Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer

Oncogene

Volumn 30, Issue 35, 2011, Pages 3784-3791

  Gill, R K ^a   Yang, S H ^a   Meerzaman, D ^b   Mechanic, L E ^a   Bowman, E D ^a   Jeon, H S ^a   Roy Chowdhuri, S ^b   Shakoori, A ^a   Dracheva, T ^a   Hong, K M ^b,c   Fukuoka, J ^a   Zhang, J H ^b   Harris, C C ^a   Jen, J ^d  

^a Laboratory of Human Carcinogenesis   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c National Cancer Center   (South Korea)

^d MAYO CLINIC   (United States)

Author keywords

CISH; homozygous deletion; LKB1 gene; LOH; mutation; primary lung cancer

Indexed keywords

TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN LKB 1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHROMOGENIC IN SITU HYBRIDIZATION; CHROMOSOME 19P; CLINICAL FEATURE; ETHNICITY; FEMALE; GENE DELETION; GENE LOCUS; GENETIC ASSOCIATION; HETEROZYGOSITY LOSS; HOMOZYGOSITY; HUMAN; IN SITU HYBRIDIZATION; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; PRIORITY JOURNAL; SOMATIC MUTATION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; GENE DELETION; HOMOZYGOTE; HUMANS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES;

MAMMALIA;

EID: 80052297991     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.98     Document Type: Article

References (44)

