Resveratrol in mammals: Effects on aging biomarkers, age-related diseases, and life span

Annals of the New York Academy of Sciences

Volumn 1290, Issue 1, 2013, Pages 67-73

  Marchal, Julia ^a   Pifferi, Fabien ^a   Aujard, Fabienne ^a  

^a MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

Antiaging strategy; Life span; Mimetic effect; Nutrition; Resveratrol

Indexed keywords

ADENYLATE KINASE; CYTOCHROME P450; MALONALDEHYDE; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHODIESTERASE INHIBITOR; PHYTOESTROGEN; PICEATANNOL; REACTIVE OXYGEN METABOLITE; RESVERATROL; SIRTUIN 1; SOMATOMEDIN C; SUPEROXIDE DISMUTASE;

AGING; AMNESIA; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CARDIOVASCULAR DISEASE; CELL CYCLE ARREST; COMPARATIVE STUDY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENZYME ACTIVATION; HEART PROTECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INSULIN RELEASE; INSULIN SENSITIVITY; ISCHEMIC HEART DISEASE; KILLIFISH; LIFESPAN; LIPID DIET; LIPID PEROXIDATION; MAMMAL; METABOLIC DISORDER; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRITION; OBESITY; OXIDATIVE STRESS; REFERENCE MEMORY; SMALL MAMMAL; WORKING MEMORY;

EID: 84880378679     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12214     Document Type: Article

References (64)

