
-
Khongkow, M.1
Olmos, Y.2
Gong, C.3
Gomes, A.R.4
Monteiro, L.J.5
Yagüe, E.6
Cavaco, T.B.7
Khongkow, P.8
Man, E.P.9
Laohasinnarong, S.10
Koo, C.Y.11
Harada-Shoji, N.12
Tsang, J.W.13
Coombes, R.C.14
Schwer, B.15
Khoo, U.S.16
Lam, E.W.17
-
85
-
-
33744466971
-
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
-
Ford, E., Voit, R., Liszt, G., Magin, C., Grummt, I. and Guarente, L. (2006) Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 20, 1075-1080.
-
(2006)
Genes Dev
, vol.20
, pp. 1075-1080
-
-
Ford, E.1
Voit, R.2
Liszt, G.3
Magin, C.4
Grummt, I.5
Guarente, L.6
-
86
-
-
41449083867
-
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
-
Vakhrusheva, O., Smolka, C., Gajawada, P., Kostin, S., Boettger, T., Kubin, T., Braun, T. and Bober, E. (2008) Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 102, 703-710.
-
(2008)
Circ. Res.
, vol.102
, pp. 703-710
-
-
Vakhrusheva, O.1
Smolka, C.2
Gajawada, P.3
Kostin, S.4
Boettger, T.5
Kubin, T.6
Braun, T.7
Bober, E.8
-
87
-
-
84863453769
-
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
-
Barber, M. F., Michishita-Kioi, E., Xi, Y., Tasselli, L., Kioi, M., Moqtaderi, Z., Tennen, RI., Paredes, S., Young, N. L., Chen, K., Struhl, K., Garcia, B. A., Gozani, O., Li, W. and Chua, K. F. (2012) SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 487, 114-118.
-
(2012)
Nature
, vol.487
, pp. 114-118
-
-
Barber, M.F.1
Michishita-Kioi, E.2
Xi, Y.3
Tasselli, L.4
Kioi, M.5
Moqtaderi, Z.6
Tennen, R.I.7
Paredes, S.8
Young, N.L.9
Chen, K.10
Struhl, K.11
Garcia, B.A.12
Gozani, O.13
Li, W.14
Chua, K.F.15
-
88
-
-
80052888731
-
Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase
-
Yoon, I. S., Chung, J. H., Hahm, S. H., Park, M. J., Lee, Y. R., Kang, L. W., Kim, T. S., Kim, J. and Han, Y. S. (2011) Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase. BMB Rep. 44, 529-534.
-
(2011)
BMB Rep
, vol.44
, pp. 529-534
-
-
Yoon, I.S.1
Chung, J.H.2
Hahm, S.H.3
Park, M.J.4
Lee, Y.R.5
Kang, L.W.6
Kim, T.S.7
Kim, J.8
Han, Y.S.9
-
89
-
-
84874487252
-
Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b
-
Kim, J. K., Noh, J. H., Jung, K. H., Eun, J. W., Bae, H. J., Kim, M. G., Chang, Y. G., Shen, Q., Park, W. S., Lee, J. Y., Borlak, J. and Nam, S. W. (2013) Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b. Hepatology 57, 1055-1067.
-
(2013)
Hepatology
, vol.57
, pp. 1055-1067
-
-
Kim, J.K.1
Noh, J.H.2
Jung, K.H.3
Eun, J.W.4
Bae, H.J.5
Kim, M.G.6
Chang, Y.G.7
Shen, Q.8
Park, W.S.9
Lee, J.Y.10
Borlak, J.11
Nam, S.W.12
|