1. Alessi DR, Sakamoto K, Bayascas JR. (2006). LKB1-dependent signaling pathways. Annu Rev Biochem 75: 137-163. (Pubitemid 44118029)
2. Avizienyte E, Loukola A, Roth S, Hemminki A, Tarkkanen M, Salovaara R et al. (1999). LKB1 somatic mutations in sporadic tumors. Am J Pathol 154: 677-681. (Pubitemid 29122586)
3. Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE et al. (1998). Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. Cancer Res 58: 2087-2090. (Pubitemid 28232890)
4. Bignell GR, Barfoot R, Seal S, Collins N, Warren W, Stratton MR. (1998). Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res 58: 1384-1386. (Pubitemid 28193595)
5. Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A et al. (1995). Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nat Genet 11: 210-212.
6. Carretero J, Medina PP, Pio R, Montuenga LM, Sanchez-Cespedes M. (2004). Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 23: 4037-4040. (Pubitemid 38747933)
7. Conde E, Suarez-Gauthier A, Garcia-Garcia E, Lopez-Rios F, Lopez-Encuentra A, Garcia-Lujan R et al. (2007). Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol 38: 1351-1360. (Pubitemid 47247478)
8. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. (2004). Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 18: 1533-1538. (Pubitemid 38868905)
9. Davies H, Hunter C, Smith R, Stephens P, Greenman C, Bignell G et al. (2005). Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 65: 7591-7595. (Pubitemid 41297230)
10. Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K et al. (2008). Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455: 1069-1075.
11. Gill RK, Vazquez MF, Kramer A, Hames M, Zhang L, Heselmeyer-Haddad K et al. (2008). The use of genetic markers to identify lung cancer in fine needle aspiration samples. Clin Cancer Res 14: 7481-7487.
12. Glaros S, Cirrincione GM, Palanca A, Metzger D, Reisman D. (2008). Targeted knockout of BRG1 potentiates lung cancer development. Cancer Res 68: 3689-3696.
13. Guldberg P, thor Straten P, Ahrenkiel V, Seremet T, Kirkin AF, Zeuthen J. (1999). Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. Oncogene 18: 1777-1780. (Pubitemid 29137469)
14. Gurumurthy S, Hezel AF, Sahin E, Berger JH, Bosenberg MW, Bardeesy N. (2008). LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res 68: 55-63. (Pubitemid 351380105)
15. Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E et al. (1996). DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353.
16. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP et al. (2003). Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2: 28.
17. Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A et al. (1998). A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391: 184-187. (Pubitemid 28092478)
18. Inoki K, Zhu T, Guan KL. (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590. (Pubitemid 37506046)
19. Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H. (2009). LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev 89: 777-798.
20. Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P et al. (2007). LKB1 modulates lung cancer differentiation and metastasis. Nature 448: 807-810. (Pubitemid 47266337)
21. Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N et al. (2006). Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol 26: 8217-8227. (Pubitemid 44748559)
22. Koivunen JP, Kim J, Lee J, Rogers AM, Park JO, Zhao X et al. (2008). Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. Br J Cancer 99: 245-252.
23. Launonen V. (2005). Mutations in the human LKB1/STK11 gene. Hum Mutat 26: 291-297. (Pubitemid 41361795)
24. Levin NA, Brzoska PM, Warnock ML, Gray JW, Christman MF. (1995). Identification of novel regions of altered DNA copy number in small cell lung tumors. Genes Chromosomes Cancer 13: 175-185.
25. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947. (Pubitemid 27148818)
26. Lim W, Hearle N, Shah B, Murday V, Hodgson SV, Lucassen A et al. (2003). Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. Br J Cancer 89: 308-313. (Pubitemid 36976321)
27. Lukeis R, Irving L, Garson M, Hasthorpe S. (1990). Cytogenetics of non-small cell lung cancer: analysis of consistent non-random abnormalities. Genes Chromosomes Cancer 2: 116-124. (Pubitemid 20314570)
28. Luukko K, Ylikorkala A, Tiainen M, Makela TP. (1999). Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech Dev 83: 187-190. (Pubitemid 29302094)
29. Matsumoto S, Iwakawa R, Takahashi K, Kohno T, Nakanishi Y, Matsuno Y et al. (2007). Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 26: 5911-5918.
30. Mechanic LE, Marrogi AJ, Welsh JA, Bowman ED, Khan MA, Enewold L et al. (2005). Polymorphisms in XPD and TP53 and mutation in human lung cancer. Carcinogenesis 26: 597-604. (Pubitemid 41214149)
31. Medina PP, Romero OA, Kohno T, Montuenga LM, Pio R, Yokota J et al. (2008). Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines. Hum Mutat 29: 617-622. (Pubitemid 351614585)
32. Rowan A, Bataille V, MacKie R, Healy E, Bicknell D, Bodmer W et al. (1999). Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas. J Invest Dermatol 112: 509-511. (Pubitemid 29171943)
33. Sanchez-Cespedes M, Ahrendt SA, Piantadosi S, Rosell R, Monzo M, Wu L et al. (2001). Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Cancer Res 61: 1309-1313. (Pubitemid 34292548)
34. Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM et al. (2002). Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 62: 3659-3662. (Pubitemid 34728843)
35. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA et al. (2004a). The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6: 91-99. (Pubitemid 38903165)
36. Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA et al. (2004b). The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101: 3329-3335. (Pubitemid 38338195)
37. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA et al. (2005). The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646. (Pubitemid 41780780)
38. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH et al. (1997). Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356-362. (Pubitemid 27147102)
39. Virmani AK, Fong KM, Kodagoda D, McIntire D, Hung J, Tonk V et al. (1998). Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types. Genes Chromosomes Cancer 21: 308-319. (Pubitemid 28165038)
40. Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I. (1998). Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. Am J Pathol 153: 363-366. (Pubitemid 28373647)
41. Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T et al. (2009). Somatic LKB1 mutations promote cervical cancer progression. PLoS One 4: e5137.
42. Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D et al. (2003). LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13: 2004-2008. (Pubitemid 37425212)
43. Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI. (2008). The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res 68: 740-748. (Pubitemid 351206750)
44. Zhong D, Guo L, de Aguirre I, Liu X, Lamb N, Sun SY et al. (2006). LKB1 mutation in large cell carcinoma of the lung. Lung Cancer 53: 285-294. (Pubitemid 44189563)