1. Gollücke, A.P. & D.A. Ribeiro. 2012. Use of grape polyphenols for promoting human health: a review of patents. Recent Pat Food Nutr. Agric. 4: 26-30.
2. Bavaresco, L. 2003. Role of viticultural factors on stilbene concentrations of grapes and wine. Drugs Exp. Clin. Res. 29: 181-187.
3. Renaud, S. & M. de Lorgeril. 1992. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339: 1523-1526.
4. Wu, J.M. et al. Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (review). Int. J. Mol. Med. 8: 3-17.
5. Pervaiz, S. & A.L. Holme. 2009. Resveratrol: its biologic targets and functional activity. Antioxid Redox Signal 11: 2851-2897.
6. Aggarwal, B.B. et al. 2004. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 24: 2783-2840.
7. Chachay, V.S. et al. 2011. Resveratrol-pills to replace a healthy diet? Br. J. Clin. Pharmacol. 72: 27-38.
8. Wood, J.G. et al. 2004. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689.
9. Yamamoto, H. et al. 2007. Sirtuin functions in health and disease. Mol. Endocrinol. 21: 1745-1755.
10. Kirkwood, T.B. 2008. Gerontology: healthy old age. Nature 455: 739-740.
11. Baur, J.A. et al. 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
12. Baur, J.A. et al. 2010. Dietary restriction: standing up for sirtuins. Science 329: 1012-1013.
13. Szkudelski, T. & K. Szkudelska. 2011. Anti-diabetic effects of resveratrol. Ann. N.Y. Acad. Sci. 1215: 34-39.
14. Marchal, J. et al. 2012. Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus. PLoS One 7: e34289.
15. Elliott, P.J. et al. 2009. Resveratrol/SRT501. Sirtuin SIRT1 activator, treatment of type 2 diabetes. Drugs Fut. 34: 291-295.
16. Vetterli, L. et al. 2011. Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J. Biol. Chem. 286: 6049-6060.
17. Poulsen, M.M. et al. 2013. High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes 62: 1186-1195.
18. Sun, C. et al. 2007. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 6: 307-319.
19. Um, J.H. et al. 2010. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 59: 554-563.
20. Heilbronn, L.K. et al. 2006. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 295: 1539-1548.
21. Civitarese, A.E. et al. 2007. Diet, energy metabolism and mitochondrial biogenesis. Curr. Opin. Clin. Nutr. Metab. Care 10: 679-687.
22. Timmers, S. et al. 2011. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 14: 612-622.
23. Tauriainen, E. et al. 2011. Distinct effects of calorie restriction and resveratrol on diet-induced obesity and fatty liver formation. J. Nutr. Metab. 2011: 525094.
24. Zheng, Y.Y. et al. 2012. Dietary agents in cancer prevention: an immunological perspective. Photochem. Photobiol. 88: 1083-1098.
25. Ramprasath, V.R. & P.J. Jones. 2010. Anti-atherogenic effects of resveratrol. Eur. J. Clin. Nutr. 64: 660-668.
26. Sharma, M. & Y.K. Gupta. 2002. Chronic treatment with trans-resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci. 71: 2489-2498.
27. Candelario-Jalil, E. et al. 2007. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J. Neuroinflam. 10:25.
28. Albani, D. et al. 2010. Neuroprotective properties of resveratrol in different neurodegenerative disorders. Biofactors 36: 370-376.
29. Harada, N. et al. 2011. Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus. J. Nutr. Biochem. 22: 1150-1159.
30. Brown, V.A. et al. 2010. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 70: 9003-9011.
31. Dal-Pan, A. et al. 2011. Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus. Age 33: 15-31.
32. Holliday, R. 2006. Food, fertility and longevity. Biogerontology 7: 139-141.
33. Juan, M.E. et al. 2005. Trans-resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J. Nutr. 135: 757-760.
34. Cuzzola, V.F. et al. 2012. Pharmacogenomic update on multiple sclerosis: a focus on actual and new therapeutic strategies. Pharmacogen. J. 12: 453-461.
35. Kennedy, D.O. et al. 2010. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am. J. Clin. Nutr. 91: 1590-1597.
36. Abraham, J. & R.W. Johnson. 2009. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Res. 12: 445-453.
37. Girbovan, C. et al. 2012. Repeated resveratrol administration confers lasting protection against neuronal damage but induces dose-related alterations of behavioral impairments after global ischemia. Behav. Pharmacol. 23: 1-13.
38. Gacar, N. et al. 2011. Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats. Pharmacol. Biochem. Behav. 99: 316-323.
39. Joseph, J.A. et al. 2008. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J. Agric. Food Chem. 56: 10544-10551.
40. Dal-Pan, A. et al. 2011. Cognitive performances are selectively enhanced during chronic caloric restriction or resveratrol supplementation in a primate. PLoS One 6: e16581.
41. Kasdallah-Grissa, A. et al. 2006. Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver. Life Sci. 80: 1033-1039.
42. Mokni, M. et al. 2007. Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rats. Neurochem. Res. 32: 981-987.
43. Baur, J.A. & D.A. Sinclair. 2006. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5: 493-506.
44. Csiszar, A. et al. 2008. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am. J. Physiol. Heart Circ. Physiol. 294: H2721-H2735.
45. Delmas, D. et al. 2011. Resveratrol, a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastrophe. Curr. Med. Chem. 18: 1100-1121.
46. Piotrowska, H. et al. 2011. Biological activity of piceatannol: leaving the shadow of resveratrol. Mutat. Res. 750: 60-82.
47. Alvira, D. et al. 2007. Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons. Neuroscience 147: 746-756.
48. Howitz, K.T. et al. 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.
49. Bass, T.M. et al. 2007. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 128: 546-552.
50. Terzibasi, E. et al. 2006. The short-lived fish Nothobranchius furzeri as a new model system for aging studies. Exp. Gerontol. 42: 81-89.
51. Hector, K.L. et al. 2012. The effect of resveratrol on longevity across species: a meta-analysis. Biol. Lett. 8: 790-793.
52. Pearson, K.J. et al. 2008. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8: 157-168.
53. Miller, R.A. et al. 2011. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J. Gerontol. A. Biol. Sci. Med. Sci. 66: 191-201.
54. Strong, R. et al. 2012. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J. Gerontol. A. Biol. Sci. Med. Sci. 68: 6-16.
55. Smith, D.L. et al. 2010. Calorie restriction: what recent results suggest for the future of ageing research. Eur J Clin Invest. 40: 440-450.
56. Colman, R.J. et al. 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325: 201-204.
57. Mattison, J.A. et al. 2012. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489: 318-321.
58. Ferguson, M. et al. 2008. Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restriction. Exp. Gerontol. 43: 757-763.
59. Liao, C.Y. et al. 2010. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 9: 92-95.
60. Hu, Y. et al. 2011. The controversial links among calorie restriction, SIRT1, and resveratrol. Free Radic. Biol. Med. 15; 51: 250-256.
61. Houtkooper R.H. et al. 2012. Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell. Biol 13: 225-238.
62. Burnett, C. et al. 2011. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477: 482-485.
63. Viswanathan, M. & L. Guarente. 2011. Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 477: E1-E2.
64. Park, S.J. et al. 2012. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148: 421-433.